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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063614
Ensembl Protein ID ENSMUSP00000005108.7
UniProt Accession Q3UXZ9; Q3TM94; Q3UMI5; Q66JZ3; KDM5A_MOUSE
Genbank Protein ID BAE22414.1; BAE26113.1; BAE38548.1; AAH80691.1
Protein Name Lysine-specific demethylase 5A; Histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; Retinoblastoma-binding protein 2
Genbank Nucleotide ID AC155720; AK144877; AK166055; BC080691
Gene Name Kdm5a; Jarid1a; Rbp2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030180.15 ENSMUST00000135802.7 ENSMUSP00000145021.1
ENSMUSG00000030180.15 ENSMUST00000005108.9 ENSMUSP00000005108.7
ENSMUSG00000030180.15 ENSMUST00000132009.3 ENSMUSP00000145375.1
ENSMUSG00000030180.15 ENSMUST00000203373.1 ENSMUSP00000144720.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRecordsRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.10e-18 65.5 295 342
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           vC +Cg+g +++ +l+ C+ C++ +H  Cl ++  +++p+ + w CpkC +
   Q: 295  VCMFCGRGNNED-KLLLCDGCDDSYHTFCLLPP-LPDVPKGD-WRCPKCVA 342
           8*********88.6*******************.*******7.******75 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1.
 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1.
Protein Sequence
(Fasta)
MASVGPGGYA AEFVPPPECP VFEPSWEEFT DPLSFIGRIR PFAEKTGICK IRPPKDWQPP 60
FACEVKTFRF TPRVQRLNEL EAMTRVRLDF LDQLAKFWEL QGSTLKIPVV ERKILDLYAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063614|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
GGAAGCGCGC GTTCCACCTT GCGGGGTAGC TTTTCCCTCG CCTCTCCTCG AGAGAGGTCG 60
CGGCGCCTTG AGGGGCCGCG CACCCGGGGT GGACGGAGGG CGCAGAACTT TGACAGGCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063614|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0223--Dioxygenase
KW-0903--Direct protein sequencing
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
SMART

SM00501--BRIGHT
SM00558--JmjC
SM00545--JmjN
SM00249--PHD
Gene Ontology

GO:0019907--C:cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0032993--C:protein-DNA complex
GO:0003682--F:chromatin binding
GO:0031490--F:chromatin DNA binding
GO:0003677--F:DNA binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0032922--P:circadian regulation of gene expression
GO:0034720--P:histone H3-K4 demethylation
GO:0008584--P:male gonad development
GO:1901726--P:negative regulation of histone deacetylase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
KEGG mmu:214899
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002061 Ailuropoda melanoleuca 96.69 0.00e+00 2946.00
IUUC-Atr-002595 Amborella trichopoda 30.63 1.00e-124 442.00
IUUC-Apl-004141 Anas platyrhynchos 91.39 0.00e+00 2782.00
IUUC-Aca-004952 Anolis carolinensis 89.65 0.00e+00 2793.00
IUUC-Aly-006097 Arabidopsis lyrata 63.64 5.00e-09 58.50
IUUC-Ani-009139 Aspergillus nidulans 32.38 2.00e-107 385.00
IUUC-Ate-010453 Aspergillus terreus 29.67 9.00e-114 405.00
IUUC-Ame-011323 Astyanax mexicanus 75.83 0.00e+00 2051.00
IUUC-Bta-012902 Bos taurus 95.57 0.00e+00 2932.00
IUUC-Cja-018988 Callithrix jacchus 94.50 0.00e+00 2752.00
IUUC-Cfa-020212 Canis familiaris 95.68 0.00e+00 2905.00
IUUC-Cpo-022221 Cavia porcellus 96.34 0.00e+00 2069.00
IUUC-Csa-023575 Chlorocebus sabaeus 96.92 0.00e+00 2833.00
IUUC-Cho-024280 Choloepus hoffmanni 91.95 0.00e+00 2721.00
IUUC-Cin-025321 Ciona intestinalis 48.98 0.00e+00 1072.00
IUUC-Csv-026185 Ciona savignyi 48.16 0.00e+00 1171.00
IUUC-Dre-027909 Danio rerio 75.20 0.00e+00 1640.00
IUUC-Dno-029473 Dasypus novemcinctus 96.17 0.00e+00 2658.00
IUUC-Dor-030281 Dipodomys ordii 94.59 0.00e+00 1202.00
IUUC-Dme-032021 Drosophila melanogaster 46.82 0.00e+00 1113.00
IUUC-Eca-034265 Equus caballus 95.04 0.00e+00 2934.00
IUUC-Fca-035476 Felis catus 95.74 0.00e+00 2939.00
IUUC-Fal-037078 Ficedula albicollis 90.59 0.00e+00 2463.00
IUUC-Ggr-039929 Gaeumannomyces graminis 28.49 7.00e-104 372.00
IUUC-Gga-040466 Gallus gallus 90.15 0.00e+00 2867.00
IUUC-Gac-042566 Gasterosteus aculeatus 75.12 0.00e+00 2098.00
IUUC-Ggo-044524 Gorilla gorilla 89.87 0.00e+00 2474.00
IUUC-Hsa-045821 Homo sapiens 96.69 0.00e+00 2943.00
IUUC-Kpa-049245 Komagataella pastoris 22.96 2.00e-38 155.00
IUUC-Lch-050630 Latimeria chalumnae 74.13 0.00e+00 2097.00
IUUC-Loc-051963 Lepisosteus oculatus 75.30 0.00e+00 2056.00
IUUC-Laf-053918 Loxodonta africana 89.67 0.00e+00 2544.00
IUUC-Mcc-055672 Macaca mulatta 95.27 0.00e+00 2924.00
IUUC-Mor-057198 Magnaporthe oryzae 30.35 1.00e-120 428.00
IUUC-Mpo-057317 Magnaporthe poae 33.93 2.00e-102 368.00
IUUC-Mtr-058113 Medicago truncatula 32.27 5.00e-98 353.00
IUUC-Mga-059192 Meleagris gallopavo 82.63 0.00e+00 2424.00
IUUC-Mmr-060968 Microcebus murinus 95.10 0.00e+00 2973.00
IUUC-Mdo-062945 Monodelphis domestica 94.46 0.00e+00 2763.00
IUUC-Mpu-066349 Mustela putorius furo 96.64 0.00e+00 2825.00
IUUC-Mlu-067363 Myotis lucifugus 96.09 0.00e+00 2995.00
IUUC-Nle-070142 Nomascus leucogenys 96.63 0.00e+00 2940.00
IUUC-Opr-071002 Ochotona princeps 89.61 0.00e+00 1371.00
IUUC-Ont-072471 Oreochromis niloticus 77.67 0.00e+00 1867.00
IUUC-Oan-072797 Ornithorhynchus anatinus 78.32 0.00e+00 1998.00
IUUC-Ocu-074164 Oryctolagus cuniculus 95.21 0.00e+00 2993.00
IUUC-Oba-075388 Oryza barthii 32.07 2.00e-83 304.00
IUUC-Obr-076296 Oryza brachyantha 33.97 4.00e-97 350.00
IUUC-Ogu-079040 Oryza glumaepatula 27.92 2.00e-83 305.00
IUUC-Ome-081764 Oryza meridionalis 29.81 1.00e-101 365.00
IUUC-Oni-083012 Oryza nivara 32.02 7.00e-83 303.00
IUUC-Oru-084630 Oryza rufipogon 27.57 1.00e-82 302.00
IUUC-Ola-087076 Oryzias latipes 74.18 0.00e+00 2078.00
IUUC-Oga-088350 Otolemur garnettii 94.73 0.00e+00 2878.00
IUUC-Oar-090045 Ovis aries 95.44 0.00e+00 2920.00
IUUC-Ptr-091199 Pan troglodytes 96.15 0.00e+00 2930.00
IUUC-Pan-092094 Papio anubis 93.11 0.00e+00 2674.00
IUUC-Psi-093550 Pelodiscus sinensis 90.84 0.00e+00 2556.00
IUUC-Pfo-097266 Poecilia formosa 77.64 0.00e+00 1844.00
IUUC-Pab-098576 Pongo abelii 96.80 0.00e+00 2940.00
IUUC-Pca-100123 Procavia capensis 93.23 0.00e+00 1638.00
IUUC-Ppe-101504 Prunus persica 32.25 2.00e-103 371.00
IUUC-Pva-103109 Pteropus vampyrus 90.41 0.00e+00 2779.00
IUUC-Pte-104195 Pyrenophora teres 30.24 5.00e-122 433.00
IUUC-Pyt-104566 Pyrenophora triticirepentis 30.24 7.00e-124 439.00
IUUC-Rno-105664 Rattus norvegicus 98.88 0.00e+00 2996.00
IUUC-Sha-107506 Sarcophilus harrisii 93.22 0.00e+00 2513.00
IUUC-Sja-107734 Schizosaccharomyces japonicus 20.96 1.00e-33 139.00
IUUC-Spo-108283 Schizosaccharomyces pombe 23.29 1.00e-54 209.00
IUUC-Smo-108843 Selaginella moellendorffii 52.08 1.00e-10 62.40
IUUC-Sit-110534 Setaria italica 29.51 6.00e-121 429.00
IUUC-Sar-113052 Sorex araneus 95.38 0.00e+00 2935.00
IUUC-Sbi-114173 Sorghum bicolor 58.14 8.00e-12 64.70
IUUC-Tgu-116613 Taeniopygia guttata 90.11 0.00e+00 2771.00
IUUC-Tru-118604 Takifugu rubripes 74.65 0.00e+00 2137.00
IUUC-Tsy-119237 Tarsius syrichta 96.25 0.00e+00 1286.00
IUUC-Tni-120779 Tetraodon nigroviridis 74.48 0.00e+00 2114.00
IUUC-Tae-125894 Triticum aestivum 29.21 1.00e-111 399.00
IUUC-Tme-127087 Tuber melanosporum 30.97 3.00e-132 467.00
IUUC-Ttr-129242 Tursiops truncatus 93.85 0.00e+00 2835.00
IUUC-Uma-129590 Ustilago maydis 30.62 3.00e-134 474.00
IUUC-Vda-129733 Verticillium dahliae 29.24 1.00e-105 379.00
IUUC-Vpa-130429 Vicugna pacos 88.32 0.00e+00 1438.00
IUUC-Xtr-131762 Xenopus tropicalis 76.21 0.00e+00 2247.00
IUUC-Xma-133693 Xiphophorus maculatus 77.56 0.00e+00 1863.00
Created Date 25-Jun-2017

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