iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007130

Ensembl Protein ID

AT5G35210.1

UniProt Accession

F4JYC8; F4JYC9; Q56XE1; Q9LHR7; PTM_ARATH

Genbank Protein ID

BAA98208.1; AED93945.1; AED93946.1; BAD93752.1

Protein Name

DDT domain-containing protein PTM; DDT domain-containing protein 1; Membrane-bound transcription factor PTM; PHD type transcription factor with transmembrane domains

Genbank Nucleotide ID

AP002031; CP002688; CP002688; AK221734

Gene Name

PTM; DDP1; At5g35210; K3D20.8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G35210	AT5G35210.1	AT5G35210.1
AT5G35210	AT5G35210.2	AT5G35210.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.10e-09	37.1	413	456

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
            C +Cg  g     l++C+ C  ++H +C +   +   p+  +w+Cp+C+
   Q: 413  ECRICGMDGT----LLCCDGCPLAYHSRCIGVV-KMYIPDG-PWFCPECT 456
           6****99999....******************9.*******.6******6 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Membrane-bound transcription factor required for the plastid-to-nucleus retrograde signaling. Functions in multiple retrograde pathways. The plastid-to-nucleus signal plays an important role in the coordinated expression of both nuclear- and chloroplast-localized genes that encode photosynthesis-related proteins. In the nucleus, activates ABI4 transcription in a PHD-dependent manner associated with histone modifications. Localized primarily in the chloroplast outer membrane as dormant form and, in response to retrograde signals, is released from the membrane through proteolytic cleavage and its cleaved fragment containing the transcription factor domain is redistributed to the nucleus, where it regulates the expression of particular nuclear genes.

Protein Sequence
(Fasta)

MEAKVPRPRG RPRKRQRLED DNRKLNNRGK KQVLEVEPAV PISLLGCYML KDFDDNEVFL 60
GKIVSYDTGL YRVIYEDGDC EELESGDLRR LIISDSYLDD ELRVRRKKLD KLILKKEEKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCTTAAAG GAAAAAGCAC TCTCCTTCTT CTTCTTCTTC GTCTTCTCTC TCTTATGTCC 60
TTGTCCAATT CCCAAATCCT TCGTTGTTGA ATTTTGTCTT CTTTCTTCCT GAGTTTTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0150--Chloroplast
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0934--Plastid
KW-1002--Plastid outer membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018501--DDT_dom
IPR028942--WHIM1_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50827--DDT
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF02791--DDT
PF00628--PHD
PF15612--WHIM1

SMART

SM00571--DDT
SM00249--PHD

Gene Ontology

GO:0009707--C:chloroplast outer membrane
GO:0016021--C:integral component of membrane
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0010019--P:chloroplast-nucleus signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT5G35210

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006239	Arabidopsis lyrata	88.53	0.00e+00	2627.00
IUUC-Bci-013636	Botrytis cinerea	44.23	3.00e-08	54.30
IUUC-Bdi-014067	Brachypodium distachyon	33.74	3.00e-138	486.00
IUUC-Fox-038014	Fusarium oxysporum	41.94	1.00e-10	61.60
IUUC-Mor-056922	Magnaporthe oryzae	37.04	9.00e-09	55.80
IUUC-Obr-076575	Oryza brachyantha	32.26	3.00e-134	473.00
IUUC-Ppe-101582	Prunus persica	29.22	2.00e-122	433.00
IUUC-Smo-108764	Selaginella moellendorffii	30.94	5.00e-128	451.00
IUUC-Sit-109749	Setaria italica	32.52	4.00e-128	452.00
IUUC-Sbi-114633	Sorghum bicolor	31.43	4.00e-126	446.00
IUUC-Vvi-131129	Vitis vinifera	40.90	4.00e-70	260.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence