iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000009109.1	ENSSHAT00000010644.1	ENSSHAP00000010551.1
ENSSHAG00000009109.1	ENSSHAT00000010645.1	ENSSHAP00000010552.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-08	35.7	362	400
UBD/Alpha-Helix/CUE	2.20e-11	43.6	477	518

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 362  CAICWDSMQS-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 400
           ********99.9*****************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 477  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 518
           5889*********************.***************95 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MISGGGRGRV RGAAFSPSLE AGGSGLRGSE RPNRGPEAHX XXXXXXXXXX XXXXXXXXXX 60
XXXXXXXXXX XXPPPQPPPP SSPPGPGGPR ARDVIQYLLS DSLFVWVLVN TACCFLMLVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATTTCTG GAGGCGGAAG AGGGAGGGTC CGCGGCGCCG CCTTCAGTCC CAGCCTGGAG 60
GCGGGCGGCT CCGGGCTCCG CGGCTCCGAG CGGCCCAACA GAGGGCCCGA GGCCCATCNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	92.58	0.00e+00	934.00
IUUC-Apl-003404	Anas platyrhynchos	91.05	0.00e+00	914.00
IUUC-Aca-004559	Anolis carolinensis	87.58	0.00e+00	846.00
IUUC-Ame-011640	Astyanax mexicanus	76.34	0.00e+00	775.00
IUUC-Bta-012980	Bos taurus	92.31	0.00e+00	975.00
IUUC-Cel-018598	Caenorhabditis elegans	25.29	4.00e-34	139.00
IUUC-Cja-019577	Callithrix jacchus	93.92	0.00e+00	1013.00
IUUC-Cfa-020793	Canis familiaris	93.92	0.00e+00	977.00
IUUC-Cpo-022387	Cavia porcellus	94.49	0.00e+00	974.00
IUUC-Csa-023168	Chlorocebus sabaeus	93.36	0.00e+00	1009.00
IUUC-Cho-024433	Choloepus hoffmanni	93.62	0.00e+00	828.00
IUUC-Cin-025215	Ciona intestinalis	47.68	5.00e-140	491.00
IUUC-Csv-026133	Ciona savignyi	47.67	1.00e-127	450.00
IUUC-Dre-027594	Danio rerio	74.37	0.00e+00	733.00
IUUC-Dno-029407	Dasypus novemcinctus	94.31	0.00e+00	950.00
IUUC-Dor-030961	Dipodomys ordii	93.92	0.00e+00	969.00
IUUC-Ete-032962	Echinops telfairi	85.49	0.00e+00	804.00
IUUC-Eca-033683	Equus caballus	90.34	0.00e+00	943.00
IUUC-Eeu-034515	Erinaceus europaeus	95.56	2.00e-77	283.00
IUUC-Fca-035398	Felis catus	92.97	0.00e+00	961.00
IUUC-Fal-036758	Ficedula albicollis	82.82	0.00e+00	861.00
IUUC-Gmo-039014	Gadus morhua	73.76	0.00e+00	720.00
IUUC-Gga-040575	Gallus gallus	90.32	0.00e+00	966.00
IUUC-Gac-041414	Gasterosteus aculeatus	73.14	0.00e+00	699.00
IUUC-Hsa-046272	Homo sapiens	93.13	0.00e+00	999.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	93.39	0.00e+00	943.00
IUUC-Lch-050491	Latimeria chalumnae	82.31	0.00e+00	836.00
IUUC-Loc-052758	Lepisosteus oculatus	79.48	0.00e+00	797.00
IUUC-Laf-053452	Loxodonta africana	93.95	0.00e+00	948.00
IUUC-Mcc-055820	Macaca mulatta	93.40	0.00e+00	956.00
IUUC-Meu-056726	Macropus eugenii	91.32	0.00e+00	823.00
IUUC-Mga-059937	Meleagris gallopavo	90.02	0.00e+00	910.00
IUUC-Mmr-060730	Microcebus murinus	94.10	0.00e+00	969.00
IUUC-Mdo-062771	Monodelphis domestica	96.77	0.00e+00	1040.00
IUUC-Mmu-064219	Mus musculus	93.55	0.00e+00	1000.00
IUUC-Mpu-066796	Mustela putorius furo	94.00	0.00e+00	959.00
IUUC-Mlu-068189	Myotis lucifugus	91.20	0.00e+00	942.00
IUUC-Nle-069239	Nomascus leucogenys	93.36	0.00e+00	1008.00
IUUC-Opr-070702	Ochotona princeps	87.55	3.00e-119	421.00
IUUC-Ont-072033	Oreochromis niloticus	76.05	0.00e+00	765.00
IUUC-Oan-073717	Ornithorhynchus anatinus	92.78	0.00e+00	861.00
IUUC-Ocu-074145	Oryctolagus cuniculus	93.74	0.00e+00	1009.00
IUUC-Ogl-077929	Oryza glaberrima	51.16	1.00e-11	62.00
IUUC-Ola-087152	Oryzias latipes	74.19	0.00e+00	739.00
IUUC-Oga-088486	Otolemur garnettii	93.98	0.00e+00	948.00
IUUC-Oar-089310	Ovis aries	93.35	0.00e+00	970.00
IUUC-Ptr-090649	Pan troglodytes	93.14	0.00e+00	973.00
IUUC-Pan-091692	Papio anubis	88.55	0.00e+00	939.00
IUUC-Psi-093064	Pelodiscus sinensis	94.72	0.00e+00	776.00
IUUC-Pma-094763	Petromyzon marinus	78.28	7.00e-97	346.00
IUUC-Ppa-095969	Physcomitrella patens	29.94	1.00e-37	150.00
IUUC-Pfo-096810	Poecilia formosa	75.90	0.00e+00	749.00
IUUC-Pab-097859	Pongo abelii	93.60	0.00e+00	959.00
IUUC-Pop-099576	Populus trichocarpa	26.47	9.00e-28	118.00
IUUC-Pca-100344	Procavia capensis	92.25	0.00e+00	955.00
IUUC-Pva-103114	Pteropus vampyrus	64.05	3.00e-171	595.00
IUUC-Rno-105880	Rattus norvegicus	91.46	0.00e+00	975.00
IUUC-Smo-109664	Selaginella moellendorffii	30.55	1.00e-32	134.00
IUUC-Sar-113397	Sorex araneus	95.96	0.00e+00	750.00
IUUC-Ssc-115988	Sus scrofa	88.28	5.00e-123	433.00
IUUC-Tgu-116717	Taeniopygia guttata	90.70	0.00e+00	917.00
IUUC-Tru-117805	Takifugu rubripes	74.86	0.00e+00	748.00
IUUC-Tsy-119442	Tarsius syrichta	87.45	0.00e+00	878.00
IUUC-Tni-119777	Tetraodon nigroviridis	73.16	3.00e-171	594.00
IUUC-Tbe-127322	Tupaia belangeri	66.57	3.00e-112	398.00
IUUC-Ttr-128181	Tursiops truncatus	93.52	0.00e+00	969.00
IUUC-Vpa-130483	Vicugna pacos	83.81	0.00e+00	652.00
IUUC-Xtr-132614	Xenopus tropicalis	81.42	0.00e+00	777.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence