iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sja-107940

Ensembl Protein ID

EEB06499

UniProt Accession

B6JY81; B6JY81_SCHJY

Genbank Protein ID

EEB06499.1

Protein Name

Cullin 4

Genbank Nucleotide ID

KE651168

Gene Name

SJAG_01540

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SJAG_01540	EEB06499	EEB06499

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	5.30e-117	390.0	45	630

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 14   svkkeyeelytavynlclskvgaklYkklkevleefikqvkkkveesedeq...lLktynreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldl 111
            +++ y+ely +v+nl+ +   +   + l   +++ i+++k+   +s   +     k+++++W++++e ++ +++if y+dr y  +    +++ ++++ l
   Q: 45   GLNSGYQELYVGVQNLVRAGQTESCLELLLRHCQKGIAELKELALASISTAvdeSCKAVIHCWRQWTERIELIHNIFYYMDRAYLIRVAGQTSILEFSVSL 145
           45788***************999999999999999999999998888765512358999****************************9999********** PP
   S: 112  wrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeer 210
           +r+++++   i+   l++l  l e++R+g++vd+ ll+++ ++l     ++ ++  + F   +l + +  y+  s++ lq+  +de+l + e  l+ ee+ 
   Q: 146  FRDDFMSFdeIRVPFLNQLTSLFEQLRNGNNVDKTLLKDASKML-----QQTHLFDKLFFPMYLCSLETNYTSASQAELQKVPLDEFLLYIERCLKHEEDI 241
           ****988778*********************************3.....5568999999999*************************************** PP
   S: 211  aaryleestetkLlevvekeliakhlesllaelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknkl 311
           ++++     +  + +v++++l+++h+ s++++l+  + + kt+  + +y Ll+rv + ++ l++ +++ i   g+ ++ +++++++    + +lle++  l
   Q: 242  VHEMFADNVLVDVNAVLDRCLVSQHISSMTPGLKDFVLKRKTDSCKSLYTLLKRVDE-TKLLCDPWSQGIVALGSSLVNDPNHDDS---LISELLEIHIFL 338
           *******************************************************87.589**********************999...************ PP
   S: 312  qklvseaFnndakFlkaldkafetfvnknsvlkaakspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksass 412
           ++++++aF  d++   +++k+fetf+   + +++ k +EllA+yiD+l+r++   + ++  ++   ++l +f+y+ +kdvFe++Yk++ akRLl++ksa  
   Q: 339  KDVLKHAFLGDEALSYSMRKSFETFLSSLPSTRREKPAELLAKYIDHLMRSTKSVVGNNTFDNVCAELLDIFRYLPNKDVFEAFYKRDVAKRLLLNKSANT 439
           ****************************************************99999999***************************************** PP
   S: 413  eaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqW 513
           + E++++e Lke+cg  ft+ Le+Mf+d+  S+d  + Fk  +++   s + +l v+vLs  +Wpt+++t  ++LP+ele  +++f++fYl++++ R+L W
   Q: 440  DNERKLLEMLKEKCGSTFTHSLEGMFKDVDFSKDFSKSFK--ESKFGRSLHYDLFVNVLSLAYWPTYPDTT-ITLPPELETDLDIFKNFYLSQQTARRLAW 537
           ****************************************..9999*********************9977.***************************** PP
   S: 514  qhtlgraelkaelkkgkyelqVstfQmavLLafnns..ekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
              l+ + lkae+  g +el Vs fQ++vLL+fn+   e +s+ +++k t+l++++L+rtlqsL + + + l ++p+s+ i++e+ f  Nq+f
   Q: 538  RPALCYCLLKAEFPSGSKELSVSLFQACVLLLFNDVgdEGLSYVDIQKRTQLNDNDLTRTLQSLCCAHVRPLLMQPKSRRITKEHRFFYNQHF 630
           ***********************************98899**************************998999*******************98 PP

Organism

Schizosaccharomyces japonicus

Protein Sequence
(Fasta)

MQGKVKKIVV RGFDPKKTKE RQENYYHDTL KKLDVALSVI MSGLGLNSGY QELYVGVQNL 60
VRAGQTESCL ELLLRHCQKG IAELKELALA SISTAVDESC KAVIHCWRQW TERIELIHNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGCAATAT GGACACTCAA CCCCACTAAG ATAAAAATAA ACTTATCTTC TTATCTGTTC 60
TATCAGCAAT TCCAAGAAAA CTAACACTCG GCAGGGAAGA ACACAGAAGG AGTAGGCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0000781--C:chromosome, telomeric region
GO:0043494--C:CLRC ubiquitin ligase complex
GO:0008180--C:COP9 signalosome
GO:0005829--C:cytosol
GO:0034613--P:cellular protein localization
GO:0030702--P:chromatin silencing at centromere
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0031048--P:chromatin silencing by small RNA
GO:0031507--P:heterochromatin assembly
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051446--P:positive regulation of meiotic cell cycle
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051570--P:regulation of histone H3-K9 methylation
GO:0006283--P:transcription-coupled nucleotide-excision repair

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000285	Aegilops tauschii	35.36	2.00e-118	418.00
IUUC-Aml-002062	Ailuropoda melanoleuca	34.25	4.00e-120	423.00
IUUC-Atr-002727	Amborella trichopoda	33.42	4.00e-106	377.00
IUUC-Apl-004157	Anas platyrhynchos	34.06	2.00e-118	418.00
IUUC-Aca-004430	Anolis carolinensis	33.70	2.00e-118	417.00
IUUC-Aly-006547	Arabidopsis lyrata	33.89	6.00e-107	379.00
IUUC-Ath-006748	Arabidopsis thaliana	34.09	2.00e-106	378.00
IUUC-Acl-008359	Aspergillus clavatus	34.27	2.00e-107	381.00
IUUC-Afl-008567	Aspergillus flavus	33.77	1.00e-112	399.00
IUUC-Afu-008833	Aspergillus fumigatus	34.11	2.00e-109	388.00
IUUC-Ani-009373	Aspergillus nidulans	34.66	1.00e-116	412.00
IUUC-Ang-009622	Aspergillus niger	34.70	3.00e-117	414.00
IUUC-Aor-010241	Aspergillus oryzae	34.06	9.00e-113	399.00
IUUC-Ate-010251	Aspergillus terreus	34.74	5.00e-117	413.00
IUUC-Ame-011580	Astyanax mexicanus	34.29	1.00e-117	415.00
IUUC-Bgr-012219	Blumeria graminis	32.44	8.00e-100	356.00
IUUC-Bta-013244	Bos taurus	34.24	7.00e-120	422.00
IUUC-Bci-013744	Botrytis cinerea	35.05	8.00e-99	352.00
IUUC-Bdi-014223	Brachypodium distachyon	35.12	1.00e-117	415.00
IUUC-Bra-018012	Brassica rapa	33.85	5.00e-109	386.00
IUUC-Cel-018369	Caenorhabditis elegans	28.81	7.00e-61	226.00
IUUC-Cja-019180	Callithrix jacchus	34.24	8.00e-120	422.00
IUUC-Cfa-021189	Canis familiaris	34.24	3.00e-119	421.00
IUUC-Cpo-021928	Cavia porcellus	34.11	8.00e-119	419.00
IUUC-Cre-022739	Chlamydomonas reinhardtii	31.00	2.00e-81	295.00
IUUC-Csa-023831	Chlorocebus sabaeus	34.24	6.00e-120	423.00
IUUC-Cho-024899	Choloepus hoffmanni	37.55	7.00e-98	349.00
IUUC-Cin-025727	Ciona intestinalis	34.63	1.00e-105	375.00
IUUC-Csv-026117	Ciona savignyi	29.83	6.00e-102	363.00
IUUC-Cgl-026761	Colletotrichum gloeosporioides	34.03	3.00e-113	400.00
IUUC-Cne-027026	Cryptococcus neoformans	28.00	1.00e-69	255.00
IUUC-Dre-027916	Danio rerio	34.20	6.00e-116	409.00
IUUC-Dno-029483	Dasypus novemcinctus	33.77	9.00e-111	392.00
IUUC-Dor-030698	Dipodomys ordii	33.42	3.00e-109	387.00
IUUC-Dse-031159	Dothistroma septosporum	30.92	6.00e-96	343.00
IUUC-Dme-031652	Drosophila melanogaster	35.56	4.00e-115	406.00
IUUC-Ete-033101	Echinops telfairi	32.82	5.00e-104	369.00
IUUC-Eca-033952	Equus caballus	34.24	1.00e-119	422.00
IUUC-Eeu-034767	Erinaceus europaeus	35.66	2.00e-112	397.00
IUUC-Fca-036211	Felis catus	34.81	4.00e-120	423.00
IUUC-Fal-037248	Ficedula albicollis	34.11	5.00e-119	419.00
IUUC-Fox-037854	Fusarium oxysporum	33.16	5.00e-103	367.00
IUUC-Fso-038138	Fusarium solani	33.38	1.00e-108	385.00
IUUC-Gmo-038754	Gadus morhua	34.15	4.00e-117	413.00
IUUC-Ggr-040003	Gaeumannomyces graminis	34.07	3.00e-97	347.00
IUUC-Gga-041002	Gallus gallus	34.11	5.00e-119	420.00
IUUC-Gac-041555	Gasterosteus aculeatus	33.74	5.00e-114	403.00
IUUC-Gma-043960	Glycine max	33.61	7.00e-113	399.00
IUUC-Ggo-045468	Gorilla gorilla	34.14	6.00e-115	406.00
IUUC-Hsa-046848	Homo sapiens	34.24	6.00e-120	422.00
IUUC-Itr-048365	Ictidomys tridecemlineatus	34.38	2.00e-120	424.00
IUUC-Lch-050417	Latimeria chalumnae	34.66	2.00e-119	421.00
IUUC-Lpe-051446	Leersia perrieri	35.06	2.00e-117	414.00
IUUC-Loc-051804	Lepisosteus oculatus	33.70	4.00e-114	403.00
IUUC-Lma-053080	Leptosphaeria maculans	31.78	2.00e-106	378.00
IUUC-Laf-053701	Loxodonta africana	34.02	2.00e-118	417.00
IUUC-Mcc-055538	Macaca mulatta	34.02	1.00e-118	418.00
IUUC-Mor-057102	Magnaporthe oryzae	31.96	1.00e-103	369.00
IUUC-Mpo-057342	Magnaporthe poae	34.09	3.00e-97	347.00
IUUC-Mla-058936	Melampsora laricipopulina	30.72	5.00e-70	256.00
IUUC-Mga-059754	Meleagris gallopavo	34.06	1.00e-118	418.00
IUUC-Mvi-060455	Microbotryum violaceum	33.20	6.00e-99	353.00
IUUC-Mmr-060870	Microcebus murinus	34.11	1.00e-118	419.00
IUUC-Mdo-062015	Monodelphis domestica	33.88	2.00e-116	411.00
IUUC-Mmu-063751	Mus musculus	34.24	7.00e-120	422.00
IUUC-Mac-064443	Musa acuminata	33.80	4.00e-116	410.00
IUUC-Mpu-065903	Mustela putorius furo	34.24	2.00e-119	421.00
IUUC-Mlu-068213	Myotis lucifugus	34.24	3.00e-120	424.00
IUUC-Nfi-068363	Neosartorya fischeri	34.91	8.00e-113	399.00
IUUC-Ncr-068950	Neurospora crassa	33.81	7.00e-105	373.00
IUUC-Nle-069480	Nomascus leucogenys	34.24	6.00e-120	423.00
IUUC-Ont-071562	Oreochromis niloticus	33.56	2.00e-112	397.00
IUUC-Oan-073607	Ornithorhynchus anatinus	34.24	2.00e-119	421.00
IUUC-Ocu-074446	Oryctolagus cuniculus	34.24	1.00e-119	422.00
IUUC-Oba-075198	Oryza barthii	35.20	3.00e-118	417.00
IUUC-Obr-076095	Oryza brachyantha	35.48	3.00e-119	420.00
IUUC-Ogl-077032	Oryza glaberrima	35.20	3.00e-118	417.00
IUUC-Ogu-078051	Oryza glumaepatula	35.20	2.00e-118	417.00
IUUC-Oin-079399	Oryza indica	38.37	2.00e-110	390.00
IUUC-Olo-080988	Oryza longistaminata	35.47	2.00e-118	418.00
IUUC-Ome-081600	Oryza meridionalis	35.10	5.00e-118	416.00
IUUC-Oni-082623	Oryza nivara	35.24	2.00e-118	418.00
IUUC-Opu-083762	Oryza punctata	35.27	2.00e-116	411.00
IUUC-Oru-084499	Oryza rufipogon	35.20	3.00e-118	417.00
IUUC-Ola-087101	Oryzias latipes	33.42	1.00e-112	398.00
IUUC-Olu-087650	Ostreococcus lucimarinus	32.95	2.00e-91	327.00
IUUC-Oga-088416	Otolemur garnettii	33.97	3.00e-115	407.00
IUUC-Oar-090230	Ovis aries	34.24	1.00e-119	422.00
IUUC-Ptr-091153	Pan troglodytes	34.24	6.00e-120	423.00
IUUC-Pan-091729	Papio anubis	34.24	6.00e-120	423.00
IUUC-Psi-093773	Pelodiscus sinensis	34.15	5.00e-119	420.00
IUUC-Pma-094678	Petromyzon marinus	31.70	9.00e-83	299.00
IUUC-Pno-094946	Phaeosphaeria nodorum	32.53	9.00e-93	332.00
IUUC-Ppa-095688	Physcomitrella patens	34.76	4.00e-115	406.00
IUUC-Pfo-097037	Poecilia formosa	33.47	1.00e-110	392.00
IUUC-Pab-097622	Pongo abelii	34.17	4.00e-113	400.00
IUUC-Pca-100391	Procavia capensis	41.30	9.00e-87	312.00
IUUC-Ppe-101142	Prunus persica	33.42	2.00e-110	391.00
IUUC-Pva-102995	Pteropus vampyrus	38.14	6.00e-98	350.00
IUUC-Pgr-103334	Puccinia graminis	29.83	9.00e-73	266.00
IUUC-Ptt-103903	Puccinia triticina	36.42	4.00e-70	257.00
IUUC-Pte-104167	Pyrenophora teres	32.94	1.00e-107	382.00
IUUC-Pyt-104736	Pyrenophora triticirepentis	32.16	2.00e-106	377.00
IUUC-Rno-106119	Rattus norvegicus	34.24	6.00e-120	423.00
IUUC-Sha-106958	Sarcophilus harrisii	33.70	4.00e-116	410.00
IUUC-Spo-108109	Schizosaccharomyces pombe	48.23	0.00e+00	710.00
IUUC-Ssl-108537	Sclerotinia sclerotiorum	34.21	1.00e-97	348.00
IUUC-Smo-109313	Selaginella moellendorffii	34.69	2.00e-118	417.00
IUUC-Sit-110626	Setaria italica	34.09	1.00e-114	405.00
IUUC-Sly-111497	Solanum lycopersicum	34.03	2.00e-115	407.00
IUUC-Sar-113581	Sorex araneus	33.03	2.00e-84	304.00
IUUC-Sbi-113931	Sorghum bicolor	34.23	5.00e-115	406.00
IUUC-Sre-114943	Sporisorium reilianum	38.57	1.00e-86	312.00
IUUC-Ssc-116133	Sus scrofa	33.52	1.00e-108	385.00
IUUC-Tgu-116462	Taeniopygia guttata	33.97	1.00e-118	419.00
IUUC-Tru-118299	Takifugu rubripes	33.70	9.00e-116	409.00
IUUC-Tsy-119517	Tarsius syrichta	43.84	1.00e-82	298.00
IUUC-Tni-119798	Tetraodon nigroviridis	33.42	2.00e-110	391.00
IUUC-Tre-121907	Trichoderma reesei	34.36	4.00e-110	390.00
IUUC-Tvi-122568	Trichoderma virens	34.06	2.00e-108	384.00
IUUC-Tae-123442	Triticum aestivum	35.08	3.00e-118	417.00
IUUC-Tur-126032	Triticum urartu	35.22	4.00e-118	416.00
IUUC-Tme-127162	Tuber melanosporum	34.82	2.00e-115	407.00
IUUC-Tbe-127658	Tupaia belangeri	33.83	2.00e-113	401.00
IUUC-Ttr-128326	Tursiops truncatus	31.71	2.00e-93	335.00
IUUC-Uma-129531	Ustilago maydis	33.23	2.00e-75	275.00
IUUC-Vda-129701	Verticillium dahliae	34.49	7.00e-115	406.00
IUUC-Vpa-130217	Vicugna pacos	31.62	2.00e-83	302.00
IUUC-Vvi-131133	Vitis vinifera	34.41	1.00e-113	402.00
IUUC-Xtr-132761	Xenopus tropicalis	34.92	2.00e-115	407.00
IUUC-Xma-134149	Xiphophorus maculatus	34.11	1.00e-116	412.00
IUUC-Zma-135529	Zea mays	34.25	2.00e-115	408.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence