iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010612

Ensembl Protein ID

ENSAMXP00000013406.1

UniProt Accession

W5L0P4; W5L0P4_ASTMX

Genbank Protein ID

ENSAMXP00000013406

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

APWO01080883

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000013022.1	ENSAMXT00000013406.1	ENSAMXP00000013406.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.90e-34	117.8	264	313

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrsk 54
           kvC  C+++ged+ ++++C+ C++ +H  Cl+++  +++p ++ w C++Cr +
   Q: 264  KVCQTCRQPGEDS-KMLVCDACDKGYHTFCLQPA-MDSVPPDS-WKCRRCRVC 313
           58*********87.6*******************.77777776.******965 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MDEQKSNCEE NDSETAADDG ASSKETVPPP GDPNTPHAAE DISGTTVDTS SAPAEIVRAC 60
ALCNCVERSL HGQRELRCFG PSSHCPHPEA STSSLPPPGN DDLSSIGFYE SNSPAILFDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGAGC AGAAGTCAAA CTGCGAAGAA AATGATTCAG AAACGGCAGG TATGTGAGCA 60
GTTTAGTGTT TGGACCGTGA CTAAAACAGA TTCCTACTTA CAGTTTAGGA AATTATTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	31.90	6.00e-14	72.80
IUUC-Aml-001806	Ailuropoda melanoleuca	82.06	0.00e+00	1001.00
IUUC-Apl-003311	Anas platyrhynchos	72.88	0.00e+00	865.00
IUUC-Aca-005364	Anolis carolinensis	81.11	0.00e+00	977.00
IUUC-Bta-013011	Bos taurus	80.83	0.00e+00	1006.00
IUUC-Cel-018354	Caenorhabditis elegans	37.19	7.00e-65	243.00
IUUC-Cja-019841	Callithrix jacchus	82.27	0.00e+00	1004.00
IUUC-Cfa-021131	Canis familiaris	81.72	0.00e+00	1007.00
IUUC-Cpo-021957	Cavia porcellus	81.00	0.00e+00	1006.00
IUUC-Csa-023722	Chlorocebus sabaeus	81.90	0.00e+00	1007.00
IUUC-Cho-024469	Choloepus hoffmanni	57.09	2.00e-87	320.00
IUUC-Dre-028110	Danio rerio	65.17	0.00e+00	807.00
IUUC-Dno-029932	Dasypus novemcinctus	81.72	0.00e+00	1007.00
IUUC-Dor-030569	Dipodomys ordii	68.83	0.00e+00	792.00
IUUC-Dme-031590	Drosophila melanogaster	32.15	1.00e-57	219.00
IUUC-Ete-032572	Echinops telfairi	82.51	0.00e+00	826.00
IUUC-Eca-033945	Equus caballus	50.76	2.00e-127	451.00
IUUC-Eeu-034848	Erinaceus europaeus	54.11	0.00e+00	714.00
IUUC-Fca-035424	Felis catus	81.37	0.00e+00	1003.00
IUUC-Fal-037179	Ficedula albicollis	81.23	0.00e+00	979.00
IUUC-Gmo-038719	Gadus morhua	66.98	0.00e+00	1147.00
IUUC-Gga-040815	Gallus gallus	51.89	0.00e+00	724.00
IUUC-Gac-042436	Gasterosteus aculeatus	62.02	0.00e+00	1535.00
IUUC-Ggo-044711	Gorilla gorilla	81.72	0.00e+00	1007.00
IUUC-Hsa-046567	Homo sapiens	81.72	0.00e+00	1007.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	81.72	0.00e+00	1008.00
IUUC-Lch-050086	Latimeria chalumnae	72.60	0.00e+00	856.00
IUUC-Loc-051979	Lepisosteus oculatus	61.95	0.00e+00	1268.00
IUUC-Laf-054377	Loxodonta africana	81.00	0.00e+00	1008.00
IUUC-Mcc-055577	Macaca mulatta	75.92	0.00e+00	911.00
IUUC-Meu-055992	Macropus eugenii	82.60	0.00e+00	953.00
IUUC-Mga-059541	Meleagris gallopavo	71.02	0.00e+00	712.00
IUUC-Mmr-061772	Microcebus murinus	81.72	0.00e+00	1006.00
IUUC-Mdo-062876	Monodelphis domestica	63.24	7.00e-128	452.00
IUUC-Mmu-063903	Mus musculus	82.21	0.00e+00	999.00
IUUC-Mpu-066700	Mustela putorius furo	81.90	0.00e+00	1006.00
IUUC-Mlu-068180	Myotis lucifugus	81.17	0.00e+00	1009.00
IUUC-Nle-069232	Nomascus leucogenys	70.55	0.00e+00	885.00
IUUC-Opr-070304	Ochotona princeps	71.63	0.00e+00	804.00
IUUC-Ont-071881	Oreochromis niloticus	70.62	0.00e+00	1131.00
IUUC-Oan-072945	Ornithorhynchus anatinus	70.89	0.00e+00	891.00
IUUC-Ocu-074053	Oryctolagus cuniculus	81.72	0.00e+00	1005.00
IUUC-Ola-086384	Oryzias latipes	59.63	0.00e+00	1501.00
IUUC-Oga-088450	Otolemur garnettii	81.17	0.00e+00	1009.00
IUUC-Oar-089975	Ovis aries	80.48	0.00e+00	997.00
IUUC-Ptr-091073	Pan troglodytes	80.00	0.00e+00	882.00
IUUC-Pan-092871	Papio anubis	81.90	0.00e+00	1009.00
IUUC-Pma-094252	Petromyzon marinus	45.36	1.00e-94	342.00
IUUC-Pfo-097525	Poecilia formosa	56.92	0.00e+00	1231.00
IUUC-Pab-097679	Pongo abelii	81.72	0.00e+00	1008.00
IUUC-Pca-100499	Procavia capensis	81.37	0.00e+00	1005.00
IUUC-Ppe-101920	Prunus persica	32.77	1.00e-24	108.00
IUUC-Pva-102898	Pteropus vampyrus	81.20	0.00e+00	994.00
IUUC-Rno-105660	Rattus norvegicus	80.51	0.00e+00	932.00
IUUC-Sha-107431	Sarcophilus harrisii	82.60	0.00e+00	966.00
IUUC-Sar-113183	Sorex araneus	71.01	6.00e-91	331.00
IUUC-Sbi-113816	Sorghum bicolor	31.31	4.00e-12	67.40
IUUC-Ssc-115678	Sus scrofa	81.59	0.00e+00	1000.00
IUUC-Tgu-116677	Taeniopygia guttata	72.88	0.00e+00	866.00
IUUC-Tru-117922	Takifugu rubripes	59.65	0.00e+00	2153.00
IUUC-Tsy-118932	Tarsius syrichta	70.80	0.00e+00	894.00
IUUC-Tni-119970	Tetraodon nigroviridis	57.59	0.00e+00	702.00
IUUC-Tur-126151	Triticum urartu	34.62	6.00e-11	62.40
IUUC-Tbe-127625	Tupaia belangeri	67.87	4.00e-103	371.00
IUUC-Ttr-129162	Tursiops truncatus	80.66	0.00e+00	1009.00
IUUC-Vpa-130236	Vicugna pacos	49.33	6.00e-88	321.00
IUUC-Xtr-132455	Xenopus tropicalis	79.49	0.00e+00	958.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence