iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013101

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; Ubiquitin carrier protein C; Ubiquitin-protein ligase C

Genbank Nucleotide ID

BC108195

Gene Name

UBE2C; UBCH10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000016746.5	ENSBTAT00000022264.5	ENSBTAP00000022264.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.20e-45	153.4	34	166

Active Site

Position(s)	Description	Evidence
114	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           Rl++el++l+ +  +gisa p+++ +l++w  +i G ++t+Ye+  +kl++efp+ YP+++P+vkflt+++hPnv+++G++Cl+ilk  
   Q: 34   RLQQELMTLMMSGDKGISAFPESD-NLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILK-- 119
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           +kWs+ ++v+++llsiqsll epn++spln++aael+k+   ++kk +
   Q: 120  DKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPT-AFKKYL 166
           ***********************************997655.488765 PP

Organism

Bos taurus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Protein Sequence
(Fasta)

MASQNRDPVA ASVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF 60
KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTGGAACT GTGAGCTCCG CGTACCGCTT TTCTCCGTCT CATCGCCGCC CGGATGGCTT 60
CCCAGAACCG CGACCCAGTC GCCGCCAGCG TCGCCGCCGC CCGTAAAGGA GCCGAGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0010458--P:exit from mitosis
GO:0010994--P:free ubiquitin chain polymerization
GO:0031536--P:positive regulation of exit from mitosis
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:506962

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001924	Ailuropoda melanoleuca	97.24	9.00e-96	342.00
IUUC-Atr-002885	Amborella trichopoda	60.62	1.00e-53	201.00
IUUC-Aly-006086	Arabidopsis lyrata	58.90	1.00e-52	198.00
IUUC-Ath-006897	Arabidopsis thaliana	58.97	4.00e-52	197.00
IUUC-Acl-008223	Aspergillus clavatus	66.93	2.00e-39	154.00
IUUC-Afl-008675	Aspergillus flavus	54.82	1.00e-38	152.00
IUUC-Afu-008997	Aspergillus fumigatus	66.14	2.00e-38	151.00
IUUC-Ani-009470	Aspergillus nidulans	56.02	3.00e-39	154.00
IUUC-Ang-009648	Aspergillus niger	60.69	8.00e-39	152.00
IUUC-Aor-009977	Aspergillus oryzae	61.67	1.00e-31	129.00
IUUC-Ate-010318	Aspergillus terreus	60.00	2.00e-38	151.00
IUUC-Ame-011302	Astyanax mexicanus	77.06	2.00e-75	274.00
IUUC-Bci-013787	Botrytis cinerea	57.32	6.00e-45	172.00
IUUC-Bdi-014144	Brachypodium distachyon	69.29	3.00e-57	213.00
IUUC-Bol-015613	Brassica oleracea	58.54	2.00e-53	201.00
IUUC-Bra-017562	Brassica rapa	58.54	2.00e-53	201.00
IUUC-Cfa-020588	Canis familiaris	99.44	7.00e-98	348.00
IUUC-Cpo-021384	Cavia porcellus	97.77	4.00e-100	356.00
IUUC-Csa-023437	Chlorocebus sabaeus	97.21	2.00e-103	367.00
IUUC-Cho-024330	Choloepus hoffmanni	99.15	5.00e-68	248.00
IUUC-Cin-025365	Ciona intestinalis	56.88	1.00e-32	131.00
IUUC-Csv-025933	Ciona savignyi	60.92	4.00e-59	220.00
IUUC-Cgl-026494	Colletotrichum gloeosporioides	57.74	6.00e-45	173.00
IUUC-Cme-027266	Cyanidioschyzon merolae	51.61	1.00e-37	149.00
IUUC-Dre-027375	Danio rerio	77.06	7.00e-75	272.00
IUUC-Dno-029921	Dasypus novemcinctus	95.53	6.00e-94	335.00
IUUC-Dor-030209	Dipodomys ordii	94.41	1.00e-95	341.00
IUUC-Dse-031516	Dothistroma septosporum	54.67	4.00e-38	150.00
IUUC-Dme-031942	Drosophila melanogaster	67.13	1.00e-55	208.00
IUUC-Ete-032827	Echinops telfairi	84.69	6.00e-41	158.00
IUUC-Eca-034073	Equus caballus	98.88	2.00e-97	347.00
IUUC-Eeu-034854	Erinaceus europaeus	74.30	3.00e-68	250.00
IUUC-Fca-035666	Felis catus	98.88	2.00e-97	347.00
IUUC-Fal-037652	Ficedula albicollis	86.67	1.00e-53	200.00
IUUC-Fox-037793	Fusarium oxysporum	57.32	7.00e-44	169.00
IUUC-Fso-038151	Fusarium solani	57.41	3.00e-45	174.00
IUUC-Gmo-038894	Gadus morhua	77.85	4.00e-61	226.00
IUUC-Ggr-039730	Gaeumannomyces graminis	61.03	2.00e-35	141.00
IUUC-Gga-040537	Gallus gallus	86.76	1.00e-70	257.00
IUUC-Gac-041346	Gasterosteus aculeatus	72.16	3.00e-62	230.00
IUUC-Gma-043989	Glycine max	61.29	2.00e-54	204.00
IUUC-Ggo-045594	Gorilla gorilla	96.13	6.00e-102	362.00
IUUC-Hsa-046216	Homo sapiens	97.21	2.00e-103	367.00
IUUC-Hvu-047797	Hordeum vulgare	70.15	2.00e-54	204.00
IUUC-Itr-048402	Ictidomys tridecemlineatus	98.88	2.00e-97	347.00
IUUC-Kpa-049294	Komagataella pastoris	57.32	3.00e-48	184.00
IUUC-Lch-049761	Latimeria chalumnae	69.83	3.00e-71	260.00
IUUC-Lpe-051089	Leersia perrieri	63.46	1.00e-55	208.00
IUUC-Loc-052297	Lepisosteus oculatus	77.06	3.00e-73	268.00
IUUC-Lma-053214	Leptosphaeria maculans	54.93	5.00e-43	166.00
IUUC-Laf-054468	Loxodonta africana	96.13	2.00e-101	361.00
IUUC-Mcc-055338	Macaca mulatta	97.21	2.00e-103	367.00
IUUC-Meu-056147	Macropus eugenii	92.18	1.00e-93	334.00
IUUC-Mor-057239	Magnaporthe oryzae	58.50	6.00e-42	163.00
IUUC-Mpo-057491	Magnaporthe poae	62.50	6.00e-44	169.00
IUUC-Mtr-057687	Medicago truncatula	59.64	3.00e-48	184.00
IUUC-Mla-058880	Melampsora laricipopulina	64.29	2.00e-50	191.00
IUUC-Mga-059929	Meleagris gallopavo	86.73	4.00e-49	185.00
IUUC-Mvi-060528	Microbotryum violaceum	56.44	6.00e-46	177.00
IUUC-Mmr-060747	Microcebus murinus	98.76	2.00e-86	310.00
IUUC-Mdo-062343	Monodelphis domestica	93.33	3.00e-94	337.00
IUUC-Mmu-063563	Mus musculus	97.21	9.00e-99	352.00
IUUC-Mac-064823	Musa acuminata	63.83	4.00e-53	200.00
IUUC-Mpu-065746	Mustela putorius furo	98.34	2.00e-96	344.00
IUUC-Mlu-067388	Myotis lucifugus	96.13	2.00e-94	337.00
IUUC-Nfi-068577	Neosartorya fischeri	63.04	6.00e-39	153.00
IUUC-Ncr-068803	Neurospora crassa	56.44	4.00e-39	153.00
IUUC-Opr-070902	Ochotona princeps	95.00	2.00e-95	340.00
IUUC-Ont-071672	Oreochromis niloticus	70.29	1.00e-64	238.00
IUUC-Oan-073728	Ornithorhynchus anatinus	83.13	1.00e-38	150.00
IUUC-Ocu-074566	Oryctolagus cuniculus	94.44	3.00e-92	330.00
IUUC-Oba-075538	Oryza barthii	67.94	5.00e-52	196.00
IUUC-Obr-076757	Oryza brachyantha	70.65	2.00e-36	143.00
IUUC-Ogu-078467	Oryza glumaepatula	66.44	3.00e-56	210.00
IUUC-Oin-079533	Oryza indica	67.18	2.00e-51	194.00
IUUC-Olo-080673	Oryza longistaminata	68.70	1.00e-52	197.00
IUUC-Ome-081483	Oryza meridionalis	67.86	2.00e-55	208.00
IUUC-Oni-082321	Oryza nivara	66.44	3.00e-56	210.00
IUUC-Opu-083245	Oryza punctata	66.43	3.00e-54	204.00
IUUC-Oru-084641	Oryza rufipogon	63.64	2.00e-54	204.00
IUUC-Osa-085992	Oryza sativa	66.44	3.00e-56	210.00
IUUC-Ola-086807	Oryzias latipes	72.47	7.00e-72	262.00
IUUC-Olu-087834	Ostreococcus lucimarinus	70.07	2.00e-55	207.00
IUUC-Oga-088699	Otolemur garnettii	96.15	3.00e-102	363.00
IUUC-Oar-089542	Ovis aries	98.34	2.00e-96	344.00
IUUC-Ptr-091069	Pan troglodytes	97.21	2.00e-103	367.00
IUUC-Pan-092533	Papio anubis	96.13	5.00e-102	362.00
IUUC-Psi-093581	Pelodiscus sinensis	69.28	6.00e-60	222.00
IUUC-Pma-094607	Petromyzon marinus	71.18	6.00e-70	256.00
IUUC-Pno-094829	Phaeosphaeria nodorum	61.42	4.00e-43	166.00
IUUC-Ppa-095861	Physcomitrella patens	67.14	6.00e-56	209.00
IUUC-Pfo-096836	Poecilia formosa	70.69	3.00e-67	247.00
IUUC-Pab-098707	Pongo abelii	97.21	2.00e-103	367.00
IUUC-Pop-099021	Populus trichocarpa	67.14	2.00e-54	204.00
IUUC-Pca-100661	Procavia capensis	97.21	3.00e-99	353.00
IUUC-Ppe-101289	Prunus persica	58.29	4.00e-54	203.00
IUUC-Pva-103235	Pteropus vampyrus	93.85	7.00e-89	319.00
IUUC-Pte-104292	Pyrenophora teres	59.40	2.00e-43	168.00
IUUC-Rno-105501	Rattus norvegicus	96.65	7.00e-99	352.00
IUUC-Sce-106133	Saccharomyces cerevisiae	62.02	5.00e-37	146.00
IUUC-Sha-107205	Sarcophilus harrisii	92.91	5.00e-77	280.00
IUUC-Sja-108009	Schizosaccharomyces japonicus	57.56	9.00e-51	192.00
IUUC-Spo-108136	Schizosaccharomyces pombe	55.56	2.00e-50	191.00
IUUC-Ssl-108394	Sclerotinia sclerotiorum	57.23	8.00e-45	172.00
IUUC-Smo-109014	Selaginella moellendorffii	65.44	2.00e-52	198.00
IUUC-Sit-110754	Setaria italica	67.14	1.00e-55	208.00
IUUC-Sly-111137	Solanum lycopersicum	66.20	6.00e-54	203.00
IUUC-Stu-112305	Solanum tuberosum	65.97	3.00e-54	204.00
IUUC-Sbi-114299	Sorghum bicolor	64.08	6.00e-52	196.00
IUUC-Ssc-115625	Sus scrofa	98.32	2.00e-97	347.00
IUUC-Tru-118289	Takifugu rubripes	76.74	5.00e-37	144.00
IUUC-Tni-120070	Tetraodon nigroviridis	72.52	2.00e-56	210.00
IUUC-Tca-121158	Theobroma cacao	59.88	6.00e-55	206.00
IUUC-Tre-121973	Trichoderma reesei	59.24	5.00e-45	173.00
IUUC-Tvi-122496	Trichoderma virens	59.24	5.00e-45	173.00
IUUC-Tae-123596	Triticum aestivum	66.44	1.00e-56	212.00
IUUC-Tur-126818	Triticum urartu	65.52	8.00e-43	165.00
IUUC-Tme-127044	Tuber melanosporum	66.42	2.00e-42	165.00
IUUC-Ttr-128548	Tursiops truncatus	77.09	2.00e-68	251.00
IUUC-Vda-129840	Verticillium dahliae	56.29	4.00e-44	170.00
IUUC-Vvi-131685	Vitis vinifera	62.26	9.00e-56	209.00
IUUC-Xtr-132953	Xenopus tropicalis	80.45	3.00e-83	300.00
IUUC-Xma-134093	Xiphophorus maculatus	70.69	2.00e-67	247.00
IUUC-Yli-134548	Yarrowia lipolytica	56.65	7.00e-51	192.00
IUUC-Zma-135182	Zea mays	66.43	6.00e-55	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence