iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046248

UUCD1 version

UUC-HoS-01068

Ensembl Protein ID

ENSP00000348056.4

UniProt Accession

P63279; D3DU69; P50550; Q15698; Q59GX1; Q86VB3; UBC9_HUMAN

Genbank Protein ID

CAA65287.1; AAA86662.1; BAA08091.1; AAC51361.1; AAB02181.1; AAC50603.1; AAC50716.1; AAC50715.1; AAB09410.1; CAA05359.1; AAP35578.1; BAD92225.1; AAK61274.1; CAB45853.1; EAW85673.1; EAW85676.1; EAW85677.1; EAW85678.1; EAW85679.1; AAH00427.1; AAH04429.1; AAH51289.3

Protein Name

SUMO-conjugating enzyme UBC9; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18

Genbank Nucleotide ID

X96427; U45328; D45050; U29092; U31933; U31882; U66867; U66818; U38785; AJ002385; BT006932; AB208988; AE006466; AL031714; CH471112; CH471112; CH471112; CH471112; CH471112; BC000427; BC004429; BC051289

Gene Name

UBE2I; UBC9; UBCE9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103275.19	ENST00000355803.8	ENSP00000348056.4
ENSG00000103275.19	ENST00000402301.5	ENSP00000384361.1
ENSG00000103275.19	ENST00000566775.1	ENSP00000455252.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20704751; 19557165; 19498170; 19450230; 19407830; 19307308; 18625722; 17439403

Classification

Family	E-value	Score	Start	End
E2/UBC	2.30e-49	168.4	8	149

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd....ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilke 88
           Rl++e k+++kd+p g++a p+++ d    l++we++i G+++tp+egg+Fkl++ f++dYP++PPk+kf+ ++fhPnvy++G+vClsil+e
   Q: 8    RLAQERKAWRKDHPFGFVAVPTKNPDgtmnLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEE 99
           99*****************99998877777************************************************************** PP
   S: 89   eekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +++W+pa++++++ll+iq+ll+epn+++p+++ea++++++nr ey+k+vr
   Q: 100  DKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVR 149
           ************************************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'.

Protein Sequence
(Fasta)

MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG TPWEGGLFKL 60
RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED KDWRPAITIK QILLGIQELL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCCGGTCC TGCTTGTTGC GTGGGCGGGA GGGGGGACCG GAAGCGCCCC TCCCCCACGG 60
GCTCGCCCCG CCCCCGCCGC TCGCGGTCCC CCACGTCCCG CCCGCGCCCC GGCCCAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR027230--Ubc9
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:1990356--C:sumoylated E2 ligase complex
GO:0000795--C:synaptonemal complex
GO:1990234--C:transferase complex
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0043398--F:HLH domain binding
GO:0071535--F:RING-like zinc finger domain binding
GO:0003723--F:RNA binding
GO:0044388--F:small protein activating enzyme binding
GO:0061656--F:SUMO conjugating enzyme activity
GO:0019789--F:SUMO transferase activity
GO:0008134--F:transcription factor binding
GO:0051301--P:cell division
GO:0006464--P:cellular protein modification process
GO:0007059--P:chromosome segregation
GO:0070911--P:global genome nucleotide-excision repair
GO:0007067--P:mitotic nuclear division
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903755--P:positive regulation of SUMO transferase activity
GO:0016925--P:protein sumoylation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process

KEGG

hsa:7329

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000510	Aegilops tauschii	64.76	1.00e-38	152.00
IUUC-Aml-002383	Ailuropoda melanoleuca	100.00	1.00e-92	331.00
IUUC-Atr-002982	Amborella trichopoda	64.10	2.00e-49	187.00
IUUC-Apl-003840	Anas platyrhynchos	100.00	2.00e-92	331.00
IUUC-Aca-004772	Anolis carolinensis	100.00	1.00e-92	331.00
IUUC-Aly-005652	Arabidopsis lyrata	66.23	5.00e-60	223.00
IUUC-Ath-007084	Arabidopsis thaliana	66.23	5.00e-60	223.00
IUUC-Ago-007998	Ashbya gossypii	57.69	3.00e-53	200.00
IUUC-Acl-008040	Aspergillus clavatus	63.16	5.00e-50	189.00
IUUC-Afl-008563	Aspergillus flavus	62.50	1.00e-49	188.00
IUUC-Afu-008873	Aspergillus fumigatus	65.25	3.00e-47	181.00
IUUC-Ani-009222	Aspergillus nidulans	64.47	1.00e-50	192.00
IUUC-Ang-009740	Aspergillus niger	68.61	3.00e-48	184.00
IUUC-Aor-010170	Aspergillus oryzae	63.16	5.00e-50	189.00
IUUC-Ate-010410	Aspergillus terreus	63.82	3.00e-50	190.00
IUUC-Ame-011711	Astyanax mexicanus	94.30	8.00e-89	318.00
IUUC-Bgr-012012	Blumeria graminis	55.92	2.00e-48	184.00
IUUC-Bta-013269	Bos taurus	100.00	1.00e-92	331.00
IUUC-Bci-013748	Botrytis cinerea	61.59	4.00e-47	180.00
IUUC-Bdi-014883	Brachypodium distachyon	64.94	1.00e-58	218.00
IUUC-Bol-016125	Brassica oleracea	66.03	2.00e-51	194.00
IUUC-Bra-017235	Brassica rapa	66.03	2.00e-51	194.00
IUUC-Cel-018448	Caenorhabditis elegans	76.92	7.00e-75	272.00
IUUC-Cja-019349	Callithrix jacchus	100.00	1.00e-92	331.00
IUUC-Cfa-021008	Canis familiaris	99.11	6.00e-65	239.00
IUUC-Cpo-021324	Cavia porcellus	100.00	1.00e-92	331.00
IUUC-Cre-022836	Chlamydomonas reinhardtii	61.15	6.00e-57	213.00
IUUC-Csa-024207	Chlorocebus sabaeus	100.00	1.00e-92	331.00
IUUC-Cin-025734	Ciona intestinalis	82.69	7.00e-79	285.00
IUUC-Csv-026049	Ciona savignyi	81.41	1.00e-77	281.00
IUUC-Cgl-026699	Colletotrichum gloeosporioides	63.70	2.00e-54	204.00
IUUC-Cne-027034	Cryptococcus neoformans	61.78	5.00e-60	223.00
IUUC-Cme-027203	Cyanidioschyzon merolae	59.35	3.00e-49	187.00
IUUC-Dre-027701	Danio rerio	99.36	1.00e-91	328.00
IUUC-Dno-030037	Dasypus novemcinctus	100.00	1.00e-92	331.00
IUUC-Dor-030622	Dipodomys ordii	98.54	2.00e-78	283.00
IUUC-Dse-031366	Dothistroma septosporum	62.91	8.00e-56	209.00
IUUC-Dme-031818	Drosophila melanogaster	85.44	5.00e-82	296.00
IUUC-Ete-032517	Echinops telfairi	100.00	2.00e-79	287.00
IUUC-Eca-033789	Equus caballus	100.00	1.00e-92	331.00
IUUC-Fca-035851	Felis catus	100.00	1.00e-92	331.00
IUUC-Fal-037177	Ficedula albicollis	100.00	2.00e-92	331.00
IUUC-Fox-037789	Fusarium oxysporum	62.50	2.00e-57	214.00
IUUC-Fso-038166	Fusarium solani	64.63	6.00e-57	212.00
IUUC-Gmo-039482	Gadus morhua	99.37	3.00e-92	330.00
IUUC-Ggr-039892	Gaeumannomyces graminis	65.93	6.00e-53	200.00
IUUC-Gga-041199	Gallus gallus	100.00	1.00e-92	331.00
IUUC-Gac-042250	Gasterosteus aculeatus	99.37	3.00e-92	330.00
IUUC-Gma-043827	Glycine max	66.24	3.00e-61	227.00
IUUC-Ggo-045530	Gorilla gorilla	100.00	1.00e-92	331.00
IUUC-Hvu-047363	Hordeum vulgare	62.34	5.00e-57	213.00
IUUC-Itr-048429	Ictidomys tridecemlineatus	100.00	1.00e-92	331.00
IUUC-Kpa-049362	Komagataella pastoris	58.33	5.00e-53	199.00
IUUC-Lch-050644	Latimeria chalumnae	97.47	5.00e-91	326.00
IUUC-Lpe-051643	Leersia perrieri	65.58	1.00e-59	222.00
IUUC-Loc-052357	Lepisosteus oculatus	99.37	4.00e-92	329.00
IUUC-Lma-053142	Leptosphaeria maculans	61.59	7.00e-57	212.00
IUUC-Laf-053577	Loxodonta africana	100.00	1.00e-92	331.00
IUUC-Mcc-054925	Macaca mulatta	100.00	1.00e-92	331.00
IUUC-Meu-056094	Macropus eugenii	81.75	2.00e-60	224.00
IUUC-Mor-057141	Magnaporthe oryzae	61.22	6.00e-56	209.00
IUUC-Mpo-057613	Magnaporthe poae	65.19	5.00e-52	196.00
IUUC-Mtr-058465	Medicago truncatula	67.10	2.00e-62	231.00
IUUC-Mla-059115	Melampsora laricipopulina	65.19	2.00e-61	228.00
IUUC-Mga-059384	Meleagris gallopavo	100.00	1.00e-92	331.00
IUUC-Mvi-060328	Microbotryum violaceum	62.18	7.00e-48	182.00
IUUC-Mmr-061541	Microcebus murinus	100.00	1.00e-92	331.00
IUUC-Mdo-062540	Monodelphis domestica	100.00	1.00e-92	331.00
IUUC-Mmu-063818	Mus musculus	100.00	1.00e-92	331.00
IUUC-Mac-065019	Musa acuminata	65.38	3.00e-60	223.00
IUUC-Mpu-065734	Mustela putorius furo	100.00	1.00e-92	331.00
IUUC-Mlu-067619	Myotis lucifugus	100.00	1.00e-92	331.00
IUUC-Nfi-068567	Neosartorya fischeri	63.82	1.00e-50	192.00
IUUC-Ncr-068897	Neurospora crassa	62.99	6.00e-57	213.00
IUUC-Nle-069541	Nomascus leucogenys	100.00	8.00e-92	328.00
IUUC-Ont-071585	Oreochromis niloticus	99.37	3.00e-92	330.00
IUUC-Oan-073178	Ornithorhynchus anatinus	100.00	2.00e-42	162.00
IUUC-Ocu-074588	Oryctolagus cuniculus	92.41	2.00e-82	297.00
IUUC-Oba-075371	Oryza barthii	64.74	5.00e-59	219.00
IUUC-Obr-076199	Oryza brachyantha	64.74	4.00e-59	220.00
IUUC-Ogl-077506	Oryza glaberrima	64.74	5.00e-59	219.00
IUUC-Ogu-078474	Oryza glumaepatula	64.74	5.00e-59	219.00
IUUC-Oin-080036	Oryza indica	64.74	5.00e-59	219.00
IUUC-Olo-080940	Oryza longistaminata	58.44	4.00e-50	190.00
IUUC-Ome-081909	Oryza meridionalis	64.29	4.00e-58	217.00
IUUC-Oni-082340	Oryza nivara	64.74	5.00e-59	219.00
IUUC-Opu-083206	Oryza punctata	64.74	4.00e-59	219.00
IUUC-Oru-084239	Oryza rufipogon	64.74	5.00e-59	219.00
IUUC-Osa-086213	Oryza sativa	64.74	5.00e-59	219.00
IUUC-Ola-086314	Oryzias latipes	95.57	1.00e-89	321.00
IUUC-Olu-087715	Ostreococcus lucimarinus	54.09	5.00e-48	183.00
IUUC-Oga-088729	Otolemur garnettii	100.00	1.00e-79	288.00
IUUC-Oar-090221	Ovis aries	100.00	3.00e-92	330.00
IUUC-Ptr-090528	Pan troglodytes	100.00	1.00e-92	331.00
IUUC-Pan-092834	Papio anubis	100.00	1.00e-92	331.00
IUUC-Psi-093001	Pelodiscus sinensis	100.00	2.00e-92	331.00
IUUC-Pma-094539	Petromyzon marinus	96.84	1.00e-90	324.00
IUUC-Pno-094954	Phaeosphaeria nodorum	60.65	2.00e-55	207.00
IUUC-Ppa-095314	Physcomitrella patens	64.74	3.00e-59	220.00
IUUC-Pfo-097457	Poecilia formosa	98.73	6.00e-92	328.00
IUUC-Pab-098205	Pongo abelii	100.00	1.00e-92	331.00
IUUC-Pop-099063	Populus trichocarpa	66.23	7.00e-60	222.00
IUUC-Pca-100603	Procavia capensis	100.00	3.00e-79	287.00
IUUC-Ppe-101501	Prunus persica	66.67	4.00e-51	193.00
IUUC-Pva-103251	Pteropus vampyrus	78.10	6.00e-56	209.00
IUUC-Pte-104067	Pyrenophora teres	58.28	7.00e-55	206.00
IUUC-Pyt-104436	Pyrenophora triticirepentis	58.28	5.00e-55	206.00
IUUC-Rno-105794	Rattus norvegicus	100.00	1.00e-92	331.00
IUUC-Sce-106308	Saccharomyces cerevisiae	56.41	6.00e-53	199.00
IUUC-Sha-106997	Sarcophilus harrisii	90.62	1.00e-82	298.00
IUUC-Sja-108000	Schizosaccharomyces japonicus	67.31	6.00e-56	209.00
IUUC-Spo-108311	Schizosaccharomyces pombe	66.24	4.00e-55	206.00
IUUC-Smo-108685	Selaginella moellendorffii	66.67	6.00e-52	196.00
IUUC-Sit-109792	Setaria italica	65.58	2.00e-59	221.00
IUUC-Sly-110998	Solanum lycopersicum	63.46	3.00e-59	220.00
IUUC-Stu-111975	Solanum tuberosum	66.23	4.00e-54	203.00
IUUC-Sbi-114672	Sorghum bicolor	65.58	2.00e-59	221.00
IUUC-Sre-114957	Sporisorium reilianum	69.23	1.00e-65	241.00
IUUC-Ssc-116173	Sus scrofa	100.00	1.00e-92	331.00
IUUC-Tgu-116668	Taeniopygia guttata	100.00	2.00e-92	331.00
IUUC-Tru-118365	Takifugu rubripes	97.47	1.00e-90	325.00
IUUC-Tni-120455	Tetraodon nigroviridis	95.57	2.00e-89	320.00
IUUC-Tca-120956	Theobroma cacao	65.38	8.00e-59	219.00
IUUC-Tre-121927	Trichoderma reesei	63.95	1.00e-57	215.00
IUUC-Tvi-122363	Trichoderma virens	63.95	3.00e-57	213.00
IUUC-Tae-125311	Triticum aestivum	65.58	3.00e-59	220.00
IUUC-Tur-126625	Triticum urartu	64.94	8.00e-59	219.00
IUUC-Tme-126981	Tuber melanosporum	55.10	2.00e-37	147.00
IUUC-Ttr-128280	Tursiops truncatus	100.00	2.00e-48	183.00
IUUC-Uma-129582	Ustilago maydis	69.23	3.00e-65	240.00
IUUC-Vda-129845	Verticillium dahliae	65.99	6.00e-58	216.00
IUUC-Vpa-130242	Vicugna pacos	100.00	2.00e-79	287.00
IUUC-Vvi-130948	Vitis vinifera	64.74	4.00e-59	219.00
IUUC-Xtr-132540	Xenopus tropicalis	100.00	3.00e-92	330.00
IUUC-Xma-133010	Xiphophorus maculatus	98.73	6.00e-92	328.00
IUUC-Yli-134673	Yarrowia lipolytica	54.36	1.00e-50	192.00
IUUC-Zma-135055	Zea mays	65.58	2.00e-59	221.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence