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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045841
UUCD1 version UUC-HoS-00033
Ensembl Protein ID ENSP00000217964.7
UniProt Accession O60907; A8K044; A8K4J7; Q86UY2; TBL1X_HUMAN
Genbank Protein ID CAA73319.1; BAF82098.1; BAF83651.1; AAH32708.1; AAH52304.1
Protein Name F-box-like/WD repeat-containing protein TBL1X; SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked
Genbank Nucleotide ID Y12781; AK289409; AK290962; AC003036; BC052304
Gene Name TBL1X; TBL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101849.15 ENST00000217964.11 ENSP00000217964.7
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18803400; 19759827
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 18803400; 19759827
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.20e-53 176.9 504 542
UBD/Beta-Prp 4.60e-63 214.8 376 575
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g+l++s
   Q: 504  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGNLVHS 542
           9**********999********************99886 PP
   

   UBD/Beta-Prp
   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp.. 104
           +v++ ++++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++  c+h l++h+++++++++sp  
   Q: 376  DVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPtg 466
           3333.444445555555555555555555555555555555555555555555555555555555555555555555555555555554444 PP
   S: 105  .......sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfd 189
                  s+  l+s+s d+t+r+wd+e g c + tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+ +  + ++
   Q: 467  patsnpnSNIMLASASFDSTVRLWDIERGVCTH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG--TGGIFEVCWN 555
           433333222345555555555555555555555.5555555555555555555555555555555555555555555554..5555555555 PP
   S: 190  sngkelvsgsldgtvklwdl 209
             g  + + + dg+v + dl
   Q: 556  ARGDKVGASASDGSVCVLDL 575
           55555555555555554444 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
Protein Sequence
(Fasta)
MTELAGASSS CCHRPAGRGA MQSVLHHFQR LRGREGGSHF INTSSPRGEA KMSITSDEVN 60
FLVYRYLQES GFSHSAFTFG IESHISQSNI NGTLVPPAAL ISILQKGLQY VEAEISINED 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045841|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGCATGTA ATACCTCAGC ATCAGTCTGC ACAAGCCCAG GGAGCCCAGG AGCAACGAAG 60
GGCAGGCTCA AGGGAAGGCC CCACCATGTC CTTCTGGGGG GCCTTGAATG GCAACTGATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045841|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0209--Deafness
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08513--LisH
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0008013--F:beta-catenin binding
GO:0042393--F:histone binding
GO:0008022--F:protein C-terminus binding
GO:0019904--F:protein domain specific binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0044255--P:cellular lipid metabolic process
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0007605--P:sensory perception of sound
GO:0006351--P:transcription, DNA-templated
KEGG hsa:6907
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001450 Ailuropoda melanoleuca 89.74 0.00e+00 1000.00
IUUC-Apl-003232 Anas platyrhynchos 93.35 0.00e+00 974.00
IUUC-Aca-005035 Anolis carolinensis 92.09 0.00e+00 987.00
IUUC-Bta-013202 Bos taurus 94.51 0.00e+00 989.00
IUUC-Cja-019281 Callithrix jacchus 91.68 0.00e+00 1065.00
IUUC-Cfa-020929 Canis familiaris 93.92 0.00e+00 986.00
IUUC-Csa-023943 Chlorocebus sabaeus 97.40 0.00e+00 1119.00
IUUC-Dno-028926 Dasypus novemcinctus 92.60 0.00e+00 971.00
IUUC-Dme-031939 Drosophila melanogaster 80.38 3.00e-174 605.00
IUUC-Ete-032822 Echinops telfairi 83.11 0.00e+00 838.00
IUUC-Eca-033897 Equus caballus 95.06 0.00e+00 989.00
IUUC-Fca-036462 Felis catus 93.74 0.00e+00 983.00
IUUC-Fal-037388 Ficedula albicollis 93.73 0.00e+00 984.00
IUUC-Gga-040671 Gallus gallus 93.54 0.00e+00 984.00
IUUC-Gac-041851 Gasterosteus aculeatus 88.40 0.00e+00 925.00
IUUC-Ggo-045373 Gorilla gorilla 98.44 0.00e+00 1129.00
IUUC-Itr-048236 Ictidomys tridecemlineatus 95.97 0.00e+00 760.00
IUUC-Lch-050535 Latimeria chalumnae 90.11 0.00e+00 962.00
IUUC-Laf-054071 Loxodonta africana 93.57 0.00e+00 986.00
IUUC-Mcc-055233 Macaca mulatta 97.37 0.00e+00 1105.00
IUUC-Mga-059895 Meleagris gallopavo 94.11 0.00e+00 984.00
IUUC-Mvi-060557 Microbotryum violaceum 37.30 2.00e-70 260.00
IUUC-Mmr-061286 Microcebus murinus 94.15 0.00e+00 993.00
IUUC-Mmu-063447 Mus musculus 93.93 0.00e+00 986.00
IUUC-Nle-069151 Nomascus leucogenys 97.57 0.00e+00 1127.00
IUUC-Ont-072252 Oreochromis niloticus 88.02 0.00e+00 943.00
IUUC-Oan-073562 Ornithorhynchus anatinus 94.12 0.00e+00 988.00
IUUC-Oba-075618 Oryza barthii 48.29 6.00e-144 504.00
IUUC-Ogl-077302 Oryza glaberrima 50.09 3.00e-155 541.00
IUUC-Ogu-078718 Oryza glumaepatula 50.09 2.00e-155 542.00
IUUC-Oin-079515 Oryza indica 44.34 3.00e-95 343.00
IUUC-Ome-081696 Oryza meridionalis 49.01 5.00e-150 524.00
IUUC-Oni-082137 Oryza nivara 50.09 2.00e-155 542.00
IUUC-Opu-083505 Oryza punctata 48.29 1.00e-143 503.00
IUUC-Oru-085276 Oryza rufipogon 50.09 1.00e-155 543.00
IUUC-Osa-085791 Oryza sativa 50.09 2.00e-155 542.00
IUUC-Oar-089506 Ovis aries 92.40 0.00e+00 985.00
IUUC-Pan-091909 Papio anubis 97.24 0.00e+00 1124.00
IUUC-Psi-093358 Pelodiscus sinensis 89.56 0.00e+00 944.00
IUUC-Pma-094105 Petromyzon marinus 62.19 3.00e-102 364.00
IUUC-Pfo-097214 Poecilia formosa 86.50 0.00e+00 909.00
IUUC-Pab-098317 Pongo abelii 99.47 0.00e+00 1115.00
IUUC-Ppe-101572 Prunus persica 50.81 1.00e-142 499.00
IUUC-Rno-105857 Rattus norvegicus 93.93 0.00e+00 986.00
IUUC-Sha-107326 Sarcophilus harrisii 91.44 0.00e+00 991.00
IUUC-Ssc-115646 Sus scrofa 93.93 0.00e+00 1014.00
IUUC-Tgu-116898 Taeniopygia guttata 93.54 0.00e+00 976.00
IUUC-Tru-117862 Takifugu rubripes 88.45 0.00e+00 938.00
IUUC-Tni-119656 Tetraodon nigroviridis 88.53 0.00e+00 937.00
IUUC-Tae-125368 Triticum aestivum 50.36 1.00e-155 543.00
IUUC-Tur-126856 Triticum urartu 43.38 6.00e-77 281.00
IUUC-Ttr-128826 Tursiops truncatus 91.72 0.00e+00 927.00
IUUC-Uma-129469 Ustilago maydis 43.14 9.00e-59 222.00
IUUC-Vvi-131193 Vitis vinifera 59.26 3.00e-129 455.00
Created Date 25-Jun-2017

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