iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-40	135.4	91	127
UBD/Beta-Prp	1.10e-78	265.4	3	322

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH d ++ ++f ++ + +vs+sdD ti++W++ + ++
   Q: 91   GHLDYIRTVQFhHEnPWIVSASDDQTIRIWNWQSRTC 127
           8**********95569***************987766 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
           t +++++++++ + f+p++++++++  +g i++wd+++g+l+ ++ +he++v+ v f+++++++v+g++D+ ikvw+++t  c+ tl gh d++++++
   Q: 3    TKFETKSNRVKGLSFHPKRPWILASLHSGVIQLWDYRMGTLIDRFDEHEGPVRGVHFHNSQPLFVSGGDDYKIKVWNYKTHRCLFTLLGHLDYIRTVQ 100
           67889999****************************************************************************************** PP
   S: 102  fspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...............ktgkllrtl......... 175
           f+ ++ ++vs+s+d+tir+w++++++c++ +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               ++ ++  +l         
   Q: 101  FHHENPWIVSASDDQTIRIWNWQSRTCIS-VLTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIgalkkksaspaddlmRFSQMNSDLfggvdaivk 197
           *****************************.****************************************9999999999444444444566666666 PP
   S: 176  ..tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
              +gh++ v++ sf+++ + +vsg++d++vklw + +++   v+tl+gh +nv+sv f+ +++++vs s+D+sir+Wd ++++ ++t+ +++++++ 
   Q: 198  yvLEGHDRGVNWASFHPTLPLIVSGADDRQVKLWRMNETKAweVDTLRGHMNNVSSVMFHAKQDIIVSNSEDKSIRVWDATKRTGIQTFRREHDRFWI 295
           66555********************************887778******************************************************* PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkkne 298
            av +++ n l++g + +   ++kl++++
   Q: 296  LAV-HPEINLLAAGHD-NGMIVFKLERER 322
           ***.888777777755.566677887766 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

Protein Sequence
(Fasta)

MLTKFETKSN RVKGLSFHPK RPWILASLHS GVIQLWDYRM GTLIDRFDEH EGPVRGVHFH 60
NSQPLFVSGG DDYKIKVWNY KTHRCLFTLL GHLDYIRTVQ FHHENPWIVS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTGATGCT TCCATATAAA ATAAAAGTAA AAATGAGTAA TTCATGCCAA TTAAATTAGC 60
GAGACGCAAA TTGGAGACAG AGATAACTGA GCGGAGGGAT TCAGATCTAT ACGACGAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0016020--C:membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

ath:AT2G21390

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005526	Arabidopsis lyrata	95.17	0.00e+00	2265.00
IUUC-Acl-008027	Aspergillus clavatus	55.66	0.00e+00	980.00
IUUC-Afl-008644	Aspergillus flavus	54.76	0.00e+00	974.00
IUUC-Afu-008964	Aspergillus fumigatus	55.70	0.00e+00	982.00
IUUC-Ani-009379	Aspergillus nidulans	55.58	0.00e+00	989.00
IUUC-Ang-009756	Aspergillus niger	55.56	0.00e+00	985.00
IUUC-Aor-010174	Aspergillus oryzae	54.76	0.00e+00	974.00
IUUC-Ate-010302	Aspergillus terreus	47.47	0.00e+00	1149.00
IUUC-Bci-013781	Botrytis cinerea	47.44	0.00e+00	1121.00
IUUC-Bol-015925	Brassica oleracea	91.16	0.00e+00	2208.00
IUUC-Bra-016978	Brassica rapa	92.38	0.00e+00	2224.00
IUUC-Csv-025864	Ciona savignyi	58.33	0.00e+00	999.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	54.99	0.00e+00	978.00
IUUC-Cne-027053	Cryptococcus neoformans	50.97	0.00e+00	1181.00
IUUC-Dme-031945	Drosophila melanogaster	61.42	0.00e+00	1040.00
IUUC-Fox-037738	Fusarium oxysporum	46.79	0.00e+00	1129.00
IUUC-Fso-038153	Fusarium solani	46.59	0.00e+00	1113.00
IUUC-Ggr-039931	Gaeumannomyces graminis	54.08	0.00e+00	961.00
IUUC-Gma-043585	Glycine max	82.24	0.00e+00	2087.00
IUUC-Loc-051867	Lepisosteus oculatus	50.23	0.00e+00	816.00
IUUC-Lma-053138	Leptosphaeria maculans	55.29	0.00e+00	983.00
IUUC-Mor-057172	Magnaporthe oryzae	45.93	0.00e+00	1099.00
IUUC-Mtr-058248	Medicago truncatula	81.79	0.00e+00	2097.00
IUUC-Mvi-060336	Microbotryum violaceum	51.05	0.00e+00	1216.00
IUUC-Nfi-068270	Neosartorya fischeri	55.78	0.00e+00	981.00
IUUC-Ncr-068892	Neurospora crassa	55.82	0.00e+00	983.00
IUUC-Pno-094839	Phaeosphaeria nodorum	53.79	0.00e+00	907.00
IUUC-Pfo-097493	Poecilia formosa	53.60	0.00e+00	1304.00
IUUC-Ppe-101899	Prunus persica	83.00	0.00e+00	2104.00
IUUC-Pgr-103376	Puccinia graminis	50.77	0.00e+00	1231.00
IUUC-Ptt-103978	Puccinia triticina	51.54	0.00e+00	813.00
IUUC-Pte-104126	Pyrenophora teres	54.52	0.00e+00	936.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	47.27	0.00e+00	1122.00
IUUC-Sre-115209	Sporisorium reilianum	55.67	0.00e+00	1009.00
IUUC-Tca-120918	Theobroma cacao	81.34	0.00e+00	2094.00
IUUC-Tre-121951	Trichoderma reesei	56.82	0.00e+00	970.00
IUUC-Tvi-122359	Trichoderma virens	46.63	0.00e+00	1123.00
IUUC-Tme-127170	Tuber melanosporum	48.69	0.00e+00	1177.00
IUUC-Uma-129337	Ustilago maydis	56.15	0.00e+00	1009.00
IUUC-Vda-129828	Verticillium dahliae	46.39	0.00e+00	1107.00
IUUC-Xma-133138	Xiphophorus maculatus	53.60	0.00e+00	1306.00
IUUC-Yli-134399	Yarrowia lipolytica	49.25	0.00e+00	850.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence