iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000021203.15	ENSMUST00000101094.8	ENSMUSP00000098655.2
ENSMUSG00000021203.15	ENSMUST00000021620.12	ENSMUSP00000021620.6
ENSMUSG00000021203.15	ENSMUST00000148371.7	ENSMUSP00000115673.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Post-translational Modifications (PTMs)
CPLM	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	5.70e-46	157.5	130	319

Active Site

Position(s)	Description	Evidence
137	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
140	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
313		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
            i+ktkgDGnC++rA+++s                                                          ll+vf+d+s sd
   Q: 130  SIRKTKGDGNCFYRALGYSylesllgksreilkfkervlqtpndllaagfeehkfrnffnafysvvelvekdssvssLLKVFNDQSSSD 218
           699************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
            +v++Lr+lts+++++++dff++fi+e++d+k+fc+++vep+a  +++++i+aL+q+L+++++v++vd++++    +l++++fpe++  
   Q: 219  RIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMAMeCDHVQITALSQALNIALQVEYVDEMDT----ALNHHVFPEAA-I 302
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 303  PSVYLLYKTSHYNILYA 319
           ***************97 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MALPSSLQDL IPRFHLRRHP RGLFCASSCQ RSHTESSGKT PTLPSVLRLV LPTPKSPLVA 60
CSQLRRLLQH PPGRCPSCSH CPIPKPSCLQ SETSFNLISE KCDILSILRD HPENRIYQRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTGTGCGT CTTGCTGGGA CACAGTGGAG GTCTGCGCTC CGGTCTGAGG GGCGGTCGGG 60
TGTATTCTGC GCTCACCCAC ACCCGCGAGG CCCGCGCCGC CCGACCCAAC GGCGGAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	96.57	3.00e-134	470.00
IUUC-Bta-012766	Bos taurus	96.14	9.00e-133	465.00
IUUC-Cja-019480	Callithrix jacchus	93.99	2.00e-130	457.00
IUUC-Cfa-021106	Canis familiaris	96.57	4.00e-134	469.00
IUUC-Cpo-022187	Cavia porcellus	95.32	1.00e-133	468.00
IUUC-Csa-023493	Chlorocebus sabaeus	91.50	8.00e-132	462.00
IUUC-Cho-024411	Choloepus hoffmanni	77.07	4.00e-86	310.00
IUUC-Dno-029346	Dasypus novemcinctus	96.55	5.00e-133	466.00
IUUC-Dor-031012	Dipodomys ordii	97.00	5.00e-135	473.00
IUUC-Ete-032266	Echinops telfairi	86.21	3.00e-118	417.00
IUUC-Eca-033356	Equus caballus	91.63	1.00e-134	471.00
IUUC-Eeu-034775	Erinaceus europaeus	96.55	4.00e-133	466.00
IUUC-Fca-035363	Felis catus	94.85	5.00e-132	462.00
IUUC-Ggo-045023	Gorilla gorilla	94.42	1.00e-130	458.00
IUUC-Hsa-046984	Homo sapiens	94.85	2.00e-131	460.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	95.71	3.00e-133	467.00
IUUC-Lch-050514	Latimeria chalumnae	56.08	6.00e-84	303.00
IUUC-Loc-052003	Lepisosteus oculatus	50.90	3.00e-64	238.00
IUUC-Laf-054382	Loxodonta africana	95.71	1.00e-132	465.00
IUUC-Mcc-055516	Macaca mulatta	94.04	1.00e-131	461.00
IUUC-Meu-056038	Macropus eugenii	88.36	4.00e-99	353.00
IUUC-Mmr-060918	Microcebus murinus	96.57	3.00e-134	470.00
IUUC-Mdo-062638	Monodelphis domestica	90.09	9.00e-124	435.00
IUUC-Mpu-066013	Mustela putorius furo	95.69	9.00e-133	465.00
IUUC-Mlu-067509	Myotis lucifugus	93.99	9.00e-130	455.00
IUUC-Nle-069673	Nomascus leucogenys	94.85	2.00e-131	460.00
IUUC-Opr-070761	Ochotona princeps	89.70	4.00e-82	296.00
IUUC-Oan-072922	Ornithorhynchus anatinus	85.02	3.00e-113	400.00
IUUC-Ocu-074643	Oryctolagus cuniculus	95.28	1.00e-132	465.00
IUUC-Oni-082026	Oryza nivara	29.95	5.00e-16	79.00
IUUC-Oru-084761	Oryza rufipogon	29.95	5.00e-16	79.00
IUUC-Ola-086603	Oryzias latipes	45.83	2.00e-51	195.00
IUUC-Oga-088936	Otolemur garnettii	95.30	3.00e-133	467.00
IUUC-Oar-089460	Ovis aries	95.76	1.00e-133	468.00
IUUC-Ptr-090805	Pan troglodytes	94.42	7.00e-131	459.00
IUUC-Pan-091969	Papio anubis	94.85	2.00e-131	460.00
IUUC-Pab-098476	Pongo abelii	94.04	4.00e-131	460.00
IUUC-Pca-100252	Procavia capensis	91.00	2.00e-52	198.00
IUUC-Pva-102204	Pteropus vampyrus	94.85	2.00e-132	464.00
IUUC-Pgr-103552	Puccinia graminis	75.00	3.80e-02	30.80
IUUC-Rno-105062	Rattus norvegicus	99.14	3.00e-136	477.00
IUUC-Sha-106968	Sarcophilus harrisii	90.04	3.00e-123	434.00
IUUC-Sar-113295	Sorex araneus	96.55	4.00e-131	460.00
IUUC-Ssc-115288	Sus scrofa	96.98	2.00e-133	467.00
IUUC-Tni-120440	Tetraodon nigroviridis	40.09	1.00e-42	166.00
IUUC-Tbe-127717	Tupaia belangeri	96.62	1.00e-79	288.00
IUUC-Ttr-128221	Tursiops truncatus	77.59	7.00e-101	359.00
IUUC-Uma-129443	Ustilago maydis	34.55	3.00e-25	108.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence