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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046811
UUCD1 version UUC-HoS-01072
Ensembl Protein ID ENSP00000292211.4
UniProt Accession Q7Z7E8; B4DF92; Q29SN7; Q3B841; Q5I0X2; Q6IS04; Q6P7P2; Q96MV4; Q9BVX5; Q9UGL6; UB2Q1_HUMAN
Genbank Protein ID AAM60814.1; AAY23342.1; BAB71173.1; BAG57353.1; CAI16186.1; EAW53193.1; AAH00848.1; AAH15316.2; AAH61583.1; AAH70158.1; AAH87836.1; AAI07058.1; CAB65097.1; AAF71141.1; CAG33500.1
Protein Name Ubiquitin-conjugating enzyme E2 Q1; E2 ubiquitin-conjugating enzyme Q1; Protein NICE-5; Ubiquitin carrier protein Q1; Ubiquitin-protein ligase Q1
Genbank Nucleotide ID AY112698; AY948200; AK056388; AK293986; AL592078; CH471121; BC000848; BC015316; BC061583; BC070158; BC087836; BC107057; AJ243666; AF116721; CR457219
Gene Name UBE2Q1; NICE5; UBE2Q; PRO3094
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000160714.9 ENST00000292211.4 ENSP00000292211.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanmiRecordsRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 20682791
Classification
Family E-value Score Start End
E2/UBC 1.10e-18 69.0 314 406
Active Site
Position(s) Description Evidence
351 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388}
Domain Profile

   E2/UBC
   S: 46   vFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvllsiqsll..aepnpesplneeaaellkknreeyk 134
           +  l+++f++++Pf+PP v+++++++++ +    G++C+++l +++ Ws+a+s+esv+++i ++l   +++++ ++n+++++l++++++ yk
   Q: 314  FILLNFSFKDNFPFDPPFVRVVSPVLSGGYVLGgGAICMELL-TKQGWSSAYSIESVIMQISATLvkGKARVQFGANKSQYSLTRAQQS-YK 403
           45689***********************999998********.59********************77789************9999998.99 PP
   S: 135  kkv 137
           + v
   Q: 404  SLV 406
           887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation.
 Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation.
Protein Sequence
(Fasta)
MQQPQPQGQQ QPGPGQQLGG QGAAPGAGGG PGGGPGPGPC LRRELKLLES IFHRGHERFR 60
IASACLDELS CEFLLAGAGG AGAGAAPGPH LPPRGSVPGD PVRIHCNITE SYPAVPPIWS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046811|E2,E2/UBC|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGCGCGGGT AGCCCCTGGG AGCACGCGGC ACCGAGTCAC GTGAGAGGGG AGCGCAGGCG 60
AAGGGGCGTC GCGCGCAAGC ACGCACGACA TACGCAAACT CGCACTGAGG CGCCCACAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046811|E2,E2/UBC|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005829--C:cytosol
GO:0030175--C:filopodium
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0007566--P:embryo implantation
GO:0009566--P:fertilization
GO:0007617--P:mating behavior
GO:0070459--P:prolactin secretion
GO:0061458--P:reproductive system development
GO:0001967--P:suckling behavior
KEGG hsa:55585
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001442 Ailuropoda melanoleuca 99.44 2.00e-179 621.00
IUUC-Apl-003281 Anas platyrhynchos 94.61 2.00e-153 534.00
IUUC-Aca-004783 Anolis carolinensis 56.21 6.00e-49 186.00
IUUC-Ani-009397 Aspergillus nidulans 34.25 1.00e-14 75.90
IUUC-Bta-012947 Bos taurus 100.00 0.00e+00 710.00
IUUC-Cel-018705 Caenorhabditis elegans 43.66 2.00e-86 312.00
IUUC-Cja-019951 Callithrix jacchus 99.74 0.00e+00 707.00
IUUC-Cfa-020682 Canis familiaris 98.94 0.00e+00 662.00
IUUC-Cpo-022277 Cavia porcellus 99.48 0.00e+00 707.00
IUUC-Cre-022858 Chlamydomonas reinhardtii 31.52 2.00e-13 70.90
IUUC-Csa-023839 Chlorocebus sabaeus 100.00 0.00e+00 710.00
IUUC-Cho-024360 Choloepus hoffmanni 100.00 6.00e-74 270.00
IUUC-Csv-025853 Ciona savignyi 36.29 2.00e-20 92.80
IUUC-Dno-029771 Dasypus novemcinctus 97.83 9.00e-173 599.00
IUUC-Dor-030292 Dipodomys ordii 96.37 4.00e-147 514.00
IUUC-Eca-034172 Equus caballus 100.00 0.00e+00 676.00
IUUC-Eeu-034522 Erinaceus europaeus 97.91 0.00e+00 686.00
IUUC-Fca-036468 Felis catus 95.54 2.00e-151 528.00
IUUC-Fal-037276 Ficedula albicollis 94.90 4.00e-164 570.00
IUUC-Fox-038074 Fusarium oxysporum 33.33 2.00e-13 71.60
IUUC-Gga-041233 Gallus gallus 86.06 3.00e-171 594.00
IUUC-Ggo-044565 Gorilla gorilla 96.34 0.00e+00 702.00
IUUC-Itr-048119 Ictidomys tridecemlineatus 99.74 0.00e+00 710.00
IUUC-Lch-049417 Latimeria chalumnae 88.48 0.00e+00 646.00
IUUC-Laf-053736 Loxodonta africana 92.02 0.00e+00 644.00
IUUC-Mcc-055356 Macaca mulatta 100.00 0.00e+00 710.00
IUUC-Meu-056466 Macropus eugenii 77.02 5.00e-147 513.00
IUUC-Mga-059752 Meleagris gallopavo 89.81 3.00e-162 564.00
IUUC-Mmr-061169 Microcebus murinus 99.74 0.00e+00 708.00
IUUC-Mdo-062451 Monodelphis domestica 100.00 6.00e-178 616.00
IUUC-Mmu-064110 Mus musculus 99.48 0.00e+00 707.00
IUUC-Mpu-065975 Mustela putorius furo 99.17 0.00e+00 634.00
IUUC-Mlu-067549 Myotis lucifugus 99.22 0.00e+00 691.00
IUUC-Nle-069199 Nomascus leucogenys 100.00 0.00e+00 710.00
IUUC-Ocu-074575 Oryctolagus cuniculus 94.75 0.00e+00 640.00
IUUC-Oga-088404 Otolemur garnettii 99.20 0.00e+00 652.00
IUUC-Oar-089852 Ovis aries 99.74 0.00e+00 708.00
IUUC-Ptr-091578 Pan troglodytes 100.00 0.00e+00 710.00
IUUC-Pan-092384 Papio anubis 100.00 0.00e+00 710.00
IUUC-Psi-093619 Pelodiscus sinensis 88.92 4.00e-146 510.00
IUUC-Pma-094631 Petromyzon marinus 71.28 2.00e-137 481.00
IUUC-Ppa-095767 Physcomitrella patens 37.40 1.00e-16 82.80
IUUC-Pab-098221 Pongo abelii 100.00 0.00e+00 710.00
IUUC-Pca-100506 Procavia capensis 81.72 1.00e-154 539.00
IUUC-Pva-103011 Pteropus vampyrus 90.72 2.00e-174 604.00
IUUC-Rno-105296 Rattus norvegicus 99.48 0.00e+00 707.00
IUUC-Sha-107320 Sarcophilus harrisii 100.00 8.00e-172 595.00
IUUC-Ssc-115905 Sus scrofa 100.00 0.00e+00 710.00
IUUC-Tbe-127490 Tupaia belangeri 99.69 2.00e-173 601.00
Created Date 25-Jun-2017

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