iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062306

UUCD1 version

UUC-MoD-00448

Ensembl Protein ID

ENSMODP00000022263.3

UniProt Accession

F6YIN6; F6YIN6_MONDO

Protein Name

Uncharacterized protein

Gene Name

UBR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000017858.3	ENSMODT00000022652.3	ENSMODP00000022263.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	2.40e-34	117.5	159	235
E3 activity/RING/RING	4.20e-07	30.5	1033	1136
E3 activity/N-recognin/UBR-box	1.30e-30	105.9	30	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslqkAl +e+ ea+ ++t+idkeGRravk G+   c eak++i+ +se+++q+pL+Vev
   Q: 159  YYCVLFNDEHHSYDHVIYSLQKALKCELTEAQVHTTAIDKEGRRAVKLGSGVHCREAKENIKFHSENVSQHPLHVEV 235
           9**************************************************************************97 PP

E3 activity/RING/RING

   S: 1    CaiCledf.............................................kdgplvlpCgHvfhadClqkw............. 29
           C++C+e+                                               +g+++++CgHv+ha C+qk+             
   Q: 1033 CILCQEEQevrlenaamvlsacvqkssaltqqrekplelsgetpdplfmdpnlACGTHTGSCGHVMHAVCWQKYfeaiqinsrqrlh 1119
           8888665544444444444433333333333333333333333333333333344799****************9999999999999 PP
   S: 30   pglknssskefrCPlCr 46
           +   +++++e +CPlC+
   Q: 1120 VEFFDLENGEYLCPLCK 1136
           999999999999****6 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++ Hk+H+yk+++s+gggfCdCGdteAw++g++C  ++
   Q: 30   QLCGKVFKSGETTYSCRDCAIDPTCVLCMNCFQNSAHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCSIHE 100
           68*****************************************************************9986 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MMILTPLEWY LFKEDPVLSL EKLKQSGAFQ LCGKVFKSGE TTYSCRDCAI DPTCVLCMNC 60
FQNSAHKNHR YKMHTSTGGG FCDCGDTEAW KTGPFCSIHE PRTTRSNNEN LGCPLTEEVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATGATAT TAACTCCACT GGAATGGTAC CTATTTAAAG AAGATCCAGT TCTTTCTTTA 60
GAGAAATTGA AACAAAGTGG AGCATTTCAA CTTTGTGGGA AGGTTTTCAA AAGTGGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001354	Ailuropoda melanoleuca	80.96	0.00e+00	2768.00
IUUC-Apl-004160	Anas platyrhynchos	78.27	0.00e+00	2668.00
IUUC-Aca-004982	Anolis carolinensis	75.12	0.00e+00	2562.00
IUUC-Ago-007752	Ashbya gossypii	24.59	3.00e-29	125.00
IUUC-Acl-008055	Aspergillus clavatus	23.76	5.00e-50	194.00
IUUC-Ani-009334	Aspergillus nidulans	24.25	4.00e-52	201.00
IUUC-Ate-010550	Aspergillus terreus	23.54	3.00e-50	194.00
IUUC-Ame-011231	Astyanax mexicanus	58.12	0.00e+00	1886.00
IUUC-Bgr-011999	Blumeria graminis	22.69	1.00e-47	186.00
IUUC-Bta-012347	Bos taurus	80.70	0.00e+00	2753.00
IUUC-Bci-013834	Botrytis cinerea	24.85	1.00e-47	186.00
IUUC-Cja-018911	Callithrix jacchus	78.02	0.00e+00	2650.00
IUUC-Cfa-020991	Canis familiaris	81.61	0.00e+00	2788.00
IUUC-Cpo-021448	Cavia porcellus	79.03	0.00e+00	2737.00
IUUC-Csa-024255	Chlorocebus sabaeus	81.01	0.00e+00	2273.00
IUUC-Cho-024550	Choloepus hoffmanni	62.29	0.00e+00	2003.00
IUUC-Cgl-026605	Colletotrichum gloeosporioides	23.98	4.00e-52	201.00
IUUC-Cne-026823	Cryptococcus neoformans	23.36	9.00e-41	163.00
IUUC-Dno-029427	Dasypus novemcinctus	79.38	0.00e+00	2677.00
IUUC-Dor-031073	Dipodomys ordii	69.97	0.00e+00	1229.00
IUUC-Ete-032318	Echinops telfairi	65.30	0.00e+00	1006.00
IUUC-Eca-033348	Equus caballus	80.69	0.00e+00	2666.00
IUUC-Eeu-034664	Erinaceus europaeus	73.64	0.00e+00	2491.00
IUUC-Fca-035604	Felis catus	78.39	0.00e+00	1297.00
IUUC-Fal-037333	Ficedula albicollis	78.74	0.00e+00	2684.00
IUUC-Gmo-039363	Gadus morhua	55.56	0.00e+00	1638.00
IUUC-Gga-040486	Gallus gallus	77.29	0.00e+00	2583.00
IUUC-Gac-041985	Gasterosteus aculeatus	56.47	0.00e+00	1719.00
IUUC-Ggo-044704	Gorilla gorilla	75.08	0.00e+00	2154.00
IUUC-Hsa-046753	Homo sapiens	80.84	0.00e+00	2773.00
IUUC-Itr-048410	Ictidomys tridecemlineatus	81.10	0.00e+00	2763.00
IUUC-Lch-049904	Latimeria chalumnae	63.17	0.00e+00	2105.00
IUUC-Loc-052624	Lepisosteus oculatus	61.62	0.00e+00	2019.00
IUUC-Laf-053857	Loxodonta africana	78.42	0.00e+00	2700.00
IUUC-Mcc-054873	Macaca mulatta	80.78	0.00e+00	2735.00
IUUC-Meu-056858	Macropus eugenii	75.66	0.00e+00	1187.00
IUUC-Mga-059917	Meleagris gallopavo	78.74	0.00e+00	2699.00
IUUC-Mmr-061128	Microcebus murinus	77.70	0.00e+00	2601.00
IUUC-Mmu-063389	Mus musculus	79.70	0.00e+00	2750.00
IUUC-Mpu-065983	Mustela putorius furo	81.14	0.00e+00	2801.00
IUUC-Mlu-068013	Myotis lucifugus	78.19	0.00e+00	2693.00
IUUC-Nle-070031	Nomascus leucogenys	80.90	0.00e+00	2779.00
IUUC-Opr-070551	Ochotona princeps	60.10	0.00e+00	1063.00
IUUC-Ont-072035	Oreochromis niloticus	58.19	0.00e+00	1934.00
IUUC-Ocu-074930	Oryctolagus cuniculus	77.21	0.00e+00	2618.00
IUUC-Ogl-077571	Oryza glaberrima	24.47	4.00e-27	118.00
IUUC-Osa-086106	Oryza sativa	45.00	4.00e-14	73.60
IUUC-Ola-086683	Oryzias latipes	57.58	0.00e+00	1881.00
IUUC-Oga-088017	Otolemur garnettii	78.45	0.00e+00	2664.00
IUUC-Oar-089557	Ovis aries	80.45	0.00e+00	2749.00
IUUC-Ptr-091366	Pan troglodytes	79.83	0.00e+00	2748.00
IUUC-Pan-092184	Papio anubis	80.78	0.00e+00	2734.00
IUUC-Psi-093720	Pelodiscus sinensis	80.04	0.00e+00	2658.00
IUUC-Pma-094152	Petromyzon marinus	39.54	6.00e-145	508.00
IUUC-Ppa-095780	Physcomitrella patens	21.44	7.00e-26	113.00
IUUC-Pfo-097124	Poecilia formosa	57.97	0.00e+00	1885.00
IUUC-Pab-098586	Pongo abelii	80.96	0.00e+00	2776.00
IUUC-Pop-099184	Populus trichocarpa	45.26	1.00e-14	73.90
IUUC-Pca-100673	Procavia capensis	73.93	0.00e+00	1419.00
IUUC-Pva-102724	Pteropus vampyrus	75.12	0.00e+00	2518.00
IUUC-Pte-104174	Pyrenophora teres	23.55	1.00e-48	189.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	23.56	1.00e-47	186.00
IUUC-Rno-105474	Rattus norvegicus	76.62	0.00e+00	2016.00
IUUC-Sha-106993	Sarcophilus harrisii	95.37	0.00e+00	3274.00
IUUC-Sar-113447	Sorex araneus	77.91	0.00e+00	1845.00
IUUC-Ssc-115768	Sus scrofa	77.37	0.00e+00	2548.00
IUUC-Tgu-116949	Taeniopygia guttata	73.14	0.00e+00	2446.00
IUUC-Tru-117782	Takifugu rubripes	57.34	0.00e+00	1890.00
IUUC-Tsy-119177	Tarsius syrichta	71.97	0.00e+00	1941.00
IUUC-Tni-120884	Tetraodon nigroviridis	53.42	0.00e+00	1712.00
IUUC-Tre-122137	Trichoderma reesei	26.19	3.00e-63	238.00
IUUC-Tbe-128088	Tupaia belangeri	71.69	0.00e+00	1093.00
IUUC-Ttr-129062	Tursiops truncatus	75.76	0.00e+00	2555.00
IUUC-Vpa-130578	Vicugna pacos	73.78	0.00e+00	2472.00
IUUC-Vvi-130900	Vitis vinifera	45.83	2.00e-14	73.60
IUUC-Xtr-132244	Xenopus tropicalis	61.25	0.00e+00	2079.00
IUUC-Xma-134112	Xiphophorus maculatus	57.98	0.00e+00	1882.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence