iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.40e-27	93.6	263	294
UBD/Beta-Prp	8.60e-40	137.9	12	294

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtll.vsGsdDgtikvWDl 30
           gH ++++c++f +d+ l +sGs Dgt+++W +
   Q: 263  GHFGPIHCVRFsPDGELyASGSEDGTLRLWQT 294
           799*********997776************85 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkf...spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           gh   ++ +++f   +p + +l+++++dg+  + + +tg+ + ++ gh+++v+  ++++d+   +t++ D t+kvwd  +g+ ++tl  
   Q: 12   GHTR-PVVDLAFsgiTPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLA- 98
           4444.5555888888899999*******************************************************************. PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h++ v +++f +++++l++G++d+ +r++dl++ +   +  sgh++ +  + + +d++ + s ++D+tvrlWd +t++ ++ l    + 
   Q: 99   HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSDDKQILS-ADDKTVRLWDHATMTEVKSLN--FNM 184
           *******************************************************8877766.69******************5..699 PP
   S: 182  svyslsfdsng........................................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrf 230
           sv s+++ ++g                                        ++lv+g++d ++  +d+ +ge +++++gh  ++ +vrf
   Q: 185  SVSSMEYIPEGeilvitygrsiafhsavslepiksfeapatinsaslhpekEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRF 273
           9*****888888888888888888888888888888888888888888888************************************** PP
   S: 231  spnderlvsgssDgsiriWdl 251
           sp++e+++sgs+Dg++r+W +
   Q: 274  SPDGELYASGSEDGTLRLWQT 294
           *******************65 PP

Organism

Mus musculus

Functional Description
(View)

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).

Protein Sequence
(Fasta)

MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG 60
AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK HIVKTVDFTQ DSNYLLTGGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCGTCACT TCCGGCTGAC GCGACGCGTC GGGCGACGTC ACGTCCTGCC GCTACCGGTA 60
GGGACCGTGA GTGGCGGCAG GCCGGCTCTC CGGCGCTCCC CTCCCCTCCT CCCTCCCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0032797--C:SMN complex
GO:0034719--C:SMN-Sm protein complex
GO:0005102--F:receptor binding
GO:0003723--F:RNA binding
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0010633--P:negative regulation of epithelial cell migration
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0060394--P:negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0000387--P:spliceosomal snRNP assembly

KEGG

mmu:20901

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000668	Aegilops tauschii	50.17	4.00e-76	278.00
IUUC-Aml-002091	Ailuropoda melanoleuca	95.05	0.00e+00	639.00
IUUC-Atr-002571	Amborella trichopoda	51.55	2.00e-78	285.00
IUUC-Apl-003327	Anas platyrhynchos	86.71	8.00e-148	516.00
IUUC-Aca-005324	Anolis carolinensis	87.71	6.00e-167	579.00
IUUC-Aly-006452	Arabidopsis lyrata	50.00	2.00e-77	282.00
IUUC-Ath-006646	Arabidopsis thaliana	50.00	2.00e-77	282.00
IUUC-Acl-008014	Aspergillus clavatus	40.72	4.00e-48	185.00
IUUC-Afl-008701	Aspergillus flavus	40.07	7.00e-33	134.00
IUUC-Afu-008942	Aspergillus fumigatus	31.38	1.00e-34	140.00
IUUC-Ani-009394	Aspergillus nidulans	41.44	9.00e-49	187.00
IUUC-Ang-009593	Aspergillus niger	38.18	7.00e-35	141.00
IUUC-Aor-010206	Aspergillus oryzae	42.64	3.00e-49	188.00
IUUC-Ame-011328	Astyanax mexicanus	83.07	2.00e-144	505.00
IUUC-Bgr-012308	Blumeria graminis	39.53	4.00e-56	211.00
IUUC-Bta-013429	Bos taurus	98.86	0.00e+00	648.00
IUUC-Bci-013803	Botrytis cinerea	40.06	3.00e-54	205.00
IUUC-Bdi-014996	Brachypodium distachyon	49.30	5.00e-76	277.00
IUUC-Bol-016595	Brassica oleracea	50.34	2.00e-79	288.00
IUUC-Bra-017775	Brassica rapa	49.49	2.00e-78	287.00
IUUC-Cja-018740	Callithrix jacchus	93.39	0.00e+00	632.00
IUUC-Cfa-021145	Canis familiaris	98.57	0.00e+00	649.00
IUUC-Cpo-022373	Cavia porcellus	98.57	0.00e+00	648.00
IUUC-Cre-022806	Chlamydomonas reinhardtii	44.18	4.00e-60	224.00
IUUC-Csa-023098	Chlorocebus sabaeus	97.43	0.00e+00	643.00
IUUC-Cho-024856	Choloepus hoffmanni	89.71	9.00e-161	559.00
IUUC-Cin-025541	Ciona intestinalis	58.71	1.00e-103	369.00
IUUC-Csv-026287	Ciona savignyi	57.79	9.00e-93	333.00
IUUC-Cgl-026513	Colletotrichum gloeosporioides	40.90	1.00e-53	203.00
IUUC-Cne-026869	Cryptococcus neoformans	46.54	5.00e-70	258.00
IUUC-Dre-028457	Danio rerio	76.64	5.00e-148	516.00
IUUC-Dno-029213	Dasypus novemcinctus	97.71	0.00e+00	644.00
IUUC-Dse-031350	Dothistroma septosporum	39.58	2.00e-49	189.00
IUUC-Dme-031857	Drosophila melanogaster	60.69	2.00e-107	382.00
IUUC-Ete-032558	Echinops telfairi	87.21	1.00e-120	425.00
IUUC-Eca-033934	Equus caballus	99.14	0.00e+00	648.00
IUUC-Eeu-034650	Erinaceus europaeus	84.86	4.00e-164	570.00
IUUC-Fca-035909	Felis catus	98.57	0.00e+00	643.00
IUUC-Fal-036706	Ficedula albicollis	87.90	9.00e-144	502.00
IUUC-Fox-037780	Fusarium oxysporum	40.77	2.00e-51	196.00
IUUC-Fso-038197	Fusarium solani	41.19	3.00e-53	202.00
IUUC-Gmo-039707	Gadus morhua	78.64	2.00e-134	471.00
IUUC-Ggr-040054	Gaeumannomyces graminis	39.70	3.00e-54	205.00
IUUC-Gga-040901	Gallus gallus	89.43	2.00e-172	598.00
IUUC-Gac-041876	Gasterosteus aculeatus	74.00	1.00e-141	495.00
IUUC-Gma-043984	Glycine max	50.86	2.00e-78	285.00
IUUC-Ggo-044583	Gorilla gorilla	91.17	4.00e-169	587.00
IUUC-Hsa-046553	Homo sapiens	94.21	0.00e+00	634.00
IUUC-Hvu-047544	Hordeum vulgare	48.43	3.00e-78	285.00
IUUC-Itr-047980	Ictidomys tridecemlineatus	98.86	0.00e+00	650.00
IUUC-Lch-050078	Latimeria chalumnae	82.34	5.00e-156	543.00
IUUC-Lpe-051246	Leersia perrieri	50.86	1.00e-78	286.00
IUUC-Loc-052598	Lepisosteus oculatus	78.06	1.00e-150	525.00
IUUC-Lma-053226	Leptosphaeria maculans	45.57	6.00e-56	211.00
IUUC-Laf-054053	Loxodonta africana	97.14	0.00e+00	641.00
IUUC-Mcc-054652	Macaca mulatta	93.96	0.00e+00	634.00
IUUC-Mor-057256	Magnaporthe oryzae	39.17	3.00e-52	199.00
IUUC-Mpo-057303	Magnaporthe poae	40.06	1.00e-54	207.00
IUUC-Mtr-058421	Medicago truncatula	50.86	2.00e-78	285.00
IUUC-Mla-059073	Melampsora laricipopulina	45.43	9.00e-64	237.00
IUUC-Mga-059664	Meleagris gallopavo	89.17	4.00e-171	593.00
IUUC-Mvi-060534	Microbotryum violaceum	34.83	8.00e-40	157.00
IUUC-Mmr-061044	Microcebus murinus	99.07	0.00e+00	628.00
IUUC-Mdo-063019	Monodelphis domestica	96.00	0.00e+00	635.00
IUUC-Mac-065143	Musa acuminata	51.38	2.00e-77	282.00
IUUC-Mpu-066557	Mustela putorius furo	98.86	0.00e+00	650.00
IUUC-Mlu-068179	Myotis lucifugus	97.71	0.00e+00	642.00
IUUC-Nfi-068553	Neosartorya fischeri	40.36	1.00e-47	183.00
IUUC-Ncr-068934	Neurospora crassa	38.82	4.00e-48	185.00
IUUC-Nle-069482	Nomascus leucogenys	93.94	0.00e+00	630.00
IUUC-Opr-071055	Ochotona princeps	77.43	5.00e-133	467.00
IUUC-Ont-072663	Oreochromis niloticus	74.59	9.00e-139	486.00
IUUC-Ocu-074942	Oryctolagus cuniculus	99.14	0.00e+00	649.00
IUUC-Oba-075160	Oryza barthii	50.68	1.00e-78	286.00
IUUC-Obr-076864	Oryza brachyantha	50.86	1.00e-78	286.00
IUUC-Ogl-077076	Oryza glaberrima	50.68	1.00e-78	286.00
IUUC-Ogu-078591	Oryza glumaepatula	50.68	1.00e-78	286.00
IUUC-Oin-079631	Oryza indica	49.66	7.00e-77	280.00
IUUC-Olo-080389	Oryza longistaminata	44.60	1.00e-50	192.00
IUUC-Ome-081693	Oryza meridionalis	49.31	1.00e-75	276.00
IUUC-Oni-082190	Oryza nivara	51.20	6.00e-79	287.00
IUUC-Opu-084163	Oryza punctata	50.86	8.00e-79	286.00
IUUC-Oru-084730	Oryza rufipogon	50.68	1.00e-78	286.00
IUUC-Osa-086010	Oryza sativa	50.86	1.00e-78	286.00
IUUC-Ola-086704	Oryzias latipes	77.21	2.00e-150	525.00
IUUC-Olu-087796	Ostreococcus lucimarinus	50.85	3.00e-79	288.00
IUUC-Oga-088932	Otolemur garnettii	75.71	4.00e-128	451.00
IUUC-Oar-090398	Ovis aries	99.14	0.00e+00	649.00
IUUC-Ptr-091202	Pan troglodytes	97.71	0.00e+00	643.00
IUUC-Pan-091948	Papio anubis	97.71	0.00e+00	644.00
IUUC-Psi-093863	Pelodiscus sinensis	87.62	2.00e-152	531.00
IUUC-Pma-094255	Petromyzon marinus	78.26	2.00e-142	498.00
IUUC-Pno-095075	Phaeosphaeria nodorum	46.35	9.00e-59	220.00
IUUC-Ppa-095169	Physcomitrella patens	50.84	1.00e-80	293.00
IUUC-Pfo-096438	Poecilia formosa	76.92	4.00e-148	517.00
IUUC-Pab-097994	Pongo abelii	97.43	0.00e+00	642.00
IUUC-Pop-099172	Populus trichocarpa	50.00	1.00e-77	283.00
IUUC-Pca-100761	Procavia capensis	87.93	2.00e-155	541.00
IUUC-Ppe-102035	Prunus persica	51.55	2.00e-76	278.00
IUUC-Pva-102794	Pteropus vampyrus	89.71	1.00e-164	572.00
IUUC-Pgr-103581	Puccinia graminis	46.52	8.00e-65	240.00
IUUC-Ptt-103862	Puccinia triticina	46.60	1.00e-62	233.00
IUUC-Pte-104245	Pyrenophora teres	46.01	9.00e-59	220.00
IUUC-Pyt-104537	Pyrenophora triticirepentis	46.01	9.00e-59	220.00
IUUC-Rno-105712	Rattus norvegicus	99.71	0.00e+00	652.00
IUUC-Sha-107568	Sarcophilus harrisii	95.14	0.00e+00	629.00
IUUC-Ssl-108655	Sclerotinia sclerotiorum	39.18	2.00e-52	199.00
IUUC-Smo-108784	Selaginella moellendorffii	53.77	6.00e-83	300.00
IUUC-Sit-109807	Setaria italica	52.07	1.00e-79	290.00
IUUC-Sly-111555	Solanum lycopersicum	51.38	2.00e-77	283.00
IUUC-Stu-111953	Solanum tuberosum	50.69	1.00e-76	280.00
IUUC-Sar-113491	Sorex araneus	87.50	8.00e-119	419.00
IUUC-Sbi-114290	Sorghum bicolor	51.72	7.00e-80	290.00
IUUC-Sre-115008	Sporisorium reilianum	43.08	2.00e-63	235.00
IUUC-Ssc-116392	Sus scrofa	94.49	0.00e+00	634.00
IUUC-Tgu-116835	Taeniopygia guttata	87.94	7.00e-146	509.00
IUUC-Tru-117558	Takifugu rubripes	76.14	5.00e-148	517.00
IUUC-Tsy-119522	Tarsius syrichta	95.71	1.00e-174	605.00
IUUC-Tni-120330	Tetraodon nigroviridis	81.25	1.00e-141	496.00
IUUC-Tca-121759	Theobroma cacao	51.55	8.00e-78	283.00
IUUC-Tre-122163	Trichoderma reesei	41.49	2.00e-52	199.00
IUUC-Tvi-122609	Trichoderma virens	42.94	2.00e-53	202.00
IUUC-Tae-123053	Triticum aestivum	50.34	2.00e-77	282.00
IUUC-Tur-126808	Triticum urartu	47.29	5.00e-63	234.00
IUUC-Tme-127137	Tuber melanosporum	48.87	9.00e-68	250.00
IUUC-Tbe-127324	Tupaia belangeri	85.12	7.00e-94	337.00
IUUC-Ttr-128202	Tursiops truncatus	98.57	0.00e+00	644.00
IUUC-Uma-129433	Ustilago maydis	44.65	8.00e-63	233.00
IUUC-Vda-129675	Verticillium dahliae	39.23	8.00e-53	200.00
IUUC-Vpa-130382	Vicugna pacos	99.14	0.00e+00	649.00
IUUC-Vvi-131432	Vitis vinifera	51.89	6.00e-81	294.00
IUUC-Xtr-132648	Xenopus tropicalis	72.75	8.00e-134	469.00
IUUC-Xma-133969	Xiphophorus maculatus	73.50	2.00e-138	485.00
IUUC-Yli-134670	Yarrowia lipolytica	34.84	1.00e-44	173.00
IUUC-Zma-135878	Zea mays	51.72	4.00e-80	291.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence