iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117152

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

ABQF01033845

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000004108.1	ENSTGUT00000004282.1	ENSTGUP00000004237.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.00e-89	300.2	1	297

Active Site

Position(s)	Description	Evidence
63	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
139	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 26   gvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedk 114
           g+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakqvi+N+Cat+A++svllnc ++
   Q: 1    GCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCAHQ 78
           78899.****************.********************.........899********************************** PP
   S: 115  lldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldl 203
            ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + + +++    +++afhfvsyv++ngrlyeldgl++ P+dl
   Q: 79   DIHLGETLSEFKEFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSSAK----EEDAFHFVSYVPVNGRLYELDGLREGPIDL 163
           *************************************************888776....89**************************** PP
   S: 204  gkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqldde 283
           g+ + ++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++r+  l+ +          +  ++l+ i+se++k+++ +++e
   Q: 164  GA-CHQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQRIAELQQQlaqeepmdtDQSSNMLSSIQSEVAKYQMLIEEE 249
           *9.67889*********..******************************987766677888888755678******************* PP
   S: 284  kekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgv 334
           ++k k++ki++irR++ny  fi++++k+la++++l  lve+    + ++++
   Q: 250  NQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQNA 297
           ****************************************93...333554 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

GCRGAQVEEI WSLEPENFEK LKPVHGLIFL FKWQPGEEPA GSVVQDSRLD TIFFAKQVIN 60
NACATQAIVS VLLNCAHQDI HLGETLSEFK EFSQSFDAAM KGLALSNSEV IRQVHNSFAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGTAGAG GAGCACAAGT TGAAGAAATA TGGAGTTTGG AGCCAGAGAA TTTTGAAAAA 60
TTGAAGTAAG GCACATGTTT TGTAATCATG TTTGTCTGAA GTCCCTGAAA GAATGTGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.37	4.00e-75	274.00
IUUC-Aml-001866	Ailuropoda melanoleuca	95.49	8.00e-166	575.00
IUUC-Atr-002966	Amborella trichopoda	48.29	2.00e-78	285.00
IUUC-Apl-003306	Anas platyrhynchos	90.06	3.00e-172	597.00
IUUC-Aca-004763	Anolis carolinensis	96.18	1.00e-167	581.00
IUUC-Aly-005581	Arabidopsis lyrata	47.57	6.00e-71	260.00
IUUC-Ath-007283	Arabidopsis thaliana	47.25	5.00e-73	267.00
IUUC-Ago-007999	Ashbya gossypii	36.70	1.00e-26	113.00
IUUC-Acl-008231	Aspergillus clavatus	42.66	6.00e-46	177.00
IUUC-Afl-008557	Aspergillus flavus	36.97	2.00e-47	182.00
IUUC-Afu-008988	Aspergillus fumigatus	43.58	1.00e-46	179.00
IUUC-Ani-009420	Aspergillus nidulans	37.58	1.00e-47	182.00
IUUC-Ang-009859	Aspergillus niger	40.81	1.00e-42	166.00
IUUC-Aor-010145	Aspergillus oryzae	36.97	2.00e-47	182.00
IUUC-Ate-010347	Aspergillus terreus	41.81	1.00e-46	179.00
IUUC-Ame-010791	Astyanax mexicanus	90.46	4.00e-168	583.00
IUUC-Bgr-012298	Blumeria graminis	38.49	6.00e-44	170.00
IUUC-Bta-013251	Bos taurus	95.49	2.00e-164	571.00
IUUC-Bci-013786	Botrytis cinerea	37.11	6.00e-51	194.00
IUUC-Bdi-014132	Brachypodium distachyon	47.88	2.00e-72	265.00
IUUC-Bol-015611	Brassica oleracea	48.21	1.00e-75	275.00
IUUC-Bra-017769	Brassica rapa	48.21	1.00e-75	275.00
IUUC-Cel-018604	Caenorhabditis elegans	45.21	2.00e-71	261.00
IUUC-Cja-019768	Callithrix jacchus	85.76	7.00e-159	552.00
IUUC-Cfa-020207	Canis familiaris	95.49	8.00e-166	575.00
IUUC-Cpo-021925	Cavia porcellus	91.32	4.00e-157	546.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.00	1.00e-65	243.00
IUUC-Csa-023958	Chlorocebus sabaeus	94.79	4.00e-163	566.00
IUUC-Cho-024928	Choloepus hoffmanni	97.40	3.00e-42	164.00
IUUC-Cin-025771	Ciona intestinalis	52.00	2.00e-88	318.00
IUUC-Csv-026149	Ciona savignyi	55.89	2.00e-92	331.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.59	5.00e-51	194.00
IUUC-Cne-026955	Cryptococcus neoformans	35.46	5.00e-46	177.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.35	4.00e-41	161.00
IUUC-Dre-027409	Danio rerio	90.13	3.00e-166	577.00
IUUC-Dno-028921	Dasypus novemcinctus	95.49	4.00e-166	576.00
IUUC-Dse-031170	Dothistroma septosporum	37.29	3.00e-50	191.00
IUUC-Dme-031677	Drosophila melanogaster	60.34	1.00e-102	365.00
IUUC-Ete-032707	Echinops telfairi	69.12	4.00e-103	367.00
IUUC-Eca-033776	Equus caballus	95.14	9.00e-166	575.00
IUUC-Eeu-035305	Erinaceus europaeus	74.23	4.00e-66	244.00
IUUC-Fca-035846	Felis catus	87.30	7.00e-161	559.00
IUUC-Fal-037597	Ficedula albicollis	99.65	6.00e-166	575.00
IUUC-Fox-037670	Fusarium oxysporum	49.74	2.00e-47	182.00
IUUC-Fso-038243	Fusarium solani	49.74	5.00e-47	181.00
IUUC-Gmo-038499	Gadus morhua	84.72	2.00e-149	521.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.54	1.00e-42	166.00
IUUC-Gga-040904	Gallus gallus	97.70	3.00e-177	613.00
IUUC-Gac-042058	Gasterosteus aculeatus	89.93	1.00e-158	551.00
IUUC-Gma-043763	Glycine max	49.06	4.00e-77	281.00
IUUC-Ggo-044699	Gorilla gorilla	88.30	7.00e-148	515.00
IUUC-Hsa-046227	Homo sapiens	94.79	9.00e-165	572.00
IUUC-Hvu-047359	Hordeum vulgare	46.13	2.00e-74	272.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	86.21	2.00e-160	558.00
IUUC-Lch-049829	Latimeria chalumnae	93.06	4.00e-162	563.00
IUUC-Lpe-050899	Leersia perrieri	46.31	2.00e-69	255.00
IUUC-Loc-052264	Lepisosteus oculatus	91.70	1.00e-160	558.00
IUUC-Lma-053110	Leptosphaeria maculans	36.82	2.00e-42	166.00
IUUC-Laf-053639	Loxodonta africana	95.49	8.00e-166	575.00
IUUC-Mcc-055506	Macaca mulatta	94.79	4.00e-163	566.00
IUUC-Mor-057001	Magnaporthe oryzae	43.81	7.00e-48	183.00
IUUC-Mpo-057608	Magnaporthe poae	39.76	4.00e-27	114.00
IUUC-Mtr-057731	Medicago truncatula	47.78	2.00e-76	278.00
IUUC-Mla-059016	Melampsora laricipopulina	42.62	8.00e-38	149.00
IUUC-Mga-060178	Meleagris gallopavo	98.03	2.00e-178	617.00
IUUC-Mvi-060353	Microbotryum violaceum	37.74	3.00e-48	184.00
IUUC-Mmr-060738	Microcebus murinus	95.14	3.00e-165	573.00
IUUC-Mdo-062266	Monodelphis domestica	96.22	4.00e-107	379.00
IUUC-Mmu-063619	Mus musculus	93.06	3.00e-162	563.00
IUUC-Mac-065301	Musa acuminata	50.17	2.00e-80	291.00
IUUC-Mpu-066058	Mustela putorius furo	95.83	3.00e-166	577.00
IUUC-Mlu-067292	Myotis lucifugus	94.44	1.00e-162	565.00
IUUC-Nfi-068275	Neosartorya fischeri	37.33	3.00e-48	185.00
IUUC-Ncr-068713	Neurospora crassa	38.51	1.00e-51	196.00
IUUC-Nle-069013	Nomascus leucogenys	94.44	1.00e-162	565.00
IUUC-Opr-070628	Ochotona princeps	85.99	2.00e-158	551.00
IUUC-Ont-072688	Oreochromis niloticus	90.69	7.00e-159	552.00
IUUC-Oan-073004	Ornithorhynchus anatinus	95.88	1.00e-140	491.00
IUUC-Ocu-074303	Oryctolagus cuniculus	95.83	1.00e-166	579.00
IUUC-Oba-075002	Oryza barthii	47.44	6.00e-74	270.00
IUUC-Obr-076392	Oryza brachyantha	48.32	2.00e-71	262.00
IUUC-Ogl-077271	Oryza glaberrima	47.44	6.00e-74	270.00
IUUC-Ogu-078493	Oryza glumaepatula	47.28	1.00e-74	273.00
IUUC-Oin-080084	Oryza indica	47.28	1.00e-74	273.00
IUUC-Olo-080803	Oryza longistaminata	46.96	2.00e-74	271.00
IUUC-Ome-081146	Oryza meridionalis	46.33	3.00e-73	268.00
IUUC-Oni-082146	Oryza nivara	47.28	1.00e-74	273.00
IUUC-Opu-083633	Oryza punctata	47.65	3.00e-70	258.00
IUUC-Oru-084789	Oryza rufipogon	47.28	1.00e-74	273.00
IUUC-Osa-086196	Oryza sativa	47.28	1.00e-74	273.00
IUUC-Ola-087126	Oryzias latipes	90.97	1.00e-154	538.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.89	6.00e-61	227.00
IUUC-Oga-089140	Otolemur garnettii	86.35	1.00e-159	555.00
IUUC-Oar-090296	Ovis aries	95.49	4.00e-166	576.00
IUUC-Ptr-090566	Pan troglodytes	94.79	9.00e-165	572.00
IUUC-Pan-092052	Papio anubis	94.79	5.00e-163	566.00
IUUC-Psi-093723	Pelodiscus sinensis	97.57	2.00e-169	587.00
IUUC-Pma-094568	Petromyzon marinus	61.11	2.00e-108	384.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.93	1.00e-43	169.00
IUUC-Ppa-095761	Physcomitrella patens	47.06	2.00e-76	278.00
IUUC-Pfo-096210	Poecilia formosa	89.58	2.00e-158	551.00
IUUC-Pab-098463	Pongo abelii	94.79	8.00e-165	572.00
IUUC-Pop-099423	Populus trichocarpa	49.84	9.00e-78	283.00
IUUC-Pca-100108	Procavia capensis	94.12	5.00e-124	436.00
IUUC-Ppe-101176	Prunus persica	49.83	5.00e-76	277.00
IUUC-Pva-102629	Pteropus vampyrus	92.41	1.00e-129	455.00
IUUC-Pgr-103419	Puccinia graminis	40.32	2.00e-50	191.00
IUUC-Pte-104207	Pyrenophora teres	42.57	8.00e-26	108.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.03	4.00e-50	191.00
IUUC-Rno-105579	Rattus norvegicus	83.59	2.00e-157	547.00
IUUC-Sha-106894	Sarcophilus harrisii	92.75	8.00e-154	535.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	37.81	2.00e-52	198.00
IUUC-Spo-108371	Schizosaccharomyces pombe	40.00	7.00e-54	203.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.13	3.00e-48	184.00
IUUC-Smo-109396	Selaginella moellendorffii	50.33	2.00e-80	291.00
IUUC-Sit-110630	Setaria italica	49.03	7.00e-78	283.00
IUUC-Sly-110972	Solanum lycopersicum	49.84	1.00e-81	296.00
IUUC-Stu-112185	Solanum tuberosum	49.52	3.00e-81	294.00
IUUC-Sar-113294	Sorex araneus	78.42	1.00e-146	511.00
IUUC-Sbi-113951	Sorghum bicolor	49.35	4.00e-78	284.00
IUUC-Ssc-115501	Sus scrofa	95.83	1.00e-166	578.00
IUUC-Tru-118388	Takifugu rubripes	90.28	1.00e-159	555.00
IUUC-Tsy-119109	Tarsius syrichta	95.14	3.00e-165	573.00
IUUC-Tni-120048	Tetraodon nigroviridis	90.28	4.00e-160	556.00
IUUC-Tca-121750	Theobroma cacao	49.22	1.00e-80	292.00
IUUC-Tre-122130	Trichoderma reesei	37.63	2.00e-48	185.00
IUUC-Tvi-122284	Trichoderma virens	38.61	2.00e-46	178.00
IUUC-Tae-124082	Triticum aestivum	46.75	4.00e-74	271.00
IUUC-Tur-126366	Triticum urartu	43.65	2.00e-65	242.00
IUUC-Tme-127187	Tuber melanosporum	40.07	9.00e-53	199.00
IUUC-Tbe-127619	Tupaia belangeri	86.41	3.00e-139	487.00
IUUC-Ttr-128867	Tursiops truncatus	84.90	2.00e-121	427.00
IUUC-Vda-129912	Verticillium dahliae	37.32	1.00e-46	179.00
IUUC-Vpa-130552	Vicugna pacos	97.28	2.00e-108	384.00
IUUC-Vvi-130881	Vitis vinifera	50.00	6.00e-77	280.00
IUUC-Xtr-131934	Xenopus tropicalis	85.53	4.00e-160	556.00
IUUC-Xma-133312	Xiphophorus maculatus	89.24	3.00e-157	546.00
IUUC-Zma-135639	Zea mays	49.83	9.00e-71	259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence