iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Stu-112676

Ensembl Protein ID

PGSC0003DMT400069532

UniProt Accession

M1CKM2; M1CKM2_SOLTU

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PGSC0003DMG401027032	PGSC0003DMT400069531	PGSC0003DMT400069531
PGSC0003DMG401027032	PGSC0003DMT400069532	PGSC0003DMT400069532

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	1.90e-123	412.9	128	434
E3 adaptor/Cullin RING/DCX/DWD	1.30e-23	83.3	312	351
UBD/Beta-Prp	5.60e-40	138.6	258	430

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 2    ekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkv 89
           e+ ldap+l dd+ylnLldW+s+nvl++aLgs+vylw+a++g+ s+l  + ee+  vtsv+w ++g ++a+G +++ v+++D+++++ +
   Q: 128  ERTLDAPDLVDDYYLNLLDWGSSNVLSIALGSTVYLWDASDGATSELVTVdEEHGPVTSVKWAPDGRHIALGLNNSDVQLWDTTANRLL 216
           689***********************************************888899********************************* PP
   S: 90   rtl.tghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse......P 171
           rt+  gh +rvgaL+Wn++vl++G+ dg+i  +dvrv+   ++t+q+h+qevCGlkw+ ++++LasGGnDn +++wd s  +       
   Q: 217  RTMrGGHRSRVGALDWNNHVLTTGGMDGQIINNDVRVRSPIVDTYQGHHQEVCGLKWSASGQQLASGGNDNLLHIWDRSMASsntsteW 305
           ***889***********************************************************************876655566668 PP
   S: 172  lkkfkehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskv 260
           l++ ++h+aavka+aw+P+q++lLasGGG  Dr ikfwnt tga+l++idtgsqvc llw k+++el+s+hGf++n++tlwkyps+ k 
   Q: 306  LHRLEDHTAAVKALAWCPFQSNLLASGGGGGDRSIKFWNTHTGACLNSIDTGSQVCALLWNKNERELLSSHGFTKNQLTLWKYPSMVKT 394
           9999************************************************************************************* PP
   S: 261  aelkgheaRvlslalspdgeaivtaagDetlrfwklfdkk 300
           ael+gh++Rvl +a spdg ++++aagDetlrfw++f + 
   Q: 395  AELTGHTSRVLFMAQSPDGCTVASAAGDETLRFWNVFGTP 434
           *************************************875 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGs..dDgtikvWDlrtgvll 36
           Ht+ v +la+   +++ll+sG+  +D +ik W+++tg +l
   Q: 312  HTAAVKALAWcpfQSNLLASGGggGDRSIKFWNTHTGACL 351
           9***********8559****5555*************997 PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgkilvtgseDrtikvwdls......tgkcvhtlkghedsvlslsfsp.sgdklvsG..shdrtirvwdle 124
           + +++gh +ev  +k+s +g+ l++g++D+++++wd s      + + +h l+ h++ v +l+++p +++ l+sG  + dr i+ w+++
   Q: 258  VDTYQGHHQEVCGLKWSASGQQLASGGNDNLLHIWDRSmassntSTEWLHRLEDHTAAVKALAWCPfQSNLLASGggGGDRSIKFWNTH 346
           45677888888888888888888888888888888666666666777888888888888888888866688888622468888888888 PP
   S: 125  tgqcleetlsghdgvvncvvvhpdg.nllvs.GslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           tg cl+++++g +  v+ + +++++  ll s G++ +++ lW+ +++    +ltg ht++v  ++ +++g  ++s++ d t+++w++
   Q: 347  TGACLNSIDTGSQ--VCALLWNKNErELLSShGFTKNQLTLWKYPSMVKTAELTG-HTSRVLFMAQSPDGCTVASAAGDETLRFWNV 430
           8888887777777..7777777777544443577888888888877777777787.8888888888888888888888888888876 PP

Organism

Solanum tuberosum

Protein Sequence
(Fasta)

MDAGSLSSVS ASKTKSRCPL QEQYLQKRNS RENLDRFIPN RSAMDMDYAH YMLTEGRKGK 60
ENPAVDSPSR EAYRKQLAET FNMNRTRILA FKNKPPTSVE AIPNDFSSSV HQQAKTAKPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAATTTTAA TCATCATCTT TGTTTGCAGG ACACAACTCG GGTCCCTCCA TCTTCTTCTT 60
CTCTCTCTTC TTAAGCGAAC CCGCAAGCGC ACTTCCAACT TACTTGCTTT AATTTGTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

KEGG

sot:102581964

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001545	Ailuropoda melanoleuca	45.06	2.00e-102	364.00
IUUC-Aly-006253	Arabidopsis lyrata	78.12	0.00e+00	770.00
IUUC-Ath-006795	Arabidopsis thaliana	78.34	0.00e+00	773.00
IUUC-Bol-015368	Brassica oleracea	78.83	0.00e+00	765.00
IUUC-Cja-019132	Callithrix jacchus	45.29	1.00e-103	369.00
IUUC-Cpo-022223	Cavia porcellus	44.83	4.00e-94	337.00
IUUC-Csa-023666	Chlorocebus sabaeus	45.06	7.00e-103	366.00
IUUC-Cin-025675	Ciona intestinalis	48.41	4.00e-109	387.00
IUUC-Cme-027234	Cyanidioschyzon merolae	45.68	2.00e-102	365.00
IUUC-Dse-031391	Dothistroma septosporum	48.25	2.00e-93	335.00
IUUC-Ete-032387	Echinops telfairi	40.92	3.00e-91	327.00
IUUC-Fca-036346	Felis catus	42.93	2.00e-88	318.00
IUUC-Gga-040790	Gallus gallus	45.83	2.00e-108	385.00
IUUC-Gac-041431	Gasterosteus aculeatus	42.18	3.00e-96	344.00
IUUC-Ggo-045052	Gorilla gorilla	44.83	1.00e-102	365.00
IUUC-Hsa-046305	Homo sapiens	44.83	1.00e-102	365.00
IUUC-Hvu-047565	Hordeum vulgare	73.91	0.00e+00	681.00
IUUC-Itr-048461	Ictidomys tridecemlineatus	44.80	7.00e-95	339.00
IUUC-Lch-050174	Latimeria chalumnae	40.57	6.00e-84	303.00
IUUC-Loc-052638	Lepisosteus oculatus	40.96	1.00e-87	315.00
IUUC-Lma-052998	Leptosphaeria maculans	46.34	1.00e-93	335.00
IUUC-Mcc-054948	Macaca mulatta	45.06	7.00e-103	366.00
IUUC-Mga-060102	Meleagris gallopavo	45.83	1.00e-108	385.00
IUUC-Mmr-061615	Microcebus murinus	45.29	4.00e-103	367.00
IUUC-Mac-064861	Musa acuminata	75.56	0.00e+00	694.00
IUUC-Mpu-066502	Mustela putorius furo	45.70	6.00e-104	369.00
IUUC-Nle-070149	Nomascus leucogenys	44.83	6.00e-101	360.00
IUUC-Ont-071660	Oreochromis niloticus	45.12	4.00e-96	343.00
IUUC-Ola-086907	Oryzias latipes	45.70	2.00e-96	345.00
IUUC-Pan-091845	Papio anubis	45.06	7.00e-103	366.00
IUUC-Psi-093188	Pelodiscus sinensis	43.82	2.00e-105	375.00
IUUC-Pma-094187	Petromyzon marinus	45.52	7.00e-98	349.00
IUUC-Pno-094809	Phaeosphaeria nodorum	47.24	3.00e-94	338.00
IUUC-Pab-098603	Pongo abelii	45.06	8.00e-103	366.00
IUUC-Pop-098890	Populus trichocarpa	82.89	0.00e+00	764.00
IUUC-Pte-104142	Pyrenophora teres	45.71	3.00e-93	335.00
IUUC-Pyt-104693	Pyrenophora triticirepentis	45.71	3.00e-93	334.00
IUUC-Sja-107919	Schizosaccharomyces japonicus	48.08	1.00e-92	332.00
IUUC-Sit-110032	Setaria italica	74.72	0.00e+00	667.00
IUUC-Sly-111025	Solanum lycopersicum	98.02	0.00e+00	865.00
IUUC-Ssc-115710	Sus scrofa	44.83	5.00e-102	363.00
IUUC-Tru-118184	Takifugu rubripes	42.26	2.00e-89	321.00
IUUC-Tni-120474	Tetraodon nigroviridis	44.09	7.00e-93	333.00
IUUC-Tca-120949	Theobroma cacao	83.74	0.00e+00	815.00
IUUC-Ttr-128511	Tursiops truncatus	44.60	1.00e-101	362.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence