iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ppa-095875

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

DS544968

Gene Name

PHYPADRAFT_212439

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PP1S79_267V6	PP1S79_267V6.1	PP1S79_267V6.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.80e-91	306.3	8	511

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahee 95
           YDRQ+r+wGe++q +l++a+v+++++g+ G+E lKnLvl+G+gs+tvvD ++v+ s+l+++FL++ e+ g+sKA+++++ l+eln +v ++++ee
   Q: 8    YDRQLRIWGEHGQTALERARVCVLNCGPSGSEALKNLVLGGIGSFTVVDASKVTESDLGNNFLVEWENLGQSKAKSVCALLQELNESVGAKFVEE 102
           *********************************************************************************************** PP
   S: 96   siteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn..... 181
           s+++l e+++ Ff +f++V+++++ ++a +k+ ++c++ +v l++++++Gl G vr +i ++ +++s++d   +++++ +P+++l++++n     
   Q: 103  SPEALLESNPaFFAQFTLVIATQMTEAALLKLEEICRQQKVMLVIARSYGLAGLVRLSIGEHDVIESKPDskvEDLRLHKPWPELQSYVNefdid 197
           ****************************************************************************************8888888 PP
   S: 182  ....aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtksksp 271
               + +++i+ avl+ k+ ee++++++++ + +   ++e+  + +   ++e+e+n+ ea ++a   + + +ins    +l++ + + v  s+s+
   Q: 198  tpdnNLHKHIPFAVLLIKISEEWKKAHDGKLPPNVRLFKEAISARR--RVEEEEDNYTEALKNAYIVLFPPQINSqLHAVLDD-KAADVDASSSD 289
           8888**************************9977555555444443..3356799************9999999977777777.66688****** PP
   S: 272  fwv...........................................................................sfcsnaealq....... 284
           fwv                                                                            fc+na+ l+       
   Q: 290  FWVmvaalklfmanegqgdppldgaipdmhsftdyyiklqmiyqaraeadliameghvarilkrigresspiprstlkLFCKNARNLKvlrckrl 384
           ****************************************************************************************7777777 PP
   S: 285  ....vpekvekdeevvkasap....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipaia 370
               +p ++ + ++ ++++++    ly+llra++ f+++++r pg+++ e+++d + +l++ a  l   ++g  +  l++d i+e++++++++++
   Q: 385  geefSPRSGPELQRLLAVEESshpaLYVLLRAVDHFSATYNRFPGVFDREMEED-VSRLKALAVGL-LNDMGGGGaSLPEDIISEVCRFGAGEMH 477
           777766888888888888888889******************************.66666655555.599999999******************* PP
   S: 371  ttnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            ++++vgG+a+qE iK+++g+f+p++ +f+++a+
   Q: 478  CVASIVGGIASQECIKLLTGQFTPIQGVFIYNAM 511
           *******************************997 PP

Organism

Physcomitrella patens

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAQRNHKYDR QLRIWGEHGQ TALERARVCV LNCGPSGSEA LKNLVLGGIG SFTVVDASKV 60
TESDLGNNFL VEWENLGQSK AKSVCALLQE LNESVGAKFV EESPEALLES NPAFFAQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCAGC GCAACCACAA GTACGATCGT CAGCTCAGGT GAGTCTCTAT TTTGCCGTGG 60
TTCGGCAGGC TGCCGCACTT GTGACCCTTA ATGTAGCTGG TTCACCCATG GTTTGAAGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

ppp:PHYPADRAFT_212439

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002333	Ailuropoda melanoleuca	40.45	7.00e-122	430.00
IUUC-Apl-003446	Anas platyrhynchos	40.38	3.00e-117	414.00
IUUC-Ago-007900	Ashbya gossypii	26.27	3.00e-37	149.00
IUUC-Acl-008333	Aspergillus clavatus	31.27	3.00e-66	245.00
IUUC-Afu-009071	Aspergillus fumigatus	31.35	2.00e-68	252.00
IUUC-Ani-009443	Aspergillus nidulans	30.43	2.00e-62	233.00
IUUC-Ame-011183	Astyanax mexicanus	40.26	7.00e-123	433.00
IUUC-Bta-012583	Bos taurus	40.42	5.00e-124	437.00
IUUC-Cel-018456	Caenorhabditis elegans	30.33	2.00e-63	236.00
IUUC-Cja-020007	Callithrix jacchus	39.96	4.00e-122	431.00
IUUC-Cfa-020324	Canis familiaris	40.42	4.00e-124	437.00
IUUC-Cpo-022248	Cavia porcellus	31.47	7.00e-64	237.00
IUUC-Csa-023149	Chlorocebus sabaeus	37.97	2.00e-95	342.00
IUUC-Cho-024537	Choloepus hoffmanni	33.98	1.00e-82	299.00
IUUC-Cme-027210	Cyanidioschyzon merolae	33.33	4.00e-16	79.30
IUUC-Dre-028140	Danio rerio	40.23	4.00e-121	427.00
IUUC-Dno-030033	Dasypus novemcinctus	40.52	6.00e-108	383.00
IUUC-Dor-030513	Dipodomys ordii	32.19	5.00e-32	131.00
IUUC-Ete-032420	Echinops telfairi	35.38	1.00e-99	356.00
IUUC-Eca-033992	Equus caballus	38.06	8.00e-94	336.00
IUUC-Eeu-034713	Erinaceus europaeus	31.43	2.00e-35	142.00
IUUC-Fca-036548	Felis catus	39.66	3.00e-121	428.00
IUUC-Fal-037600	Ficedula albicollis	41.95	3.00e-118	418.00
IUUC-Fso-038387	Fusarium solani	31.24	1.00e-61	229.00
IUUC-Gmo-038562	Gadus morhua	39.51	3.00e-117	414.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.88	4.00e-63	234.00
IUUC-Gga-041129	Gallus gallus	40.75	1.00e-119	422.00
IUUC-Gac-042558	Gasterosteus aculeatus	39.92	3.00e-118	418.00
IUUC-Ggo-045611	Gorilla gorilla	40.00	3.00e-121	428.00
IUUC-Hsa-046563	Homo sapiens	40.23	2.00e-122	432.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	40.61	5.00e-123	434.00
IUUC-Kpa-049309	Komagataella pastoris	33.98	5.00e-74	271.00
IUUC-Lma-053112	Leptosphaeria maculans	32.14	2.00e-75	275.00
IUUC-Laf-053690	Loxodonta africana	40.61	3.00e-124	437.00
IUUC-Mcc-055117	Macaca mulatta	39.74	2.00e-119	421.00
IUUC-Meu-056761	Macropus eugenii	32.33	2.00e-84	306.00
IUUC-Mor-057230	Magnaporthe oryzae	29.16	1.00e-59	223.00
IUUC-Mpo-057514	Magnaporthe poae	31.08	6.00e-59	221.00
IUUC-Mga-060144	Meleagris gallopavo	40.27	3.00e-115	407.00
IUUC-Mmr-061325	Microcebus murinus	40.00	2.00e-120	425.00
IUUC-Mdo-062532	Monodelphis domestica	40.80	5.00e-123	434.00
IUUC-Mmu-063956	Mus musculus	40.23	6.00e-124	437.00
IUUC-Mpu-066716	Mustela putorius furo	40.20	5.00e-114	404.00
IUUC-Mlu-067459	Myotis lucifugus	40.75	7.00e-124	436.00
IUUC-Nfi-068245	Neosartorya fischeri	31.12	4.00e-67	248.00
IUUC-Nle-070034	Nomascus leucogenys	39.58	4.00e-118	417.00
IUUC-Opr-070552	Ochotona princeps	37.42	1.00e-94	339.00
IUUC-Ont-071426	Oreochromis niloticus	40.64	1.00e-123	436.00
IUUC-Oan-073389	Ornithorhynchus anatinus	38.84	3.00e-89	321.00
IUUC-Ocu-074911	Oryctolagus cuniculus	41.18	4.00e-125	441.00
IUUC-Ola-086420	Oryzias latipes	37.60	2.00e-74	271.00
IUUC-Oga-088810	Otolemur garnettii	40.04	5.00e-123	433.00
IUUC-Oar-089196	Ovis aries	40.19	2.00e-122	432.00
IUUC-Ptr-090617	Pan troglodytes	40.23	8.00e-123	433.00
IUUC-Pan-092761	Papio anubis	40.42	4.00e-124	437.00
IUUC-Psi-093191	Pelodiscus sinensis	39.96	1.00e-120	426.00
IUUC-Pno-095084	Phaeosphaeria nodorum	30.78	3.00e-62	233.00
IUUC-Pfo-096467	Poecilia formosa	39.77	1.00e-116	412.00
IUUC-Pab-098255	Pongo abelii	40.83	4.00e-102	363.00
IUUC-Pca-100807	Procavia capensis	48.13	9.00e-53	200.00
IUUC-Pva-102333	Pteropus vampyrus	39.25	4.00e-115	407.00
IUUC-Pte-104355	Pyrenophora teres	32.62	2.00e-70	259.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.74	1.00e-72	266.00
IUUC-Rno-105810	Rattus norvegicus	40.23	1.00e-122	432.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.19	9.00e-39	153.00
IUUC-Sha-106770	Sarcophilus harrisii	44.32	7.00e-68	249.00
IUUC-Spo-108276	Schizosaccharomyces pombe	32.95	4.00e-80	291.00
IUUC-Tgu-116772	Taeniopygia guttata	42.56	8.00e-120	423.00
IUUC-Tsy-119111	Tarsius syrichta	39.27	5.00e-56	211.00
IUUC-Tre-122103	Trichoderma reesei	31.88	6.00e-66	244.00
IUUC-Tvi-122672	Trichoderma virens	32.30	3.00e-65	241.00
IUUC-Ttr-128465	Tursiops truncatus	38.49	7.00e-114	403.00
IUUC-Uma-129645	Ustilago maydis	30.08	1.00e-66	246.00
IUUC-Vpa-130529	Vicugna pacos	39.62	2.00e-117	415.00
IUUC-Xma-133930	Xiphophorus maculatus	40.26	2.00e-120	425.00
IUUC-Yli-134505	Yarrowia lipolytica	31.93	1.00e-76	279.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence