iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007272

UUCD1 version

UUC-ArT-01568

Ensembl Protein ID

AT3G52450.1

UniProt Accession

Q9SVC6; PUB22_ARATH

Genbank Protein ID

CAB43434.1; AEE78947.1; AAU90053.1; AAV59269.1; BAF00881.1

Protein Name

E3 ubiquitin-protein ligase PUB22; Plant U-box protein 22; RING-type E3 ubiquitin transferase PUB22; U-box domain-containing protein 22

Genbank Nucleotide ID

AL050300; CP002686; BT015763; BT020203; AK228993

Gene Name

PUB22; At3g52450; F22O6_170

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G52450	AT3G52450.1	AT3G52450.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	19826220

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.00e-34	119.3	6	79
E3 activity/RING/RING	0.028	15.8	13	51

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk.tcPvtrqplteedlvPnltlrrliqawceens 73
           e+p++flCpIsl++M+dPv++++Gitydr+sIekwl sg+k +cPvt+q +te+dl+Pn+tlrrliq+wc  n+
   Q: 6    EIPSFFLCPISLDIMKDPVIVSTGITYDRESIEKWLFSGKKnSCPVTKQVITETDLTPNHTLRRLIQSWCTLNA 79
           69**********************************999999****************************9876 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C+i l+ +kd p++++ g ++ ++ ++kw     +s k+ +CP+
   Q: 13   CPISLDIMKD-PVIVSTGITYDRESIEKW----LFSGKKNSCPV 51
           **********.999***************....99********8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that negatively regulates water stress response. May control in coordination with PUB23 a drought signaling pathway by ubiquitinating cytosolic RPN12a. Acts as negative regulator of the immunity triggered by the pathogen-associated molecular patterns (PAMPs), in association with PUB23 and PUB24.

Protein Sequence
(Fasta)

MDQEIEIPSF FLCPISLDIM KDPVIVSTGI TYDRESIEKW LFSGKKNSCP VTKQVITETD 60
LTPNHTLRRL IQSWCTLNAS YGIERIPTPK PPICKSEIEK LIKESSSSHL NQVKCLKRLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATCCCTTTA TATTTAAAGA CCCAAACTCT TCATCTATCT TCTTGCTAAC TTATTCAAAC 60
CAATTCACAT ATCTCCTAAA TCTCAACGAC TGCACTTTGA AGCTTTTTGT TTAGATTCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX

Pfam

PF04564--U-box

SMART

SM00504--Ubox

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006952--P:defense response
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
GO:0010200--P:response to chitin
GO:0009414--P:response to water deprivation

KEGG

ath:AT3G52450

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000554	Aegilops tauschii	41.78	2.00e-89	322.00
IUUC-Aly-005797	Arabidopsis lyrata	97.70	0.00e+00	788.00
IUUC-Bol-015372	Brassica oleracea	92.64	0.00e+00	746.00
IUUC-Bra-016912	Brassica rapa	92.64	0.00e+00	746.00
IUUC-Gma-043412	Glycine max	58.49	2.00e-140	491.00
IUUC-Mtr-058052	Medicago truncatula	59.23	4.00e-145	506.00
IUUC-Ogu-079030	Oryza glumaepatula	42.70	5.00e-68	250.00
IUUC-Oin-079734	Oryza indica	42.70	7.00e-68	250.00
IUUC-Oni-082818	Oryza nivara	44.04	2.00e-69	255.00
IUUC-Oru-085239	Oryza rufipogon	42.70	5.00e-68	251.00
IUUC-Osa-086041	Oryza sativa	42.70	5.00e-68	250.00
IUUC-Pop-099305	Populus trichocarpa	59.82	2.00e-146	511.00
IUUC-Stu-112276	Solanum tuberosum	55.09	1.00e-137	482.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence