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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046309
Ensembl Protein ID ENSP00000262942.5
UniProt Accession Q92747; A4D276; B4DLQ7; D6W5S1; Q7Z5U8; Q86WU5; Q8IXQ0; ARC1A_HUMAN
Genbank Protein ID CAA70203.1; BAG59619.1; EAL23883.1; EAW76682.1; EAW76683.1; AAH39594.2; AAH47889.2; AAH54027.1
Protein Name Actin-related protein 2/3 complex subunit 1A; SOP2-like protein
Genbank Nucleotide ID Y08999; AK297111; AC004834; CH471091; CH471091; BC039594; BC047889; BC054027
Gene Name ARPC1A; SOP2L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000241685.8 ENST00000441989.6 ENSP00000412879.1
ENSG00000241685.8 ENST00000262942.9 ENSP00000262942.5
ENSG00000241685.8 ENST00000432786.5 ENSP00000408711.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.10e-14 53.2 51 85
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           H++ +t++++ +  +++v+++ D + +vW+ ++gv
   Q: 51   HNGHITGIDWaPKsDRIVTCGADRNAYVWSQKDGV 85
           9999*******6669**************988776 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Belongs to the WD repeat ARPC1 family.
 Belongs to the WD repeat ARPC1 family.
Protein Sequence
(Fasta)
MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWVKAHELKE HNGHITGIDW 60
APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046309|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTGGGCTT CCGTCCTCCG CCCGCGCCCG ACGGAGCCTG TTCGCGTCGA CTGCCCAGAG 60
TCCGCGAATC CTCCGCTCCG AGCCCGTCCG GACTCCCCCG ATCCCAGGTA ACGGCCAGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046309|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR030140--ARC1A
IPR017383--ARPC1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005885--C:Arp2/3 protein complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0003779--F:actin binding
GO:0051015--F:actin filament binding
GO:0030036--P:actin cytoskeleton organization
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0061024--P:membrane organization
KEGG hsa:10552
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002044 Ailuropoda melanoleuca 100.00 0.00e+00 741.00
IUUC-Atr-002844 Amborella trichopoda 51.89 3.00e-55 208.00
IUUC-Apl-003325 Anas platyrhynchos 95.14 0.00e+00 743.00
IUUC-Aca-004736 Anolis carolinensis 95.14 0.00e+00 741.00
IUUC-Ago-007966 Ashbya gossypii 38.99 1.00e-65 243.00
IUUC-Acl-008334 Aspergillus clavatus 46.67 5.00e-92 331.00
IUUC-Afl-008485 Aspergillus flavus 46.52 6.00e-89 322.00
IUUC-Afu-008780 Aspergillus fumigatus 46.39 6.00e-93 334.00
IUUC-Ani-009417 Aspergillus nidulans 47.63 2.00e-93 335.00
IUUC-Ang-009543 Aspergillus niger 48.75 4.00e-95 341.00
IUUC-Aor-010234 Aspergillus oryzae 47.22 8.00e-91 327.00
IUUC-Ate-010386 Aspergillus terreus 47.63 2.00e-95 342.00
IUUC-Ame-011852 Astyanax mexicanus 91.08 0.00e+00 715.00
IUUC-Bgr-012192 Blumeria graminis 43.33 9.00e-84 303.00
IUUC-Bta-012530 Bos taurus 99.73 0.00e+00 739.00
IUUC-Bci-013616 Botrytis cinerea 44.44 1.00e-87 316.00
IUUC-Bdi-014632 Brachypodium distachyon 43.09 7.00e-78 284.00
IUUC-Cel-018122 Caenorhabditis elegans 56.71 5.00e-113 400.00
IUUC-Cja-019362 Callithrix jacchus 99.73 0.00e+00 741.00
IUUC-Cfa-020167 Canis familiaris 100.00 0.00e+00 741.00
IUUC-Cpo-021933 Cavia porcellus 100.00 0.00e+00 742.00
IUUC-Cho-024449 Choloepus hoffmanni 75.83 1.00e-98 353.00
IUUC-Cin-025186 Ciona intestinalis 56.49 7.00e-118 417.00
IUUC-Csv-026275 Ciona savignyi 56.32 1.00e-113 402.00
IUUC-Cgl-026732 Colletotrichum gloeosporioides 44.57 2.00e-88 318.00
IUUC-Cne-026926 Cryptococcus neoformans 45.91 8.00e-98 350.00
IUUC-Dre-028057 Danio rerio 90.54 0.00e+00 710.00
IUUC-Dno-029092 Dasypus novemcinctus 98.88 0.00e+00 709.00
IUUC-Dor-030391 Dipodomys ordii 98.88 0.00e+00 709.00
IUUC-Dse-031574 Dothistroma septosporum 44.66 4.00e-83 301.00
IUUC-Dme-031907 Drosophila melanogaster 58.47 2.00e-124 438.00
IUUC-Eca-034074 Equus caballus 100.00 0.00e+00 740.00
IUUC-Eeu-035041 Erinaceus europaeus 83.68 4.00e-94 338.00
IUUC-Fca-036154 Felis catus 100.00 0.00e+00 741.00
IUUC-Fal-037279 Ficedula albicollis 95.14 0.00e+00 742.00
IUUC-Fox-037842 Fusarium oxysporum 45.96 2.00e-88 319.00
IUUC-Fso-038276 Fusarium solani 45.68 3.00e-88 318.00
IUUC-Gmo-039673 Gadus morhua 87.57 0.00e+00 645.00
IUUC-Ggr-039762 Gaeumannomyces graminis 44.44 3.00e-87 315.00
IUUC-Gga-040189 Gallus gallus 95.95 0.00e+00 747.00
IUUC-Gac-042531 Gasterosteus aculeatus 88.38 0.00e+00 652.00
IUUC-Hvu-047456 Hordeum vulgare 29.78 6.00e-16 77.00
IUUC-Itr-047864 Ictidomys tridecemlineatus 100.00 0.00e+00 741.00
IUUC-Lch-050427 Latimeria chalumnae 89.76 0.00e+00 704.00
IUUC-Loc-052532 Lepisosteus oculatus 91.67 0.00e+00 689.00
IUUC-Lma-053109 Leptosphaeria maculans 45.30 8.00e-88 317.00
IUUC-Laf-054271 Loxodonta africana 99.73 0.00e+00 739.00
IUUC-Mcc-054857 Macaca mulatta 98.64 0.00e+00 717.00
IUUC-Meu-056540 Macropus eugenii 92.82 0.00e+00 626.00
IUUC-Mor-057167 Magnaporthe oryzae 42.78 3.00e-84 305.00
IUUC-Mla-058886 Melampsora laricipopulina 44.16 2.00e-90 326.00
IUUC-Mga-059327 Meleagris gallopavo 95.95 0.00e+00 747.00
IUUC-Mvi-060302 Microbotryum violaceum 46.41 3.00e-94 338.00
IUUC-Mmr-060765 Microcebus murinus 98.37 0.00e+00 719.00
IUUC-Mdo-062326 Monodelphis domestica 96.22 0.00e+00 723.00
IUUC-Mmu-063819 Mus musculus 98.65 0.00e+00 735.00
IUUC-Mac-064632 Musa acuminata 42.12 1.00e-80 293.00
IUUC-Mlu-067184 Myotis lucifugus 99.73 0.00e+00 738.00
IUUC-Nfi-068383 Neosartorya fischeri 46.67 5.00e-93 334.00
IUUC-Ncr-068777 Neurospora crassa 43.41 5.00e-87 314.00
IUUC-Nle-069900 Nomascus leucogenys 100.00 0.00e+00 741.00
IUUC-Opr-070386 Ochotona princeps 90.27 0.00e+00 650.00
IUUC-Ont-071283 Oreochromis niloticus 88.92 0.00e+00 655.00
IUUC-Oan-073139 Ornithorhynchus anatinus 95.95 0.00e+00 716.00
IUUC-Ocu-074340 Oryctolagus cuniculus 100.00 0.00e+00 741.00
IUUC-Opu-083392 Oryza punctata 33.52 8.00e-54 204.00
IUUC-Ola-087274 Oryzias latipes 87.33 0.00e+00 635.00
IUUC-Oga-088016 Otolemur garnettii 99.46 0.00e+00 738.00
IUUC-Oar-089613 Ovis aries 99.46 0.00e+00 738.00
IUUC-Ptr-091548 Pan troglodytes 100.00 0.00e+00 741.00
IUUC-Psi-093767 Pelodiscus sinensis 95.14 0.00e+00 741.00
IUUC-Pma-094124 Petromyzon marinus 78.59 3.00e-180 624.00
IUUC-Pno-095031 Phaeosphaeria nodorum 45.33 1.00e-87 317.00
IUUC-Ppa-095858 Physcomitrella patens 45.53 8.00e-86 310.00
IUUC-Pfo-097107 Poecilia formosa 88.38 0.00e+00 650.00
IUUC-Pop-098954 Populus trichocarpa 37.50 8.00e-43 167.00
IUUC-Pva-102908 Pteropus vampyrus 97.99 0.00e+00 652.00
IUUC-Pgr-103309 Puccinia graminis 44.64 7.00e-92 330.00
IUUC-Ptt-103959 Puccinia triticina 44.84 6.00e-94 337.00
IUUC-Pte-104384 Pyrenophora teres 46.24 3.00e-87 315.00
IUUC-Pyt-104686 Pyrenophora triticirepentis 46.24 6.00e-87 314.00
IUUC-Rno-105008 Rattus norvegicus 98.78 0.00e+00 647.00
IUUC-Sce-106411 Saccharomyces cerevisiae 37.20 2.00e-65 242.00
IUUC-Sha-106691 Sarcophilus harrisii 96.73 0.00e+00 719.00
IUUC-Sja-107792 Schizosaccharomyces japonicus 45.68 1.00e-87 316.00
IUUC-Spo-108053 Schizosaccharomyces pombe 44.77 8.00e-89 320.00
IUUC-Ssl-108606 Sclerotinia sclerotiorum 44.72 6.00e-88 317.00
IUUC-Smo-108836 Selaginella moellendorffii 46.28 6.00e-84 304.00
IUUC-Sit-110150 Setaria italica 42.39 3.00e-79 288.00
IUUC-Sar-113599 Sorex araneus 85.47 7.00e-172 596.00
IUUC-Sre-115090 Sporisorium reilianum 46.08 6.00e-97 347.00
IUUC-Ssc-115851 Sus scrofa 99.46 0.00e+00 738.00
IUUC-Tgu-116701 Taeniopygia guttata 95.14 0.00e+00 742.00
IUUC-Tru-117603 Takifugu rubripes 87.23 0.00e+00 657.00
IUUC-Tsy-119515 Tarsius syrichta 89.58 2.00e-74 273.00
IUUC-Tni-119844 Tetraodon nigroviridis 89.46 0.00e+00 651.00
IUUC-Tca-121645 Theobroma cacao 42.86 1.00e-79 290.00
IUUC-Tre-122045 Trichoderma reesei 44.85 2.00e-86 312.00
IUUC-Tvi-122523 Trichoderma virens 45.00 4.00e-87 314.00
IUUC-Tme-127018 Tuber melanosporum 44.93 9.00e-85 306.00
IUUC-Tbe-127321 Tupaia belangeri 99.69 0.00e+00 650.00
IUUC-Ttr-128178 Tursiops truncatus 99.14 0.00e+00 684.00
IUUC-Uma-129423 Ustilago maydis 45.81 2.00e-98 352.00
IUUC-Vda-129706 Verticillium dahliae 45.30 3.00e-88 318.00
IUUC-Xtr-132735 Xenopus tropicalis 84.64 0.00e+00 631.00
IUUC-Xma-133435 Xiphophorus maculatus 88.38 0.00e+00 650.00
IUUC-Yli-134471 Yarrowia lipolytica 46.07 6.00e-82 297.00
IUUC-Zma-135615 Zea mays 42.04 5.00e-80 291.00
Created Date 25-Jun-2017

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