iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088713

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AAQR03132511

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000004669.2	ENSOGAT00000004672.2	ENSOGAP00000004171.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.30e-90	303.2	196	825

Active Site

Position(s)	Description	Evidence
205	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
761	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 196  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 275
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk  +s+++++F+g+l+
   Q: 276  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKAIPSFVDRIFGGELT 364
           *************************************************************9999999999999999************ PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 365  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmedededseeekdndsymkernempsgtskhlqkkakkqakkqakn 453
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 454  qrrqqkiqgkvlhlkdictsdhpedneceaemslqgevdtksnhisqeevthkeyyinqkelngqekmiegvtdnqkcteeidmknvnm 542
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 543  gndlevlassptecsrnlngaylkegsngevdistgfqnltlnavlhpdeinieivndshspgtkvyevvnedpetafstlanreafnt 631
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 632  ddySIQHCLYQFTRNEKLRDANKLLCEVCTGRQYngpkanvkgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 718
           ******************************877778888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   k+ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 719  FPEILDLAPFCTLKCKNVAEentKVMYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdvpqdfemesTKGQWFHISDTHVQA 807
           *************999888777799*************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 808  VPATKVLN---SQAYLLFYER 825
           ********...********98 PP

Organism

Otolemur garnettii

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSESL DPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEETEENPS VWLCLKCGHQ GCGRNSQEQH ALKHYMTLRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAAGA AACGGACAAA GGGAAAAACT GTTCCAATTG ATGATTCCTC TGAATCTTTA 60
GGTATATTTT CACTAATTAA ATTTTTAAAG TAGTGTTAAT ATCCCTAAAT GAGTATATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.68	9.00e-29	122.00
IUUC-Aml-001931	Ailuropoda melanoleuca	89.84	0.00e+00	1392.00
IUUC-Atr-003015	Amborella trichopoda	32.37	5.00e-37	150.00
IUUC-Apl-004145	Anas platyrhynchos	61.86	0.00e+00	904.00
IUUC-Aca-004314	Anolis carolinensis	58.99	0.00e+00	882.00
IUUC-Aly-006422	Arabidopsis lyrata	28.79	2.00e-29	124.00
IUUC-Ath-006732	Arabidopsis thaliana	33.02	4.00e-33	137.00
IUUC-Ame-011659	Astyanax mexicanus	50.00	6.00e-109	388.00
IUUC-Bta-013362	Bos taurus	89.72	0.00e+00	1392.00
IUUC-Bdi-014465	Brachypodium distachyon	31.61	9.00e-30	125.00
IUUC-Bol-015941	Brassica oleracea	30.00	6.00e-33	136.00
IUUC-Bra-016751	Brassica rapa	29.50	8.00e-31	129.00
IUUC-Cja-019177	Callithrix jacchus	91.17	0.00e+00	1451.00
IUUC-Cfa-020051	Canis familiaris	90.57	0.00e+00	1412.00
IUUC-Cpo-021886	Cavia porcellus	80.24	0.00e+00	1282.00
IUUC-Csa-024103	Chlorocebus sabaeus	91.78	0.00e+00	1463.00
IUUC-Cho-024315	Choloepus hoffmanni	77.08	7.00e-129	454.00
IUUC-Cin-025775	Ciona intestinalis	49.65	6.00e-40	155.00
IUUC-Csv-026075	Ciona savignyi	51.03	4.00e-55	209.00
IUUC-Cme-027348	Cyanidioschyzon merolae	37.84	9.00e-20	92.00
IUUC-Dre-028388	Danio rerio	45.98	0.00e+00	642.00
IUUC-Dno-029409	Dasypus novemcinctus	87.79	0.00e+00	1398.00
IUUC-Dor-030443	Dipodomys ordii	77.76	0.00e+00	651.00
IUUC-Ete-032807	Echinops telfairi	83.49	0.00e+00	679.00
IUUC-Eca-033479	Equus caballus	91.17	0.00e+00	1452.00
IUUC-Eeu-034835	Erinaceus europaeus	82.03	0.00e+00	652.00
IUUC-Fca-036320	Felis catus	91.17	0.00e+00	1462.00
IUUC-Fal-037029	Ficedula albicollis	59.79	0.00e+00	838.00
IUUC-Gmo-039480	Gadus morhua	52.59	2.00e-112	400.00
IUUC-Gga-040527	Gallus gallus	63.32	0.00e+00	909.00
IUUC-Gma-044402	Glycine max	28.01	3.00e-32	134.00
IUUC-Ggo-045598	Gorilla gorilla	90.93	0.00e+00	1447.00
IUUC-Hsa-046598	Homo sapiens	91.17	0.00e+00	1446.00
IUUC-Hvu-047146	Hordeum vulgare	29.05	6.00e-28	119.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	90.57	0.00e+00	1444.00
IUUC-Lch-050536	Latimeria chalumnae	57.34	1.00e-130	460.00
IUUC-Lpe-050703	Leersia perrieri	29.63	6.00e-29	123.00
IUUC-Loc-051814	Lepisosteus oculatus	57.14	7.00e-128	451.00
IUUC-Laf-053732	Loxodonta africana	85.42	0.00e+00	1383.00
IUUC-Mcc-054661	Macaca mulatta	91.90	0.00e+00	1464.00
IUUC-Meu-055967	Macropus eugenii	74.26	5.00e-159	555.00
IUUC-Mtr-057945	Medicago truncatula	31.74	4.00e-33	137.00
IUUC-Mga-059551	Meleagris gallopavo	62.77	0.00e+00	929.00
IUUC-Mvi-060391	Microbotryum violaceum	32.14	2.00e-19	90.90
IUUC-Mmr-061747	Microcebus murinus	92.81	0.00e+00	1439.00
IUUC-Mdo-062220	Monodelphis domestica	67.96	0.00e+00	1049.00
IUUC-Mmu-063582	Mus musculus	81.54	0.00e+00	1252.00
IUUC-Mac-064941	Musa acuminata	32.84	7.00e-38	152.00
IUUC-Mpu-066339	Mustela putorius furo	89.60	0.00e+00	1436.00
IUUC-Mlu-067511	Myotis lucifugus	85.13	0.00e+00	1329.00
IUUC-Nle-069252	Nomascus leucogenys	91.66	0.00e+00	1463.00
IUUC-Opr-070969	Ochotona princeps	85.47	0.00e+00	1303.00
IUUC-Ont-071786	Oreochromis niloticus	50.95	5.00e-115	408.00
IUUC-Ocu-074704	Oryctolagus cuniculus	90.11	0.00e+00	1402.00
IUUC-Oba-075094	Oryza barthii	30.12	2.00e-30	128.00
IUUC-Obr-076743	Oryza brachyantha	31.48	8.00e-32	132.00
IUUC-Ogl-077739	Oryza glaberrima	30.12	2.00e-30	128.00
IUUC-Ogu-078851	Oryza glumaepatula	30.12	2.00e-30	127.00
IUUC-Oin-079402	Oryza indica	30.12	2.00e-30	127.00
IUUC-Olo-080431	Oryza longistaminata	30.12	2.00e-30	127.00
IUUC-Ome-081580	Oryza meridionalis	29.82	3.00e-30	127.00
IUUC-Oni-082644	Oryza nivara	30.12	2.00e-30	127.00
IUUC-Opu-083452	Oryza punctata	29.45	9.00e-30	125.00
IUUC-Oru-084546	Oryza rufipogon	30.12	2.00e-30	127.00
IUUC-Osa-085858	Oryza sativa	30.12	2.00e-30	128.00
IUUC-Oar-089887	Ovis aries	90.21	0.00e+00	1408.00
IUUC-Ptr-091670	Pan troglodytes	91.17	0.00e+00	1455.00
IUUC-Pan-092293	Papio anubis	91.90	0.00e+00	1464.00
IUUC-Psi-093101	Pelodiscus sinensis	66.67	0.00e+00	936.00
IUUC-Ppa-095622	Physcomitrella patens	30.77	1.00e-33	139.00
IUUC-Pfo-097202	Poecilia formosa	52.97	8.00e-117	414.00
IUUC-Pab-098773	Pongo abelii	91.47	0.00e+00	1132.00
IUUC-Pop-099136	Populus trichocarpa	30.23	2.00e-38	154.00
IUUC-Pca-101069	Procavia capensis	69.17	0.00e+00	1137.00
IUUC-Ppe-101794	Prunus persica	30.90	1.00e-34	141.00
IUUC-Pva-103092	Pteropus vampyrus	85.87	0.00e+00	679.00
IUUC-Rno-105237	Rattus norvegicus	82.75	0.00e+00	1268.00
IUUC-Sha-106889	Sarcophilus harrisii	74.28	0.00e+00	1132.00
IUUC-Spo-108149	Schizosaccharomyces pombe	34.29	5.00e-20	93.20
IUUC-Ssl-108648	Sclerotinia sclerotiorum	27.17	3.00e-11	63.90
IUUC-Sit-110283	Setaria italica	31.49	3.00e-28	120.00
IUUC-Sly-111487	Solanum lycopersicum	30.77	1.00e-39	158.00
IUUC-Stu-112820	Solanum tuberosum	29.41	1.00e-36	149.00
IUUC-Sar-113530	Sorex araneus	82.73	0.00e+00	1296.00
IUUC-Sbi-113785	Sorghum bicolor	38.71	4.00e-25	110.00
IUUC-Ssc-116091	Sus scrofa	89.41	0.00e+00	1375.00
IUUC-Tgu-117478	Taeniopygia guttata	60.24	0.00e+00	865.00
IUUC-Tru-118640	Takifugu rubripes	53.37	4.00e-119	422.00
IUUC-Tsy-119042	Tarsius syrichta	77.83	0.00e+00	910.00
IUUC-Tni-120015	Tetraodon nigroviridis	45.42	5.00e-178	617.00
IUUC-Tca-121701	Theobroma cacao	30.15	1.00e-37	151.00
IUUC-Tae-125351	Triticum aestivum	29.66	1.00e-26	115.00
IUUC-Tur-126788	Triticum urartu	29.36	3.00e-26	114.00
IUUC-Tbe-127309	Tupaia belangeri	76.80	0.00e+00	1105.00
IUUC-Ttr-128271	Tursiops truncatus	89.48	0.00e+00	1423.00
IUUC-Vpa-130674	Vicugna pacos	89.58	0.00e+00	1314.00
IUUC-Xtr-131869	Xenopus tropicalis	52.21	0.00e+00	791.00
IUUC-Xma-134195	Xiphophorus maculatus	53.55	2.00e-116	413.00
IUUC-Zma-135157	Zea mays	31.29	2.00e-26	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence