iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048496

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AGTP01015556

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000015507.2	ENSSTOT00000015509.2	ENSSTOP00000013884.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	5.60e-63	213.3	2	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P+++++++ ++gv +++++ ++ +L+++ lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+i
   Q: 2    QLKPMEINPEMLNKVLARLGVAGQWRFADVLGLEEDALGSVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTI 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t++l+++++n++dkl ++ G+ l++++++t+++spe++a++++++++++++h+++a++++++ +          +k +fhf+++
   Q: 87   GNSCGTIGLIHAVANNQDKLeFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DKVNFHFILF 165
           *******************************************************************99..........5679****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
            n++g+lyeldg++pfP+++g ++e   l+d++kv+r+f+er    e++e+rf+++a++++
   Q: 166  NNVDGHLYELDGRMPFPVNHGTSSEGSLLQDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ******************************************....************987 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLARL GVAGQWRFAD VLGLEEDALG SVPAPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLEFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATGCAGCT CAAACCGATG GAGATTAACC CTGAGGTGAG CGCCGAGTGC ACCGTTGCCC 60
GGGGGAGCGG AGGGCTTAGG GTCGGCGGTG GCAAAGGAGT GGTATTGCTG ACTTAATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	38.43	3.00e-44	171.00
IUUC-Aml-001376	Ailuropoda melanoleuca	81.25	1.00e-113	401.00
IUUC-Atr-002931	Amborella trichopoda	43.28	1.00e-39	155.00
IUUC-Apl-003693	Anas platyrhynchos	69.20	9.00e-91	325.00
IUUC-Aca-004716	Anolis carolinensis	75.00	2.00e-100	357.00
IUUC-Aly-005721	Arabidopsis lyrata	41.18	1.00e-46	179.00
IUUC-Ath-006827	Arabidopsis thaliana	41.74	4.00e-48	184.00
IUUC-Acl-008305	Aspergillus clavatus	34.98	4.00e-29	121.00
IUUC-Afl-008611	Aspergillus flavus	36.96	5.00e-33	134.00
IUUC-Afu-008945	Aspergillus fumigatus	36.09	5.00e-31	127.00
IUUC-Ani-009339	Aspergillus nidulans	35.65	1.00e-31	129.00
IUUC-Ang-009691	Aspergillus niger	35.65	3.00e-32	131.00
IUUC-Aor-009961	Aspergillus oryzae	36.96	5.00e-33	134.00
IUUC-Ate-010316	Aspergillus terreus	36.09	4.00e-33	134.00
IUUC-Ame-011806	Astyanax mexicanus	66.82	2.00e-84	304.00
IUUC-Bgr-012125	Blumeria graminis	34.04	9.00e-30	123.00
IUUC-Bta-013521	Bos taurus	82.14	3.00e-115	407.00
IUUC-Bci-013734	Botrytis cinerea	34.91	7.00e-33	133.00
IUUC-Bdi-014330	Brachypodium distachyon	41.36	3.00e-46	178.00
IUUC-Bol-015214	Brassica oleracea	41.28	3.00e-48	184.00
IUUC-Bra-017721	Brassica rapa	41.74	1.00e-48	186.00
IUUC-Cel-018302	Caenorhabditis elegans	35.35	7.00e-33	133.00
IUUC-Cja-018752	Callithrix jacchus	96.43	3.00e-117	413.00
IUUC-Cfa-020442	Canis familiaris	97.77	1.00e-118	418.00
IUUC-Cpo-021723	Cavia porcellus	98.80	1.00e-95	341.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	38.86	2.00e-32	131.00
IUUC-Csa-023626	Chlorocebus sabaeus	96.86	9.00e-119	418.00
IUUC-Cho-024548	Choloepus hoffmanni	87.04	2.00e-41	161.00
IUUC-Cin-025545	Ciona intestinalis	46.22	2.00e-55	208.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	33.19	4.00e-27	114.00
IUUC-Cne-026914	Cryptococcus neoformans	33.33	2.00e-23	102.00
IUUC-Cme-027216	Cyanidioschyzon merolae	32.89	2.00e-19	88.60
IUUC-Dre-027854	Danio rerio	64.29	5.00e-83	300.00
IUUC-Dno-029325	Dasypus novemcinctus	97.76	8.00e-120	422.00
IUUC-Dor-030114	Dipodomys ordii	94.62	3.00e-126	443.00
IUUC-Dme-032146	Drosophila melanogaster	44.69	3.00e-53	201.00
IUUC-Ete-033092	Echinops telfairi	78.03	4.00e-97	346.00
IUUC-Eca-033854	Equus caballus	97.89	3.00e-80	289.00
IUUC-Eeu-034493	Erinaceus europaeus	92.83	3.00e-113	400.00
IUUC-Fal-036693	Ficedula albicollis	72.86	2.00e-91	327.00
IUUC-Fox-037830	Fusarium oxysporum	34.76	3.00e-32	131.00
IUUC-Fso-038259	Fusarium solani	33.62	8.00e-31	129.00
IUUC-Gmo-038848	Gadus morhua	61.32	7.00e-75	272.00
IUUC-Ggr-039832	Gaeumannomyces graminis	34.06	1.00e-25	109.00
IUUC-Gga-041078	Gallus gallus	73.66	3.00e-100	357.00
IUUC-Gac-042064	Gasterosteus aculeatus	62.27	6.00e-78	283.00
IUUC-Gma-043057	Glycine max	42.73	8.00e-43	166.00
IUUC-Ggo-044827	Gorilla gorilla	95.96	2.00e-117	414.00
IUUC-Hsa-045820	Homo sapiens	95.96	2.00e-117	414.00
IUUC-Hvu-047176	Hordeum vulgare	36.16	7.00e-38	150.00
IUUC-Lch-050121	Latimeria chalumnae	72.97	4.00e-97	346.00
IUUC-Lpe-051377	Leersia perrieri	42.05	4.00e-40	157.00
IUUC-Loc-052342	Lepisosteus oculatus	69.03	3.00e-91	327.00
IUUC-Lma-053316	Leptosphaeria maculans	35.93	2.00e-33	135.00
IUUC-Laf-053916	Loxodonta africana	95.11	2.00e-116	410.00
IUUC-Mcc-054838	Macaca mulatta	96.86	9.00e-119	418.00
IUUC-Meu-056478	Macropus eugenii	88.34	4.00e-120	423.00
IUUC-Mor-057271	Magnaporthe oryzae	33.62	3.00e-31	127.00
IUUC-Mpo-057343	Magnaporthe poae	31.49	1.00e-17	82.40
IUUC-Mtr-057713	Medicago truncatula	40.45	7.00e-43	166.00
IUUC-Mla-058942	Melampsora laricipopulina	34.91	2.00e-36	145.00
IUUC-Mga-059878	Meleagris gallopavo	72.35	3.00e-94	337.00
IUUC-Mdo-062544	Monodelphis domestica	87.89	1.00e-109	388.00
IUUC-Mmu-063300	Mus musculus	96.41	6.00e-128	449.00
IUUC-Mac-065075	Musa acuminata	40.72	1.00e-43	169.00
IUUC-Mpu-066128	Mustela putorius furo	96.50	2.00e-104	370.00
IUUC-Mlu-067778	Myotis lucifugus	96.41	1.00e-127	448.00
IUUC-Ncr-068673	Neurospora crassa	34.06	6.00e-33	133.00
IUUC-Nle-069686	Nomascus leucogenys	95.96	2.00e-117	414.00
IUUC-Opr-070535	Ochotona princeps	78.92	2.00e-99	354.00
IUUC-Ont-071510	Oreochromis niloticus	62.16	6.00e-79	286.00
IUUC-Ocu-074590	Oryctolagus cuniculus	95.96	6.00e-118	416.00
IUUC-Oba-075098	Oryza barthii	38.25	1.00e-43	169.00
IUUC-Obr-076041	Oryza brachyantha	40.27	4.00e-45	174.00
IUUC-Ogl-076980	Oryza glaberrima	40.72	1.00e-44	172.00
IUUC-Ogu-078978	Oryza glumaepatula	36.18	1.00e-41	162.00
IUUC-Oin-079285	Oryza indica	37.79	5.00e-43	166.00
IUUC-Olo-080671	Oryza longistaminata	37.79	2.00e-42	165.00
IUUC-Ome-081428	Oryza meridionalis	36.87	6.00e-41	160.00
IUUC-Oni-082406	Oryza nivara	38.25	1.00e-43	169.00
IUUC-Opu-083305	Oryza punctata	36.87	6.00e-42	163.00
IUUC-Oru-084969	Oryza rufipogon	38.25	1.00e-43	169.00
IUUC-Osa-085830	Oryza sativa	40.72	1.00e-44	172.00
IUUC-Ola-086893	Oryzias latipes	57.21	2.00e-66	244.00
IUUC-Olu-087858	Ostreococcus lucimarinus	35.45	2.00e-36	145.00
IUUC-Oga-089013	Otolemur garnettii	82.14	7.00e-114	402.00
IUUC-Oar-089861	Ovis aries	82.14	2.00e-115	407.00
IUUC-Ptr-091536	Pan troglodytes	94.17	5.00e-115	405.00
IUUC-Pan-092909	Papio anubis	96.86	9.00e-119	418.00
IUUC-Psi-093818	Pelodiscus sinensis	78.57	2.00e-103	367.00
IUUC-Ppa-095519	Physcomitrella patens	41.70	4.00e-46	177.00
IUUC-Pfo-097335	Poecilia formosa	58.22	1.00e-76	278.00
IUUC-Pab-098048	Pongo abelii	95.96	2.00e-117	414.00
IUUC-Pop-099282	Populus trichocarpa	43.18	1.00e-45	176.00
IUUC-Pca-100818	Procavia capensis	73.33	2.00e-67	247.00
IUUC-Ppe-101332	Prunus persica	42.27	1.00e-46	178.00
IUUC-Pva-102954	Pteropus vampyrus	95.52	9.00e-113	398.00
IUUC-Pgr-103430	Puccinia graminis	36.10	5.00e-35	140.00
IUUC-Ptt-103955	Puccinia triticina	38.30	8.00e-36	143.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	36.54	7.00e-30	123.00
IUUC-Rno-105966	Rattus norvegicus	96.41	6.00e-128	449.00
IUUC-Sha-107111	Sarcophilus harrisii	86.67	1.00e-86	311.00
IUUC-Ssl-108641	Sclerotinia sclerotiorum	34.47	1.00e-30	126.00
IUUC-Smo-109283	Selaginella moellendorffii	40.79	2.00e-42	165.00
IUUC-Sit-110163	Setaria italica	40.27	1.00e-45	176.00
IUUC-Sly-111832	Solanum lycopersicum	44.50	8.00e-49	186.00
IUUC-Stu-112526	Solanum tuberosum	44.50	5.00e-49	187.00
IUUC-Sar-113190	Sorex araneus	74.56	1.00e-38	150.00
IUUC-Sbi-114545	Sorghum bicolor	40.54	6.00e-44	170.00
IUUC-Ssc-115908	Sus scrofa	80.00	4.00e-101	360.00
IUUC-Tgu-117465	Taeniopygia guttata	68.72	4.00e-85	306.00
IUUC-Tru-118565	Takifugu rubripes	60.29	6.00e-69	253.00
IUUC-Tsy-119561	Tarsius syrichta	78.92	2.00e-98	351.00
IUUC-Tca-120976	Theobroma cacao	43.12	3.00e-47	181.00
IUUC-Tre-122149	Trichoderma reesei	37.66	2.00e-34	138.00
IUUC-Tvi-122450	Trichoderma virens	36.80	2.00e-34	139.00
IUUC-Tae-122693	Triticum aestivum	39.82	1.00e-45	176.00
IUUC-Tur-126250	Triticum urartu	38.43	8.00e-44	169.00
IUUC-Tme-126961	Tuber melanosporum	36.91	2.00e-31	129.00
IUUC-Tbe-128048	Tupaia belangeri	96.36	2.00e-93	333.00
IUUC-Ttr-128494	Tursiops truncatus	95.95	4.00e-116	409.00
IUUC-Vda-129850	Verticillium dahliae	33.77	5.00e-28	117.00
IUUC-Vvi-131661	Vitis vinifera	39.91	9.00e-46	176.00
IUUC-Xtr-132286	Xenopus tropicalis	67.71	4.00e-90	323.00
IUUC-Xma-133019	Xiphophorus maculatus	58.74	9.00e-77	279.00
IUUC-Yli-134570	Yarrowia lipolytica	34.20	5.00e-30	124.00
IUUC-Zma-134740	Zea mays	40.54	3.00e-44	171.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence