iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cme-027290

Ensembl Protein ID

CMI034CT

UniProt Accession

M1VBY6; M1VBY6_CYAM1

Genbank Protein ID

BAM79942.1

Protein Name

Ubiquitin-activating enzyme E1

Genbank Nucleotide ID

AP006491

Gene Name

CYME_CMI034C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CMI034C	CMI034CT	CMI034CT

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	7.00e-149	494.5	437	731

Active Site

Position(s)	Description	Evidence
619	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv......gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahee 95
           YD+Qi+++G   q+ +    ++ vGag++++EllK  + +G+      gsi ++Dmdt+e snlnrqFLfra d+g+sK+ +a +a+ +lnp  nv a e 
   Q: 437  YDGQIAVFGRALQDTIHDLAYFCVGAGAIAAELLKCWACMGLglashgGSIAITDMDTIERSNLNRQFLFRATDIGRSKSLAARDAALRLNPELNVRALEM 537
           ***************************************************************************************************** PP
   S: 96   siteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa... 190
           ++ +++e+++   F + +d+V++aldn++ar++++++c+++ +pl++sgtlG++G ++v++++lte+y +s+dpp+++iP+ctlk++p+ +eht++wa   
   Q: 538  RVGPDTEHVFsddFWEPLDGVCTALDNVDARLYIDQRCVYYLKPLLDSGTLGTKGSTQVVVPYLTESYGSSRDPPERSIPMCTLKNFPYRIEHTLQWArdl 638
           ********8889999999*********************************************************************************** PP
   S: 191  .........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv 274
                    +  +++le  ++   +lek     ++ +++ v ++l++ +++nf++++ +a+++f++ + n+i+qll+ f++d v +s++pfw+
   Q: 639  feglfkasiEDTKQYLERGSEYIAELEKQGPGIFSGALENVLENLQTYRPQNFKDCVVWARNKFEELYVNNIRQLLHAFPPDMVDSSGQPFWS 731
           **87776666666666666666666666666777888999****************************************************7 PP

Organism

Cyanidioschyzon merolae

Protein Sequence
(Fasta)

MLRLGDSVPP ERVSRTQAES GAIDESLYSR QLYVLGHEAQ RRLAGASVLV IGLTGTGTEI 60
AKDLALAGFH ALHVYDPAPL ALQHMAANFY ACDASLLGTP LHTVVVPHLV ELNPYCHVYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGCGGC TGGGGGACTC TGTCCCACCG GAACGCGTGT CGCGCACGCA AGCAGAGAGC 60
GGGGCCATAG ACGAGTCCCT GTACTCGCGT CAACTGTACG TGCTGGGTCA CGAGGCGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

KEGG

cme:CYME_CMI034C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	39.92	0.00e+00	717.00
IUUC-Aml-001311	Ailuropoda melanoleuca	44.77	0.00e+00	843.00
IUUC-Atr-002684	Amborella trichopoda	39.62	0.00e+00	734.00
IUUC-Apl-004158	Anas platyrhynchos	36.43	9.00e-160	555.00
IUUC-Aca-004620	Anolis carolinensis	43.96	0.00e+00	829.00
IUUC-Aly-005418	Arabidopsis lyrata	38.67	0.00e+00	716.00
IUUC-Ath-006992	Arabidopsis thaliana	38.58	0.00e+00	707.00
IUUC-Ago-007873	Ashbya gossypii	41.34	0.00e+00	763.00
IUUC-Acl-008181	Aspergillus clavatus	44.85	0.00e+00	840.00
IUUC-Afl-008455	Aspergillus flavus	44.26	0.00e+00	792.00
IUUC-Afu-009065	Aspergillus fumigatus	44.67	0.00e+00	856.00
IUUC-Ani-009371	Aspergillus nidulans	44.71	0.00e+00	821.00
IUUC-Ang-009737	Aspergillus niger	44.76	0.00e+00	827.00
IUUC-Aor-010007	Aspergillus oryzae	44.26	0.00e+00	791.00
IUUC-Ate-010466	Aspergillus terreus	44.32	0.00e+00	840.00
IUUC-Ame-010933	Astyanax mexicanus	44.00	0.00e+00	771.00
IUUC-Bgr-012281	Blumeria graminis	42.53	0.00e+00	799.00
IUUC-Bta-012767	Bos taurus	45.04	0.00e+00	846.00
IUUC-Bci-013721	Botrytis cinerea	42.54	0.00e+00	749.00
IUUC-Bdi-014009	Brachypodium distachyon	39.08	0.00e+00	690.00
IUUC-Bol-015161	Brassica oleracea	38.56	0.00e+00	712.00
IUUC-Bra-017252	Brassica rapa	38.56	0.00e+00	713.00
IUUC-Cel-018260	Caenorhabditis elegans	40.06	0.00e+00	679.00
IUUC-Cja-019152	Callithrix jacchus	45.52	0.00e+00	846.00
IUUC-Cfa-020622	Canis familiaris	44.13	0.00e+00	797.00
IUUC-Cpo-022526	Cavia porcellus	44.59	0.00e+00	827.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	40.51	0.00e+00	646.00
IUUC-Csa-023780	Chlorocebus sabaeus	45.04	0.00e+00	845.00
IUUC-Cho-024682	Choloepus hoffmanni	33.53	4.00e-68	250.00
IUUC-Cin-025790	Ciona intestinalis	43.23	0.00e+00	835.00
IUUC-Csv-026084	Ciona savignyi	42.35	0.00e+00	816.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	42.61	0.00e+00	816.00
IUUC-Cne-026960	Cryptococcus neoformans	43.16	0.00e+00	786.00
IUUC-Dre-028149	Danio rerio	45.11	0.00e+00	827.00
IUUC-Dno-028884	Dasypus novemcinctus	44.86	0.00e+00	845.00
IUUC-Dor-030229	Dipodomys ordii	43.04	0.00e+00	781.00
IUUC-Dse-031524	Dothistroma septosporum	42.04	0.00e+00	783.00
IUUC-Dme-032045	Drosophila melanogaster	43.47	0.00e+00	813.00
IUUC-Ete-033124	Echinops telfairi	36.56	3.00e-107	380.00
IUUC-Eca-033330	Equus caballus	45.04	0.00e+00	849.00
IUUC-Eeu-035323	Erinaceus europaeus	37.55	3.00e-123	433.00
IUUC-Fca-036255	Felis catus	45.04	0.00e+00	848.00
IUUC-Fal-036848	Ficedula albicollis	36.05	2.00e-160	557.00
IUUC-Fox-038007	Fusarium oxysporum	45.88	5.00e-131	459.00
IUUC-Fso-038339	Fusarium solani	42.51	0.00e+00	762.00
IUUC-Gmo-039338	Gadus morhua	44.09	0.00e+00	809.00
IUUC-Ggr-039823	Gaeumannomyces graminis	43.67	0.00e+00	832.00
IUUC-Gga-040747	Gallus gallus	36.34	2.00e-161	560.00
IUUC-Gac-041773	Gasterosteus aculeatus	44.13	0.00e+00	802.00
IUUC-Gma-043165	Glycine max	38.66	0.00e+00	715.00
IUUC-Ggo-045336	Gorilla gorilla	44.77	0.00e+00	832.00
IUUC-Hsa-045982	Homo sapiens	44.77	0.00e+00	831.00
IUUC-Hvu-047418	Hordeum vulgare	39.19	0.00e+00	696.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	45.04	0.00e+00	845.00
IUUC-Kpa-049112	Komagataella pastoris	40.71	0.00e+00	751.00
IUUC-Lch-050371	Latimeria chalumnae	44.84	0.00e+00	836.00
IUUC-Lpe-051299	Leersia perrieri	38.41	0.00e+00	717.00
IUUC-Loc-052936	Lepisosteus oculatus	45.30	0.00e+00	830.00
IUUC-Lma-053315	Leptosphaeria maculans	42.75	0.00e+00	824.00
IUUC-Laf-053948	Loxodonta africana	43.86	0.00e+00	810.00
IUUC-Mcc-055843	Macaca mulatta	45.04	0.00e+00	845.00
IUUC-Meu-056258	Macropus eugenii	43.95	0.00e+00	816.00
IUUC-Mor-057269	Magnaporthe oryzae	43.11	0.00e+00	811.00
IUUC-Mpo-057435	Magnaporthe poae	43.13	0.00e+00	789.00
IUUC-Mtr-058572	Medicago truncatula	39.58	0.00e+00	714.00
IUUC-Mla-059176	Melampsora laricipopulina	43.40	0.00e+00	761.00
IUUC-Mga-059721	Meleagris gallopavo	36.61	8.00e-161	558.00
IUUC-Mvi-060437	Microbotryum violaceum	41.94	0.00e+00	787.00
IUUC-Mmr-061405	Microcebus murinus	44.36	0.00e+00	813.00
IUUC-Mdo-062032	Monodelphis domestica	42.83	0.00e+00	783.00
IUUC-Mmu-063280	Mus musculus	44.13	0.00e+00	824.00
IUUC-Mac-065505	Musa acuminata	38.69	0.00e+00	701.00
IUUC-Mpu-066409	Mustela putorius furo	44.77	0.00e+00	844.00
IUUC-Mlu-067217	Myotis lucifugus	44.40	0.00e+00	827.00
IUUC-Nfi-068407	Neosartorya fischeri	44.90	0.00e+00	839.00
IUUC-Ncr-068698	Neurospora crassa	44.03	0.00e+00	813.00
IUUC-Nle-070072	Nomascus leucogenys	43.78	0.00e+00	779.00
IUUC-Opr-070715	Ochotona princeps	36.33	3.00e-128	450.00
IUUC-Ont-071671	Oreochromis niloticus	44.75	0.00e+00	821.00
IUUC-Oan-073268	Ornithorhynchus anatinus	37.27	3.00e-150	523.00
IUUC-Ocu-074544	Oryctolagus cuniculus	44.68	0.00e+00	841.00
IUUC-Oba-075934	Oryza barthii	38.93	0.00e+00	717.00
IUUC-Obr-076557	Oryza brachyantha	38.97	0.00e+00	688.00
IUUC-Ogl-077762	Oryza glaberrima	38.93	0.00e+00	718.00
IUUC-Ogu-078305	Oryza glumaepatula	38.93	0.00e+00	717.00
IUUC-Oin-080154	Oryza indica	39.03	0.00e+00	719.00
IUUC-Olo-081089	Oryza longistaminata	39.21	0.00e+00	723.00
IUUC-Ome-081942	Oryza meridionalis	38.31	0.00e+00	703.00
IUUC-Oni-082447	Oryza nivara	38.93	0.00e+00	716.00
IUUC-Opu-083301	Oryza punctata	38.79	0.00e+00	702.00
IUUC-Oru-084469	Oryza rufipogon	39.03	0.00e+00	719.00
IUUC-Osa-085625	Oryza sativa	39.03	0.00e+00	719.00
IUUC-Ola-087002	Oryzias latipes	44.65	0.00e+00	819.00
IUUC-Olu-087687	Ostreococcus lucimarinus	40.13	0.00e+00	672.00
IUUC-Oga-088594	Otolemur garnettii	44.82	0.00e+00	827.00
IUUC-Oar-090068	Ovis aries	44.95	0.00e+00	847.00
IUUC-Ptr-090609	Pan troglodytes	35.54	3.00e-165	573.00
IUUC-Pan-092114	Papio anubis	45.04	0.00e+00	847.00
IUUC-Psi-093489	Pelodiscus sinensis	36.27	2.00e-165	573.00
IUUC-Pma-094214	Petromyzon marinus	36.05	4.00e-24	101.00
IUUC-Pno-095154	Phaeosphaeria nodorum	41.22	0.00e+00	808.00
IUUC-Ppa-095416	Physcomitrella patens	40.22	0.00e+00	701.00
IUUC-Pfo-097184	Poecilia formosa	44.74	0.00e+00	829.00
IUUC-Pab-097861	Pongo abelii	44.68	0.00e+00	818.00
IUUC-Pop-098934	Populus trichocarpa	38.50	0.00e+00	696.00
IUUC-Pca-100347	Procavia capensis	43.76	0.00e+00	712.00
IUUC-Ppe-102012	Prunus persica	38.37	0.00e+00	708.00
IUUC-Pva-102584	Pteropus vampyrus	45.31	0.00e+00	874.00
IUUC-Pgr-103336	Puccinia graminis	41.86	0.00e+00	723.00
IUUC-Ptt-103939	Puccinia triticina	41.56	0.00e+00	729.00
IUUC-Pte-104200	Pyrenophora teres	41.63	0.00e+00	815.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	41.22	0.00e+00	810.00
IUUC-Rno-105462	Rattus norvegicus	44.69	0.00e+00	825.00
IUUC-Sce-106245	Saccharomyces cerevisiae	40.31	0.00e+00	790.00
IUUC-Sha-107142	Sarcophilus harrisii	44.75	0.00e+00	830.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	41.35	0.00e+00	786.00
IUUC-Spo-108034	Schizosaccharomyces pombe	42.22	0.00e+00	792.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	42.51	0.00e+00	753.00
IUUC-Smo-109211	Selaginella moellendorffii	39.58	0.00e+00	694.00
IUUC-Sit-110294	Setaria italica	38.65	0.00e+00	732.00
IUUC-Sly-111237	Solanum lycopersicum	39.17	0.00e+00	681.00
IUUC-Stu-112109	Solanum tuberosum	39.26	0.00e+00	717.00
IUUC-Sar-113737	Sorex araneus	44.59	0.00e+00	837.00
IUUC-Sbi-114774	Sorghum bicolor	38.91	0.00e+00	731.00
IUUC-Sre-115148	Sporisorium reilianum	43.15	0.00e+00	751.00
IUUC-Ssc-115777	Sus scrofa	44.95	0.00e+00	845.00
IUUC-Tgu-116565	Taeniopygia guttata	35.95	7.00e-163	565.00
IUUC-Tru-118742	Takifugu rubripes	44.20	0.00e+00	792.00
IUUC-Tsy-119436	Tarsius syrichta	31.90	1.00e-134	471.00
IUUC-Tni-120401	Tetraodon nigroviridis	45.12	0.00e+00	804.00
IUUC-Tca-121672	Theobroma cacao	38.20	0.00e+00	707.00
IUUC-Tre-122009	Trichoderma reesei	43.79	0.00e+00	748.00
IUUC-Tvi-122259	Trichoderma virens	44.08	0.00e+00	751.00
IUUC-Tae-125702	Triticum aestivum	39.07	0.00e+00	725.00
IUUC-Tur-126330	Triticum urartu	39.83	0.00e+00	718.00
IUUC-Tme-127055	Tuber melanosporum	41.40	0.00e+00	737.00
IUUC-Tbe-127587	Tupaia belangeri	40.21	2.00e-127	447.00
IUUC-Ttr-128331	Tursiops truncatus	45.04	0.00e+00	842.00
IUUC-Uma-129387	Ustilago maydis	42.65	0.00e+00	745.00
IUUC-Vda-129977	Verticillium dahliae	42.60	0.00e+00	749.00
IUUC-Vpa-130716	Vicugna pacos	34.29	1.00e-158	551.00
IUUC-Vvi-130857	Vitis vinifera	38.75	0.00e+00	712.00
IUUC-Xtr-132947	Xenopus tropicalis	33.24	8.00e-149	518.00
IUUC-Xma-133805	Xiphophorus maculatus	44.37	0.00e+00	812.00
IUUC-Yli-134547	Yarrowia lipolytica	41.38	0.00e+00	795.00
IUUC-Zma-134970	Zea mays	38.76	0.00e+00	727.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence