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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046666
UUCD1 version UUC-HoS-00051
Ensembl Protein ID ENSP00000326731.5
UniProt Accession O95628; B7Z6I4; E7ET38; F8VQP3; O95339; O95627; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6; CNOT4_HUMAN
Genbank Protein ID AAD00179.1; AAD00180.1; AAF29829.1; CAB97536.1; BAC11125.1; BAH13270.1; AAH35590.1; AAC72963.1
Protein Name CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4
Genbank Nucleotide ID U71267; U71268; AF180475; AL389980; AK074671; AK300365; AC083871; AF091094
Gene Name CNOT4; NOT4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000080802.18 ENST00000451834.5 ENSP00000388491.1
ENSG00000080802.18 ENST00000423368.6 ENSP00000406777.2
ENSG00000080802.18 ENST00000361528.8 ENSP00000354673.4
ENSG00000080802.18 ENST00000414802.5 ENSP00000416532.1
ENSG00000080802.18 ENST00000428680.6 ENSP00000399108.2
ENSG00000080802.18 ENST00000541284.5 ENSP00000445508.1
ENSG00000080802.18 ENST00000315544.6 ENSP00000326731.5
ENSG00000080802.18 ENST00000356162.5 ENSP00000348485.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19346402
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.93 11.7 14 57
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlp..CgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+e++  +d   + p  Cg ++++ C++++      +  + +CP Cr
   Q: 14   CPLCMEPLeiDD-INFFPctCGYQICRFCWHRI-----RTDENGLCPACR 57
           ******997644.4444434999******9999.....5777778****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.
 Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.
Protein Sequence
(Fasta)
MSRSPDAKED PVECPLCMEP LEIDDINFFP CTCGYQICRF CWHRIRTDEN GLCPACRKPY 60
PEDPAVYKPL SQEELQRIKN EKKQKQNERK QKISENRKHL ASVRVVQKNL VFVVGLSQRL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046666|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCGTGCGCC TGCGCACGGG AGGCCGGAGG AGTCTTACCC TAATGTAAGA TGGTGGCCCG 60
TCTGGCTGTG GAACCCACCG AAAGCTGAGA GTCTCTCTCT CAGCCGTAAA GGTCGGACTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046666|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034261--CNOT4_RRM
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR003954--RRM_dom_euk
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50102--RRM
PS50103--ZF_C3H1
PS50089--ZF_RING_2
Pfam

PF00076--RRM_1
SMART

SM00361--RRM_1
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0051865--P:protein autoubiquitination
KEGG hsa:4850
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000464 Aegilops tauschii 42.48 8.00e-54 206.00
IUUC-Aml-002384 Ailuropoda melanoleuca 99.45 0.00e+00 1048.00
IUUC-Atr-002462 Amborella trichopoda 46.64 4.00e-61 230.00
IUUC-Apl-003756 Anas platyrhynchos 87.48 0.00e+00 1004.00
IUUC-Aca-004643 Anolis carolinensis 87.48 0.00e+00 966.00
IUUC-Aly-006093 Arabidopsis lyrata 39.76 8.00e-55 209.00
IUUC-Ath-007371 Arabidopsis thaliana 41.73 2.00e-54 207.00
IUUC-Ago-007799 Ashbya gossypii 48.94 1.00e-56 214.00
IUUC-Acl-008077 Aspergillus clavatus 39.21 7.00e-41 163.00
IUUC-Afl-008720 Aspergillus flavus 40.09 3.00e-45 178.00
IUUC-Afu-008905 Aspergillus fumigatus 40.00 5.00e-42 167.00
IUUC-Ani-009264 Aspergillus nidulans 40.44 6.00e-27 116.00
IUUC-Ang-009537 Aspergillus niger 40.09 8.00e-45 176.00
IUUC-Aor-010123 Aspergillus oryzae 35.68 6.00e-28 120.00
IUUC-Ate-010409 Aspergillus terreus 40.97 3.00e-45 178.00
IUUC-Ame-011538 Astyanax mexicanus 96.05 2.00e-131 463.00
IUUC-Bgr-012062 Blumeria graminis 43.59 2.00e-54 208.00
IUUC-Bta-012419 Bos taurus 99.63 0.00e+00 1039.00
IUUC-Bci-013633 Botrytis cinerea 43.35 2.00e-53 205.00
IUUC-Bdi-014913 Brachypodium distachyon 43.81 5.00e-54 206.00
IUUC-Bol-016407 Brassica oleracea 44.80 5.00e-57 216.00
IUUC-Bra-017755 Brassica rapa 45.25 2.00e-57 217.00
IUUC-Cel-018123 Caenorhabditis elegans 59.66 4.00e-85 309.00
IUUC-Cja-019705 Callithrix jacchus 98.89 0.00e+00 1035.00
IUUC-Cfa-020440 Canis familiaris 98.89 0.00e+00 1038.00
IUUC-Cpo-022091 Cavia porcellus 94.26 0.00e+00 1066.00
IUUC-Cre-022872 Chlamydomonas reinhardtii 35.71 1.00e-11 64.70
IUUC-Csa-024202 Chlorocebus sabaeus 99.26 0.00e+00 1016.00
IUUC-Cho-024410 Choloepus hoffmanni 99.47 4.00e-100 359.00
IUUC-Cin-025558 Ciona intestinalis 70.04 2.00e-112 399.00
IUUC-Cgl-026687 Colletotrichum gloeosporioides 45.57 7.00e-56 212.00
IUUC-Cne-027084 Cryptococcus neoformans 37.75 2.00e-44 174.00
IUUC-Cme-027148 Cyanidioschyzon merolae 30.39 7.00e-22 99.00
IUUC-Dre-028377 Danio rerio 96.03 3.00e-130 459.00
IUUC-Dno-029100 Dasypus novemcinctus 98.71 0.00e+00 1068.00
IUUC-Dor-030310 Dipodomys ordii 85.08 0.00e+00 728.00
IUUC-Dse-031514 Dothistroma septosporum 42.51 1.00e-48 188.00
IUUC-Dme-031735 Drosophila melanogaster 73.47 4.00e-107 383.00
IUUC-Ete-033091 Echinops telfairi 95.76 0.00e+00 1004.00
IUUC-Eca-033506 Equus caballus 98.89 0.00e+00 1032.00
IUUC-Eeu-034506 Erinaceus europaeus 92.25 0.00e+00 984.00
IUUC-Fca-036033 Felis catus 98.78 0.00e+00 1100.00
IUUC-Fal-037540 Ficedula albicollis 88.16 0.00e+00 1024.00
IUUC-Fox-037944 Fusarium oxysporum 46.29 5.00e-58 219.00
IUUC-Fso-038172 Fusarium solani 42.55 4.00e-47 184.00
IUUC-Gmo-039211 Gadus morhua 58.92 5.00e-164 571.00
IUUC-Ggr-040096 Gaeumannomyces graminis 47.68 8.00e-61 229.00
IUUC-Gga-040487 Gallus gallus 88.16 0.00e+00 1021.00
IUUC-Gac-042294 Gasterosteus aculeatus 58.25 2.00e-159 556.00
IUUC-Gma-043229 Glycine max 45.11 6.00e-56 213.00
IUUC-Ggo-044950 Gorilla gorilla 99.59 0.00e+00 900.00
IUUC-Hvu-047405 Hordeum vulgare 42.92 8.00e-54 206.00
IUUC-Itr-047888 Ictidomys tridecemlineatus 100.00 3.00e-152 530.00
IUUC-Kpa-049260 Komagataella pastoris 47.03 1.00e-54 207.00
IUUC-Lch-050203 Latimeria chalumnae 83.81 0.00e+00 945.00
IUUC-Lpe-051195 Leersia perrieri 43.67 4.00e-53 203.00
IUUC-Loc-052886 Lepisosteus oculatus 78.89 0.00e+00 835.00
IUUC-Lma-053073 Leptosphaeria maculans 43.67 5.00e-52 199.00
IUUC-Laf-053490 Loxodonta africana 97.79 0.00e+00 1021.00
IUUC-Mcc-055724 Macaca mulatta 100.00 0.00e+00 1030.00
IUUC-Meu-056787 Macropus eugenii 82.47 0.00e+00 825.00
IUUC-Mor-056921 Magnaporthe oryzae 47.01 5.00e-59 222.00
IUUC-Mpo-057616 Magnaporthe poae 47.26 8.00e-60 225.00
IUUC-Mtr-058426 Medicago truncatula 43.35 9.00e-53 202.00
IUUC-Mla-059146 Melampsora laricipopulina 41.70 1.00e-45 178.00
IUUC-Mga-059372 Meleagris gallopavo 87.65 0.00e+00 1002.00
IUUC-Mvi-060479 Microbotryum violaceum 36.04 6.00e-31 130.00
IUUC-Mmr-061012 Microcebus murinus 99.63 0.00e+00 1052.00
IUUC-Mdo-062330 Monodelphis domestica 97.23 0.00e+00 1020.00
IUUC-Mmu-063894 Mus musculus 98.15 0.00e+00 1059.00
IUUC-Mac-064805 Musa acuminata 45.33 1.00e-57 217.00
IUUC-Mpu-066894 Mustela putorius furo 98.89 0.00e+00 1038.00
IUUC-Mlu-067321 Myotis lucifugus 99.63 0.00e+00 1038.00
IUUC-Nfi-068451 Neosartorya fischeri 39.65 5.00e-42 167.00
IUUC-Ncr-068667 Neurospora crassa 45.85 2.00e-52 202.00
IUUC-Nle-070058 Nomascus leucogenys 99.63 0.00e+00 994.00
IUUC-Opr-071108 Ochotona princeps 75.65 0.00e+00 793.00
IUUC-Ont-071541 Oreochromis niloticus 88.32 1.00e-129 457.00
IUUC-Oan-073232 Ornithorhynchus anatinus 95.96 0.00e+00 1002.00
IUUC-Ocu-074893 Oryctolagus cuniculus 98.89 0.00e+00 1009.00
IUUC-Oba-075623 Oryza barthii 39.38 2.00e-28 119.00
IUUC-Obr-076653 Oryza brachyantha 43.36 3.00e-55 210.00
IUUC-Ogl-077946 Oryza glaberrima 43.07 3.00e-43 168.00
IUUC-Ogu-078775 Oryza glumaepatula 44.05 2.00e-53 202.00
IUUC-Oin-079214 Oryza indica 44.05 3.00e-55 210.00
IUUC-Olo-080799 Oryza longistaminata 32.74 3.00e-28 118.00
IUUC-Ome-081843 Oryza meridionalis 40.83 2.00e-52 200.00
IUUC-Oni-082944 Oryza nivara 39.38 1.00e-28 119.00
IUUC-Opu-083668 Oryza punctata 43.61 4.00e-55 210.00
IUUC-Oru-084249 Oryza rufipogon 35.29 5.00e-35 143.00
IUUC-Osa-086233 Oryza sativa 44.05 2.00e-55 211.00
IUUC-Ola-087121 Oryzias latipes 66.40 0.00e+00 660.00
IUUC-Olu-087772 Ostreococcus lucimarinus 42.11 3.00e-41 161.00
IUUC-Oga-088556 Otolemur garnettii 99.63 0.00e+00 1052.00
IUUC-Oar-089768 Ovis aries 99.63 0.00e+00 1052.00
IUUC-Ptr-090585 Pan troglodytes 99.82 0.00e+00 1028.00
IUUC-Pan-092625 Papio anubis 99.08 0.00e+00 1014.00
IUUC-Psi-093462 Pelodiscus sinensis 86.49 0.00e+00 937.00
IUUC-Pma-094468 Petromyzon marinus 86.75 1.00e-124 440.00
IUUC-Pno-094812 Phaeosphaeria nodorum 40.45 6.00e-29 124.00
IUUC-Ppa-095589 Physcomitrella patens 51.79 8.00e-15 75.10
IUUC-Pfo-096762 Poecilia formosa 59.05 1.00e-157 550.00
IUUC-Pab-097890 Pongo abelii 99.26 0.00e+00 1015.00
IUUC-Pop-099764 Populus trichocarpa 45.50 1.00e-58 222.00
IUUC-Pca-101121 Procavia capensis 94.83 0.00e+00 891.00
IUUC-Ppe-102076 Prunus persica 42.75 9.00e-56 212.00
IUUC-Pva-102489 Pteropus vampyrus 99.08 0.00e+00 1045.00
IUUC-Pgr-103568 Puccinia graminis 41.70 3.00e-48 187.00
IUUC-Ptt-103721 Puccinia triticina 37.08 2.00e-29 124.00
IUUC-Pte-104118 Pyrenophora teres 42.98 5.00e-54 206.00
IUUC-Pyt-104612 Pyrenophora triticirepentis 42.98 3.00e-54 207.00
IUUC-Rno-105627 Rattus norvegicus 97.97 0.00e+00 1013.00
IUUC-Sce-106312 Saccharomyces cerevisiae 44.90 1.00e-54 207.00
IUUC-Sha-106619 Sarcophilus harrisii 97.23 0.00e+00 1021.00
IUUC-Sja-107765 Schizosaccharomyces japonicus 50.65 1.00e-56 214.00
IUUC-Spo-108328 Schizosaccharomyces pombe 51.29 4.00e-62 232.00
IUUC-Ssl-108577 Sclerotinia sclerotiorum 44.54 2.00e-50 194.00
IUUC-Smo-108760 Selaginella moellendorffii 44.21 9.00e-56 209.00
IUUC-Sit-109923 Setaria italica 40.68 4.00e-52 200.00
IUUC-Sly-110900 Solanum lycopersicum 39.15 2.00e-50 194.00
IUUC-Stu-112226 Solanum tuberosum 39.15 2.00e-50 194.00
IUUC-Sar-113620 Sorex araneus 99.47 0.00e+00 733.00
IUUC-Sbi-114318 Sorghum bicolor 40.95 8.00e-54 206.00
IUUC-Sre-114956 Sporisorium reilianum 47.74 7.00e-65 242.00
IUUC-Ssc-116116 Sus scrofa 100.00 1.00e-154 539.00
IUUC-Tgu-117357 Taeniopygia guttata 88.16 0.00e+00 1023.00
IUUC-Tru-118759 Takifugu rubripes 88.97 2.00e-134 473.00
IUUC-Tsy-119387 Tarsius syrichta 94.45 0.00e+00 980.00
IUUC-Tni-120536 Tetraodon nigroviridis 71.76 0.00e+00 712.00
IUUC-Tca-121035 Theobroma cacao 45.74 2.00e-57 217.00
IUUC-Tre-121996 Trichoderma reesei 42.98 4.00e-47 184.00
IUUC-Tvi-122371 Trichoderma virens 44.26 5.00e-54 207.00
IUUC-Tae-124373 Triticum aestivum 42.92 6.00e-54 206.00
IUUC-Tur-126324 Triticum urartu 42.92 5.00e-54 206.00
IUUC-Tme-127072 Tuber melanosporum 40.00 2.00e-42 168.00
IUUC-Tbe-128107 Tupaia belangeri 95.76 0.00e+00 1016.00
IUUC-Ttr-128846 Tursiops truncatus 98.16 0.00e+00 1023.00
IUUC-Uma-129607 Ustilago maydis 47.74 5.00e-65 243.00
IUUC-Vda-129971 Verticillium dahliae 42.86 6.00e-47 183.00
IUUC-Vpa-130298 Vicugna pacos 93.17 0.00e+00 964.00
IUUC-Vvi-131651 Vitis vinifera 45.74 3.00e-58 220.00
IUUC-Xtr-132728 Xenopus tropicalis 98.18 4.00e-153 535.00
IUUC-Xma-133789 Xiphophorus maculatus 65.44 0.00e+00 633.00
IUUC-Yli-134461 Yarrowia lipolytica 42.22 2.00e-47 183.00
IUUC-Zma-135031 Zea mays 42.37 3.00e-54 206.00
Created Date 25-Jun-2017

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