iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048989

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AGTP01082737

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000000772.2	ENSSTOT00000000770.2	ENSSTOP00000000691.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	9.30e-97	324.4	13	364

Active Site

Position(s)	Description	Evidence
100	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
176	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 13   MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 90
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++af
   Q: 91   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTSAK----EEDAF 175
           ****************************************************************************9887....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvv..............................raflerikllesdeirfn 237
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v                              ++  ++++ ++++eirfn
   Q: 176  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPViekriqnfvfdgflrlkpgmlcyelppqpfMQIPQKVR-YSEGEIRFN 262
           **************************9.78899*********************************9966533345554.89999**** PP
   S: 238  llaivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregi 317
           l+aiv+dr++i+++++  l+ +          +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++
   Q: 263  LMAIVSDRKMIYEQKIAELQRQlaeeepmdtDQGSNMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQ 351
           ***************976665567777777755568***************************************************** PP
   S: 318  lrklveetisevrefg 333
           l  lve+    + +++
   Q: 352  LIPLVEKA---KEKQN 364
           *****993...33344 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

TRGGVGRCVA GAMTGNAGEW CLMESDPGVF TELIKGFGCR GAQVEEIWSL EPENFEKLKP 60
VHGLIFLFKW QPGEEPAGSV VQDSRLDTIF FAKQVINNAC ATQAIVSVLL NCTHQDVHLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCGAGGTG GAGTGGGGCG GTGTGTGGCC GGGGCCATGA CGGGCAATGC CGGGGAGTGG 60
TGCCTCATGG AAAGCGACCC CGGAGTCTTC ACCGAGCTCA TTAAAGGATT CGGTGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	43.25	4.00e-79	287.00
IUUC-Aml-001866	Ailuropoda melanoleuca	90.41	0.00e+00	631.00
IUUC-Atr-002966	Amborella trichopoda	42.19	2.00e-75	275.00
IUUC-Apl-003306	Anas platyrhynchos	86.58	2.00e-179	621.00
IUUC-Aca-004763	Anolis carolinensis	86.38	2.00e-174	604.00
IUUC-Aly-005581	Arabidopsis lyrata	44.44	1.00e-74	272.00
IUUC-Ath-007283	Arabidopsis thaliana	44.44	3.00e-77	281.00
IUUC-Ago-007999	Ashbya gossypii	40.29	2.00e-31	129.00
IUUC-Acl-008231	Aspergillus clavatus	37.78	2.00e-47	182.00
IUUC-Afl-008557	Aspergillus flavus	34.32	8.00e-50	190.00
IUUC-Afu-008988	Aspergillus fumigatus	40.22	1.00e-49	189.00
IUUC-Ani-009420	Aspergillus nidulans	34.76	6.00e-48	184.00
IUUC-Ang-009859	Aspergillus niger	36.59	1.00e-44	173.00
IUUC-Aor-010145	Aspergillus oryzae	34.32	8.00e-50	190.00
IUUC-Ate-010347	Aspergillus terreus	37.41	3.00e-48	185.00
IUUC-Ame-010791	Astyanax mexicanus	82.22	2.00e-176	611.00
IUUC-Bgr-012298	Blumeria graminis	34.33	2.00e-44	172.00
IUUC-Bta-013251	Bos taurus	90.12	1.00e-180	625.00
IUUC-Bci-013786	Botrytis cinerea	34.86	7.00e-53	200.00
IUUC-Bdi-014132	Brachypodium distachyon	44.82	1.00e-76	279.00
IUUC-Bol-015611	Brassica oleracea	45.68	1.00e-79	289.00
IUUC-Bra-017769	Brassica rapa	45.68	1.00e-79	289.00
IUUC-Cel-018604	Caenorhabditis elegans	42.61	1.00e-76	279.00
IUUC-Cja-019768	Callithrix jacchus	90.81	0.00e+00	658.00
IUUC-Cfa-020207	Canis familiaris	90.41	0.00e+00	631.00
IUUC-Cpo-021925	Cavia porcellus	86.63	4.00e-174	603.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	41.37	4.00e-69	254.00
IUUC-Csa-023958	Chlorocebus sabaeus	89.68	0.00e+00	631.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	2.00e-42	165.00
IUUC-Cin-025771	Ciona intestinalis	49.72	7.00e-95	340.00
IUUC-Csv-026149	Ciona savignyi	52.71	4.00e-98	350.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	33.66	2.00e-46	178.00
IUUC-Cne-026955	Cryptococcus neoformans	34.96	3.00e-50	191.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.06	1.00e-45	176.00
IUUC-Dre-027409	Danio rerio	81.39	6.00e-173	599.00
IUUC-Dno-028921	Dasypus novemcinctus	89.83	0.00e+00	627.00
IUUC-Dse-031170	Dothistroma septosporum	36.34	6.00e-54	204.00
IUUC-Dme-031677	Drosophila melanogaster	54.67	1.00e-109	389.00
IUUC-Ete-032707	Echinops telfairi	63.41	1.00e-120	425.00
IUUC-Eca-033776	Equus caballus	89.34	1.00e-165	575.00
IUUC-Eeu-035305	Erinaceus europaeus	80.00	4.00e-88	317.00
IUUC-Fca-035846	Felis catus	91.85	0.00e+00	656.00
IUUC-Fal-037597	Ficedula albicollis	86.52	4.00e-154	536.00
IUUC-Fox-037670	Fusarium oxysporum	44.23	1.00e-50	192.00
IUUC-Fso-038243	Fusarium solani	44.62	4.00e-50	191.00
IUUC-Gmo-038499	Gadus morhua	76.74	3.00e-156	543.00
IUUC-Ggr-039975	Gaeumannomyces graminis	36.46	2.00e-43	169.00
IUUC-Gga-040904	Gallus gallus	86.15	0.00e+00	629.00
IUUC-Gac-042058	Gasterosteus aculeatus	80.81	2.00e-165	573.00
IUUC-Gma-043763	Glycine max	44.57	3.00e-80	291.00
IUUC-Ggo-044699	Gorilla gorilla	84.32	9.00e-165	572.00
IUUC-Hsa-046227	Homo sapiens	89.83	0.00e+00	627.00
IUUC-Hvu-047359	Hordeum vulgare	43.33	8.00e-78	283.00
IUUC-Lch-049829	Latimeria chalumnae	84.30	3.00e-170	590.00
IUUC-Lpe-050899	Leersia perrieri	44.25	5.00e-73	267.00
IUUC-Loc-052264	Lepisosteus oculatus	82.61	5.00e-168	583.00
IUUC-Lma-053110	Leptosphaeria maculans	35.14	7.00e-44	171.00
IUUC-Laf-053639	Loxodonta africana	90.41	0.00e+00	631.00
IUUC-Mcc-055506	Macaca mulatta	89.68	0.00e+00	631.00
IUUC-Mor-057001	Magnaporthe oryzae	40.52	4.00e-50	191.00
IUUC-Mpo-057608	Magnaporthe poae	40.64	2.00e-32	132.00
IUUC-Mtr-057731	Medicago truncatula	45.36	2.00e-80	292.00
IUUC-Mla-059016	Melampsora laricipopulina	42.93	2.00e-43	168.00
IUUC-Mga-060178	Meleagris gallopavo	86.57	1.00e-168	585.00
IUUC-Mvi-060353	Microbotryum violaceum	35.52	1.00e-49	189.00
IUUC-Mmr-060738	Microcebus murinus	89.83	0.00e+00	628.00
IUUC-Mdo-062266	Monodelphis domestica	98.03	2.00e-119	421.00
IUUC-Mmu-063619	Mus musculus	87.79	5.00e-178	616.00
IUUC-Mac-065301	Musa acuminata	45.98	3.00e-83	301.00
IUUC-Mpu-066058	Mustela putorius furo	90.70	0.00e+00	632.00
IUUC-Mlu-067292	Myotis lucifugus	88.95	3.00e-178	616.00
IUUC-Nfi-068275	Neosartorya fischeri	34.30	2.00e-50	192.00
IUUC-Ncr-068713	Neurospora crassa	35.53	2.00e-53	202.00
IUUC-Nle-069013	Nomascus leucogenys	89.04	0.00e+00	640.00
IUUC-Opr-070628	Ochotona princeps	85.39	2.00e-173	601.00
IUUC-Ont-072688	Oreochromis niloticus	81.50	9.00e-166	575.00
IUUC-Oan-073004	Ornithorhynchus anatinus	85.92	4.00e-137	479.00
IUUC-Ocu-074303	Oryctolagus cuniculus	90.40	0.00e+00	651.00
IUUC-Oba-075002	Oryza barthii	44.35	9.00e-77	280.00
IUUC-Obr-076392	Oryza brachyantha	45.11	7.00e-75	273.00
IUUC-Ogl-077271	Oryza glaberrima	44.35	9.00e-77	280.00
IUUC-Ogu-078493	Oryza glumaepatula	44.35	1.00e-77	283.00
IUUC-Oin-080084	Oryza indica	44.35	1.00e-77	283.00
IUUC-Olo-080803	Oryza longistaminata	44.08	2.00e-77	281.00
IUUC-Ome-081146	Oryza meridionalis	43.53	3.00e-76	278.00
IUUC-Oni-082146	Oryza nivara	44.35	1.00e-77	283.00
IUUC-Opu-083633	Oryza punctata	44.25	1.00e-73	270.00
IUUC-Oru-084789	Oryza rufipogon	44.35	1.00e-77	283.00
IUUC-Osa-086196	Oryza sativa	44.35	1.00e-77	283.00
IUUC-Ola-087126	Oryzias latipes	81.40	4.00e-162	563.00
IUUC-Olu-087665	Ostreococcus lucimarinus	37.93	2.00e-64	238.00
IUUC-Oga-089140	Otolemur garnettii	89.94	0.00e+00	636.00
IUUC-Oar-090296	Ovis aries	89.83	0.00e+00	626.00
IUUC-Ptr-090566	Pan troglodytes	89.83	0.00e+00	627.00
IUUC-Pan-092052	Papio anubis	89.68	0.00e+00	630.00
IUUC-Psi-093723	Pelodiscus sinensis	86.21	2.00e-160	557.00
IUUC-Pma-094568	Petromyzon marinus	55.49	2.00e-101	362.00
IUUC-Pno-095120	Phaeosphaeria nodorum	35.44	2.00e-45	175.00
IUUC-Ppa-095761	Physcomitrella patens	43.43	1.00e-78	286.00
IUUC-Pfo-096210	Poecilia formosa	80.81	1.00e-165	575.00
IUUC-Pab-098463	Pongo abelii	89.61	0.00e+00	649.00
IUUC-Pop-099423	Populus trichocarpa	45.11	1.00e-79	289.00
IUUC-Pca-100108	Procavia capensis	87.36	3.00e-140	490.00
IUUC-Ppe-101176	Prunus persica	46.83	7.00e-81	293.00
IUUC-Pva-102629	Pteropus vampyrus	85.81	9.00e-149	519.00
IUUC-Pgr-103419	Puccinia graminis	36.41	4.00e-52	197.00
IUUC-Pte-104207	Pyrenophora teres	44.38	9.00e-33	132.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	36.01	3.00e-52	198.00
IUUC-Rno-105579	Rattus norvegicus	79.10	3.00e-157	547.00
IUUC-Sha-106894	Sarcophilus harrisii	84.69	1.00e-150	525.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	34.94	8.00e-54	203.00
IUUC-Spo-108371	Schizosaccharomyces pombe	38.02	5.00e-55	207.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	34.85	1.00e-42	166.00
IUUC-Smo-109396	Selaginella moellendorffii	46.35	2.00e-82	298.00
IUUC-Sit-110630	Setaria italica	45.25	7.00e-81	293.00
IUUC-Sly-110972	Solanum lycopersicum	45.93	2.00e-75	275.00
IUUC-Stu-112185	Solanum tuberosum	45.48	1.00e-83	303.00
IUUC-Sar-113294	Sorex araneus	95.96	1.00e-110	392.00
IUUC-Sbi-113951	Sorghum bicolor	45.53	3.00e-81	295.00
IUUC-Ssc-115501	Sus scrofa	89.02	1.00e-169	588.00
IUUC-Tgu-117152	Taeniopygia guttata	86.21	4.00e-154	536.00
IUUC-Tru-118388	Takifugu rubripes	80.52	2.00e-165	574.00
IUUC-Tsy-119109	Tarsius syrichta	90.14	0.00e+00	651.00
IUUC-Tni-120048	Tetraodon nigroviridis	80.52	7.00e-166	575.00
IUUC-Tca-121750	Theobroma cacao	44.99	3.00e-83	301.00
IUUC-Tre-122130	Trichoderma reesei	35.95	8.00e-51	193.00
IUUC-Tvi-122284	Trichoderma virens	36.14	4.00e-48	184.00
IUUC-Tae-124082	Triticum aestivum	43.80	2.00e-78	285.00
IUUC-Tur-126366	Triticum urartu	39.32	4.00e-61	228.00
IUUC-Tme-127187	Tuber melanosporum	37.13	3.00e-53	201.00
IUUC-Tbe-127619	Tupaia belangeri	81.13	1.00e-139	488.00
IUUC-Ttr-128867	Tursiops truncatus	86.75	7.00e-123	432.00
IUUC-Vda-129912	Verticillium dahliae	33.84	2.00e-47	182.00
IUUC-Vpa-130552	Vicugna pacos	100.00	7.00e-126	443.00
IUUC-Vvi-130881	Vitis vinifera	46.20	2.00e-79	288.00
IUUC-Xtr-131934	Xenopus tropicalis	78.33	2.00e-168	584.00
IUUC-Xma-133312	Xiphophorus maculatus	80.81	2.00e-165	574.00
IUUC-Zma-135462	Zea mays	40.17	1.00e-66	246.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence