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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046229
UUCD1 version UUC-HoS-01204
Ensembl Protein ID ENSP00000394791.2
UniProt Accession Q9P0U3; A8K7P5; Q86XC8; SENP1_HUMAN
Genbank Protein ID AAF31171.1; BAF84749.1; AAH45639.2
Protein Name Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1
Genbank Nucleotide ID AF149770; AK292060; AC074029
Gene Name SENP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000079387.13 ENST00000552189.5 ENSP00000447593.1
ENSG00000079387.13 ENST00000448372.5 ENSP00000394791.2
ENSG00000079387.13 ENST00000549595.5 ENSP00000450076.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTDGRACPDTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/ULP ULP 20457756; 15767674; 20637912; 19615980; 18854179; 17934453; 16862185
Classification
Family E-value Score Start End
DUB/ULP 3.30e-58 198.3 451 613
Active Site
Position(s) Description Evidence
603 Nucleophile N/A
Domain Profile

   DUB/ULP
   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpineaaHWslavvcf 93
           ++t++d+++L++ ++lnD+ii+fy++ +++e+ k++ ++++h+f++ff++klk+ ++++vk+wt+kvd+f+ d+++vpi+ ++HW+lavv+f
   Q: 451  TITRKDIQTLNHLNWLNDEIINFYMN-MLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDF 541
           79************************.99*************************************************************** PP
   S: 94   kkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk...vpqQkNssDCGvyvlqyves 163
           +kk+i+++DS+ g  +++++++l +yl++e+ +k+++ef+++ ++  ++k   +pqQ N+sDCG++ ++y+++
   Q: 542  RKKNITYYDSM-GGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKsqeIPQQMNGSDCGMFACKYADC 613
           ***********.********************************988877778*****************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
Protein Sequence
(Fasta)
MDDIADRMRM DAGEVTLVNH NSVFKTHLLP QTGFPEDQLS LSDQQILSSR QGHLDRSFTC 60
STRSAAYNPS YYSDNPSSDS FLGSGDLRTF GQSANGQWRN STPSSSSSLQ KSRNSRSLYL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046229|DUB,ULP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTCCGAGTA CGAGAAAGCG AAAAAGCCCA GACTGAAAAG GGTACTGAGA AATTACGACT 60
AGTCTTAAAT GCTCCCTTCG CTTCTCGGGC CTCGCCACAC CGCGCAGGCG CCCCACTGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046229|DUB,ULP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR003653--Peptidase_C48_C
IPR033387--SENP1
PROSITE

PS50600--ULP_PROTEASE
Pfam

PF02902--Peptidase_C48
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005925--C:focal adhesion
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0070139--F:SUMO-specific endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190--P:apoptotic signaling pathway
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016926--P:protein desumoylation
GO:0016925--P:protein sumoylation
GO:0006508--P:proteolysis
GO:0010724--P:regulation of definitive erythrocyte differentiation
KEGG hsa:29843
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001166 Aegilops tauschii 39.61 5.00e-39 154.00
IUUC-Aml-001885 Ailuropoda melanoleuca 93.65 0.00e+00 1173.00
IUUC-Atr-003110 Amborella trichopoda 37.97 3.00e-43 169.00
IUUC-Apl-004162 Anas platyrhynchos 69.83 0.00e+00 717.00
IUUC-Aca-005011 Anolis carolinensis 66.72 0.00e+00 796.00
IUUC-Aly-006005 Arabidopsis lyrata 34.83 6.00e-43 168.00
IUUC-Ath-007093 Arabidopsis thaliana 39.22 1.00e-42 167.00
IUUC-Ago-007930 Ashbya gossypii 30.87 2.00e-23 103.00
IUUC-Acl-008277 Aspergillus clavatus 28.51 6.00e-28 120.00
IUUC-Afu-008940 Aspergillus fumigatus 27.13 4.00e-29 124.00
IUUC-Ani-009245 Aspergillus nidulans 31.03 2.00e-32 134.00
IUUC-Ang-009510 Aspergillus niger 29.18 5.00e-27 117.00
IUUC-Ate-010312 Aspergillus terreus 33.33 1.00e-22 102.00
IUUC-Bgr-012165 Blumeria graminis 32.78 2.00e-17 84.00
IUUC-Bta-012319 Bos taurus 91.47 0.00e+00 1100.00
IUUC-Bci-013594 Botrytis cinerea 32.04 7.00e-17 82.00
IUUC-Bdi-014678 Brachypodium distachyon 40.41 7.00e-44 171.00
IUUC-Bol-015882 Brassica oleracea 34.34 1.00e-42 167.00
IUUC-Bra-017525 Brassica rapa 38.89 5.00e-44 172.00
IUUC-Cel-018426 Caenorhabditis elegans 43.86 5.00e-62 232.00
IUUC-Cja-019463 Callithrix jacchus 93.82 0.00e+00 1047.00
IUUC-Cfa-020654 Canis familiaris 93.33 0.00e+00 1123.00
IUUC-Cpo-022243 Cavia porcellus 90.22 0.00e+00 1088.00
IUUC-Cho-024917 Choloepus hoffmanni 93.03 2.00e-170 592.00
IUUC-Cin-025277 Ciona intestinalis 56.15 2.00e-62 231.00
IUUC-Csv-026222 Ciona savignyi 51.52 2.00e-61 228.00
IUUC-Cne-026848 Cryptococcus neoformans 37.56 8.00e-37 147.00
IUUC-Cme-027184 Cyanidioschyzon merolae 35.00 2.00e-39 157.00
IUUC-Dre-028702 Danio rerio 67.58 3.00e-126 446.00
IUUC-Dno-029507 Dasypus novemcinctus 90.88 0.00e+00 1079.00
IUUC-Dse-031477 Dothistroma septosporum 38.14 5.00e-11 64.30
IUUC-Dme-031646 Drosophila melanogaster 50.75 3.00e-57 218.00
IUUC-Eca-033511 Equus caballus 94.26 0.00e+00 1122.00
IUUC-Eeu-034586 Erinaceus europaeus 98.17 2.00e-133 469.00
IUUC-Fca-036580 Felis catus 93.68 0.00e+00 1091.00
IUUC-Fal-037325 Ficedula albicollis 67.83 2.00e-118 418.00
IUUC-Gmo-039275 Gadus morhua 66.13 6.00e-109 387.00
IUUC-Ggr-039948 Gaeumannomyces graminis 31.52 3.00e-17 83.60
IUUC-Gga-040844 Gallus gallus 69.67 0.00e+00 716.00
IUUC-Gac-042067 Gasterosteus aculeatus 67.72 3.00e-121 427.00
IUUC-Itr-048917 Ictidomys tridecemlineatus 92.39 0.00e+00 1073.00
IUUC-Kpa-049223 Komagataella pastoris 36.87 3.00e-31 130.00
IUUC-Lch-049483 Latimeria chalumnae 55.04 9.00e-153 534.00
IUUC-Lpe-051248 Leersia perrieri 37.39 5.00e-43 168.00
IUUC-Loc-052844 Lepisosteus oculatus 71.97 2.00e-137 483.00
IUUC-Laf-053658 Loxodonta africana 89.89 0.00e+00 1074.00
IUUC-Mcc-055432 Macaca mulatta 98.60 0.00e+00 1070.00
IUUC-Meu-055923 Macropus eugenii 71.56 0.00e+00 803.00
IUUC-Mpo-057341 Magnaporthe poae 26.78 2.00e-17 85.10
IUUC-Mtr-058174 Medicago truncatula 39.15 2.00e-38 153.00
IUUC-Mla-059033 Melampsora laricipopulina 37.98 1.00e-37 150.00
IUUC-Mga-059454 Meleagris gallopavo 68.23 0.00e+00 652.00
IUUC-Mvi-060257 Microbotryum violaceum 36.28 3.00e-37 150.00
IUUC-Mmr-061104 Microcebus murinus 92.12 0.00e+00 1058.00
IUUC-Mdo-062439 Monodelphis domestica 91.88 1.00e-164 572.00
IUUC-Mmu-063629 Mus musculus 84.78 0.00e+00 1006.00
IUUC-Mac-064839 Musa acuminata 41.35 6.00e-43 168.00
IUUC-Mpu-066790 Mustela putorius furo 91.04 0.00e+00 1083.00
IUUC-Mlu-067849 Myotis lucifugus 91.16 0.00e+00 1084.00
IUUC-Nfi-068579 Neosartorya fischeri 27.13 6.00e-29 123.00
IUUC-Nle-069931 Nomascus leucogenys 99.05 0.00e+00 1051.00
IUUC-Opr-070528 Ochotona princeps 88.08 0.00e+00 700.00
IUUC-Ont-072628 Oreochromis niloticus 53.16 4.00e-115 408.00
IUUC-Ocu-074506 Oryctolagus cuniculus 90.06 0.00e+00 1108.00
IUUC-Oba-074983 Oryza barthii 40.85 3.00e-41 162.00
IUUC-Obr-076231 Oryza brachyantha 41.86 2.00e-40 159.00
IUUC-Ogl-077509 Oryza glaberrima 38.24 4.00e-43 168.00
IUUC-Ogu-078967 Oryza glumaepatula 38.24 2.00e-43 170.00
IUUC-Oin-079674 Oryza indica 40.85 9.00e-42 164.00
IUUC-Olo-080443 Oryza longistaminata 40.85 1.00e-41 164.00
IUUC-Ome-081681 Oryza meridionalis 41.03 3.00e-42 166.00
IUUC-Oni-082881 Oryza nivara 38.17 8.00e-44 171.00
IUUC-Opu-083766 Oryza punctata 40.17 2.00e-40 160.00
IUUC-Oru-084743 Oryza rufipogon 40.85 9.00e-42 164.00
IUUC-Osa-085764 Oryza sativa 40.85 8.00e-42 164.00
IUUC-Ola-087348 Oryzias latipes 64.58 7.00e-106 376.00
IUUC-Olu-087729 Ostreococcus lucimarinus 41.38 4.00e-39 154.00
IUUC-Oga-088308 Otolemur garnettii 85.16 0.00e+00 949.00
IUUC-Oar-090004 Ovis aries 92.58 0.00e+00 1106.00
IUUC-Ptr-091310 Pan troglodytes 99.07 0.00e+00 1076.00
IUUC-Pan-092232 Papio anubis 98.74 0.00e+00 1080.00
IUUC-Psi-093705 Pelodiscus sinensis 72.45 0.00e+00 811.00
IUUC-Pma-094606 Petromyzon marinus 69.47 9.00e-97 345.00
IUUC-Ppa-095465 Physcomitrella patens 38.52 5.00e-50 192.00
IUUC-Pfo-096571 Poecilia formosa 47.55 2.00e-113 403.00
IUUC-Pab-097640 Pongo abelii 99.37 0.00e+00 1052.00
IUUC-Pop-098978 Populus trichocarpa 38.40 4.00e-36 145.00
IUUC-Pca-100611 Procavia capensis 88.65 0.00e+00 1007.00
IUUC-Pva-102437 Pteropus vampyrus 88.04 0.00e+00 991.00
IUUC-Pgr-103284 Puccinia graminis 36.04 5.00e-34 138.00
IUUC-Ptt-103854 Puccinia triticina 38.57 4.00e-08 52.40
IUUC-Rno-105520 Rattus norvegicus 88.35 0.00e+00 1045.00
IUUC-Sce-106442 Saccharomyces cerevisiae 31.86 1.00e-26 114.00
IUUC-Sha-106929 Sarcophilus harrisii 91.54 2.00e-155 541.00
IUUC-Sja-107906 Schizosaccharomyces japonicus 37.25 3.00e-52 199.00
IUUC-Spo-108221 Schizosaccharomyces pombe 39.13 5.00e-49 189.00
IUUC-Ssl-108445 Sclerotinia sclerotiorum 27.04 2.00e-18 87.00
IUUC-Smo-108869 Selaginella moellendorffii 38.40 5.00e-39 154.00
IUUC-Sly-111206 Solanum lycopersicum 40.43 3.00e-41 163.00
IUUC-Sar-113387 Sorex araneus 83.37 0.00e+00 662.00
IUUC-Sre-115071 Sporisorium reilianum 29.51 5.00e-35 143.00
IUUC-Ssc-115376 Sus scrofa 93.63 0.00e+00 1101.00
IUUC-Tgu-116621 Taeniopygia guttata 84.87 1.00e-160 559.00
IUUC-Tru-118431 Takifugu rubripes 61.40 5.00e-118 418.00
IUUC-Tsy-119028 Tarsius syrichta 72.36 0.00e+00 794.00
IUUC-Tni-120194 Tetraodon nigroviridis 63.27 3.00e-119 422.00
IUUC-Tca-121652 Theobroma cacao 38.20 5.00e-38 152.00
IUUC-Tme-126945 Tuber melanosporum 37.39 1.00e-41 165.00
IUUC-Tbe-127763 Tupaia belangeri 83.49 3.00e-163 568.00
IUUC-Uma-129373 Ustilago maydis 32.40 8.00e-39 155.00
IUUC-Vpa-130375 Vicugna pacos 89.26 0.00e+00 1002.00
IUUC-Vvi-131660 Vitis vinifera 37.45 8.00e-38 151.00
IUUC-Xtr-132587 Xenopus tropicalis 57.17 9.00e-163 566.00
IUUC-Xma-133896 Xiphophorus maculatus 51.43 1.00e-119 423.00
Created Date 25-Jun-2017

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