iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19269966; 20385102

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.40e-07	32.2	26	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  +v  CgH+f+  Cl +w    +   +++ CP+C+
   Q: 26   CNICLDAAKD-AVVSLCGHLFCWPCLSQW---LDTRPNNQVCPVCK 67
           99********.66688*************...788999*******7 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MASETKAPSE EPTSSSNKDE SARFECNICL DAAKDAVVSL CGHLFCWPCL SQWLDTRPNN 60
QVCPVCKSAI DGNKVVPIYG RGGDSSDPRK KVPPRPKGQR SEPPPQSFAG FNWGGDGGMM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGTTCGGA GCCAATGGCG TCGGAGACGA AAGCTCCATC CGAGGAGCCC ACGAGCTCCA 60
GTAATAAAGA TGAATCTGCG AGGTAAATTT AGAAAAAAAT CGATGTTTTA ATCGTTAGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0030054--C:cell junction
GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005634--C:nucleus
GO:0055120--C:striated muscle dense body
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0040039--P:inductive cell migration
GO:0018996--P:molting cycle, collagen and cuticulin-based cuticle
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0055002--P:striated muscle cell development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001042	Aegilops tauschii	51.72	1.00e-24	105.00
IUUC-Aml-001875	Ailuropoda melanoleuca	68.92	8.00e-29	118.00
IUUC-Atr-002444	Amborella trichopoda	47.79	3.00e-27	114.00
IUUC-Apl-003744	Anas platyrhynchos	72.86	2.00e-28	115.00
IUUC-Aca-004254	Anolis carolinensis	60.49	5.00e-27	112.00
IUUC-Aly-006065	Arabidopsis lyrata	57.65	1.00e-26	111.00
IUUC-Ath-007401	Arabidopsis thaliana	51.72	1.00e-25	108.00
IUUC-Acl-008372	Aspergillus clavatus	39.29	3.00e-11	61.60
IUUC-Afl-008450	Aspergillus flavus	38.18	2.00e-10	58.90
IUUC-Afu-009049	Aspergillus fumigatus	39.29	4.00e-11	61.20
IUUC-Ani-009256	Aspergillus nidulans	39.29	2.00e-11	61.60
IUUC-Ang-009867	Aspergillus niger	37.70	4.00e-11	61.20
IUUC-Aor-010008	Aspergillus oryzae	38.18	2.00e-10	58.90
IUUC-Ate-010548	Aspergillus terreus	39.29	6.00e-11	60.50
IUUC-Ame-011316	Astyanax mexicanus	56.35	7.00e-35	138.00
IUUC-Bgr-012234	Blumeria graminis	36.07	3.00e-10	58.20
IUUC-Bta-012734	Bos taurus	68.92	1.00e-28	118.00
IUUC-Bci-013613	Botrytis cinerea	36.51	2.00e-09	55.50
IUUC-Bdi-014183	Brachypodium distachyon	50.00	7.00e-25	105.00
IUUC-Bol-016132	Brassica oleracea	42.00	7.00e-30	122.00
IUUC-Bra-017113	Brassica rapa	56.47	4.00e-26	109.00
IUUC-Cja-019136	Callithrix jacchus	68.92	8.00e-29	118.00
IUUC-Cfa-020308	Canis familiaris	68.92	8.00e-29	118.00
IUUC-Cpo-021347	Cavia porcellus	68.92	7.00e-29	118.00
IUUC-Cre-022829	Chlamydomonas reinhardtii	52.63	1.00e-25	105.00
IUUC-Csa-023755	Chlorocebus sabaeus	68.92	6.00e-29	119.00
IUUC-Cin-025421	Ciona intestinalis	24.82	5.00e-07	48.50
IUUC-Cgl-026468	Colletotrichum gloeosporioides	32.76	6.00e-09	52.40
IUUC-Cme-027164	Cyanidioschyzon merolae	45.45	7.00e-16	76.30
IUUC-Dre-028094	Danio rerio	68.49	4.00e-28	116.00
IUUC-Dno-029402	Dasypus novemcinctus	68.92	8.00e-29	118.00
IUUC-Dor-030373	Dipodomys ordii	68.92	8.00e-29	118.00
IUUC-Dse-031244	Dothistroma septosporum	39.29	4.00e-11	61.20
IUUC-Dme-031966	Drosophila melanogaster	37.61	6.00e-36	142.00
IUUC-Ete-032786	Echinops telfairi	68.92	7.00e-29	118.00
IUUC-Eca-034261	Equus caballus	68.92	8.00e-29	118.00
IUUC-Eeu-034614	Erinaceus europaeus	50.00	9.00e-17	78.60
IUUC-Fca-036049	Felis catus	68.92	8.00e-29	118.00
IUUC-Fal-037085	Ficedula albicollis	68.83	1.00e-28	117.00
IUUC-Fso-038195	Fusarium solani	44.00	8.00e-09	53.50
IUUC-Gmo-039369	Gadus morhua	64.94	9.00e-28	114.00
IUUC-Ggr-040036	Gaeumannomyces graminis	33.33	6.00e-09	54.30
IUUC-Gga-040514	Gallus gallus	68.92	2.00e-28	117.00
IUUC-Gac-041719	Gasterosteus aculeatus	73.44	1.00e-27	114.00
IUUC-Gma-043248	Glycine max	33.63	9.00e-27	112.00
IUUC-Ggo-044504	Gorilla gorilla	68.92	8.00e-29	118.00
IUUC-Hsa-045707	Homo sapiens	68.92	8.00e-29	118.00
IUUC-Hvu-047487	Hordeum vulgare	50.00	2.00e-25	107.00
IUUC-Itr-048343	Ictidomys tridecemlineatus	68.92	8.00e-29	118.00
IUUC-Lch-050658	Latimeria chalumnae	68.92	1.00e-28	117.00
IUUC-Lpe-051034	Leersia perrieri	53.93	7.00e-26	108.00
IUUC-Loc-052118	Lepisosteus oculatus	74.63	8.00e-28	115.00
IUUC-Lma-053179	Leptosphaeria maculans	32.79	2.00e-10	58.50
IUUC-Laf-054438	Loxodonta africana	68.92	7.00e-29	119.00
IUUC-Mcc-054833	Macaca mulatta	52.63	4.00e-32	129.00
IUUC-Meu-055984	Macropus eugenii	57.53	1.00e-23	100.00
IUUC-Mpo-057431	Magnaporthe poae	38.98	2.00e-09	56.20
IUUC-Mtr-058130	Medicago truncatula	53.12	2.00e-27	114.00
IUUC-Mga-059554	Meleagris gallopavo	68.92	2.00e-28	117.00
IUUC-Mvi-060316	Microbotryum violaceum	37.08	2.00e-11	60.80
IUUC-Mmr-061662	Microcebus murinus	58.44	1.00e-20	91.30
IUUC-Mdo-062774	Monodelphis domestica	68.92	8.00e-29	118.00
IUUC-Mmu-063372	Mus musculus	68.92	2.00e-28	117.00
IUUC-Mac-065390	Musa acuminata	44.68	3.00e-27	113.00
IUUC-Mpu-066033	Mustela putorius furo	68.92	6.00e-29	122.00
IUUC-Mlu-067254	Myotis lucifugus	68.92	8.00e-29	118.00
IUUC-Nfi-068271	Neosartorya fischeri	39.29	4.00e-11	61.20
IUUC-Ncr-068628	Neurospora crassa	43.10	1.00e-09	56.60
IUUC-Nle-069850	Nomascus leucogenys	68.92	8.00e-29	118.00
IUUC-Opr-070197	Ochotona princeps	74.60	2.00e-27	114.00
IUUC-Ont-071950	Oreochromis niloticus	74.29	9.00e-29	118.00
IUUC-Oan-073480	Ornithorhynchus anatinus	68.92	8.00e-29	118.00
IUUC-Ocu-074208	Oryctolagus cuniculus	54.47	4.00e-32	129.00
IUUC-Oba-075461	Oryza barthii	46.15	4.00e-25	107.00
IUUC-Obr-076382	Oryza brachyantha	44.70	8.00e-27	112.00
IUUC-Ogl-077553	Oryza glaberrima	49.49	4.00e-27	113.00
IUUC-Ogu-078463	Oryza glumaepatula	52.69	4.00e-27	113.00
IUUC-Oin-080177	Oryza indica	51.04	5.00e-27	112.00
IUUC-Olo-080653	Oryza longistaminata	46.15	2.00e-25	107.00
IUUC-Ome-081605	Oryza meridionalis	54.02	3.00e-26	110.00
IUUC-Oni-082458	Oryza nivara	52.69	1.00e-26	112.00
IUUC-Opu-083362	Oryza punctata	42.18	6.00e-26	109.00
IUUC-Oru-084757	Oryza rufipogon	52.22	3.00e-26	110.00
IUUC-Osa-086198	Oryza sativa	51.61	5.00e-26	110.00
IUUC-Ola-086800	Oryzias latipes	74.60	2.00e-27	114.00
IUUC-Olu-087623	Ostreococcus lucimarinus	37.08	1.00e-14	71.20
IUUC-Oga-088197	Otolemur garnettii	68.92	8.00e-29	118.00
IUUC-Oar-090284	Ovis aries	53.28	1.00e-33	134.00
IUUC-Ptr-090919	Pan troglodytes	52.45	3.00e-34	136.00
IUUC-Pan-092671	Papio anubis	68.92	6.00e-29	119.00
IUUC-Psi-093323	Pelodiscus sinensis	68.92	9.00e-29	118.00
IUUC-Pno-094942	Phaeosphaeria nodorum	36.27	1.00e-10	59.30
IUUC-Ppa-095474	Physcomitrella patens	43.33	2.00e-26	111.00
IUUC-Pfo-096943	Poecilia formosa	74.60	3.00e-27	113.00
IUUC-Pab-097845	Pongo abelii	68.92	8.00e-29	118.00
IUUC-Pop-099595	Populus trichocarpa	49.57	3.00e-29	120.00
IUUC-Pca-100319	Procavia capensis	53.33	2.00e-33	133.00
IUUC-Ppe-102011	Prunus persica	46.09	2.00e-28	117.00
IUUC-Pva-102298	Pteropus vampyrus	68.92	9.00e-29	118.00
IUUC-Pgr-103455	Puccinia graminis	35.48	8.00e-10	57.00
IUUC-Pte-104170	Pyrenophora teres	38.98	2.00e-10	58.50
IUUC-Pyt-104531	Pyrenophora triticirepentis	38.98	2.00e-10	58.50
IUUC-Rno-105293	Rattus norvegicus	68.92	6.00e-29	119.00
IUUC-Sce-106361	Saccharomyces cerevisiae	35.59	8.00e-07	46.60
IUUC-Sha-107361	Sarcophilus harrisii	68.92	5.00e-29	119.00
IUUC-Sja-107981	Schizosaccharomyces japonicus	35.29	7.00e-08	49.70
IUUC-Spo-108048	Schizosaccharomyces pombe	40.00	2.00e-08	51.20
IUUC-Ssl-108393	Sclerotinia sclerotiorum	36.51	1.00e-09	56.20
IUUC-Smo-109663	Selaginella moellendorffii	57.78	1.00e-27	113.00
IUUC-Sit-110376	Setaria italica	49.55	7.00e-28	115.00
IUUC-Sly-110917	Solanum lycopersicum	48.98	2.00e-27	114.00
IUUC-Stu-112552	Solanum tuberosum	48.98	4.00e-27	113.00
IUUC-Sar-113669	Sorex araneus	63.83	2.00e-14	68.90
IUUC-Sbi-114275	Sorghum bicolor	50.56	1.00e-24	105.00
IUUC-Sre-115184	Sporisorium reilianum	31.03	2.00e-07	48.50
IUUC-Ssc-116228	Sus scrofa	68.92	8.00e-29	118.00
IUUC-Tgu-116886	Taeniopygia guttata	68.83	1.00e-28	117.00
IUUC-Tru-118679	Takifugu rubripes	50.00	2.00e-15	73.20
IUUC-Tsy-119615	Tarsius syrichta	51.75	1.00e-33	134.00
IUUC-Tni-120909	Tetraodon nigroviridis	62.35	4.00e-30	122.00
IUUC-Tca-121264	Theobroma cacao	54.74	2.00e-27	114.00
IUUC-Tre-121931	Trichoderma reesei	32.76	5.00e-09	54.30
IUUC-Tvi-122477	Trichoderma virens	32.76	3.00e-09	54.70
IUUC-Tae-124257	Triticum aestivum	49.45	1.00e-24	105.00
IUUC-Tur-126443	Triticum urartu	49.45	1.00e-24	105.00
IUUC-Tme-127099	Tuber melanosporum	35.19	1.00e-09	56.20
IUUC-Tbe-127360	Tupaia belangeri	68.92	2.00e-28	117.00
IUUC-Ttr-129044	Tursiops truncatus	68.92	8.00e-29	118.00
IUUC-Uma-129328	Ustilago maydis	30.00	1.00e-07	49.70
IUUC-Vda-129983	Verticillium dahliae	41.18	2.00e-08	50.80
IUUC-Vpa-130365	Vicugna pacos	67.57	7.00e-28	115.00
IUUC-Vvi-131725	Vitis vinifera	43.20	4.00e-28	116.00
IUUC-Xtr-131916	Xenopus tropicalis	64.20	1.00e-29	120.00
IUUC-Xma-133333	Xiphophorus maculatus	73.44	3.00e-27	113.00
IUUC-Yli-134363	Yarrowia lipolytica	31.58	3.00e-09	54.70
IUUC-Zma-135492	Zea mays	56.18	8.00e-28	115.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence