iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-28	96.8	750	781
UBD/Beta-Prp	2.60e-49	168.0	553	825

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gH++++t+l +   +++lvsG+dD+ i++WD+
   Q: 750  GHKSRITALIYsiCGRYLVSGGDDNLIMIWDT 781
           8****9**98898669***************6 PP

UBD/Beta-Prp

   S: 10   ksvitcvkfspdksllatgsrdgtikvwdvttgkl...............................lrslsgheaevtavkfspdgkilvtgseDrti 76
           ++v+ c +fs+++s+la g  ++++ v+++++ kl                                r+l+gh+++v+ ++f+p++ +l+t+seD  +
   Q: 553  DEVVICATFSEGNSMLALGTVSSKVYVFSLKPSKLvqvkaaqwlknldtgmagvdkdmidpikkftRRTLYGHQGPVYGCSFNPEDRFLITCSEDFSV 650
           567778***********************************************************9999***************************** PP
   S: 77   kvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
           ++w l + +cv++++gh + v+ + f p g++++++s+d t+rvw  ++ +  + +l+gh +   +  +hp+  ++++Gs+D tvr+Wd+  +  +r 
   Q: 651  RLWCLLSWSCVVIFSGHLAPVCFVVFAPRGYYFATASDDCTARVWMQDNTKPAR-ILQGHLAELGVCLFHPNRHYMATGSADCTVRIWDIVKAVQVRI 747
           *********************************************999999998.******************************************* PP
   S: 175  ltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
           ++g h+++++ l+++  g++lvsg++d+ + +wd  ++  ++ +  h++ ++ ++ s ++++lv+g++D ++ +Wd ++
   Q: 748  FRG-HKSRITALIYSICGRYLVSGGDDNLIMIWDTANEILMQFFDHHKASINTMEISLDNNILVVGGQDCQLTLWDFEQ 825
           **9.*******************************99999999999*****************************9764 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MDLPLPILIP SSDEVYVISD SDDSDSDDIR NELMKLEDNK DKPKNKERQK SKNENSQIKM 60
NKWYLKEFED LMGLEIACSD DEDDIDDRNS EIWSSSESDK ISDSDDSNSD GSPTEWINRI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACTAGGGC TGATTTGGAT TGTTCAAATA TTTAAGAGCA ATAAAGATGG ATTTACCATT 60
GCCAATACTA ATACCATCTA GTGATGTGAG TAAGAATATG TATGCGCTTT CTAACAACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR007582--TFIID_NTD2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04494--TFIID_NTD2
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0001673--C:male germ cell nucleus
GO:0005730--C:nucleolus
GO:0005669--C:transcription factor TFIID complex
GO:0007141--P:male meiosis I
GO:0007126--P:meiotic nuclear division
GO:0010468--P:regulation of gene expression
GO:0007286--P:spermatid development
GO:0048515--P:spermatid differentiation
GO:0007283--P:spermatogenesis
GO:0006367--P:transcription initiation from RNA polymerase II promoter

KEGG

dme:Dmel_CG6577

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Fso-038302	Fusarium solani	31.78	5.00e-36	145.00
IUUC-Ggr-039878	Gaeumannomyces graminis	33.22	4.00e-40	159.00
IUUC-Mpo-057520	Magnaporthe poae	33.56	3.00e-40	159.00
IUUC-Oni-082431	Oryza nivara	38.22	2.00e-49	189.00
IUUC-Pno-094823	Phaeosphaeria nodorum	31.11	2.00e-43	169.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence