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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106244
Ensembl Protein ID YDL126C
UniProt Accession P25694; D6VRM4; CDC48_YEAST
Genbank Protein ID CAA40276.1; CAA98694.1; DAA11734.1
Protein Name Cell division control protein 48; Cell division cycle protein 48
Genbank Nucleotide ID X56956; Z74174; BK006938
Gene Name CDC48; YDL126C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDL126C YDL126C YDL126C
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Other/Other UBD/Other/Other 11733065; 15732117
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/Other/Other 69.97 0.00e+00 1049.00 IUUC-Hsa-046162
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD (PubMed:11733065, PubMed:11740563, PubMed:11813000, PubMed:11847109, PubMed:21070972, PubMed:21148305). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel (PubMed:23178123, PubMed:24261871).
 Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD (PubMed:11733065, PubMed:11740563, PubMed:11813000, PubMed:11847109, PubMed:21070972, PubMed:21148305). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel (PubMed:23178123, PubMed:24261871).
Protein Sequence
(Fasta)
MGEEHKPLLD ASGVDPREED KTATAILRRK KKDNMLLVDD AINDDNSVIA INSNTMDKLE 60
LFRGDTVLVK GKKRKDTVLI VLIDDELEDG ACRINRVVRN NLRIRLGDLV TIHPCPDIKY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106244|UBD,UBD/Other/Other|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGGTGAAG AACATAAACC ACTTTTGGAC GCCTCGGGTG TCGACCCTCG TGAGGAGGAT 60
AAAACCGCCA CCGCCATTTT AAGAAGAAAG AAGAAGGACA ACATGCTTTT GGTGGACGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106244|UBD,UBD/Other/Other|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-1017--Isopeptide bond
KW-0492--Microsome
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR003593--AAA+_ATPase
IPR005938--AAA_ATPase_CDC48
IPR009010--Asp_de-COase-like_dom
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR004201--Cdc48_dom2
IPR029067--CDC48_domain_2-like
IPR003338--CDC4_N-term_subdom
IPR027417--P-loop_NTPase
IPR015415--Vps4_C
PROSITE

PS00674--AAA
Pfam

PF00004--AAA
PF02933--CDC48_2
PF02359--CDC48_N
PF09336--Vps4_C
SMART

SM00382--AAA
SM01072--CDC48_2
SM01073--CDC48_N
Gene Ontology

GO:0036266--C:Cdc48p-Npl4p-Vms1p AAA ATPase complex
GO:0005829--C:cytosol
GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0005789--C:endoplasmic reticulum membrane
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0005634--C:nucleus
GO:1990112--C:RQC complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0042802--F:identical protein binding
GO:0019888--F:protein phosphatase regulator activity
GO:0043130--F:ubiquitin binding
GO:0046034--P:ATP metabolic process
GO:0016320--P:endoplasmic reticulum membrane fusion
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0016236--P:macroautophagy
GO:0072671--P:mitochondria-associated ubiquitin-dependent protein catabolic process
GO:0051228--P:mitotic spindle disassembly
GO:0051974--P:negative regulation of telomerase activity
GO:0070651--P:nonfunctional rRNA decay
GO:0034727--P:piecemeal microautophagy of nucleus
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0034517--P:ribophagy
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:1990171--P:SCF complex disassembly in response to cadmium stress
GO:0031134--P:sister chromatid biorientation
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG sce:YDL126C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000524 Aegilops tauschii 67.47 0.00e+00 1066.00
IUUC-Aml-001849 Ailuropoda melanoleuca 70.53 0.00e+00 1097.00
IUUC-Atr-002619 Amborella trichopoda 66.95 0.00e+00 1119.00
IUUC-Apl-004070 Anas platyrhynchos 70.47 0.00e+00 1092.00
IUUC-Aca-004847 Anolis carolinensis 70.23 0.00e+00 1097.00
IUUC-Aly-005470 Arabidopsis lyrata 68.37 0.00e+00 1093.00
IUUC-Ath-006796 Arabidopsis thaliana 68.56 0.00e+00 1112.00
IUUC-Ago-008001 Ashbya gossypii 88.54 0.00e+00 1332.00
IUUC-Acl-008066 Aspergillus clavatus 77.02 0.00e+00 1178.00
IUUC-Afl-008505 Aspergillus flavus 77.18 0.00e+00 1198.00
IUUC-Afu-008840 Aspergillus fumigatus 78.31 0.00e+00 1211.00
IUUC-Ani-009368 Aspergillus nidulans 73.74 0.00e+00 1196.00
IUUC-Ang-009724 Aspergillus niger 77.06 0.00e+00 1201.00
IUUC-Aor-010204 Aspergillus oryzae 77.18 0.00e+00 1198.00
IUUC-Ate-010370 Aspergillus terreus 74.64 0.00e+00 1186.00
IUUC-Ame-011388 Astyanax mexicanus 70.71 0.00e+00 1084.00
IUUC-Bgr-012223 Blumeria graminis 75.54 0.00e+00 1238.00
IUUC-Bta-013188 Bos taurus 70.23 0.00e+00 1101.00
IUUC-Bci-013831 Botrytis cinerea 77.39 0.00e+00 1189.00
IUUC-Bdi-014967 Brachypodium distachyon 68.85 0.00e+00 1103.00
IUUC-Bol-016113 Brassica oleracea 67.73 0.00e+00 1123.00
IUUC-Bra-017796 Brassica rapa 67.86 0.00e+00 1124.00
IUUC-Cel-018243 Caenorhabditis elegans 67.11 0.00e+00 1075.00
IUUC-Cja-019904 Callithrix jacchus 69.72 0.00e+00 1081.00
IUUC-Cfa-020304 Canis familiaris 70.23 0.00e+00 1100.00
IUUC-Cpo-021518 Cavia porcellus 70.66 0.00e+00 1094.00
IUUC-Cre-022719 Chlamydomonas reinhardtii 68.69 0.00e+00 1105.00
IUUC-Csa-023444 Chlorocebus sabaeus 70.36 0.00e+00 1098.00
IUUC-Cho-024482 Choloepus hoffmanni 69.63 0.00e+00 1069.00
IUUC-Cin-025517 Ciona intestinalis 69.37 0.00e+00 1080.00
IUUC-Csv-026060 Ciona savignyi 68.40 0.00e+00 1125.00
IUUC-Cgl-026690 Colletotrichum gloeosporioides 77.83 0.00e+00 1219.00
IUUC-Cne-026910 Cryptococcus neoformans 70.54 0.00e+00 1150.00
IUUC-Cme-027145 Cyanidioschyzon merolae 66.50 0.00e+00 1060.00
IUUC-Dre-028487 Danio rerio 70.58 0.00e+00 1083.00
IUUC-Dno-029257 Dasypus novemcinctus 70.36 0.00e+00 1098.00
IUUC-Dor-030473 Dipodomys ordii 68.87 0.00e+00 1058.00
IUUC-Dse-031319 Dothistroma septosporum 76.40 0.00e+00 1174.00
IUUC-Dme-032203 Drosophila melanogaster 67.36 0.00e+00 1071.00
IUUC-Eca-033311 Equus caballus 70.40 0.00e+00 1094.00
IUUC-Eeu-035293 Erinaceus europaeus 75.82 3.00e-177 613.00
IUUC-Fca-036097 Felis catus 71.72 0.00e+00 1060.00
IUUC-Fal-037292 Ficedula albicollis 70.66 0.00e+00 1096.00
IUUC-Fox-037827 Fusarium oxysporum 77.69 0.00e+00 1233.00
IUUC-Fso-038226 Fusarium solani 78.33 0.00e+00 1238.00
IUUC-Gmo-039157 Gadus morhua 65.67 0.00e+00 991.00
IUUC-Ggr-039951 Gaeumannomyces graminis 78.58 0.00e+00 1212.00
IUUC-Gga-041183 Gallus gallus 70.36 0.00e+00 1099.00
IUUC-Gac-042039 Gasterosteus aculeatus 70.36 0.00e+00 1070.00
IUUC-Gma-044090 Glycine max 66.06 0.00e+00 1107.00
IUUC-Ggo-045568 Gorilla gorilla 70.36 0.00e+00 1098.00
IUUC-Hsa-046162 Homo sapiens 70.36 0.00e+00 1098.00
IUUC-Hvu-047107 Hordeum vulgare 72.15 0.00e+00 912.00
IUUC-Itr-047885 Ictidomys tridecemlineatus 70.18 0.00e+00 1094.00
IUUC-Kpa-049220 Komagataella pastoris 83.75 0.00e+00 1399.00
IUUC-Lch-050657 Latimeria chalumnae 71.64 0.00e+00 984.00
IUUC-Lpe-051083 Leersia perrieri 68.41 0.00e+00 1098.00
IUUC-Loc-052064 Lepisosteus oculatus 70.45 0.00e+00 1083.00
IUUC-Lma-053323 Leptosphaeria maculans 77.38 0.00e+00 1203.00
IUUC-Laf-054574 Loxodonta africana 70.66 0.00e+00 1095.00
IUUC-Mcc-055448 Macaca mulatta 70.36 0.00e+00 1098.00
IUUC-Meu-056316 Macropus eugenii 65.64 0.00e+00 991.00
IUUC-Mor-057057 Magnaporthe oryzae 78.58 0.00e+00 1210.00
IUUC-Mpo-057406 Magnaporthe poae 77.82 0.00e+00 1201.00
IUUC-Mtr-057648 Medicago truncatula 68.78 0.00e+00 1114.00
IUUC-Mla-059156 Melampsora laricipopulina 74.97 0.00e+00 1195.00
IUUC-Mga-060004 Meleagris gallopavo 67.62 0.00e+00 948.00
IUUC-Mvi-060488 Microbotryum violaceum 71.46 0.00e+00 1170.00
IUUC-Mmr-061027 Microcebus murinus 70.66 0.00e+00 1094.00
IUUC-Mdo-062159 Monodelphis domestica 70.36 0.00e+00 1099.00
IUUC-Mmu-063633 Mus musculus 70.36 0.00e+00 1098.00
IUUC-Mac-064919 Musa acuminata 68.81 0.00e+00 1109.00
IUUC-Mpu-066078 Mustela putorius furo 70.23 0.00e+00 1101.00
IUUC-Mlu-067757 Myotis lucifugus 70.23 0.00e+00 1098.00
IUUC-Nfi-068533 Neosartorya fischeri 77.41 0.00e+00 1191.00
IUUC-Ncr-068775 Neurospora crassa 78.20 0.00e+00 1177.00
IUUC-Nle-069424 Nomascus leucogenys 70.66 0.00e+00 1095.00
IUUC-Opr-071147 Ochotona princeps 70.06 0.00e+00 1078.00
IUUC-Ont-071351 Oreochromis niloticus 70.71 0.00e+00 1061.00
IUUC-Oan-073335 Ornithorhynchus anatinus 67.97 0.00e+00 1095.00
IUUC-Ocu-074072 Oryctolagus cuniculus 70.36 0.00e+00 1098.00
IUUC-Oba-075914 Oryza barthii 69.62 0.00e+00 1116.00
IUUC-Obr-076224 Oryza brachyantha 70.17 0.00e+00 1107.00
IUUC-Ogl-077282 Oryza glaberrima 69.21 0.00e+00 1124.00
IUUC-Ogu-078174 Oryza glumaepatula 69.62 0.00e+00 1116.00
IUUC-Oin-079103 Oryza indica 69.62 0.00e+00 1116.00
IUUC-Olo-080675 Oryza longistaminata 69.49 0.00e+00 1115.00
IUUC-Ome-081959 Oryza meridionalis 69.21 0.00e+00 1124.00
IUUC-Oni-082078 Oryza nivara 69.62 0.00e+00 1116.00
IUUC-Opu-083806 Oryza punctata 69.57 0.00e+00 1120.00
IUUC-Oru-084634 Oryza rufipogon 69.62 0.00e+00 1118.00
IUUC-Osa-085960 Oryza sativa 69.62 0.00e+00 1116.00
IUUC-Ola-086382 Oryzias latipes 70.40 0.00e+00 1059.00
IUUC-Olu-087839 Ostreococcus lucimarinus 69.37 0.00e+00 1089.00
IUUC-Oga-088037 Otolemur garnettii 70.23 0.00e+00 1095.00
IUUC-Oar-089684 Ovis aries 70.53 0.00e+00 1097.00
IUUC-Ptr-091378 Pan troglodytes 70.36 0.00e+00 1098.00
IUUC-Pan-092849 Papio anubis 70.36 0.00e+00 1098.00
IUUC-Psi-093725 Pelodiscus sinensis 69.61 0.00e+00 1052.00
IUUC-Pma-094537 Petromyzon marinus 65.30 2.00e-158 549.00
IUUC-Pno-094915 Phaeosphaeria nodorum 81.42 0.00e+00 1142.00
IUUC-Ppa-095632 Physcomitrella patens 66.91 0.00e+00 1078.00
IUUC-Pfo-097440 Poecilia formosa 70.58 0.00e+00 1060.00
IUUC-Pab-098469 Pongo abelii 70.36 0.00e+00 1098.00
IUUC-Pop-100047 Populus trichocarpa 69.28 0.00e+00 1113.00
IUUC-Pca-100399 Procavia capensis 66.16 0.00e+00 1004.00
IUUC-Ppe-101767 Prunus persica 65.94 0.00e+00 1115.00
IUUC-Pva-102426 Pteropus vampyrus 69.59 0.00e+00 1068.00
IUUC-Pgr-103599 Puccinia graminis 75.06 0.00e+00 1171.00
IUUC-Ptt-103740 Puccinia triticina 73.97 0.00e+00 1173.00
IUUC-Pte-104030 Pyrenophora teres 73.51 0.00e+00 1183.00
IUUC-Pyt-104541 Pyrenophora triticirepentis 73.60 0.00e+00 1183.00
IUUC-Rno-105144 Rattus norvegicus 70.36 0.00e+00 1099.00
IUUC-Sha-106589 Sarcophilus harrisii 70.66 0.00e+00 1096.00
IUUC-Sja-107673 Schizosaccharomyces japonicus 74.88 0.00e+00 1218.00
IUUC-Spo-108247 Schizosaccharomyces pombe 75.76 0.00e+00 1177.00
IUUC-Ssl-108642 Sclerotinia sclerotiorum 77.51 0.00e+00 1184.00
IUUC-Smo-108877 Selaginella moellendorffii 69.67 0.00e+00 1108.00
IUUC-Sit-110368 Setaria italica 69.16 0.00e+00 1113.00
IUUC-Sly-111011 Solanum lycopersicum 67.00 0.00e+00 1122.00
IUUC-Stu-112133 Solanum tuberosum 67.04 0.00e+00 1125.00
IUUC-Sar-113021 Sorex araneus 70.66 0.00e+00 1095.00
IUUC-Sbi-114462 Sorghum bicolor 68.78 0.00e+00 1113.00
IUUC-Sre-115052 Sporisorium reilianum 73.56 0.00e+00 1179.00
IUUC-Ssc-116293 Sus scrofa 70.05 0.00e+00 1095.00
IUUC-Tgu-116544 Taeniopygia guttata 67.87 0.00e+00 1018.00
IUUC-Tru-117991 Takifugu rubripes 72.04 0.00e+00 780.00
IUUC-Tsy-119131 Tarsius syrichta 75.85 9.00e-171 591.00
IUUC-Tni-120192 Tetraodon nigroviridis 70.06 0.00e+00 1053.00
IUUC-Tca-121502 Theobroma cacao 68.48 0.00e+00 1082.00
IUUC-Tre-122189 Trichoderma reesei 74.16 0.00e+00 1214.00
IUUC-Tvi-122310 Trichoderma virens 74.16 0.00e+00 1202.00
IUUC-Tae-123524 Triticum aestivum 68.43 0.00e+00 1062.00
IUUC-Tur-126733 Triticum urartu 68.39 0.00e+00 1063.00
IUUC-Tme-127147 Tuber melanosporum 77.59 0.00e+00 1170.00
IUUC-Tbe-127255 Tupaia belangeri 65.31 0.00e+00 1023.00
IUUC-Ttr-128876 Tursiops truncatus 70.27 0.00e+00 1090.00
IUUC-Uma-129448 Ustilago maydis 72.86 0.00e+00 1156.00
IUUC-Vda-129800 Verticillium dahliae 75.00 0.00e+00 1201.00
IUUC-Vpa-130573 Vicugna pacos 76.72 0.00e+00 674.00
IUUC-Vvi-131622 Vitis vinifera 69.54 0.00e+00 1119.00
IUUC-Xtr-132458 Xenopus tropicalis 71.52 0.00e+00 1057.00
IUUC-Xma-134045 Xiphophorus maculatus 70.58 0.00e+00 1060.00
IUUC-Yli-134382 Yarrowia lipolytica 83.29 0.00e+00 1322.00
IUUC-Zma-135400 Zea mays 68.96 0.00e+00 1111.00
Created Date 25-Jun-2017

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