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Tag Content
UUCD2 ID IUUC-Eca-034180
UUCD1 version UUC-EqC-00273
Ensembl Protein ID ENSECAP00000013300.1
UniProt Accession F6U783; F6U783_HORSE
Protein Name Coatomer subunit beta'
Gene Name COPB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSECAG00000015099.1 ENSECAT00000016465.1 ENSECAP00000013300.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.30e-30 104.3 182 223
UBD/Beta-Prp 1.90e-63 214.6 12 291
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+ +v+c+++    d ++l+sG+dD  +k+WD+   +++++
   Q: 182  GHEKGVNCIDYysgGDkPYLISGADDRLVKIWDYQNKTCVQT 223
           8*********9999778****************999988875 PP
   

   UBD/Beta-Prp
   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkghe 94
           ++++++++v+ +p +++++++ ++g++ vw+ +t+  l  +  + ++++  +   ++ ++v+++ D  + i+v++++t + vh +++h+
   Q: 12   ARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQVILLFFL-CLSPIRIARSVGSQ-LIVQVGADddMQIRVFNYNTLERVHMFEAHS 98
           67899*****************************88866555.55588888877776.89988877789******************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtds 182
           d++++++++p++ ++++ s+d  i++wd+++++  +++++gh++ v+ +v++p++ n ++s+slDrt+++W+l + +   tl+g h++ 
   Q: 99   DYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDnNQFASASLDRTIKVWQLGSSSPNFTLEG-HEKG 186
           *********************************9999**********************************************9.**** PP
   S: 183  vyslsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           v+++++ s g  ++l+sg++d+ vk+wd+q+++cv+tl+gh +nv++  f+p+  ++++gs+Dg++riW + +  l +tl++  ++v++
   Q: 187  VNCIDYYSGGdkPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWC 275
           *****8887777***************************************************************************** PP
   S: 270  vavlsfgdnvlvlgse 285
           va l+ ++nv +  +e
   Q: 276  VASLRGSNNVALGYDE 291
           ***9999998755544 PP
   
Organism Equus caballus
Functional Description
(View)

Functional Description


     The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Protein Sequence
(Fasta)
PLRLDIKRKL TARSDRVKSV DLHPTEPWML ASLYNGSVCV WNHETQVILL FFLCLSPIRI 60
ARSVGSQLIV QVGADDDMQI RVFNYNTLER VHMFEAHSDY IRCIAVHPTQ PFILTSSDDM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Eca-034180|E3,WD_repeat;UBD,Beta-Prp|Equus caballus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCACTGCGAC TTGATATCAA GAGAAAGCTC ACTGCTCGAT CTGATCGAGT TAAGAGTGTG 60
GATTTGCATC CTACCGAGCC ATGGATGTTG GCGAGTCTTT ACAATGGCAG TGTATGCGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Eca-034180|E3,WD_repeat;UBD,Beta-Prp|Equus caballus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011044--Quino_amine_DH_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04053--Coatomer_WDAD
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
GO:1901998--P:toxin transport
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000654 Aegilops tauschii 51.83 0.00e+00 900.00
IUUC-Aml-002154 Ailuropoda melanoleuca 95.03 0.00e+00 1767.00
IUUC-Atr-003090 Amborella trichopoda 57.27 0.00e+00 1031.00
IUUC-Apl-003976 Anas platyrhynchos 92.73 0.00e+00 1673.00
IUUC-Aca-004301 Anolis carolinensis 91.41 0.00e+00 1657.00
IUUC-Aly-006508 Arabidopsis lyrata 59.29 0.00e+00 1053.00
IUUC-Ath-007635 Arabidopsis thaliana 59.41 0.00e+00 1053.00
IUUC-Ago-007914 Ashbya gossypii 44.89 0.00e+00 721.00
IUUC-Acl-008237 Aspergillus clavatus 55.29 0.00e+00 928.00
IUUC-Afl-008535 Aspergillus flavus 54.68 0.00e+00 875.00
IUUC-Afu-008845 Aspergillus fumigatus 53.66 0.00e+00 904.00
IUUC-Ani-009135 Aspergillus nidulans 54.60 0.00e+00 878.00
IUUC-Ang-009654 Aspergillus niger 54.66 0.00e+00 820.00
IUUC-Aor-009939 Aspergillus oryzae 53.60 0.00e+00 932.00
IUUC-Ate-010355 Aspergillus terreus 52.93 0.00e+00 881.00
IUUC-Ame-010922 Astyanax mexicanus 82.50 0.00e+00 1445.00
IUUC-Bgr-012249 Blumeria graminis 52.23 0.00e+00 892.00
IUUC-Bta-013579 Bos taurus 95.94 0.00e+00 1427.00
IUUC-Bci-013866 Botrytis cinerea 54.37 0.00e+00 889.00
IUUC-Bdi-015046 Brachypodium distachyon 59.36 0.00e+00 1063.00
IUUC-Bol-015731 Brassica oleracea 59.98 0.00e+00 1069.00
IUUC-Bra-017758 Brassica rapa 59.17 0.00e+00 1069.00
IUUC-Cel-018387 Caenorhabditis elegans 63.08 0.00e+00 1129.00
IUUC-Cja-019145 Callithrix jacchus 95.92 0.00e+00 1776.00
IUUC-Cfa-020564 Canis familiaris 96.03 0.00e+00 1770.00
IUUC-Cpo-022201 Cavia porcellus 95.04 0.00e+00 1755.00
IUUC-Cre-022938 Chlamydomonas reinhardtii 56.85 0.00e+00 941.00
IUUC-Csa-023383 Chlorocebus sabaeus 94.71 0.00e+00 1125.00
IUUC-Cho-024454 Choloepus hoffmanni 89.54 0.00e+00 1357.00
IUUC-Cin-025681 Ciona intestinalis 74.11 0.00e+00 1315.00
IUUC-Csv-026012 Ciona savignyi 75.27 0.00e+00 1290.00
IUUC-Cgl-026649 Colletotrichum gloeosporioides 50.55 0.00e+00 805.00
IUUC-Cne-026986 Cryptococcus neoformans 49.88 0.00e+00 871.00
IUUC-Cme-027219 Cyanidioschyzon merolae 47.23 0.00e+00 814.00
IUUC-Dre-027846 Danio rerio 91.24 0.00e+00 1622.00
IUUC-Dor-030462 Dipodomys ordii 89.92 0.00e+00 1220.00
IUUC-Dse-031268 Dothistroma septosporum 53.51 0.00e+00 914.00
IUUC-Dme-031791 Drosophila melanogaster 68.65 0.00e+00 1226.00
IUUC-Ete-033166 Echinops telfairi 84.95 0.00e+00 962.00
IUUC-Eeu-035086 Erinaceus europaeus 86.88 0.00e+00 897.00
IUUC-Fca-036265 Felis catus 96.35 0.00e+00 1772.00
IUUC-Fal-037202 Ficedula albicollis 90.60 0.00e+00 1616.00
IUUC-Fox-037711 Fusarium oxysporum 55.04 0.00e+00 847.00
IUUC-Fso-038268 Fusarium solani 54.39 0.00e+00 843.00
IUUC-Gmo-039046 Gadus morhua 90.52 0.00e+00 1600.00
IUUC-Ggr-039863 Gaeumannomyces graminis 53.73 0.00e+00 867.00
IUUC-Gga-041112 Gallus gallus 92.96 0.00e+00 1675.00
IUUC-Gac-041733 Gasterosteus aculeatus 90.41 0.00e+00 1560.00
IUUC-Gma-042910 Glycine max 60.90 0.00e+00 1073.00
IUUC-Ggo-044984 Gorilla gorilla 95.36 0.00e+00 1768.00
IUUC-Hsa-046698 Homo sapiens 95.47 0.00e+00 1769.00
IUUC-Hvu-047669 Hordeum vulgare 66.76 1.00e-155 542.00
IUUC-Itr-048212 Ictidomys tridecemlineatus 93.48 0.00e+00 1722.00
IUUC-Kpa-049265 Komagataella pastoris 47.76 0.00e+00 822.00
IUUC-Lch-050473 Latimeria chalumnae 88.47 0.00e+00 1661.00
IUUC-Lpe-051579 Leersia perrieri 59.43 0.00e+00 1054.00
IUUC-Loc-052675 Lepisosteus oculatus 92.50 0.00e+00 1650.00
IUUC-Lma-053218 Leptosphaeria maculans 53.12 0.00e+00 888.00
IUUC-Laf-053757 Loxodonta africana 95.48 0.00e+00 1762.00
IUUC-Mcc-054859 Macaca mulatta 95.92 0.00e+00 1775.00
IUUC-Meu-056174 Macropus eugenii 95.30 0.00e+00 748.00
IUUC-Mor-057264 Magnaporthe oryzae 54.28 0.00e+00 852.00
IUUC-Mpo-057538 Magnaporthe poae 54.12 0.00e+00 881.00
IUUC-Mtr-058310 Medicago truncatula 61.14 0.00e+00 1082.00
IUUC-Mla-058937 Melampsora laricipopulina 52.15 0.00e+00 878.00
IUUC-Mga-059875 Meleagris gallopavo 92.74 0.00e+00 1670.00
IUUC-Mvi-060240 Microbotryum violaceum 48.38 0.00e+00 883.00
IUUC-Mmr-061261 Microcebus murinus 95.81 0.00e+00 1772.00
IUUC-Mdo-062076 Monodelphis domestica 93.21 0.00e+00 1698.00
IUUC-Mmu-063324 Mus musculus 94.81 0.00e+00 1751.00
IUUC-Mac-064636 Musa acuminata 58.55 0.00e+00 1044.00
IUUC-Mpu-065961 Mustela putorius furo 95.47 0.00e+00 1766.00
IUUC-Mlu-067059 Myotis lucifugus 95.75 0.00e+00 1691.00
IUUC-Nfi-068277 Neosartorya fischeri 53.23 0.00e+00 895.00
IUUC-Ncr-068659 Neurospora crassa 51.29 0.00e+00 870.00
IUUC-Nle-069034 Nomascus leucogenys 95.81 0.00e+00 1774.00
IUUC-Opr-070334 Ochotona princeps 95.79 0.00e+00 1471.00
IUUC-Ont-071563 Oreochromis niloticus 91.48 0.00e+00 1619.00
IUUC-Oan-073416 Ornithorhynchus anatinus 95.14 0.00e+00 1602.00
IUUC-Ocu-074522 Oryctolagus cuniculus 95.58 0.00e+00 1768.00
IUUC-Oba-075760 Oryza barthii 57.63 0.00e+00 1033.00
IUUC-Obr-076163 Oryza brachyantha 60.43 0.00e+00 1053.00
IUUC-Ogl-077450 Oryza glaberrima 58.82 0.00e+00 1061.00
IUUC-Ogu-078994 Oryza glumaepatula 57.63 0.00e+00 1033.00
IUUC-Oin-079856 Oryza indica 56.18 0.00e+00 1039.00
IUUC-Olo-080731 Oryza longistaminata 56.96 0.00e+00 1016.00
IUUC-Ome-081554 Oryza meridionalis 53.18 0.00e+00 958.00
IUUC-Oni-082324 Oryza nivara 57.63 0.00e+00 1033.00
IUUC-Opu-083400 Oryza punctata 57.86 0.00e+00 1033.00
IUUC-Oru-084829 Oryza rufipogon 57.63 0.00e+00 1032.00
IUUC-Osa-086026 Oryza sativa 58.82 0.00e+00 1064.00
IUUC-Ola-087245 Oryzias latipes 85.96 0.00e+00 1615.00
IUUC-Olu-087655 Ostreococcus lucimarinus 58.12 0.00e+00 1014.00
IUUC-Oga-088163 Otolemur garnettii 92.40 0.00e+00 1692.00
IUUC-Oar-089842 Ovis aries 96.12 0.00e+00 1754.00
IUUC-Ptr-090501 Pan troglodytes 95.58 0.00e+00 1769.00
IUUC-Pan-092011 Papio anubis 95.81 0.00e+00 1773.00
IUUC-Psi-093308 Pelodiscus sinensis 94.79 0.00e+00 1672.00
IUUC-Pma-094695 Petromyzon marinus 79.16 0.00e+00 1389.00
IUUC-Pno-094785 Phaeosphaeria nodorum 62.41 1.00e-112 400.00
IUUC-Ppa-095911 Physcomitrella patens 60.07 0.00e+00 1081.00
IUUC-Pfo-096587 Poecilia formosa 90.77 0.00e+00 1616.00
IUUC-Pab-097926 Pongo abelii 93.09 0.00e+00 1683.00
IUUC-Pop-099634 Populus trichocarpa 60.17 0.00e+00 1054.00
IUUC-Pca-100965 Procavia capensis 94.03 0.00e+00 1731.00
IUUC-Ppe-101470 Prunus persica 61.14 0.00e+00 1074.00
IUUC-Pva-102451 Pteropus vampyrus 89.02 0.00e+00 1212.00
IUUC-Pgr-103453 Puccinia graminis 53.48 0.00e+00 892.00
IUUC-Ptt-103868 Puccinia triticina 53.61 0.00e+00 891.00
IUUC-Pte-104274 Pyrenophora teres 54.18 0.00e+00 918.00
IUUC-Pyt-104794 Pyrenophora triticirepentis 53.19 0.00e+00 866.00
IUUC-Rno-105979 Rattus norvegicus 83.63 0.00e+00 1240.00
IUUC-Sce-106269 Saccharomyces cerevisiae 46.23 0.00e+00 755.00
IUUC-Sha-106905 Sarcophilus harrisii 94.22 0.00e+00 1695.00
IUUC-Sja-107838 Schizosaccharomyces japonicus 46.02 0.00e+00 791.00
IUUC-Spo-108299 Schizosaccharomyces pombe 46.09 0.00e+00 790.00
IUUC-Smo-108695 Selaginella moellendorffii 60.30 0.00e+00 1033.00
IUUC-Sit-110692 Setaria italica 61.26 0.00e+00 1056.00
IUUC-Sly-111775 Solanum lycopersicum 60.75 0.00e+00 1050.00
IUUC-Stu-112906 Solanum tuberosum 61.24 0.00e+00 956.00
IUUC-Sar-113472 Sorex araneus 87.86 0.00e+00 1107.00
IUUC-Sbi-114052 Sorghum bicolor 61.60 0.00e+00 1072.00
IUUC-Sre-115040 Sporisorium reilianum 51.04 0.00e+00 875.00
IUUC-Ssc-115593 Sus scrofa 95.58 0.00e+00 1770.00
IUUC-Tgu-117239 Taeniopygia guttata 90.67 0.00e+00 1670.00
IUUC-Tru-118025 Takifugu rubripes 90.46 0.00e+00 1607.00
IUUC-Tsy-118824 Tarsius syrichta 87.10 0.00e+00 1110.00
IUUC-Tni-120142 Tetraodon nigroviridis 88.28 0.00e+00 1604.00
IUUC-Tca-121613 Theobroma cacao 57.17 0.00e+00 1067.00
IUUC-Tre-122072 Trichoderma reesei 53.68 0.00e+00 893.00
IUUC-Tvi-122546 Trichoderma virens 53.20 0.00e+00 878.00
IUUC-Tae-125292 Triticum aestivum 58.82 0.00e+00 1056.00
IUUC-Tur-126283 Triticum urartu 52.50 0.00e+00 900.00
IUUC-Tme-127041 Tuber melanosporum 54.60 0.00e+00 928.00
IUUC-Tbe-127770 Tupaia belangeri 89.02 0.00e+00 1217.00
IUUC-Ttr-129294 Tursiops truncatus 95.70 0.00e+00 1771.00
IUUC-Uma-129351 Ustilago maydis 49.57 0.00e+00 865.00
IUUC-Vda-129716 Verticillium dahliae 53.94 0.00e+00 915.00
IUUC-Vpa-130037 Vicugna pacos 88.60 0.00e+00 939.00
IUUC-Vvi-131689 Vitis vinifera 58.57 0.00e+00 1070.00
IUUC-Xtr-132633 Xenopus tropicalis 91.75 0.00e+00 1628.00
IUUC-Xma-133347 Xiphophorus maculatus 85.48 0.00e+00 1620.00
IUUC-Yli-134455 Yarrowia lipolytica 49.05 0.00e+00 796.00
IUUC-Zma-135706 Zea mays 60.12 0.00e+00 1074.00
Created Date 25-Jun-2017

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