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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Sce-106293
UUCD1 version UUC-SaC-00210
Ensembl Protein ID YDL132W
UniProt Accession Q12018; D6VRL7; CDC53_YEAST
Genbank Protein ID AAB38821.1; CAA65628.1; CAA98702.1; DAA11727.1
Protein Name Cell division control protein 53; Cullin-A; E3 ubiquitin ligase complex SCF subunit CDC53
Genbank Nucleotide ID U43564; X96876; Z74180; BK006938
Gene Name CDC53; YDL132W; D2190
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDL132W YDL132W YDL132W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 9.00e-138 459.1 45 691
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 16   kkeyeelytavynlclsk...................vgaklYkklkevleefikqvkkkveesedeqlLktynreWekfreqlkvlrkifayldrtyvkk. 97
    + y+e+yta+yn+c++k vg ++Y+klk++l+++i + k++ e ++L++y++ W++f++++ l++ f+y++r++v+k
   Q: 45 PTMYMEVYTAIYNYCVNKsrssghfstdsrtgqstilVGSEIYEKLKNYLKNYILNFKQSNSE----TFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQKe 142
    578***************************************************997765554....5*********************************8 PP
   S: 98 ....skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk.......laiykesFEakfleatqefykaesaefl 188
    ++++ +v++L l +w++ ++ + k+ l++ ll+ + R+g++++r+ +s +++slv L+++ l++y + FE++fl++tqe+y++ + +l
   Q: 143 rsdgKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLGREGQIIQRSNISTAIKSLVALGIDPqdlkklnLNVYIQVFEKPFLKKTQEYYTQYTNDYL 244
    88877788**********************************************************99********************************** PP
   S: 189 qenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaalt. 289
    ++++v+eY+ ++ + ++ ee+++ y + t+++L ++k+li++h+e+l +e+v ll+ e+++ +y L++r + + ++ +e+++k+ g++ ++
   Q: 245 EKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISs 346
    **************************************************************************************************9997 PP
   S: 290 ..aeekek....................dpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlka........akspEllAryiDqlLr 361
    a+ k++ +pk+y+++lle+++ ++k+ +e+F +d kald+a+ +f+n n+++ +k++E+lA+y D lL+
   Q: 347 llAMHKHNimknenanpkklalmtahslSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININEFALPagspksatSKTSEMLAKYSDILLK 448
    7777777799999************************************************************999889*********************** PP
   S: 362 ksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFk...eekentee 460
    k k e ++ ++++++fky+ +kd Fe +Y++++akRL++g+s s e Ee++i++L+ ++++e+t k+++Mfqd+ +S+ l+++F +++ ++++
   Q: 449 KATK--PEVASDMSDEDIITIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDFAvalKNEPDYSK 548
    **66..5666677779***************************************************************************99889999999 PP
   S: 461 sesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkg...kyelqVstfQmavLLafnnsekvsveelkk 559
    + ++l+ vL++++Wp++ + ++++LP+el + ek +e Y++kh+gR L+W++ l+r+elka + k +++++V+ fQma+LL++n+ + +++e++++
   Q: 549 AKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYSQKHNGRILKWLWPLCRGELKADIGKPgrmPFNFTVTLFQMAILLLYNDADVLTLENIQE 650
    9******************88888****************************************997656889***************************** PP
   S: 560 atelpeeeLrrtlqsLvsskkqvlkkepeske..ieeedlfsv 600
    t l + + ++ ++++ k ++++ p + + ++ e++f++
   Q: 651 GTSLTIQHIAAAMVPFIKFK--LIQQVPPGLDalVKPETQFKL 691
    ******************98..777778776556777777766 PP
   

Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The SCF complex associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the SCF complex depends on the type of F-box protein. SCF(CDC4) controls the G1-to-S phase transition; it directs ubiquitination of the phosphorylated CDK inhibitor SIC1 and of CDC6. SCF(CDC4) directs ubiquitination of GCN4. SCF(GRR1) directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. SCF(MET30) directs ubiquitination of MET4. SCF(DIA2) is specifically involved in the pheromone induced degradation of phosphorylated TEC1. SCF(MDM30) seems to direct ubiquitination of FZ01. Involved in the regulation of methionine biosynthesis genes.
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The SCF complex associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the SCF complex depends on the type of F-box protein. SCF(CDC4) controls the G1-to-S phase transition; it directs ubiquitination of the phosphorylated CDK inhibitor SIC1 and of CDC6. SCF(CDC4) directs ubiquitination of GCN4. SCF(GRR1) directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. SCF(MET30) directs ubiquitination of MET4. SCF(DIA2) is specifically involved in the pheromone induced degradation of phosphorylated TEC1. SCF(MDM30) seems to direct ubiquitination of FZ01. Involved in the regulation of methionine biosynthesis genes.
Protein Sequence
(Fasta)
MSETLPRSDD LEATWNFIEP GINQILGNEK NQASTSKRVY KILSPTMYME VYTAIYNYCV 60
NKSRSSGHFS TDSRTGQSTI LVGSEIYEKL KNYLKNYILN FKQSNSETFL QFYVKRWKRF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Sce-106293|E3,Cullin|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCTGAGA CTCTGCCTAG ATCTGATGAT TTAGAGGCCA CTTGGAACTT TATAGAGCCA 60
GGAATTAACC AAATACTGGG TAATGAGAAA AACCAAGCAT CCACGTCTAA GCGAGTTTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Sce-106293|E3,Cullin|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0003688--F:DNA replication origin binding
GO:0030674--F:protein binding, bridging
GO:0031625--F:ubiquitin protein ligase binding
GO:0051301--P:cell division
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG sce:YDL132W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000358 Aegilops tauschii 24.28 6.00e-58 216.00
IUUC-Aml-002277 Ailuropoda melanoleuca 31.39 3.00e-114 403.00
IUUC-Atr-002822 Amborella trichopoda 23.35 2.00e-56 212.00
IUUC-Apl-003503 Anas platyrhynchos 32.13 5.00e-94 336.00
IUUC-Aca-005030 Anolis carolinensis 28.59 5.00e-76 276.00
IUUC-Aly-005566 Arabidopsis lyrata 25.31 5.00e-58 217.00
IUUC-Ath-007345 Arabidopsis thaliana 24.66 1.00e-58 219.00
IUUC-Ago-007977 Ashbya gossypii 61.90 0.00e+00 1036.00
IUUC-Acl-008190 Aspergillus clavatus 31.21 3.00e-119 420.00
IUUC-Afl-008542 Aspergillus flavus 31.66 2.00e-98 351.00
IUUC-Afu-009007 Aspergillus fumigatus 33.33 2.00e-114 404.00
IUUC-Ani-009290 Aspergillus nidulans 32.93 1.00e-129 454.00
IUUC-Ang-009600 Aspergillus niger 33.61 1.00e-117 415.00
IUUC-Aor-009978 Aspergillus oryzae 32.49 2.00e-107 381.00
IUUC-Ate-010584 Aspergillus terreus 31.66 4.00e-120 423.00
IUUC-Ame-011861 Astyanax mexicanus 30.85 5.00e-108 383.00
IUUC-Bgr-012209 Blumeria graminis 32.78 8.00e-122 429.00
IUUC-Bta-012878 Bos taurus 31.52 4.00e-114 403.00
IUUC-Bci-013941 Botrytis cinerea 32.40 1.00e-132 465.00
IUUC-Bdi-014686 Brachypodium distachyon 24.49 4.00e-57 214.00
IUUC-Bol-016311 Brassica oleracea 23.58 3.00e-49 187.00
IUUC-Bra-017658 Brassica rapa 23.46 5.00e-53 200.00
IUUC-Cel-018294 Caenorhabditis elegans 29.37 7.00e-100 356.00
IUUC-Cja-018965 Callithrix jacchus 30.56 8.00e-105 372.00
IUUC-Cfa-020671 Canis familiaris 31.52 4.00e-114 403.00
IUUC-Cpo-021762 Cavia porcellus 31.64 9.00e-115 405.00
IUUC-Cre-022585 Chlamydomonas reinhardtii 23.64 5.00e-56 210.00
IUUC-Csa-023873 Chlorocebus sabaeus 31.64 1.00e-114 405.00
IUUC-Cho-024839 Choloepus hoffmanni 24.01 4.00e-45 174.00
IUUC-Cin-025547 Ciona intestinalis 31.41 6.00e-109 386.00
IUUC-Csv-026083 Ciona savignyi 31.00 2.00e-112 397.00
IUUC-Cgl-026452 Colletotrichum gloeosporioides 33.25 4.00e-128 450.00
IUUC-Cne-026919 Cryptococcus neoformans 28.64 1.00e-106 378.00
IUUC-Dre-027875 Danio rerio 31.21 4.00e-108 383.00
IUUC-Dno-028931 Dasypus novemcinctus 31.64 6.00e-113 399.00
IUUC-Dor-030846 Dipodomys ordii 32.20 7.00e-71 259.00
IUUC-Dse-031472 Dothistroma septosporum 32.11 2.00e-123 434.00
IUUC-Dme-031793 Drosophila melanogaster 29.52 2.00e-99 354.00
IUUC-Ete-032945 Echinops telfairi 27.90 2.00e-44 171.00
IUUC-Eca-034309 Equus caballus 31.52 4.00e-114 403.00
IUUC-Eeu-034502 Erinaceus europaeus 24.48 4.00e-47 181.00
IUUC-Fca-036330 Felis catus 30.88 4.00e-108 383.00
IUUC-Fal-036899 Ficedula albicollis 32.28 3.00e-99 354.00
IUUC-Fox-037705 Fusarium oxysporum 31.26 7.00e-113 399.00
IUUC-Fso-038367 Fusarium solani 32.76 4.00e-124 436.00
IUUC-Gmo-038708 Gadus morhua 30.90 2.00e-108 384.00
IUUC-Ggr-039917 Gaeumannomyces graminis 31.99 5.00e-124 436.00
IUUC-Gga-041038 Gallus gallus 31.64 1.00e-114 405.00
IUUC-Gac-041820 Gasterosteus aculeatus 31.45 1.00e-111 395.00
IUUC-Gma-044070 Glycine max 24.46 4.00e-60 224.00
IUUC-Ggo-045235 Gorilla gorilla 26.63 9.00e-81 292.00
IUUC-Hsa-046034 Homo sapiens 31.64 1.00e-114 405.00
IUUC-Hvu-047383 Hordeum vulgare 24.15 5.00e-56 210.00
IUUC-Itr-048285 Ictidomys tridecemlineatus 31.64 1.00e-114 405.00
IUUC-Kpa-049231 Komagataella pastoris 43.69 4.00e-178 616.00
IUUC-Lch-049673 Latimeria chalumnae 31.39 6.00e-113 399.00
IUUC-Lpe-051606 Leersia perrieri 23.94 3.00e-55 209.00
IUUC-Loc-052490 Lepisosteus oculatus 31.11 1.00e-110 392.00
IUUC-Lma-053191 Leptosphaeria maculans 32.15 3.00e-125 440.00
IUUC-Laf-054582 Loxodonta africana 31.64 9.00e-115 405.00
IUUC-Mcc-055162 Macaca mulatta 31.15 9.00e-110 389.00
IUUC-Meu-055904 Macropus eugenii 28.93 7.00e-35 140.00
IUUC-Mor-057035 Magnaporthe oryzae 31.53 3.00e-121 427.00
IUUC-Mpo-057555 Magnaporthe poae 31.87 1.00e-123 435.00
IUUC-Mtr-058635 Medicago truncatula 24.17 1.00e-58 219.00
IUUC-Mla-059021 Melampsora laricipopulina 30.16 1.00e-107 382.00
IUUC-Mga-060078 Meleagris gallopavo 31.64 1.00e-114 405.00
IUUC-Mvi-060519 Microbotryum violaceum 31.29 2.00e-112 399.00
IUUC-Mmr-061312 Microcebus murinus 31.64 1.00e-114 405.00
IUUC-Mdo-062867 Monodelphis domestica 31.52 3.00e-113 400.00
IUUC-Mmu-063336 Mus musculus 31.64 1.00e-114 405.00
IUUC-Mac-065440 Musa acuminata 23.95 1.00e-58 219.00
IUUC-Mpu-066400 Mustela putorius furo 32.13 9.00e-99 352.00
IUUC-Mlu-067800 Myotis lucifugus 31.39 3.00e-114 403.00
IUUC-Nfi-068384 Neosartorya fischeri 31.43 6.00e-117 412.00
IUUC-Ncr-068965 Neurospora crassa 31.06 9.00e-117 412.00
IUUC-Nle-069729 Nomascus leucogenys 31.64 1.00e-114 405.00
IUUC-Opr-071197 Ochotona princeps 28.42 3.00e-63 234.00
IUUC-Ont-071729 Oreochromis niloticus 31.27 1.00e-108 385.00
IUUC-Oan-073309 Ornithorhynchus anatinus 31.64 1.00e-114 405.00
IUUC-Ocu-074661 Oryctolagus cuniculus 31.01 2.00e-111 394.00
IUUC-Oba-075549 Oryza barthii 24.79 6.00e-62 230.00
IUUC-Ogl-077526 Oryza glaberrima 24.79 4.00e-61 227.00
IUUC-Ogu-078725 Oryza glumaepatula 24.91 1.00e-61 229.00
IUUC-Oin-079932 Oryza indica 25.87 5.00e-57 213.00
IUUC-Olo-080564 Oryza longistaminata 25.87 6.00e-58 216.00
IUUC-Ome-081179 Oryza meridionalis 24.67 2.00e-61 228.00
IUUC-Oni-082264 Oryza nivara 24.67 6.00e-61 226.00
IUUC-Opu-084006 Oryza punctata 25.03 1.00e-62 232.00
IUUC-Oru-085048 Oryza rufipogon 24.55 2.00e-60 225.00
IUUC-Osa-085323 Oryza sativa 24.55 5.00e-60 223.00
IUUC-Ola-087422 Oryzias latipes 31.56 4.00e-111 393.00
IUUC-Olu-087650 Ostreococcus lucimarinus 24.86 4.00e-50 191.00
IUUC-Oga-088130 Otolemur garnettii 31.64 1.00e-114 405.00
IUUC-Oar-089510 Ovis aries 30.48 2.00e-104 371.00
IUUC-Ptr-090665 Pan troglodytes 31.64 1.00e-114 405.00
IUUC-Pan-092218 Papio anubis 31.64 1.00e-114 405.00
IUUC-Psi-093175 Pelodiscus sinensis 31.64 2.00e-114 404.00
IUUC-Pma-094502 Petromyzon marinus 31.60 7.00e-113 399.00
IUUC-Pno-095067 Phaeosphaeria nodorum 33.09 2.00e-131 461.00
IUUC-Ppa-095910 Physcomitrella patens 24.76 1.00e-58 219.00
IUUC-Pfo-096705 Poecilia formosa 31.37 2.00e-112 397.00
IUUC-Pab-097578 Pongo abelii 31.64 1.00e-114 405.00
IUUC-Pop-100087 Populus trichocarpa 24.06 2.00e-57 215.00
IUUC-Pca-100242 Procavia capensis 33.46 2.00e-79 288.00
IUUC-Ppe-101405 Prunus persica 24.43 7.00e-57 213.00
IUUC-Pva-102155 Pteropus vampyrus 27.76 7.00e-86 309.00
IUUC-Pgr-103297 Puccinia graminis 30.41 2.00e-105 374.00
IUUC-Ptt-103706 Puccinia triticina 28.01 5.00e-39 154.00
IUUC-Pte-104257 Pyrenophora teres 32.97 4.00e-129 453.00
IUUC-Pyt-104795 Pyrenophora triticirepentis 32.97 7.00e-129 452.00
IUUC-Rno-105939 Rattus norvegicus 31.64 1.00e-114 405.00
IUUC-Sha-106949 Sarcophilus harrisii 31.64 2.00e-114 404.00
IUUC-Sja-107737 Schizosaccharomyces japonicus 31.82 7.00e-110 389.00
IUUC-Spo-108280 Schizosaccharomyces pombe 32.31 1.00e-116 412.00
IUUC-Ssl-108537 Sclerotinia sclerotiorum 25.50 5.00e-40 157.00
IUUC-Smo-109628 Selaginella moellendorffii 23.59 2.00e-54 205.00
IUUC-Sit-110443 Setaria italica 23.93 5.00e-57 213.00
IUUC-Sly-111067 Solanum lycopersicum 23.88 2.00e-57 215.00
IUUC-Stu-112374 Solanum tuberosum 24.28 1.00e-47 182.00
IUUC-Sar-113138 Sorex araneus 28.10 2.00e-80 291.00
IUUC-Sbi-114698 Sorghum bicolor 24.68 2.00e-58 218.00
IUUC-Sre-114984 Sporisorium reilianum 31.12 2.00e-109 388.00
IUUC-Ssc-115829 Sus scrofa 31.56 7.00e-111 392.00
IUUC-Tgu-116950 Taeniopygia guttata 31.64 1.00e-114 405.00
IUUC-Tru-118558 Takifugu rubripes 31.50 3.00e-112 397.00
IUUC-Tsy-119621 Tarsius syrichta 32.57 2.00e-59 222.00
IUUC-Tni-120460 Tetraodon nigroviridis 31.10 5.00e-111 393.00
IUUC-Tca-121586 Theobroma cacao 24.19 3.00e-56 211.00
IUUC-Tre-122223 Trichoderma reesei 32.00 1.00e-117 415.00
IUUC-Tvi-122539 Trichoderma virens 30.17 3.00e-111 394.00
IUUC-Tae-124198 Triticum aestivum 24.55 5.00e-59 220.00
IUUC-Tur-126509 Triticum urartu 25.23 1.00e-57 215.00
IUUC-Tme-126926 Tuber melanosporum 33.86 6.00e-135 472.00
IUUC-Tbe-127369 Tupaia belangeri 33.15 2.00e-45 175.00
IUUC-Ttr-129022 Tursiops truncatus 29.96 2.00e-75 274.00
IUUC-Uma-129341 Ustilago maydis 31.62 1.00e-100 358.00
IUUC-Vda-129857 Verticillium dahliae 31.01 6.00e-116 409.00
IUUC-Vpa-130166 Vicugna pacos 29.61 2.00e-86 310.00
IUUC-Vvi-131423 Vitis vinifera 24.20 4.00e-58 217.00
IUUC-Xtr-131818 Xenopus tropicalis 31.60 5.00e-113 399.00
IUUC-Xma-134206 Xiphophorus maculatus 31.08 3.00e-109 387.00
IUUC-Yli-134486 Yarrowia lipolytica 34.78 2.00e-136 478.00
IUUC-Zma-135737 Zea mays 23.86 3.00e-56 211.00
Created Date 25-Jun-2017

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