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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046973
Ensembl Protein ID ENSP00000221200.4
UniProt Accession Q7L273; Q6NUM8; Q9NXV4; KCTD9_HUMAN
Genbank Protein ID AAH21216.2; AAH68518.1; BAA90904.1
Protein Name BTB/POZ domain-containing protein KCTD9
Genbank Nucleotide ID BC021216; BC068518; AK000045
Gene Name KCTD9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000104756.15 ENST00000221200.8 ENSP00000221200.4
ENSG00000104756.15 ENST00000523140.5 ENSP00000467904.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.00e-07 32.4 90 161
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 2    DvilvvggeeffahkivLaas..SsvFyalf..lmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           + +l+vgg++f +++++L      s++  +f  ++ +  ++++++   i+ ++pe+f+ +l++l++g+l  n+
   Q: 90   WLTLNVGGRYFTTTRSTLVNKepDSMLAHMFkdKGVWGnKQDHRGAFLID-RSPEYFEPILNYLRHGQLIVND 161
           679****************998899******7555566566778888888.******************9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.
Protein Sequence
(Fasta)
MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI DDIALIRDDD 60
VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF TTTRSTLVNK EPDSMLAHMF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046973|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGGCCCCAG GCAGGCTGAG GAGCCTAGGG GCGGGGTGGG AAGGAGGACC GGCCGAACCT 60
TGGGTGTGGG ACAGAGTGCG TGCGTGTGGT GTGTCCCCAA GGGCAGGAAG GTGGCGAAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046973|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001646--5peptide_repeat
IPR000210--BTB/POZ_dom
IPR003533--Doublecortin_dom
IPR021789--KHA_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB
PROSITE

PS50097--BTB
PS51490--KHA
Pfam

PF02214--BTB_2
PF11834--KHA
PF00805--Pentapeptide
SMART

SM00225--BTB
Gene Ontology

GO:0097602--F:cullin family protein binding
GO:0042802--F:identical protein binding
GO:0043621--F:protein self-association
GO:0051260--P:protein homooligomerization
KEGG hsa:54793
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000385 Aegilops tauschii 28.41 5.00e-20 92.00
IUUC-Atr-002670 Amborella trichopoda 32.73 2.00e-25 109.00
IUUC-Apl-003419 Anas platyrhynchos 93.37 0.00e+00 708.00
IUUC-Aca-004286 Anolis carolinensis 91.67 0.00e+00 661.00
IUUC-Ath-007067 Arabidopsis thaliana 37.50 1.00e-09 58.20
IUUC-Afl-008739 Aspergillus flavus 36.54 1.00e-07 48.90
IUUC-Ame-010736 Astyanax mexicanus 89.20 0.00e+00 682.00
IUUC-Bra-017048 Brassica rapa 35.58 2.00e-04 40.00
IUUC-Cja-019718 Callithrix jacchus 87.15 0.00e+00 643.00
IUUC-Cho-025009 Choloepus hoffmanni 97.94 4.00e-159 554.00
IUUC-Cin-025338 Ciona intestinalis 56.04 2.00e-111 395.00
IUUC-Csv-026147 Ciona savignyi 55.41 7.00e-122 430.00
IUUC-Dre-027966 Danio rerio 87.66 0.00e+00 673.00
IUUC-Dor-031135 Dipodomys ordii 97.40 6.00e-101 360.00
IUUC-Ete-032730 Echinops telfairi 95.22 2.00e-176 611.00
IUUC-Eca-034291 Equus caballus 98.93 0.00e+00 724.00
IUUC-Eeu-034712 Erinaceus europaeus 97.61 0.00e+00 639.00
IUUC-Fal-037398 Ficedula albicollis 95.40 0.00e+00 724.00
IUUC-Gmo-038793 Gadus morhua 84.32 0.00e+00 648.00
IUUC-Gga-040956 Gallus gallus 96.14 0.00e+00 737.00
IUUC-Gac-042465 Gasterosteus aculeatus 87.15 0.00e+00 667.00
IUUC-Hvu-047615 Hordeum vulgare 28.78 2.00e-10 59.70
IUUC-Itr-048735 Ictidomys tridecemlineatus 99.74 0.00e+00 762.00
IUUC-Lch-050462 Latimeria chalumnae 89.81 0.00e+00 657.00
IUUC-Lpe-051465 Leersia perrieri 29.39 3.00e-23 102.00
IUUC-Loc-052235 Lepisosteus oculatus 89.20 0.00e+00 682.00
IUUC-Laf-054052 Loxodonta africana 84.95 4.00e-180 623.00
IUUC-Mcc-054965 Macaca mulatta 100.00 0.00e+00 764.00
IUUC-Meu-056811 Macropus eugenii 95.78 7.00e-82 295.00
IUUC-Mor-056957 Magnaporthe oryzae 34.78 5.00e-05 41.20
IUUC-Mtr-057875 Medicago truncatula 32.08 5.00e-33 134.00
IUUC-Mga-060041 Meleagris gallopavo 95.15 0.00e+00 725.00
IUUC-Mmr-061291 Microcebus murinus 99.49 0.00e+00 759.00
IUUC-Mdo-062188 Monodelphis domestica 93.88 0.00e+00 711.00
IUUC-Mmu-063814 Mus musculus 98.46 0.00e+00 754.00
IUUC-Mac-065391 Musa acuminata 31.79 8.00e-28 117.00
IUUC-Mpu-066130 Mustela putorius furo 99.23 0.00e+00 756.00
IUUC-Nle-069467 Nomascus leucogenys 100.00 0.00e+00 764.00
IUUC-Opr-071006 Ochotona princeps 76.01 8.00e-103 366.00
IUUC-Ont-072510 Oreochromis niloticus 88.69 0.00e+00 677.00
IUUC-Oan-072912 Ornithorhynchus anatinus 94.33 0.00e+00 687.00
IUUC-Oba-075534 Oryza barthii 29.43 6.00e-24 104.00
IUUC-Obr-076473 Oryza brachyantha 25.50 6.00e-14 72.80
IUUC-Ogl-076972 Oryza glaberrima 30.07 3.00e-20 92.40
IUUC-Ogu-078165 Oryza glumaepatula 31.69 6.00e-24 104.00
IUUC-Oin-079812 Oryza indica 32.39 1.00e-24 107.00
IUUC-Olo-081074 Oryza longistaminata 28.57 4.00e-21 95.50
IUUC-Ome-081152 Oryza meridionalis 29.10 2.00e-23 103.00
IUUC-Oni-082530 Oryza nivara 29.77 2.00e-24 106.00
IUUC-Opu-084029 Oryza punctata 30.99 2.00e-24 106.00
IUUC-Oru-085017 Oryza rufipogon 32.14 2.00e-23 102.00
IUUC-Osa-085633 Oryza sativa 29.43 6.00e-24 104.00
IUUC-Ola-086979 Oryzias latipes 87.40 0.00e+00 669.00
IUUC-Oga-088456 Otolemur garnettii 99.49 0.00e+00 761.00
IUUC-Ptr-090651 Pan troglodytes 99.74 0.00e+00 762.00
IUUC-Psi-093745 Pelodiscus sinensis 94.39 0.00e+00 717.00
IUUC-Pma-094233 Petromyzon marinus 65.78 6.00e-84 303.00
IUUC-Ppa-095251 Physcomitrella patens 30.54 3.00e-24 105.00
IUUC-Pfo-096418 Poecilia formosa 87.15 0.00e+00 668.00
IUUC-Pab-098309 Pongo abelii 100.00 0.00e+00 764.00
IUUC-Pop-100014 Populus trichocarpa 33.22 2.00e-28 119.00
IUUC-Ppe-101633 Prunus persica 29.79 2.00e-22 100.00
IUUC-Pva-102420 Pteropus vampyrus 93.32 0.00e+00 724.00
IUUC-Rno-105486 Rattus norvegicus 98.46 0.00e+00 754.00
IUUC-Sly-111230 Solanum lycopersicum 34.04 1.00e-30 127.00
IUUC-Sar-113407 Sorex araneus 98.46 0.00e+00 753.00
IUUC-Sbi-113950 Sorghum bicolor 30.18 6.00e-26 111.00
IUUC-Ssc-116381 Sus scrofa 97.32 2.00e-117 414.00
IUUC-Tgu-116934 Taeniopygia guttata 92.33 0.00e+00 684.00
IUUC-Tru-117616 Takifugu rubripes 87.15 0.00e+00 660.00
IUUC-Tsy-119496 Tarsius syrichta 91.42 0.00e+00 655.00
IUUC-Tni-120418 Tetraodon nigroviridis 86.41 0.00e+00 657.00
IUUC-Tca-121474 Theobroma cacao 30.51 3.00e-20 92.40
IUUC-Tae-123780 Triticum aestivum 29.82 2.00e-25 109.00
IUUC-Tbe-128011 Tupaia belangeri 89.46 3.00e-171 594.00
IUUC-Vvi-131558 Vitis vinifera 29.90 7.00e-24 104.00
IUUC-Xtr-132177 Xenopus tropicalis 85.64 0.00e+00 655.00
IUUC-Xma-133257 Xiphophorus maculatus 87.40 0.00e+00 669.00
Created Date 25-Jun-2017

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