iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089995

Ensembl Protein ID

ENSOARP00000005943.1

UniProt Accession

W5P689; W5P689_SHEEP

Genbank Protein ID

ENSOARP00000005943

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AMGL01083597

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000005531.1	ENSOART00000006033.1	ENSOARP00000005943.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.50e-64	216.7	325	855
UBD/Alpha-Helix/UBA	5.10e-23	80.7	725	762

Active Site

Position(s)	Description	Evidence
334	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
818	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 325  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGRGLlsgeyskpapesgdgeqvteQKEVQDGIA 412
           7******************************.99999999********************77777777666666665433366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 413  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 472
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke............................slqdcLesftkeeelegenkyycekckkkqeaek 219
            ++v+ ++   + ++lpvp++  ++k                              +++cLe+++++e++++   ++++  ++k+ a+k
   Q: 473  TEKVKYTQRVDYIMQLPVPMDAAMNKAeelleyeekkrqaeeeklplpelvraqvPFSSCLEAYSAPEQVDD---FWSTALQAKSVAVK 558
           *********************99888899*****************************************97...************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................................... 267
           ++++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                         
   Q: 559  TTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsph 646
           ********************997.*******************9888878888888888888888888888888888888777777777 PP
   S: 268  .............................................................................peekqke..... 274
                                                                                        p     e     
   Q: 647  fssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadppP-----Edcvtt 730
           777777777777777777777777777777777766666666666666666666666666666666555555555550.....055555 PP
   S: 275  ...................................................................kkkYeLiavvvHsG.slssGHY 295
                                                                              + kY+L+a ++H+G s+ +GHY
   Q: 731  ivsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesipvgpkvrdgPGKYQLFAFISHMGtSTMCGHY 819
           5555555555555566666666667777777777777777777777777778888888888888888********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           v+++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 820  VCHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 855
           ******.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 725  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 762
           889999******************************97 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRPK EEDATAGTGD PPRKKPTRLA IGVEGGFDLN EEKFEYDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAGC TGAGTGAAGA GGCGCTGCTG TCAGTATTAC CGACGATCCG GGTCCCCAAG 60
GCTGGAGACC GGGTCCACAA AGACGAGTGC GCCTTCTCCT TCGACACACC GGTAAGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.01	0.00e+00	638.00
IUUC-Aml-002104	Ailuropoda melanoleuca	97.18	0.00e+00	1632.00
IUUC-Atr-002580	Amborella trichopoda	45.38	0.00e+00	729.00
IUUC-Apl-003774	Anas platyrhynchos	88.78	0.00e+00	1503.00
IUUC-Aca-005368	Anolis carolinensis	83.62	0.00e+00	1478.00
IUUC-Aly-005727	Arabidopsis lyrata	46.86	0.00e+00	722.00
IUUC-Ath-006974	Arabidopsis thaliana	46.86	0.00e+00	723.00
IUUC-Ago-007890	Ashbya gossypii	29.33	2.00e-82	300.00
IUUC-Acl-008057	Aspergillus clavatus	33.69	8.00e-122	431.00
IUUC-Afl-008547	Aspergillus flavus	36.08	3.00e-115	409.00
IUUC-Afu-008805	Aspergillus fumigatus	33.78	1.00e-112	400.00
IUUC-Ani-009441	Aspergillus nidulans	32.48	4.00e-96	345.00
IUUC-Ang-009720	Aspergillus niger	33.99	5.00e-117	415.00
IUUC-Aor-010111	Aspergillus oryzae	33.79	8.00e-125	441.00
IUUC-Ate-010531	Aspergillus terreus	31.56	8.00e-103	368.00
IUUC-Ame-011893	Astyanax mexicanus	64.22	0.00e+00	977.00
IUUC-Bgr-012183	Blumeria graminis	33.64	7.00e-122	431.00
IUUC-Bta-013179	Bos taurus	97.65	0.00e+00	1641.00
IUUC-Bci-013858	Botrytis cinerea	34.76	1.00e-130	460.00
IUUC-Bdi-014904	Brachypodium distachyon	46.57	0.00e+00	701.00
IUUC-Bol-015296	Brassica oleracea	47.26	0.00e+00	735.00
IUUC-Bra-017939	Brassica rapa	47.15	0.00e+00	736.00
IUUC-Cel-018625	Caenorhabditis elegans	34.62	7.00e-133	468.00
IUUC-Cja-019063	Callithrix jacchus	96.71	0.00e+00	1619.00
IUUC-Cfa-020976	Canis familiaris	94.24	0.00e+00	1561.00
IUUC-Cpo-022265	Cavia porcellus	94.12	0.00e+00	1553.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.83	2.00e-114	406.00
IUUC-Csa-024177	Chlorocebus sabaeus	93.43	0.00e+00	1420.00
IUUC-Cho-024702	Choloepus hoffmanni	87.74	0.00e+00	969.00
IUUC-Cin-025411	Ciona intestinalis	50.12	0.00e+00	838.00
IUUC-Csv-026347	Ciona savignyi	46.41	0.00e+00	792.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.18	1.00e-113	404.00
IUUC-Cne-026831	Cryptococcus neoformans	35.37	4.00e-128	452.00
IUUC-Cme-027335	Cyanidioschyzon merolae	27.57	1.00e-62	235.00
IUUC-Dre-027982	Danio rerio	66.90	0.00e+00	1084.00
IUUC-Dno-029034	Dasypus novemcinctus	96.12	0.00e+00	1631.00
IUUC-Dor-030479	Dipodomys ordii	91.14	0.00e+00	688.00
IUUC-Dse-031467	Dothistroma septosporum	36.00	6.00e-130	458.00
IUUC-Dme-032075	Drosophila melanogaster	48.91	0.00e+00	789.00
IUUC-Ete-032865	Echinops telfairi	84.90	0.00e+00	1434.00
IUUC-Eca-034059	Equus caballus	96.51	0.00e+00	1632.00
IUUC-Eeu-035304	Erinaceus europaeus	90.35	0.00e+00	1467.00
IUUC-Fca-035515	Felis catus	96.47	0.00e+00	1624.00
IUUC-Fal-037271	Ficedula albicollis	85.28	0.00e+00	1400.00
IUUC-Fox-037745	Fusarium oxysporum	35.12	5.00e-130	458.00
IUUC-Fso-038158	Fusarium solani	35.81	2.00e-129	456.00
IUUC-Gmo-039071	Gadus morhua	64.84	0.00e+00	1068.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.02	2.00e-118	419.00
IUUC-Gga-040635	Gallus gallus	88.73	0.00e+00	1573.00
IUUC-Gac-042528	Gasterosteus aculeatus	63.85	0.00e+00	1077.00
IUUC-Gma-043614	Glycine max	45.75	0.00e+00	694.00
IUUC-Ggo-044602	Gorilla gorilla	96.12	0.00e+00	1613.00
IUUC-Hsa-045959	Homo sapiens	96.12	0.00e+00	1613.00
IUUC-Hvu-047563	Hordeum vulgare	46.86	1.00e-166	579.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	97.41	0.00e+00	1623.00
IUUC-Kpa-049156	Komagataella pastoris	33.33	4.00e-114	405.00
IUUC-Lch-049648	Latimeria chalumnae	80.78	0.00e+00	1352.00
IUUC-Lpe-051523	Leersia perrieri	45.91	0.00e+00	705.00
IUUC-Loc-052520	Lepisosteus oculatus	62.53	0.00e+00	1033.00
IUUC-Lma-053216	Leptosphaeria maculans	34.52	1.00e-112	402.00
IUUC-Laf-054327	Loxodonta africana	95.41	0.00e+00	1607.00
IUUC-Mcc-055443	Macaca mulatta	96.00	0.00e+00	1611.00
IUUC-Meu-056298	Macropus eugenii	89.81	0.00e+00	1035.00
IUUC-Mor-057106	Magnaporthe oryzae	35.54	5.00e-131	461.00
IUUC-Mpo-057589	Magnaporthe poae	34.56	5.00e-123	435.00
IUUC-Mtr-058680	Medicago truncatula	47.28	0.00e+00	722.00
IUUC-Mla-058903	Melampsora laricipopulina	32.31	7.00e-120	424.00
IUUC-Mga-059669	Meleagris gallopavo	87.80	0.00e+00	1490.00
IUUC-Mvi-060476	Microbotryum violaceum	34.40	5.00e-120	425.00
IUUC-Mmr-060575	Microcebus murinus	96.24	0.00e+00	1620.00
IUUC-Mdo-062183	Monodelphis domestica	89.41	0.00e+00	1509.00
IUUC-Mmu-063592	Mus musculus	96.00	0.00e+00	1614.00
IUUC-Mac-065634	Musa acuminata	42.31	0.00e+00	677.00
IUUC-Mpu-066082	Mustela putorius furo	93.41	0.00e+00	1545.00
IUUC-Mlu-067345	Myotis lucifugus	96.12	0.00e+00	1613.00
IUUC-Nfi-068558	Neosartorya fischeri	34.69	5.00e-121	428.00
IUUC-Ncr-068960	Neurospora crassa	34.91	1.00e-115	410.00
IUUC-Nle-070173	Nomascus leucogenys	94.00	0.00e+00	1553.00
IUUC-Opr-070556	Ochotona princeps	95.65	0.00e+00	1607.00
IUUC-Ont-071502	Oreochromis niloticus	64.28	0.00e+00	1071.00
IUUC-Ocu-074861	Oryctolagus cuniculus	93.76	0.00e+00	1559.00
IUUC-Oba-075109	Oryza barthii	45.85	0.00e+00	707.00
IUUC-Obr-076292	Oryza brachyantha	47.14	0.00e+00	703.00
IUUC-Ogl-077065	Oryza glaberrima	47.14	0.00e+00	738.00
IUUC-Ogu-078776	Oryza glumaepatula	45.73	0.00e+00	719.00
IUUC-Oin-080048	Oryza indica	47.02	0.00e+00	734.00
IUUC-Olo-080711	Oryza longistaminata	44.12	0.00e+00	649.00
IUUC-Ome-081506	Oryza meridionalis	45.17	0.00e+00	662.00
IUUC-Oni-082320	Oryza nivara	45.31	0.00e+00	705.00
IUUC-Opu-083801	Oryza punctata	46.14	0.00e+00	701.00
IUUC-Oru-085139	Oryza rufipogon	45.31	0.00e+00	707.00
IUUC-Osa-085713	Oryza sativa	47.26	0.00e+00	741.00
IUUC-Ola-086951	Oryzias latipes	65.08	0.00e+00	1064.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.85	5.00e-179	621.00
IUUC-Oga-088625	Otolemur garnettii	96.94	0.00e+00	1613.00
IUUC-Ptr-090640	Pan troglodytes	94.24	0.00e+00	1602.00
IUUC-Pan-091974	Papio anubis	97.18	0.00e+00	1625.00
IUUC-Psi-093957	Pelodiscus sinensis	88.64	0.00e+00	1570.00
IUUC-Pma-094242	Petromyzon marinus	69.90	1.00e-160	558.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.81	2.00e-105	377.00
IUUC-Ppa-095901	Physcomitrella patens	48.62	0.00e+00	772.00
IUUC-Pfo-097148	Poecilia formosa	65.85	0.00e+00	1083.00
IUUC-Pab-098068	Pongo abelii	88.47	0.00e+00	1444.00
IUUC-Pop-098943	Populus trichocarpa	46.68	0.00e+00	712.00
IUUC-Pca-100738	Procavia capensis	96.68	0.00e+00	1120.00
IUUC-Ppe-101315	Prunus persica	46.81	0.00e+00	715.00
IUUC-Pva-102154	Pteropus vampyrus	94.71	0.00e+00	1594.00
IUUC-Pgr-103343	Puccinia graminis	32.87	6.00e-106	378.00
IUUC-Ptt-103928	Puccinia triticina	30.21	3.00e-103	369.00
IUUC-Pte-104306	Pyrenophora teres	32.41	1.00e-103	370.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.60	3.00e-106	379.00
IUUC-Rno-105801	Rattus norvegicus	95.76	0.00e+00	1613.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.03	9.00e-73	268.00
IUUC-Sha-107635	Sarcophilus harrisii	89.41	0.00e+00	1515.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.40	3.00e-106	379.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.13	8.00e-112	397.00
IUUC-Smo-108848	Selaginella moellendorffii	47.48	0.00e+00	728.00
IUUC-Sit-110728	Setaria italica	47.38	0.00e+00	759.00
IUUC-Sly-111523	Solanum lycopersicum	46.52	0.00e+00	745.00
IUUC-Sbi-114419	Sorghum bicolor	46.86	0.00e+00	742.00
IUUC-Sre-115225	Sporisorium reilianum	35.24	2.00e-126	446.00
IUUC-Ssc-115686	Sus scrofa	97.18	0.00e+00	1621.00
IUUC-Tgu-117346	Taeniopygia guttata	88.28	0.00e+00	1543.00
IUUC-Tru-118350	Takifugu rubripes	64.86	0.00e+00	1093.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.28	0.00e+00	1089.00
IUUC-Tca-121585	Theobroma cacao	47.22	0.00e+00	711.00
IUUC-Tre-122043	Trichoderma reesei	34.22	3.00e-118	419.00
IUUC-Tvi-122303	Trichoderma virens	34.03	3.00e-124	439.00
IUUC-Tae-123798	Triticum aestivum	46.22	0.00e+00	721.00
IUUC-Tur-126732	Triticum urartu	44.43	0.00e+00	676.00
IUUC-Tme-126909	Tuber melanosporum	34.56	8.00e-119	421.00
IUUC-Tbe-127261	Tupaia belangeri	89.04	0.00e+00	1018.00
IUUC-Uma-129599	Ustilago maydis	34.20	2.00e-129	456.00
IUUC-Vda-129688	Verticillium dahliae	33.53	5.00e-120	425.00
IUUC-Vvi-131116	Vitis vinifera	46.98	0.00e+00	692.00
IUUC-Xtr-131953	Xenopus tropicalis	77.71	0.00e+00	1328.00
IUUC-Xma-133837	Xiphophorus maculatus	65.97	0.00e+00	1086.00
IUUC-Yli-134510	Yarrowia lipolytica	35.10	2.00e-128	452.00
IUUC-Zma-135786	Zea mays	46.86	0.00e+00	709.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence