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Tag Content
UUCD2 ID IUUC-Dre-028140
UUCD1 version UUC-DaR-01392
Ensembl Protein ID ENSDARP00000026192.5
UniProt Accession F1QR83; F1QR83_DANRE
Genbank Protein ID ENSDARP00000026192
Protein Name NEDD8-activating enzyme E1 regulatory subunit
Genbank Nucleotide ID BX511136
Gene Name nae1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000011301.11 ENSDART00000019270.7 ENSDARP00000026192.5
ENSDARG00000011301.11 ENSDART00000168859.1 ENSDARP00000131381.1
Status Unreviewed
Classification
Family E-Value Score Start End
E1 2.10e-118 397.1 12 524
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E1

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
    YDRQ+rlwG+++qe+l++a+v+l++a++ G+E+lKnLvl G+g +t+vD+++v+ ++++++F+++ + +gk++A++a e l+eln+dv+
   Q: 12 YDRQLRLWGDHGQEALENAHVCLINATASGTEILKNLVLPGIGAFTIVDGHKVSGEDVGNNFFLSSSAIGKNRAQAATELLQELNSDVS 100
    ***************************************************************************************** PP
   S: 90 veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
    + ++ees+++l +++ Ff +f++V++ + ++++ +++ ++++a vp++ ++t+Gl+G++r i+k++t+ +s++d +++++++Pf
   Q: 101 GNFVEESPDKLLDNDCeFFHRFSLVIAVQLPESTCLRLGAVLWEAGVPFLVCRTYGLIGYMRLIVKEHTVVESHPDnvlEDLRLDQPFT 189
    **************99************************************************************************* PP
   S: 175 tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
    +lk +++ +++++++w+ +++ +le+++ e++ + +++++eke+++++ ++++ + edeenfeeai+++++a+++t
   Q: 190 ELKRHVEsydldnmekKDHSHTPWIIVVARYLEKWYNENNSQLPKNYKEKEAFRQLLREGILKnengglEDEENFEEAIKNVNTALNPT 278
    *****77777777777***********************************************9************************* PP
   S: 249 tins.ikqllksfecdivtkskspfwv.............................................................. 274
    i+s ++++++ +c+++t+++s+fwv
   Q: 279 KISSgTQDIFNAEQCENITSQSSSFWVmahgvrdfvqnegngnlpvrgsipdmiadsdkfiklqnvyrdkamrdaavvskhvemllqsv 367
    ***************************************************************************************** PP
   S: 275 .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavd 334
    fc+na+ l+v ++ +kde+++ +++p lyl+lr+++rf ++++r+pg+ ++++++d + +
   Q: 368 gktpesiseqeikLFCKNAAFLRVVrcrsladeysvDTFNKDEITSCMDSPdsemvLYLMLRSVDRFYQQHSRYPGVYNYQVEED-INK 455
    ***********************666666666666699999999999998899999*****************************.777 PP
   S: 335 lvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
    l+ + +l ++++++ +++dd+i+e++++++++ +t++a++gG aaqE+iK+++++f+p++n+fl++a+
   Q: 456 LKLCVNSLL-QEYSLNVNVKDDYIHEFCRYGAAEPHTVAAFLGGSAAQEAIKIITHQFVPFNNTFLYNAM 524
    777777776.*********************************************************997 PP
   

Organism Danio rerio
Functional Description
(View)

Functional Description



     Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.
Protein Sequence
(Fasta)
MTDPKTSKEQ KYDRQLRLWG DHGQEALENA HVCLINATAS GTEILKNLVL PGIGAFTIVD 60
GHKVSGEDVG NNFFLSSSAI GKNRAQAATE LLQELNSDVS GNFVEESPDK LLDNDCEFFH 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Dre-028140|E1,E1_ThiF|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCGATCGGA AAATAGTGAA ACAGTGGCGC GCCGGTAGGA TTCAGCCGTC ACAGAGAGAG 60
AGACAGAGGA CCATGACAGA CCCCAAAACA AGCAAAGAGC AGAAGTATGA TCGACAGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Dre-028140|E1,E1_ThiF|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000764 Aegilops tauschii 40.82 2.00e-122 432.00
IUUC-Aml-002333 Ailuropoda melanoleuca 73.13 0.00e+00 850.00
IUUC-Atr-002644 Amborella trichopoda 40.30 6.00e-113 401.00
IUUC-Apl-003446 Anas platyrhynchos 73.80 0.00e+00 814.00
IUUC-Aca-004450 Anolis carolinensis 73.38 0.00e+00 841.00
IUUC-Aly-006187 Arabidopsis lyrata 42.13 2.00e-129 456.00
IUUC-Ath-007600 Arabidopsis thaliana 41.76 4.00e-128 451.00
IUUC-Ago-007900 Ashbya gossypii 26.73 2.00e-39 157.00
IUUC-Acl-008333 Aspergillus clavatus 34.65 9.00e-81 294.00
IUUC-Afl-008529 Aspergillus flavus 36.01 1.00e-88 320.00
IUUC-Afu-009071 Aspergillus fumigatus 34.53 3.00e-82 299.00
IUUC-Ani-009443 Aspergillus nidulans 34.17 8.00e-79 288.00
IUUC-Ang-009669 Aspergillus niger 33.87 2.00e-85 310.00
IUUC-Aor-009914 Aspergillus oryzae 35.51 3.00e-86 312.00
IUUC-Ate-010450 Aspergillus terreus 34.77 1.00e-85 310.00
IUUC-Ame-011183 Astyanax mexicanus 85.37 0.00e+00 980.00
IUUC-Bgr-012111 Blumeria graminis 31.25 1.00e-59 224.00
IUUC-Bta-012583 Bos taurus 73.41 0.00e+00 852.00
IUUC-Bci-013892 Botrytis cinerea 33.02 6.00e-66 244.00
IUUC-Bdi-014592 Brachypodium distachyon 41.95 2.00e-127 449.00
IUUC-Bol-016399 Brassica oleracea 41.95 2.00e-128 452.00
IUUC-Bra-017506 Brassica rapa 40.97 7.00e-124 437.00
IUUC-Cel-018456 Caenorhabditis elegans 36.18 1.00e-95 343.00
IUUC-Cja-020007 Callithrix jacchus 72.81 0.00e+00 846.00
IUUC-Cfa-020324 Canis familiaris 73.22 0.00e+00 853.00
IUUC-Cpo-022248 Cavia porcellus 49.17 6.00e-137 481.00
IUUC-Csa-023149 Chlorocebus sabaeus 69.68 0.00e+00 716.00
IUUC-Cho-024537 Choloepus hoffmanni 62.47 3.00e-176 611.00
IUUC-Cin-025763 Ciona intestinalis 49.34 5.00e-155 541.00
IUUC-Csv-026113 Ciona savignyi 45.93 1.00e-144 506.00
IUUC-Cgl-026428 Colletotrichum gloeosporioides 32.58 2.00e-69 256.00
IUUC-Cne-026884 Cryptococcus neoformans 29.93 5.00e-71 262.00
IUUC-Cme-027210 Cyanidioschyzon merolae 25.00 3.00e-19 90.10
IUUC-Dno-030033 Dasypus novemcinctus 72.38 0.00e+00 739.00
IUUC-Dor-030513 Dipodomys ordii 50.48 2.00e-84 306.00
IUUC-Dse-031536 Dothistroma septosporum 33.86 2.00e-86 313.00
IUUC-Dme-031683 Drosophila melanogaster 42.99 2.00e-123 436.00
IUUC-Ete-032420 Echinops telfairi 62.60 0.00e+00 694.00
IUUC-Eca-033992 Equus caballus 71.62 0.00e+00 698.00
IUUC-Eeu-034713 Erinaceus europaeus 59.45 4.00e-88 318.00
IUUC-Fca-036548 Felis catus 72.10 0.00e+00 838.00
IUUC-Fal-037600 Ficedula albicollis 72.41 0.00e+00 801.00
IUUC-Fox-038037 Fusarium oxysporum 31.73 2.00e-70 260.00
IUUC-Fso-038387 Fusarium solani 33.58 2.00e-74 273.00
IUUC-Gmo-038562 Gadus morhua 79.77 0.00e+00 916.00
IUUC-Ggr-040005 Gaeumannomyces graminis 34.69 1.00e-72 267.00
IUUC-Gga-041129 Gallus gallus 74.14 0.00e+00 827.00
IUUC-Gac-042558 Gasterosteus aculeatus 80.75 0.00e+00 920.00
IUUC-Gma-043610 Glycine max 40.67 3.00e-122 432.00
IUUC-Ggo-045611 Gorilla gorilla 73.12 0.00e+00 847.00
IUUC-Hsa-046563 Homo sapiens 73.35 0.00e+00 850.00
IUUC-Hvu-047790 Hordeum vulgare 37.53 3.00e-78 285.00
IUUC-Itr-048066 Ictidomys tridecemlineatus 73.03 0.00e+00 845.00
IUUC-Kpa-049309 Komagataella pastoris 32.95 4.00e-76 278.00
IUUC-Lch-050038 Latimeria chalumnae 74.15 0.00e+00 839.00
IUUC-Lpe-051535 Leersia perrieri 40.63 4.00e-110 392.00
IUUC-Loc-051917 Lepisosteus oculatus 78.00 0.00e+00 863.00
IUUC-Lma-053112 Leptosphaeria maculans 34.88 4.00e-87 315.00
IUUC-Laf-053690 Loxodonta africana 73.41 0.00e+00 857.00
IUUC-Mcc-055117 Macaca mulatta 71.56 0.00e+00 834.00
IUUC-Meu-056761 Macropus eugenii 61.09 0.00e+00 672.00
IUUC-Mor-057230 Magnaporthe oryzae 33.70 8.00e-76 278.00
IUUC-Mpo-057514 Magnaporthe poae 33.21 6.00e-69 255.00
IUUC-Mtr-058551 Medicago truncatula 39.67 5.00e-118 418.00
IUUC-Mla-059183 Melampsora laricipopulina 34.76 2.00e-96 346.00
IUUC-Mga-060144 Meleagris gallopavo 73.09 0.00e+00 809.00
IUUC-Mvi-060221 Microbotryum violaceum 33.95 8.00e-80 291.00
IUUC-Mmr-061325 Microcebus murinus 72.07 0.00e+00 834.00
IUUC-Mdo-062532 Monodelphis domestica 74.29 0.00e+00 856.00
IUUC-Mmu-063956 Mus musculus 73.41 0.00e+00 853.00
IUUC-Mac-064521 Musa acuminata 40.08 1.00e-121 430.00
IUUC-Mpu-066716 Mustela putorius furo 72.11 0.00e+00 796.00
IUUC-Mlu-067459 Myotis lucifugus 72.40 0.00e+00 841.00
IUUC-Nfi-068245 Neosartorya fischeri 34.35 3.00e-82 299.00
IUUC-Ncr-068910 Neurospora crassa 33.21 7.00e-76 278.00
IUUC-Nle-070034 Nomascus leucogenys 71.24 0.00e+00 816.00
IUUC-Opr-070552 Ochotona princeps 67.47 0.00e+00 695.00
IUUC-Ont-071426 Oreochromis niloticus 83.68 0.00e+00 959.00
IUUC-Oan-073389 Ornithorhynchus anatinus 69.59 0.00e+00 655.00
IUUC-Ocu-074911 Oryctolagus cuniculus 72.85 0.00e+00 848.00
IUUC-Oba-075437 Oryza barthii 41.35 4.00e-116 411.00
IUUC-Obr-076684 Oryza brachyantha 41.25 3.00e-111 395.00
IUUC-Ogl-077170 Oryza glaberrima 41.35 4.00e-116 411.00
IUUC-Ogu-078844 Oryza glumaepatula 41.85 1.00e-108 386.00
IUUC-Oin-079105 Oryza indica 41.35 2.00e-115 409.00
IUUC-Olo-080943 Oryza longistaminata 38.86 4.00e-103 368.00
IUUC-Oni-082891 Oryza nivara 38.35 3.00e-109 389.00
IUUC-Opu-083457 Oryza punctata 41.57 1.00e-115 410.00
IUUC-Oru-084960 Oryza rufipogon 38.70 3.00e-103 369.00
IUUC-Osa-085358 Oryza sativa 41.54 3.00e-116 412.00
IUUC-Ola-086420 Oryzias latipes 80.70 0.00e+00 646.00
IUUC-Olu-087625 Ostreococcus lucimarinus 31.00 1.00e-64 241.00
IUUC-Oga-088810 Otolemur garnettii 72.66 0.00e+00 845.00
IUUC-Oar-089196 Ovis aries 73.00 0.00e+00 847.00
IUUC-Ptr-090617 Pan troglodytes 73.53 0.00e+00 852.00
IUUC-Pan-092761 Papio anubis 73.22 0.00e+00 852.00
IUUC-Psi-093191 Pelodiscus sinensis 74.66 0.00e+00 844.00
IUUC-Pma-094380 Petromyzon marinus 62.07 0.00e+00 661.00
IUUC-Pno-095084 Phaeosphaeria nodorum 34.17 3.00e-75 277.00
IUUC-Ppa-095875 Physcomitrella patens 40.23 4.00e-118 418.00
IUUC-Pfo-096467 Poecilia formosa 82.28 0.00e+00 939.00
IUUC-Pab-098255 Pongo abelii 71.62 0.00e+00 701.00
IUUC-Pop-099722 Populus trichocarpa 42.22 1.00e-128 453.00
IUUC-Pca-100807 Procavia capensis 63.02 4.00e-94 338.00
IUUC-Ppe-101280 Prunus persica 40.49 7.00e-126 444.00
IUUC-Pva-102333 Pteropus vampyrus 71.14 0.00e+00 814.00
IUUC-Pgr-103401 Puccinia graminis 29.04 3.00e-75 276.00
IUUC-Ptt-103889 Puccinia triticina 26.51 2.00e-57 216.00
IUUC-Pte-104355 Pyrenophora teres 36.38 3.00e-88 319.00
IUUC-Pyt-104545 Pyrenophora triticirepentis 36.31 6.00e-90 325.00
IUUC-Rno-105810 Rattus norvegicus 73.35 0.00e+00 844.00
IUUC-Sce-106397 Saccharomyces cerevisiae 24.77 1.00e-36 147.00
IUUC-Sha-106770 Sarcophilus harrisii 76.81 2.00e-131 461.00
IUUC-Sja-107926 Schizosaccharomyces japonicus 33.90 9.00e-75 274.00
IUUC-Spo-108276 Schizosaccharomyces pombe 34.27 7.00e-80 291.00
IUUC-Ssl-108387 Sclerotinia sclerotiorum 32.41 5.00e-67 248.00
IUUC-Smo-109296 Selaginella moellendorffii 41.21 5.00e-119 421.00
IUUC-Sit-110157 Setaria italica 42.13 2.00e-130 459.00
IUUC-Sly-111105 Solanum lycopersicum 39.60 2.00e-123 436.00
IUUC-Stu-112469 Solanum tuberosum 39.60 2.00e-124 439.00
IUUC-Sar-113083 Sorex araneus 55.23 3.00e-171 595.00
IUUC-Sbi-113813 Sorghum bicolor 42.13 1.00e-129 456.00
IUUC-Sre-115058 Sporisorium reilianum 34.80 1.00e-74 274.00
IUUC-Tgu-116772 Taeniopygia guttata 72.11 0.00e+00 806.00
IUUC-Tru-118686 Takifugu rubripes 83.11 0.00e+00 948.00
IUUC-Tsy-119111 Tarsius syrichta 69.61 6.00e-117 414.00
IUUC-Tni-120231 Tetraodon nigroviridis 75.56 0.00e+00 850.00
IUUC-Tca-121491 Theobroma cacao 39.74 4.00e-117 415.00
IUUC-Tre-122103 Trichoderma reesei 34.00 1.00e-78 287.00
IUUC-Tvi-122672 Trichoderma virens 34.81 2.00e-73 270.00
IUUC-Tae-125950 Triticum aestivum 41.39 2.00e-124 439.00
IUUC-Tur-126487 Triticum urartu 39.92 1.00e-117 417.00
IUUC-Tme-127097 Tuber melanosporum 36.66 2.00e-93 336.00
IUUC-Ttr-128465 Tursiops truncatus 67.97 0.00e+00 778.00
IUUC-Uma-129645 Ustilago maydis 31.20 5.00e-81 295.00
IUUC-Vda-129989 Verticillium dahliae 30.07 9.00e-57 214.00
IUUC-Vpa-130529 Vicugna pacos 69.83 0.00e+00 803.00
IUUC-Vvi-131059 Vitis vinifera 41.04 1.00e-122 433.00
IUUC-Xtr-132002 Xenopus tropicalis 71.86 0.00e+00 825.00
IUUC-Xma-133930 Xiphophorus maculatus 82.18 0.00e+00 939.00
IUUC-Yli-134505 Yarrowia lipolytica 31.88 5.00e-81 295.00
IUUC-Zma-135895 Zea mays 42.32 3.00e-128 452.00
Created Date 25-Jun-2017

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