iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062458

UUCD1 version

UUC-MoD-01037

Ensembl Protein ID

ENSMODP00000025716.2

UniProt Accession

F7AQ16; F7AQ16_MONDO

Protein Name

Uncharacterized protein

Gene Name

UBE2K

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000020556.2	ENSMODT00000026174.2	ENSMODP00000025716.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	8.00e-44	148.9	8	145
UBD/Alpha-Helix/UBA	5.00e-11	42.5	160	198

Active Site

Position(s)	Description	Evidence
91	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkel...ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsi 85
           R+k+e+ke+   e++++++i++++vde ++te++ +i Gp+dtpYeg +++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+i
   Q: 8    RIKREFKEVlksEETSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEG-KYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDI 94
           7888888873335556699********.9****************95.79******************************99******* PP
   S: 86   lkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lk  ++W +a+++++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 95   LK--DQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 145
           *9..**********************************************986 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL + ++++e A+e+Ll+
   Q: 160  EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLS 198
           6789*********************************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGKYQLEIK 60
IPETYPFNPP KVRFITKIWH PNISSVTGAI CLDILKDQWA AAMTLRTVLL SLQALLAAAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGAGGCG GCGGAGGAGG TGGCGGCGGC GGCGGCGGCG GTCGTGGCGG TGGCGGAGGC 60
GGGGGGTGTG AAACGGCTGC GGGAGGAGAC ATGGCCAACA TTGCGGTGCA GCGAATCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0032433--C:filopodium tip
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0035458--P:cellular response to interferon-beta
GO:0010994--P:free ubiquitin chain polymerization
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	50.52	3.00e-26	111.00
IUUC-Aml-001286	Ailuropoda melanoleuca	99.00	2.00e-107	381.00
IUUC-Atr-003063	Amborella trichopoda	47.42	1.00e-37	149.00
IUUC-Apl-004122	Anas platyrhynchos	90.50	3.00e-94	337.00
IUUC-Aca-004565	Anolis carolinensis	93.68	1.00e-96	345.00
IUUC-Aly-006390	Arabidopsis lyrata	47.21	5.00e-42	163.00
IUUC-Ath-006637	Arabidopsis thaliana	46.38	3.00e-39	154.00
IUUC-Acl-008189	Aspergillus clavatus	49.03	1.00e-26	113.00
IUUC-Afl-008489	Aspergillus flavus	40.93	5.00e-27	114.00
IUUC-Afu-008850	Aspergillus fumigatus	39.72	2.00e-27	116.00
IUUC-Ani-009361	Aspergillus nidulans	49.32	2.00e-25	109.00
IUUC-Ang-009548	Aspergillus niger	47.10	4.00e-25	108.00
IUUC-Aor-010105	Aspergillus oryzae	40.93	5.00e-27	114.00
IUUC-Ate-010389	Aspergillus terreus	39.63	1.00e-26	113.00
IUUC-Ame-011454	Astyanax mexicanus	96.00	7.00e-105	372.00
IUUC-Bgr-012255	Blumeria graminis	47.77	9.00e-32	130.00
IUUC-Bta-012992	Bos taurus	99.00	2.00e-107	381.00
IUUC-Bci-013806	Botrytis cinerea	39.63	4.00e-34	138.00
IUUC-Bdi-015024	Brachypodium distachyon	47.72	1.00e-38	152.00
IUUC-Bol-015985	Brassica oleracea	47.72	2.00e-42	165.00
IUUC-Bra-016805	Brassica rapa	47.72	6.00e-43	166.00
IUUC-Cel-018353	Caenorhabditis elegans	51.76	2.00e-54	205.00
IUUC-Cja-019051	Callithrix jacchus	98.50	1.00e-106	378.00
IUUC-Cfa-020016	Canis familiaris	99.00	2.00e-107	381.00
IUUC-Cpo-022026	Cavia porcellus	99.00	2.00e-107	381.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	48.47	7.00e-40	156.00
IUUC-Csa-023059	Chlorocebus sabaeus	99.00	2.00e-107	381.00
IUUC-Cho-024276	Choloepus hoffmanni	95.92	3.00e-73	266.00
IUUC-Cin-025598	Ciona intestinalis	60.71	3.00e-54	204.00
IUUC-Csv-025831	Ciona savignyi	61.73	1.00e-52	199.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	43.90	4.00e-32	131.00
IUUC-Cne-027068	Cryptococcus neoformans	40.89	5.00e-39	154.00
IUUC-Dre-028139	Danio rerio	96.00	7.00e-105	372.00
IUUC-Dno-029169	Dasypus novemcinctus	92.50	1.00e-99	355.00
IUUC-Dor-030382	Dipodomys ordii	85.00	6.00e-86	309.00
IUUC-Dse-031335	Dothistroma septosporum	51.59	7.00e-36	144.00
IUUC-Dme-032003	Drosophila melanogaster	68.34	1.00e-69	255.00
IUUC-Ete-032868	Echinops telfairi	91.96	3.00e-90	323.00
IUUC-Eca-033428	Equus caballus	99.00	2.00e-107	381.00
IUUC-Eeu-035103	Erinaceus europaeus	73.44	3.00e-49	186.00
IUUC-Fca-035366	Felis catus	99.00	2.00e-107	381.00
IUUC-Fal-037016	Ficedula albicollis	99.00	2.00e-107	381.00
IUUC-Fox-037969	Fusarium oxysporum	42.08	5.00e-32	130.00
IUUC-Fso-038296	Fusarium solani	43.72	5.00e-34	137.00
IUUC-Gmo-039135	Gadus morhua	95.00	2.00e-103	367.00
IUUC-Ggr-039768	Gaeumannomyces graminis	45.00	1.00e-24	106.00
IUUC-Gga-041018	Gallus gallus	98.50	3.00e-107	380.00
IUUC-Gac-041503	Gasterosteus aculeatus	95.50	2.00e-104	370.00
IUUC-Gma-042779	Glycine max	49.74	2.00e-41	161.00
IUUC-Ggo-045032	Gorilla gorilla	99.00	2.00e-107	381.00
IUUC-Hsa-046490	Homo sapiens	99.00	2.00e-107	381.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	99.00	2.00e-107	381.00
IUUC-Kpa-049297	Komagataella pastoris	48.37	8.00e-32	130.00
IUUC-Lch-050588	Latimeria chalumnae	67.30	2.00e-73	268.00
IUUC-Lpe-051070	Leersia perrieri	47.72	1.00e-30	126.00
IUUC-Loc-052549	Lepisosteus oculatus	96.50	3.00e-105	373.00
IUUC-Lma-052949	Leptosphaeria maculans	49.36	1.00e-35	142.00
IUUC-Laf-053688	Loxodonta africana	91.18	1.00e-97	348.00
IUUC-Mcc-055606	Macaca mulatta	99.00	2.00e-107	381.00
IUUC-Mor-056946	Magnaporthe oryzae	36.45	5.00e-22	97.40
IUUC-Mpo-057441	Magnaporthe poae	47.77	1.00e-24	106.00
IUUC-Mtr-058002	Medicago truncatula	49.21	5.00e-41	160.00
IUUC-Mga-059254	Meleagris gallopavo	97.78	5.00e-95	339.00
IUUC-Mvi-060346	Microbotryum violaceum	41.00	1.00e-31	129.00
IUUC-Mmr-061211	Microcebus murinus	99.00	2.00e-107	381.00
IUUC-Mmu-063648	Mus musculus	99.00	2.00e-107	381.00
IUUC-Mac-065447	Musa acuminata	47.72	3.00e-39	154.00
IUUC-Mpu-066407	Mustela putorius furo	99.00	6.00e-107	380.00
IUUC-Mlu-067682	Myotis lucifugus	91.92	1.00e-97	348.00
IUUC-Nfi-068517	Neosartorya fischeri	39.72	1.00e-27	116.00
IUUC-Ncr-068749	Neurospora crassa	47.44	2.00e-36	145.00
IUUC-Nle-069712	Nomascus leucogenys	97.78	5.00e-95	340.00
IUUC-Opr-070651	Ochotona princeps	99.00	2.00e-107	381.00
IUUC-Ont-071595	Oreochromis niloticus	95.50	2.00e-104	370.00
IUUC-Oan-073058	Ornithorhynchus anatinus	99.32	1.00e-77	281.00
IUUC-Ocu-074939	Oryctolagus cuniculus	99.00	2.00e-107	381.00
IUUC-Oba-075530	Oryza barthii	48.48	7.00e-30	123.00
IUUC-Obr-076838	Oryza brachyantha	47.98	3.00e-29	121.00
IUUC-Ogl-077606	Oryza glaberrima	48.48	7.00e-30	123.00
IUUC-Ogu-078238	Oryza glumaepatula	48.48	7.00e-30	123.00
IUUC-Oin-079643	Oryza indica	48.48	2.00e-29	122.00
IUUC-Ome-081274	Oryza meridionalis	48.48	7.00e-30	123.00
IUUC-Oni-082651	Oryza nivara	48.48	7.00e-30	123.00
IUUC-Opu-083933	Oryza punctata	48.48	2.00e-29	122.00
IUUC-Oru-085054	Oryza rufipogon	48.48	1.00e-29	122.00
IUUC-Osa-085716	Oryza sativa	48.48	2.00e-29	122.00
IUUC-Ola-087043	Oryzias latipes	95.50	2.00e-104	370.00
IUUC-Olu-087846	Ostreococcus lucimarinus	46.11	7.00e-40	156.00
IUUC-Oga-088897	Otolemur garnettii	92.93	1.00e-97	348.00
IUUC-Oar-089673	Ovis aries	91.92	5.00e-98	349.00
IUUC-Ptr-091295	Pan troglodytes	99.00	2.00e-107	381.00
IUUC-Pan-092034	Papio anubis	98.88	4.00e-95	340.00
IUUC-Psi-093498	Pelodiscus sinensis	99.00	2.00e-107	381.00
IUUC-Pma-094115	Petromyzon marinus	81.91	3.00e-87	314.00
IUUC-Pno-095102	Phaeosphaeria nodorum	40.28	8.00e-36	143.00
IUUC-Ppa-095326	Physcomitrella patens	45.69	4.00e-38	150.00
IUUC-Pfo-096940	Poecilia formosa	95.50	2.00e-104	370.00
IUUC-Pab-098279	Pongo abelii	99.00	2.00e-107	381.00
IUUC-Pop-099543	Populus trichocarpa	48.73	3.00e-42	164.00
IUUC-Pca-100782	Procavia capensis	98.50	2.00e-105	374.00
IUUC-Ppe-101789	Prunus persica	47.42	4.00e-35	140.00
IUUC-Pva-102147	Pteropus vampyrus	71.02	9.00e-57	212.00
IUUC-Pte-104370	Pyrenophora teres	49.36	2.00e-35	142.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	40.74	2.00e-35	142.00
IUUC-Rno-104984	Rattus norvegicus	99.00	2.00e-107	381.00
IUUC-Sce-106394	Saccharomyces cerevisiae	43.01	2.00e-33	135.00
IUUC-Sha-106624	Sarcophilus harrisii	92.50	2.00e-101	360.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	42.40	1.00e-38	153.00
IUUC-Smo-109656	Selaginella moellendorffii	47.96	2.00e-38	151.00
IUUC-Sit-110639	Setaria italica	47.47	2.00e-37	148.00
IUUC-Sly-110978	Solanum lycopersicum	47.72	8.00e-42	162.00
IUUC-Stu-112088	Solanum tuberosum	47.72	4.00e-42	164.00
IUUC-Sar-113285	Sorex araneus	83.24	1.00e-73	268.00
IUUC-Sbi-113986	Sorghum bicolor	47.47	3.00e-37	147.00
IUUC-Ssc-116314	Sus scrofa	99.00	2.00e-107	381.00
IUUC-Tgu-117427	Taeniopygia guttata	98.33	2.00e-95	340.00
IUUC-Tru-118618	Takifugu rubripes	91.50	5.00e-100	356.00
IUUC-Tsy-119208	Tarsius syrichta	96.97	5.00e-104	369.00
IUUC-Tni-119667	Tetraodon nigroviridis	96.00	9.00e-105	372.00
IUUC-Tca-121446	Theobroma cacao	49.24	4.00e-43	167.00
IUUC-Tre-122053	Trichoderma reesei	38.12	9.00e-30	123.00
IUUC-Tae-124726	Triticum aestivum	48.22	2.00e-31	128.00
IUUC-Tme-127024	Tuber melanosporum	48.77	4.00e-37	147.00
IUUC-Tbe-127752	Tupaia belangeri	95.50	2.00e-102	364.00
IUUC-Ttr-128287	Tursiops truncatus	98.88	3.00e-95	340.00
IUUC-Vda-129947	Verticillium dahliae	36.23	9.00e-29	120.00
IUUC-Vpa-130481	Vicugna pacos	98.98	2.00e-105	374.00
IUUC-Vvi-131429	Vitis vinifera	45.69	2.00e-39	155.00
IUUC-Xtr-132710	Xenopus tropicalis	82.18	8.00e-93	332.00
IUUC-Xma-134165	Xiphophorus maculatus	95.00	6.00e-104	369.00
IUUC-Zma-135733	Zea mays	46.67	1.00e-35	142.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence