iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093723

Ensembl Protein ID

ENSPSIP00000009632.1

UniProt Accession

K7FNM2; K7FNM2_PELSI

Genbank Protein ID

ENSPSIP00000009632

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AGCU01128072

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000008666.1	ENSPSIT00000009679.1	ENSPSIP00000009632.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	7.80e-89	298.4	1	297

Active Site

Position(s)	Description	Evidence
63	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
139	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 26   gvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedk 114
           g+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakqvi+N+Cat+A++svllnc ++
   Q: 1    GCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCIHQ 78
           78899.****************.********************.........899********************************** PP
   S: 115  lldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldl 203
            ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + + +++    +++afhfvsyv++ngrlyeldgl++ P+dl
   Q: 79   DIHLGDTLSEFKEFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSSAK----EEDAFHFVSYVPVNGRLYELDGLREGPIDL 163
           *************************************************888776....89**************************** PP
   S: 204  gkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqldde 283
           g+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +          +  ++l+ i+se++k+++ +++e
   Q: 164  GA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKITELQQQlseeepmdtDQSSNMLSSIQSEVAKYQMLIEEE 249
           *9.78999*********..******************************987776678888888756678******************* PP
   S: 284  kekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgv 334
           ++k k++ki++irR++ny  fi++++k+la++++l  lve+    + ++++
   Q: 250  NQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQNA 297
           ****************************************93...333554 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

GCRGAQVEEI WSLEPENFEK LKPVHGLIFL FKWQPGEEPA GSVVQDSRLD TIFFAKQVIN 60
NACATQAIVS VLLNCIHQDI HLGDTLSEFK EFSQSFDAAM KGLALSNSEV IRQVHNSFAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGCAGGG GAGCACAGGT TGAAGAAATA TGGAGTCTGG AGCCAGAAAA CTTTGAAAAA 60
TTAAAGTAAG CCAGTGGTCT CCAACCTTTT TACACCCAAG ATCACATTTT AAGTCTCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	46.33	3.00e-75	275.00
IUUC-Aml-001866	Ailuropoda melanoleuca	95.49	1.00e-165	575.00
IUUC-Atr-002966	Amborella trichopoda	47.98	1.00e-77	283.00
IUUC-Apl-003306	Anas platyrhynchos	89.16	4.00e-171	593.00
IUUC-Aca-004763	Anolis carolinensis	96.53	5.00e-168	583.00
IUUC-Aly-005581	Arabidopsis lyrata	47.25	1.00e-70	259.00
IUUC-Ath-007283	Arabidopsis thaliana	46.93	1.00e-72	266.00
IUUC-Ago-007999	Ashbya gossypii	37.61	6.00e-27	114.00
IUUC-Acl-008231	Aspergillus clavatus	42.66	1.00e-45	176.00
IUUC-Afl-008557	Aspergillus flavus	36.97	8.00e-48	183.00
IUUC-Afu-008988	Aspergillus fumigatus	44.04	6.00e-47	180.00
IUUC-Ani-009420	Aspergillus nidulans	36.58	1.00e-46	180.00
IUUC-Ang-009859	Aspergillus niger	40.81	2.00e-42	166.00
IUUC-Aor-010145	Aspergillus oryzae	36.97	8.00e-48	183.00
IUUC-Ate-010347	Aspergillus terreus	41.70	3.00e-46	178.00
IUUC-Ame-010791	Astyanax mexicanus	91.45	4.00e-169	586.00
IUUC-Bgr-012298	Blumeria graminis	38.49	4.00e-44	171.00
IUUC-Bta-013251	Bos taurus	95.14	4.00e-164	570.00
IUUC-Bci-013786	Botrytis cinerea	37.11	6.00e-51	194.00
IUUC-Bdi-014132	Brachypodium distachyon	48.20	1.00e-72	266.00
IUUC-Bol-015611	Brassica oleracea	47.88	9.00e-75	273.00
IUUC-Bra-017769	Brassica rapa	47.88	1.00e-74	273.00
IUUC-Cel-018604	Caenorhabditis elegans	45.21	1.00e-70	259.00
IUUC-Cja-019768	Callithrix jacchus	85.76	8.00e-159	552.00
IUUC-Cfa-020207	Canis familiaris	95.49	1.00e-165	575.00
IUUC-Cpo-021925	Cavia porcellus	90.97	3.00e-156	544.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	44.22	7.00e-66	243.00
IUUC-Csa-023958	Chlorocebus sabaeus	94.44	7.00e-163	566.00
IUUC-Cho-024928	Choloepus hoffmanni	96.10	1.00e-41	162.00
IUUC-Cin-025771	Ciona intestinalis	52.33	8.00e-88	316.00
IUUC-Csv-026149	Ciona savignyi	56.23	5.00e-92	330.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	36.86	2.00e-51	195.00
IUUC-Cne-026955	Cryptococcus neoformans	35.46	3.00e-46	178.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.06	3.00e-40	158.00
IUUC-Dre-027409	Danio rerio	90.79	4.00e-167	579.00
IUUC-Dno-028921	Dasypus novemcinctus	94.79	1.00e-164	571.00
IUUC-Dse-031170	Dothistroma septosporum	36.95	8.00e-50	190.00
IUUC-Dme-031677	Drosophila melanogaster	60.00	7.00e-102	363.00
IUUC-Ete-032707	Echinops telfairi	69.12	4.00e-103	367.00
IUUC-Eca-033776	Equus caballus	95.14	1.00e-165	575.00
IUUC-Eeu-035305	Erinaceus europaeus	73.62	9.00e-66	243.00
IUUC-Fca-035846	Felis catus	87.30	7.00e-161	559.00
IUUC-Fal-037597	Ficedula albicollis	97.92	1.00e-163	568.00
IUUC-Fox-037670	Fusarium oxysporum	49.21	5.00e-47	181.00
IUUC-Fso-038243	Fusarium solani	49.21	2.00e-46	179.00
IUUC-Gmo-038499	Gadus morhua	85.07	2.00e-149	520.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.11	4.00e-42	164.00
IUUC-Gga-040904	Gallus gallus	96.71	3.00e-176	610.00
IUUC-Gac-042058	Gasterosteus aculeatus	90.97	3.00e-160	557.00
IUUC-Gma-043763	Glycine max	48.74	1.00e-76	279.00
IUUC-Ggo-044699	Gorilla gorilla	88.30	1.00e-147	515.00
IUUC-Hsa-046227	Homo sapiens	94.79	1.00e-164	572.00
IUUC-Hvu-047359	Hordeum vulgare	46.45	1.00e-74	272.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	86.21	2.00e-160	558.00
IUUC-Lch-049829	Latimeria chalumnae	93.75	2.00e-162	564.00
IUUC-Lpe-050899	Leersia perrieri	46.64	2.00e-69	255.00
IUUC-Loc-052264	Lepisosteus oculatus	91.70	2.00e-160	558.00
IUUC-Lma-053110	Leptosphaeria maculans	36.82	4.00e-42	165.00
IUUC-Laf-053639	Loxodonta africana	95.49	1.00e-165	575.00
IUUC-Mcc-055506	Macaca mulatta	94.44	8.00e-163	565.00
IUUC-Mor-057001	Magnaporthe oryzae	43.78	1.00e-47	183.00
IUUC-Mpo-057608	Magnaporthe poae	39.76	3.00e-27	114.00
IUUC-Mtr-057731	Medicago truncatula	48.10	7.00e-77	280.00
IUUC-Mla-059016	Melampsora laricipopulina	42.62	3.00e-37	147.00
IUUC-Mga-060178	Meleagris gallopavo	97.04	3.00e-177	613.00
IUUC-Mvi-060353	Microbotryum violaceum	38.06	1.00e-48	186.00
IUUC-Mmr-060738	Microcebus murinus	95.14	4.00e-165	573.00
IUUC-Mdo-062266	Monodelphis domestica	96.22	2.00e-107	380.00
IUUC-Mmu-063619	Mus musculus	93.06	2.00e-162	564.00
IUUC-Mac-065301	Musa acuminata	50.17	5.00e-80	290.00
IUUC-Mpu-066058	Mustela putorius furo	95.83	3.00e-166	577.00
IUUC-Mlu-067292	Myotis lucifugus	94.10	5.00e-162	563.00
IUUC-Nfi-068275	Neosartorya fischeri	37.33	2.00e-48	185.00
IUUC-Ncr-068713	Neurospora crassa	38.51	6.00e-52	197.00
IUUC-Nle-069013	Nomascus leucogenys	94.10	3.00e-162	564.00
IUUC-Opr-070628	Ochotona princeps	85.99	4.00e-158	550.00
IUUC-Ont-072688	Oreochromis niloticus	91.72	8.00e-160	555.00
IUUC-Oan-073004	Ornithorhynchus anatinus	95.88	9.00e-141	492.00
IUUC-Ocu-074303	Oryctolagus cuniculus	95.83	1.00e-166	579.00
IUUC-Oba-075002	Oryza barthii	47.12	1.00e-73	269.00
IUUC-Obr-076392	Oryza brachyantha	47.32	3.00e-71	261.00
IUUC-Ogl-077271	Oryza glaberrima	47.12	1.00e-73	269.00
IUUC-Ogu-078493	Oryza glumaepatula	46.96	4.00e-74	271.00
IUUC-Oin-080084	Oryza indica	46.96	4.00e-74	271.00
IUUC-Olo-080803	Oryza longistaminata	46.65	9.00e-74	270.00
IUUC-Ome-081146	Oryza meridionalis	45.37	9.00e-73	266.00
IUUC-Oni-082146	Oryza nivara	46.96	4.00e-74	271.00
IUUC-Opu-083633	Oryza punctata	46.64	5.00e-70	257.00
IUUC-Oru-084789	Oryza rufipogon	46.96	4.00e-74	271.00
IUUC-Osa-086196	Oryza sativa	46.96	4.00e-74	271.00
IUUC-Ola-087126	Oryzias latipes	92.01	1.00e-155	541.00
IUUC-Olu-087665	Ostreococcus lucimarinus	39.78	5.00e-60	224.00
IUUC-Oga-089140	Otolemur garnettii	86.35	1.00e-159	555.00
IUUC-Oar-090296	Ovis aries	95.49	4.00e-166	576.00
IUUC-Ptr-090566	Pan troglodytes	94.79	1.00e-164	572.00
IUUC-Pan-092052	Papio anubis	94.44	9.00e-163	565.00
IUUC-Pma-094568	Petromyzon marinus	60.07	2.00e-107	381.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.93	3.00e-43	168.00
IUUC-Ppa-095761	Physcomitrella patens	46.75	5.00e-77	280.00
IUUC-Pfo-096210	Poecilia formosa	90.62	3.00e-159	553.00
IUUC-Pab-098463	Pongo abelii	94.79	6.00e-165	573.00
IUUC-Pop-099423	Populus trichocarpa	48.26	2.00e-76	278.00
IUUC-Pca-100108	Procavia capensis	94.12	6.00e-124	436.00
IUUC-Ppe-101176	Prunus persica	50.32	2.00e-76	278.00
IUUC-Pva-102629	Pteropus vampyrus	91.98	3.00e-129	454.00
IUUC-Pgr-103419	Puccinia graminis	40.32	2.00e-49	189.00
IUUC-Pte-104207	Pyrenophora teres	42.57	2.00e-25	107.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.03	1.00e-49	189.00
IUUC-Rno-105579	Rattus norvegicus	83.28	5.00e-157	546.00
IUUC-Sha-106894	Sarcophilus harrisii	92.75	6.00e-154	536.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	37.81	4.00e-52	197.00
IUUC-Spo-108371	Schizosaccharomyces pombe	40.00	8.00e-54	203.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.13	4.00e-48	184.00
IUUC-Smo-109396	Selaginella moellendorffii	50.33	3.00e-80	291.00
IUUC-Sit-110630	Setaria italica	48.70	2.00e-77	281.00
IUUC-Sly-110972	Solanum lycopersicum	49.52	3.00e-81	294.00
IUUC-Stu-112185	Solanum tuberosum	49.20	8.00e-81	293.00
IUUC-Sar-113294	Sorex araneus	78.12	6.00e-146	509.00
IUUC-Sbi-113951	Sorghum bicolor	49.03	9.00e-78	283.00
IUUC-Ssc-115501	Sus scrofa	95.83	1.00e-166	578.00
IUUC-Tgu-117152	Taeniopygia guttata	97.57	1.00e-163	568.00
IUUC-Tru-118388	Takifugu rubripes	90.62	2.00e-160	557.00
IUUC-Tsy-119109	Tarsius syrichta	95.14	4.00e-165	573.00
IUUC-Tni-120048	Tetraodon nigroviridis	90.62	3.00e-160	556.00
IUUC-Tca-121750	Theobroma cacao	49.53	4.00e-80	291.00
IUUC-Tre-122130	Trichoderma reesei	37.63	2.00e-48	185.00
IUUC-Tvi-122284	Trichoderma virens	38.61	2.00e-46	178.00
IUUC-Tae-124082	Triticum aestivum	47.08	2.00e-74	271.00
IUUC-Tur-126366	Triticum urartu	43.32	4.00e-65	241.00
IUUC-Tme-127187	Tuber melanosporum	40.43	5.00e-53	200.00
IUUC-Tbe-127619	Tupaia belangeri	86.41	3.00e-139	487.00
IUUC-Ttr-128867	Tursiops truncatus	85.71	2.00e-122	431.00
IUUC-Vda-129912	Verticillium dahliae	36.59	7.00e-47	180.00
IUUC-Vpa-130552	Vicugna pacos	97.28	2.00e-108	385.00
IUUC-Vvi-130881	Vitis vinifera	49.53	7.00e-76	276.00
IUUC-Xtr-131934	Xenopus tropicalis	85.86	2.00e-160	558.00
IUUC-Xma-133312	Xiphophorus maculatus	90.28	4.00e-158	550.00
IUUC-Zma-135462	Zea mays	43.65	2.00e-65	242.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence