iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007954

Ensembl Protein ID

AAS54701

UniProt Accession

Q74ZJ1; NPL4_ASHGO

Genbank Protein ID

AAS54701.1

Protein Name

Nuclear protein localization protein 4

Genbank Nucleotide ID

AE016820

Gene Name

NPL4; AGR211W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AGR211W	AAS54701	AAS54701

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/NZF	36.24	9.00e-78	288.00	IUUC-Hsa-046334
UBD/ZnF/NZF	36.83	2.00e-78	290.00	IUUC-Mmu-063916
UBD/ZnF/NZF	36.63	2.00e-78	290.00	IUUC-Rno-105582
UBD/ZnF/Other	60.38	0.00e+00	706.00	IUUC-Sce-106145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ashbya gossypii

Functional Description
(View)

Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).

Protein Sequence
(Fasta)

MILRFRSKHG MQRVNCEGSE QFGTVLDRWV KLVHERAPRE AMEVGVAERQ IETRIAAEMA 60
QKTVEQLGLK HGDMLSVSFK ETGGSLAVAA APERSSELAV DRELAREEGL IRRSHSRLCR 120

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Nucleotide Sequence
(Fasta)

ATGATCCTGA GGTTCAGATC GAAGCATGGG ATGCAGCGCG TTAATTGCGA GGGGAGCGAG 60
CAGTTCGGAA CGGTGCTAGA TCGATGGGTT AAGCTGGTGC ACGAGCGGGC GCCGCGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR016563--Npl4
IPR007717--NPL4_C
IPR024682--Npl4_Ub-like_dom
IPR007716--NPL4_Zn-bd_put

Pfam

PF05021--NPL4
PF11543--UN_NPL4
PF05020--zf-NPL4

Gene Ontology

GO:0036266--C:Cdc48p-Npl4p-Vms1p AAA ATPase complex
GO:0005829--C:cytosol
GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:1990112--C:RQC complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0072671--P:mitochondria-associated ubiquitin-dependent protein catabolic process
GO:0051228--P:mitotic spindle disassembly
GO:0051028--P:mRNA transport
GO:0051974--P:negative regulation of telomerase activity
GO:0070651--P:nonfunctional rRNA decay
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ago:AGOS_AGR211W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002268	Ailuropoda melanoleuca	37.82	9.00e-79	285.00
IUUC-Apl-003496	Anas platyrhynchos	36.90	8.00e-79	285.00
IUUC-Aca-005230	Anolis carolinensis	34.70	3.00e-79	286.00
IUUC-Aly-006056	Arabidopsis lyrata	23.02	1.00e-03	35.00
IUUC-Ath-006993	Arabidopsis thaliana	23.02	4.00e-03	33.50
IUUC-Acl-008208	Aspergillus clavatus	39.78	6.00e-125	439.00
IUUC-Afl-008574	Aspergillus flavus	41.83	4.00e-124	436.00
IUUC-Afu-008825	Aspergillus fumigatus	41.69	4.00e-131	459.00
IUUC-Ani-009495	Aspergillus nidulans	40.07	1.00e-126	444.00
IUUC-Ang-009762	Aspergillus niger	41.58	4.00e-126	442.00
IUUC-Aor-010199	Aspergillus oryzae	41.67	3.00e-123	433.00
IUUC-Ate-010592	Aspergillus terreus	42.00	4.00e-123	432.00
IUUC-Ame-011438	Astyanax mexicanus	44.67	5.00e-30	120.00
IUUC-Bgr-012124	Blumeria graminis	40.07	3.00e-130	456.00
IUUC-Bta-013312	Bos taurus	35.63	3.00e-82	297.00
IUUC-Bci-013648	Botrytis cinerea	40.84	3.00e-133	466.00
IUUC-Bol-016294	Brassica oleracea	23.92	8.00e-03	32.70
IUUC-Bra-017023	Brassica rapa	28.57	8.00e-03	32.70
IUUC-Cel-018713	Caenorhabditis elegans	36.48	3.00e-79	286.00
IUUC-Cja-018869	Callithrix jacchus	34.95	4.00e-81	293.00
IUUC-Cfa-020757	Canis familiaris	34.70	4.00e-79	286.00
IUUC-Cpo-022390	Cavia porcellus	38.57	1.00e-79	288.00
IUUC-Csa-023366	Chlorocebus sabaeus	35.45	4.00e-82	296.00
IUUC-Cho-024455	Choloepus hoffmanni	34.90	6.00e-57	213.00
IUUC-Cin-025638	Ciona intestinalis	30.02	2.00e-57	214.00
IUUC-Csv-026310	Ciona savignyi	29.77	9.00e-56	209.00
IUUC-Cgl-026685	Colletotrichum gloeosporioides	40.07	1.00e-125	441.00
IUUC-Cne-026794	Cryptococcus neoformans	35.48	2.00e-100	357.00
IUUC-Cme-027248	Cyanidioschyzon merolae	25.71	6.00e-03	33.50
IUUC-Dre-027689	Danio rerio	33.69	3.00e-80	290.00
IUUC-Dno-030004	Dasypus novemcinctus	36.38	9.00e-82	295.00
IUUC-Dor-030585	Dipodomys ordii	37.72	2.00e-76	277.00
IUUC-Dse-031202	Dothistroma septosporum	38.45	2.00e-118	417.00
IUUC-Dme-032092	Drosophila melanogaster	32.97	3.00e-77	280.00
IUUC-Ete-033009	Echinops telfairi	41.61	6.00e-29	119.00
IUUC-Eca-034001	Equus caballus	35.14	9.00e-82	295.00
IUUC-Eeu-034485	Erinaceus europaeus	30.87	7.00e-35	139.00
IUUC-Fca-036128	Felis catus	38.69	1.00e-78	285.00
IUUC-Fal-037523	Ficedula albicollis	35.20	2.00e-81	294.00
IUUC-Fox-037802	Fusarium oxysporum	41.46	1.00e-133	468.00
IUUC-Fso-038152	Fusarium solani	40.87	4.00e-133	466.00
IUUC-Gmo-038486	Gadus morhua	37.33	1.00e-76	278.00
IUUC-Ggr-039916	Gaeumannomyces graminis	41.34	1.00e-130	458.00
IUUC-Gga-041208	Gallus gallus	35.38	3.00e-81	293.00
IUUC-Gac-042304	Gasterosteus aculeatus	33.52	1.00e-70	258.00
IUUC-Ggo-045236	Gorilla gorilla	34.95	7.00e-75	272.00
IUUC-Hsa-046334	Homo sapiens	35.45	4.00e-82	296.00
IUUC-Itr-047878	Ictidomys tridecemlineatus	42.96	3.00e-57	213.00
IUUC-Lch-050302	Latimeria chalumnae	33.58	5.00e-74	269.00
IUUC-Loc-052548	Lepisosteus oculatus	34.24	2.00e-79	287.00
IUUC-Lma-053092	Leptosphaeria maculans	40.99	2.00e-124	437.00
IUUC-Laf-053911	Loxodonta africana	35.82	2.00e-81	294.00
IUUC-Mcc-055830	Macaca mulatta	35.39	8.00e-82	295.00
IUUC-Meu-056460	Macropus eugenii	25.13	2.00e-08	51.20
IUUC-Mor-057189	Magnaporthe oryzae	40.85	2.00e-132	464.00
IUUC-Mpo-057366	Magnaporthe poae	41.83	3.00e-131	460.00
IUUC-Mtr-057834	Medicago truncatula	30.08	1.60e-01	28.50
IUUC-Mla-059190	Melampsora laricipopulina	39.78	9.00e-112	395.00
IUUC-Mga-060036	Meleagris gallopavo	35.26	3.00e-80	290.00
IUUC-Mvi-060275	Microbotryum violaceum	33.02	4.00e-96	343.00
IUUC-Mmr-061300	Microcebus murinus	35.58	7.00e-82	295.00
IUUC-Mdo-062911	Monodelphis domestica	35.63	1.00e-81	294.00
IUUC-Mmu-063916	Mus musculus	38.70	9.00e-79	285.00
IUUC-Mac-065303	Musa acuminata	28.05	8.20e-01	26.90
IUUC-Mpu-065912	Mustela putorius furo	35.14	6.00e-80	289.00
IUUC-Mlu-067965	Myotis lucifugus	35.89	8.00e-83	299.00
IUUC-Nfi-068465	Neosartorya fischeri	41.76	2.00e-131	461.00
IUUC-Ncr-068936	Neurospora crassa	38.46	1.00e-123	434.00
IUUC-Nle-069570	Nomascus leucogenys	35.45	4.00e-82	296.00
IUUC-Opr-071097	Ochotona princeps	37.06	3.00e-70	256.00
IUUC-Ont-071430	Oreochromis niloticus	33.76	3.00e-79	286.00
IUUC-Oan-073709	Ornithorhynchus anatinus	29.75	6.00e-53	199.00
IUUC-Ocu-074875	Oryctolagus cuniculus	34.33	3.00e-74	270.00
IUUC-Ogu-078899	Oryza glumaepatula	22.38	3.00e-01	27.30
IUUC-Opu-083122	Oryza punctata	22.57	3.40e-01	27.30
IUUC-Ola-087077	Oryzias latipes	31.82	3.00e-64	237.00
IUUC-Oga-088049	Otolemur garnettii	34.80	3.00e-63	234.00
IUUC-Oar-089678	Ovis aries	35.63	2.00e-82	298.00
IUUC-Ptr-091380	Pan troglodytes	35.33	4.00e-82	296.00
IUUC-Pan-092821	Papio anubis	34.83	2.00e-79	287.00
IUUC-Psi-093074	Pelodiscus sinensis	35.13	2.00e-81	294.00
IUUC-Pma-094102	Petromyzon marinus	32.80	4.00e-74	270.00
IUUC-Pno-094987	Phaeosphaeria nodorum	40.23	6.00e-122	429.00
IUUC-Pfo-097245	Poecilia formosa	34.62	5.00e-81	293.00
IUUC-Pab-098763	Pongo abelii	35.51	5.00e-82	296.00
IUUC-Pva-102308	Pteropus vampyrus	38.26	9.00e-54	202.00
IUUC-Pgr-103626	Puccinia graminis	38.67	5.00e-107	379.00
IUUC-Pte-104100	Pyrenophora teres	38.51	3.00e-119	420.00
IUUC-Pyt-104482	Pyrenophora triticirepentis	38.94	1.00e-121	428.00
IUUC-Rno-105582	Rattus norvegicus	38.48	1.00e-78	285.00
IUUC-Sce-106145	Saccharomyces cerevisiae	60.38	0.00e+00	716.00
IUUC-Sha-106647	Sarcophilus harrisii	36.26	2.00e-82	297.00
IUUC-Sja-107972	Schizosaccharomyces japonicus	44.39	2.00e-132	463.00
IUUC-Spo-108281	Schizosaccharomyces pombe	40.44	2.00e-125	440.00
IUUC-Ssl-108617	Sclerotinia sclerotiorum	41.00	3.00e-133	466.00
IUUC-Smo-108933	Selaginella moellendorffii	23.84	2.00e-03	34.70
IUUC-Sit-110083	Setaria italica	22.38	1.80e-02	31.60
IUUC-Stu-112422	Solanum tuberosum	26.79	3.10e-02	30.80
IUUC-Sre-115095	Sporisorium reilianum	38.22	3.00e-108	383.00
IUUC-Ssc-116141	Sus scrofa	38.20	2.00e-79	287.00
IUUC-Tgu-117492	Taeniopygia guttata	35.99	2.00e-73	267.00
IUUC-Tru-118463	Takifugu rubripes	33.51	4.00e-77	280.00
IUUC-Tsy-118993	Tarsius syrichta	30.71	3.00e-59	220.00
IUUC-Tni-119896	Tetraodon nigroviridis	34.39	3.00e-79	286.00
IUUC-Tca-121169	Theobroma cacao	19.51	4.60e-02	30.00
IUUC-Tre-122046	Trichoderma reesei	40.33	2.00e-128	450.00
IUUC-Tvi-122415	Trichoderma virens	40.73	6.00e-131	458.00
IUUC-Tme-127123	Tuber melanosporum	43.16	6.00e-137	479.00
IUUC-Tbe-127629	Tupaia belangeri	30.95	4.00e-32	130.00
IUUC-Ttr-128476	Tursiops truncatus	34.57	2.00e-65	241.00
IUUC-Uma-129492	Ustilago maydis	38.73	5.00e-111	392.00
IUUC-Vda-129702	Verticillium dahliae	39.31	2.00e-122	430.00
IUUC-Xtr-131786	Xenopus tropicalis	34.81	5.00e-81	293.00
IUUC-Xma-133997	Xiphophorus maculatus	33.39	5.00e-79	286.00
IUUC-Yli-134537	Yarrowia lipolytica	43.94	1.00e-130	457.00
IUUC-Zma-134847	Zea mays	25.22	1.30e-01	28.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence