iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068962

Ensembl Protein ID

EAA33589

UniProt Accession

Q01277; Q7RVH3; SCONB_NEUCR

Genbank Protein ID

AAA68968.1; CAE85499.1; EAA33589.2

Protein Name

Probable E3 ubiquitin ligase complex SCF subunit scon-2; Sulfur controller 2; Sulfur metabolite repression control protein 2

Genbank Nucleotide ID

U17251; BX897673; CM002238

Gene Name

scon-2; B13M15.090; NCU08563

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU08563	EAA33589	EAA33589

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-49	161.6	403	439
UBD/Beta-Prp	1.30e-71	240.2	361	539

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
           gHt+++++l+f+d  l+sGs D+tikvW+++tg +l 
   Q: 403  GHTAGIRALQFDDSKLISGSLDHTIKVWNWHTGECLS 439
           8**********6689*******************986 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsps 105
           lkgh+ + +tc++   d+++latgs+d tik+w+++t+ ++r+l gh+a+++a++f+++   l++gs D+tikvw+  tg+c++t+ +h+dsv s++f+  
   Q: 361  LKGHENG-VTCLQL--DDNILATGSYDTTIKIWNIETEECIRTLVGHTAGIRALQFDDS--KLISGSLDHTIKVWNWHTGECLSTFAAHTDSVISVHFDG- 455
           3333333.334666..6666666666666666666666666666666666666666666..366666666666666666666666666666666666655. PP
   S: 106  gdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls.....f 188
            + l+sGs+d+t++++d ++++ +  +l+gh+++vn+++v+ +++ ++s+s+D+t++lWdl t +++rt +g h + v+ +      +
   Q: 456  -HLLASGSSDKTVKIFDFNSKETY--CLKGHSDWVNSTHVDIKSRTVFSASDDTTIKLWDLDTRQVIRTYEG-HVGHVQQVLilppeY 539
           .66666666666666666555555..5666666666666666666666666666666666666666666665.666665554344443 PP

Organism

Neurospora crassa

Functional Description
(View)

Component of the SCF(scon-2) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.

Protein Sequence
(Fasta)

MDSYHLAPSR PTASFGHDND APLQHGPLVN SYSHHHNNHS RDTDSDPTDQ NCDRKRPEQQ 60
ARLRSRNSVT NMSSVLMSKT VTPFLREHIP SIYAPIGKPG NQETARAENP NSKYCYRHHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGCGATC AAGAGCGACG GCCAATCTTG TCTCTTTCCG TCTGCAACAT TTCACAGTCA 60
CACACACACA GAGAGAAGGA GCAACGAAGT CAAGACACAT CCGATTTCAG GCGGTGTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0071276--P:cellular response to cadmium ion
GO:0006270--P:DNA replication initiation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0046685--P:response to arsenic-containing substance
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

KEGG

ncr:NCU08563

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007794	Ashbya gossypii	34.74	9.00e-97	345.00
IUUC-Acl-008078	Aspergillus clavatus	51.14	0.00e+00	679.00
IUUC-Afl-008744	Aspergillus flavus	48.82	0.00e+00	645.00
IUUC-Afu-008939	Aspergillus fumigatus	51.43	0.00e+00	675.00
IUUC-Ani-009383	Aspergillus nidulans	51.99	0.00e+00	650.00
IUUC-Ang-009570	Aspergillus niger	50.97	0.00e+00	671.00
IUUC-Aor-010217	Aspergillus oryzae	51.96	0.00e+00	643.00
IUUC-Ate-010336	Aspergillus terreus	52.25	0.00e+00	671.00
IUUC-Bgr-012225	Blumeria graminis	48.35	0.00e+00	632.00
IUUC-Bci-013916	Botrytis cinerea	55.74	0.00e+00	726.00
IUUC-Cgl-026550	Colletotrichum gloeosporioides	50.07	0.00e+00	648.00
IUUC-Cne-026800	Cryptococcus neoformans	34.22	1.00e-81	295.00
IUUC-Dse-031413	Dothistroma septosporum	51.72	2.00e-133	468.00
IUUC-Fox-037683	Fusarium oxysporum	51.10	0.00e+00	709.00
IUUC-Fso-038092	Fusarium solani	59.24	0.00e+00	796.00
IUUC-Ggr-039842	Gaeumannomyces graminis	54.91	0.00e+00	763.00
IUUC-Kpa-049101	Komagataella pastoris	43.51	3.00e-148	516.00
IUUC-Lma-053200	Leptosphaeria maculans	49.33	0.00e+00	654.00
IUUC-Mor-057039	Magnaporthe oryzae	60.00	9.00e-178	615.00
IUUC-Mpo-057381	Magnaporthe poae	51.74	0.00e+00	732.00
IUUC-Mla-059099	Melampsora laricipopulina	35.64	2.00e-113	401.00
IUUC-Mvi-060426	Microbotryum violaceum	38.17	2.00e-50	192.00
IUUC-Nfi-068464	Neosartorya fischeri	51.19	0.00e+00	669.00
IUUC-Pno-095133	Phaeosphaeria nodorum	47.80	1.00e-143	501.00
IUUC-Pgr-103527	Puccinia graminis	36.52	1.00e-61	229.00
IUUC-Ptt-103819	Puccinia triticina	29.74	9.00e-39	152.00
IUUC-Pte-104035	Pyrenophora teres	50.81	2.00e-143	501.00
IUUC-Pyt-104799	Pyrenophora triticirepentis	50.81	1.00e-142	498.00
IUUC-Sce-106343	Saccharomyces cerevisiae	36.88	1.00e-120	425.00
IUUC-Sja-107945	Schizosaccharomyces japonicus	42.08	2.00e-93	334.00
IUUC-Spo-108115	Schizosaccharomyces pombe	41.11	1.00e-90	325.00
IUUC-Sre-115173	Sporisorium reilianum	37.64	2.00e-94	339.00
IUUC-Tre-122126	Trichoderma reesei	58.46	0.00e+00	793.00
IUUC-Tvi-122482	Trichoderma virens	59.05	0.00e+00	784.00
IUUC-Tme-127212	Tuber melanosporum	54.86	3.00e-150	523.00
IUUC-Uma-129406	Ustilago maydis	39.84	2.00e-57	216.00
IUUC-Vda-129799	Verticillium dahliae	59.06	0.00e+00	769.00
IUUC-Yli-134408	Yarrowia lipolytica	42.15	4.00e-149	520.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence