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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Spo-108302
UUCD1 version UUC-ScP-00138
Ensembl Protein ID SPCC895.06.1:pep
UniProt Accession O94533; ELP2_SCHPO
Genbank Protein ID CAA22842.1
Protein Name Elongator complex protein 2
Genbank Nucleotide ID CU329672
Gene Name elp2; SPCC895.06
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPCC895.06 SPCC895.06.1 SPCC895.06.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
HINTMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.70e-37 121.7 266 299
UBD/Beta-Prp 2.20e-53 179.4 101 445
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
    gH+d+v ++++ ++ +++s+s D ++ vW+++t
   Q: 266 GHEDWVMSVDWhPTkEMILSSSADSSMIVWEPDT 299
    8***********999***************9876 PP
   


   UBD/Beta-Prp

   S: 12   vitcvkfspdksllatgsrdgtikvwdvttgkl....lrslsgheae.........vtavkfspdgkilvtgseDrtikvw....dlstgkcv 87
    ++c+++ +++l++ g+ +++ +v+++ ++ +++ + + vk+++ il +++ + i v+ +s++k
   Q: 101 TVNCLCV--NENLVVCGCSNSSCIVYSWNAEQRnlteISR------FtcseiipleFAIVKLDHGI-ILTVCGSSKKIMVYgsdsAISSFKLK 184
    5889999..****************999886664455333......23334444448888888886.99999999******9988899***** PP
   S: 88 htlkghedsvlslsfsp...sgdklvsGshdrtirv.....wdletgqclee..........................tlsghdgvvncvvvh 146
    +l+gh d v++lsf + s+ +l+sGs+dr+ir+ w e ++++ee +l gh+++v++v +h
   Q: 185 AVLRGHLDWVRTLSFKKtsgSTATLASGSQDRYIRLwnislWGSEDEKVSEEffesvlsnkpvrftlgkidlkivfdaLLMGHEDWVMSVDWH 277
    *****************987789*************5555555566666666***************************************** PP
   S: 147 pdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls................fdsngkelvsgsldgtvklwdlqtgec..vrtlngh 221
    p++ ++ s+s+D+ + +W t++ + tg + s +++ng+++v ++ g +lw +g+ + + gh
   Q: 278 PTKEMILSSSADSSMIVWEPDTNTGIWVVTG-RMGEMASSHgsttatgsaggfwgglWNPNGNCVVCWGRTGGWRLWKQDAGQWlqLPSISGH 369
    ********************99999988877.5666665556777888899*****************************99886688***** PP
   S: 222 tdnvksvrfspnderlvsgssDgsiriW.dlrsgdllktlqlhn...ssvisvavlsfgdnvlvlgsedskvniwkl 294
    t+ vk v+ +p++++++s++ D++ r++ ++++ ++ +++++ ++s+++ +++ ++++++++ +++k+
   Q: 370 TKSVKGVAWDPEGKFYLSAGTDQTTRLFaRFKKDNAWHEMARPQihgYDLTSISC-MPSRIGFLSCADEKVSRVFKF 445
    ***************************9899*************99966666666.556666666666666667766 PP
   

Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description



     Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. Independently, elp2 may be involved in polarized exocytosis. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA (By similarity).
Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. Independently, elp2 may be involved in polarized exocytosis. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA (By similarity).
Protein Sequence
(Fasta)
MFQYEALHVG CNRIPTAATW SSNLGLIYGA ERLIAVADPF KEINYLMAGH SGRINCVCEL 60
ATNSEYRSPF ILSGASDKTL RLWQLEEEYF TCIKTIELEA TVNCLCVNEN LVVCGCSNSS 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Spo-108302|E3,WD_repeat;UBD,Beta-Prp|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGCCAGCAA GAAGAGGCAT TTGCGATGTT TCAGTATGAG GCTTTACATG TAGGCTGTAA 60
TCGTATACCA ACTGCAGCAA CATGGTCTTC TAATCTTGGC CTTATTTATG GAGCTGAAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Spo-108302|E3,WD_repeat;UBD,Beta-Prp|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0005829--C:cytosol
GO:0033588--C:Elongator holoenzyme complex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005634--C:nucleus
GO:0008017--F:microtubule binding
GO:0015031--P:protein transport
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0002098--P:tRNA wobble uridine modification

KEGG spo:SPCC895.06
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000056 Aegilops tauschii 30.17 2.00e-83 301.00
IUUC-Aml-002049 Ailuropoda melanoleuca 33.78 4.00e-83 300.00
IUUC-Atr-002456 Amborella trichopoda 31.48 3.00e-98 350.00
IUUC-Apl-004053 Anas platyrhynchos 32.73 1.00e-97 348.00
IUUC-Aca-004535 Anolis carolinensis 32.44 6.00e-85 306.00
IUUC-Aly-005746 Arabidopsis lyrata 31.14 1.00e-92 332.00
IUUC-Ath-006664 Arabidopsis thaliana 30.70 2.00e-89 321.00
IUUC-Ago-007971 Ashbya gossypii 35.48 4.00e-127 446.00
IUUC-Acl-008173 Aspergillus clavatus 38.16 1.00e-138 485.00
IUUC-Afl-008665 Aspergillus flavus 36.14 2.00e-59 221.00
IUUC-Afu-008976 Aspergillus fumigatus 36.95 3.00e-139 486.00
IUUC-Ani-009284 Aspergillus nidulans 35.58 6.00e-133 466.00
IUUC-Ang-009809 Aspergillus niger 36.61 2.00e-134 471.00
IUUC-Aor-009959 Aspergillus oryzae 37.84 3.00e-135 474.00
IUUC-Ate-010442 Aspergillus terreus 36.50 4.00e-135 473.00
IUUC-Ame-011409 Astyanax mexicanus 29.09 7.00e-88 316.00
IUUC-Bgr-012137 Blumeria graminis 38.76 5.00e-139 486.00
IUUC-Bta-012892 Bos taurus 33.07 5.00e-98 350.00
IUUC-Bci-013944 Botrytis cinerea 38.74 1.00e-132 464.00
IUUC-Bdi-014512 Brachypodium distachyon 30.07 8.00e-88 316.00
IUUC-Bol-015741 Brassica oleracea 30.66 8.00e-95 339.00
IUUC-Bra-017367 Brassica rapa 30.88 7.00e-97 346.00
IUUC-Cel-018712 Caenorhabditis elegans 30.56 1.00e-71 262.00
IUUC-Cja-018865 Callithrix jacchus 32.31 2.00e-89 321.00
IUUC-Cfa-021006 Canis familiaris 33.03 2.00e-98 351.00
IUUC-Cpo-021370 Cavia porcellus 32.01 1.00e-95 342.00
IUUC-Csa-023845 Chlorocebus sabaeus 31.69 1.00e-95 342.00
IUUC-Cho-024640 Choloepus hoffmanni 30.86 5.00e-55 207.00
IUUC-Cin-025772 Ciona intestinalis 30.71 7.00e-93 333.00
IUUC-Csv-025891 Ciona savignyi 30.75 6.00e-94 336.00
IUUC-Cgl-026443 Colletotrichum gloeosporioides 37.78 1.00e-129 454.00
IUUC-Cne-027081 Cryptococcus neoformans 31.87 1.00e-84 305.00
IUUC-Cme-027225 Cyanidioschyzon merolae 23.61 2.00e-28 119.00
IUUC-Dre-028250 Danio rerio 29.17 2.00e-88 318.00
IUUC-Dno-028847 Dasypus novemcinctus 32.30 8.00e-98 349.00
IUUC-Dor-030351 Dipodomys ordii 33.51 7.00e-99 353.00
IUUC-Dse-031317 Dothistroma septosporum 36.10 7.00e-129 452.00
IUUC-Dme-032019 Drosophila melanogaster 31.67 4.00e-101 360.00
IUUC-Ete-033194 Echinops telfairi 35.19 2.00e-46 179.00
IUUC-Eca-033779 Equus caballus 34.06 2.00e-99 354.00
IUUC-Eeu-034790 Erinaceus europaeus 31.29 2.00e-58 218.00
IUUC-Fca-036090 Felis catus 34.15 2.00e-99 354.00
IUUC-Fal-037663 Ficedula albicollis 31.13 2.00e-88 318.00
IUUC-Fox-037828 Fusarium oxysporum 35.79 1.00e-124 438.00
IUUC-Fso-038462 Fusarium solani 37.70 1.00e-125 442.00
IUUC-Gmo-039450 Gadus morhua 29.76 3.00e-89 320.00
IUUC-Ggr-040023 Gaeumannomyces graminis 34.09 2.00e-114 405.00
IUUC-Gga-040480 Gallus gallus 31.74 9.00e-96 342.00
IUUC-Gac-041544 Gasterosteus aculeatus 32.07 9.00e-101 359.00
IUUC-Gma-044048 Glycine max 29.40 6.00e-92 330.00
IUUC-Ggo-045381 Gorilla gorilla 31.09 3.00e-86 311.00
IUUC-Hsa-046096 Homo sapiens 31.82 1.00e-88 319.00
IUUC-Hvu-047494 Hordeum vulgare 29.91 4.00e-88 317.00
IUUC-Itr-048823 Ictidomys tridecemlineatus 31.47 3.00e-80 291.00
IUUC-Kpa-049241 Komagataella pastoris 35.30 2.00e-120 424.00
IUUC-Lch-050512 Latimeria chalumnae 33.01 6.00e-89 320.00
IUUC-Lpe-051448 Leersia perrieri 30.84 2.00e-88 318.00
IUUC-Loc-051882 Lepisosteus oculatus 30.42 4.00e-100 357.00
IUUC-Lma-053023 Leptosphaeria maculans 37.05 1.00e-129 455.00
IUUC-Laf-054519 Loxodonta africana 32.59 5.00e-99 353.00
IUUC-Mcc-055580 Macaca mulatta 32.06 6.00e-88 317.00
IUUC-Meu-056606 Macropus eugenii 38.02 2.00e-26 112.00
IUUC-Mor-057109 Magnaporthe oryzae 34.54 8.00e-129 452.00
IUUC-Mpo-057297 Magnaporthe poae 34.26 5.00e-124 436.00
IUUC-Mtr-058348 Medicago truncatula 30.60 2.00e-93 335.00
IUUC-Mla-059159 Melampsora laricipopulina 33.87 1.00e-72 265.00
IUUC-Mga-059778 Meleagris gallopavo 30.04 2.00e-57 214.00
IUUC-Mvi-060447 Microbotryum violaceum 30.52 2.00e-88 318.00
IUUC-Mmr-061139 Microcebus murinus 33.20 1.00e-92 332.00
IUUC-Mdo-061866 Monodelphis domestica 32.69 1.00e-97 349.00
IUUC-Mmu-063390 Mus musculus 32.95 2.00e-96 344.00
IUUC-Mac-064693 Musa acuminata 31.28 2.00e-93 335.00
IUUC-Mpu-066547 Mustela putorius furo 32.71 9.00e-94 335.00
IUUC-Mlu-067156 Myotis lucifugus 31.50 3.00e-94 337.00
IUUC-Nfi-068616 Neosartorya fischeri 37.25 2.00e-140 490.00
IUUC-Ncr-068915 Neurospora crassa 32.60 5.00e-116 410.00
IUUC-Nle-069958 Nomascus leucogenys 31.95 1.00e-93 336.00
IUUC-Opr-071093 Ochotona princeps 27.53 9.00e-37 146.00
IUUC-Ont-072178 Oreochromis niloticus 32.81 4.00e-100 357.00
IUUC-Oan-073667 Ornithorhynchus anatinus 31.98 3.00e-97 347.00
IUUC-Ocu-074662 Oryctolagus cuniculus 32.61 9.00e-97 345.00
IUUC-Oba-075577 Oryza barthii 30.49 1.00e-90 325.00
IUUC-Obr-076566 Oryza brachyantha 30.62 3.00e-90 324.00
IUUC-Ogl-077054 Oryza glaberrima 30.71 2.00e-90 325.00
IUUC-Ogu-078846 Oryza glumaepatula 30.49 3.00e-90 324.00
IUUC-Oin-079084 Oryza indica 30.62 4.00e-90 324.00
IUUC-Olo-080933 Oryza longistaminata 28.99 2.00e-73 268.00
IUUC-Ome-081500 Oryza meridionalis 29.48 2.00e-79 288.00
IUUC-Oni-082352 Oryza nivara 30.49 5.00e-90 323.00
IUUC-Opu-084116 Oryza punctata 31.25 6.00e-90 323.00
IUUC-Oru-085249 Oryza rufipogon 30.62 4.00e-90 324.00
IUUC-Osa-086270 Oryza sativa 30.62 4.00e-90 324.00
IUUC-Ola-086625 Oryzias latipes 28.12 4.00e-75 274.00
IUUC-Olu-087638 Ostreococcus lucimarinus 30.42 8.00e-74 269.00
IUUC-Oga-088634 Otolemur garnettii 31.68 3.00e-85 307.00
IUUC-Oar-089475 Ovis aries 32.68 2.00e-97 348.00
IUUC-Ptr-091131 Pan troglodytes 31.88 3.00e-95 341.00
IUUC-Pan-092869 Papio anubis 31.49 5.00e-95 340.00
IUUC-Psi-093146 Pelodiscus sinensis 34.13 2.00e-90 324.00
IUUC-Pma-094479 Petromyzon marinus 34.25 3.00e-85 307.00
IUUC-Pno-095061 Phaeosphaeria nodorum 35.16 2.00e-103 368.00
IUUC-Ppa-095618 Physcomitrella patens 31.23 4.00e-92 331.00
IUUC-Pfo-096816 Poecilia formosa 30.82 9.00e-97 346.00
IUUC-Pab-097548 Pongo abelii 32.30 2.00e-96 345.00
IUUC-Pop-099643 Populus trichocarpa 29.98 4.00e-94 337.00
IUUC-Pca-100983 Procavia capensis 28.77 2.00e-41 162.00
IUUC-Ppe-101301 Prunus persica 30.30 2.00e-93 335.00
IUUC-Pva-102460 Pteropus vampyrus 32.56 4.00e-93 333.00
IUUC-Pgr-103507 Puccinia graminis 28.03 1.00e-67 249.00
IUUC-Ptt-103892 Puccinia triticina 28.33 7.00e-59 220.00
IUUC-Pte-104283 Pyrenophora teres 36.85 3.00e-129 454.00
IUUC-Pyt-104465 Pyrenophora triticirepentis 36.70 3.00e-129 453.00
IUUC-Rno-105842 Rattus norvegicus 33.46 6.00e-97 346.00
IUUC-Sce-106459 Saccharomyces cerevisiae 34.30 3.00e-115 407.00
IUUC-Sha-106586 Sarcophilus harrisii 30.33 9.00e-58 216.00
IUUC-Sja-107868 Schizosaccharomyces japonicus 53.60 0.00e+00 800.00
IUUC-Smo-108919 Selaginella moellendorffii 31.47 5.00e-94 337.00
IUUC-Sit-109915 Setaria italica 30.35 2.00e-88 318.00
IUUC-Sly-111714 Solanum lycopersicum 30.07 8.00e-90 322.00
IUUC-Stu-112631 Solanum tuberosum 28.76 1.00e-87 315.00
IUUC-Sar-113200 Sorex araneus 30.32 4.00e-75 274.00
IUUC-Sbi-114582 Sorghum bicolor 30.17 3.00e-91 327.00
IUUC-Sre-115001 Sporisorium reilianum 32.08 6.00e-40 157.00
IUUC-Ssc-115519 Sus scrofa 32.56 2.00e-98 351.00
IUUC-Tgu-116987 Taeniopygia guttata 31.37 5.00e-91 327.00
IUUC-Tru-118476 Takifugu rubripes 31.26 2.00e-91 328.00
IUUC-Tsy-119230 Tarsius syrichta 36.11 4.00e-49 187.00
IUUC-Tni-120448 Tetraodon nigroviridis 26.09 9.00e-28 116.00
IUUC-Tca-121650 Theobroma cacao 29.92 9.00e-93 332.00
IUUC-Tre-122086 Trichoderma reesei 37.81 1.00e-121 428.00
IUUC-Tvi-122397 Trichoderma virens 36.89 6.00e-115 406.00
IUUC-Tae-125778 Triticum aestivum 29.95 3.00e-89 321.00
IUUC-Tur-126578 Triticum urartu 30.30 5.00e-89 320.00
IUUC-Tme-126927 Tuber melanosporum 37.45 6.00e-125 439.00
IUUC-Tbe-127922 Tupaia belangeri 41.40 4.00e-37 147.00
IUUC-Ttr-128918 Tursiops truncatus 32.99 4.00e-96 343.00
IUUC-Uma-129474 Ustilago maydis 32.53 1.00e-38 153.00
IUUC-Vda-129944 Verticillium dahliae 37.84 5.00e-127 446.00
IUUC-Vpa-130693 Vicugna pacos 32.89 6.00e-96 343.00
IUUC-Vvi-130949 Vitis vinifera 30.24 2.00e-93 335.00
IUUC-Xtr-132639 Xenopus tropicalis 29.11 1.00e-88 319.00
IUUC-Xma-134223 Xiphophorus maculatus 36.73 4.00e-68 249.00
IUUC-Yli-134601 Yarrowia lipolytica 37.40 4.00e-120 423.00
IUUC-Zma-135952 Zea mays 29.78 2.00e-92 332.00
Created Date 25-Jun-2017

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