iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ang-009570

Ensembl Protein ID

CAK47657

UniProt Accession

A2QCU8; SCONB_ASPNC

Genbank Protein ID

CAK47657.1

Protein Name

Probable E3 ubiquitin ligase complex SCF subunit sconB; Sulfur controller B; Sulfur metabolite repression control protein B

Genbank Nucleotide ID

AM270009

Gene Name

sconB; An02g04800

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
An02g04800	CAK47657	CAK47657

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-55	181.1	379	415
E3 adaptor/Cullin RING/SCF/F-box	8.50e-06	25.4	165	209
UBD/Beta-Prp	1.10e-74	250.8	337	669

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
           gH+++++cl+f+dt l+sGs Dg++kvW++rtg+++ 
   Q: 379  GHESGIRCLQFDDTKLISGSMDGSVKVWNWRTGDCIS 415
           8**********66*********************985 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            +  lp ei ++il +ld+++l++aa+v+rrw+ la+++ +w+++
   Q: 165  FIAALPPEISFKILCYLDTTSLCKAAQVSRRWRALADDDVVWHRM 209
           6789*********************************9****987 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsps 105
           +kgh  +v++ ++f  ++++latgs+d+tik+wd++tg+ +r+l ghe+++++++f+++   l++gs D+ +kvw+ +tg+c++t++gh   v  l+f++ 
   Q: 337  FKGHTNGVMC-LQF--EDNILATGSYDATIKIWDTDTGQEIRTLRGHESGIRCLQFDDT--KLISGSMDGSVKVWNWRTGDCISTYTGHRGGVIGLHFDA- 431
           5566666666.***..*******************************************..6**************************************. PP
   S: 106  gdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls..........fdsng.... 192
              l+s+s d+t+++w+ e ++    +l+gh+++vn v+v+  ++ ++s+s+D tvrlWdl t++++rt+ g h ++v+ +                    
   Q: 432  -TILASASVDKTVKIWNFEDKSTC--LLRGHTDWVNAVRVDTASRTVFSASDDCTVRLWDLDTKSCIRTFHG-HVGQVQQVVplprefefeeH---Dvece 525
           .*****************999988..59*******************************************9.*********99999775550...25555 PP
   S: 193  ..............................................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsir 247
                                                         +++v+ +ld+t++lw+ +tg+c+rt+ gh + v+ ++++  + r+vsg++D+ i+
   Q: 526  ndnlstvsgdtepaslqatlglesnavisqsspfgpsfesgrtappRYIVTSALDSTIRLWETSTGRCLRTFFGHLEGVWALAAD--TLRIVSGAEDRMIK 624
           55566666777788888888888888999999999999******************************************99999..************** PP
   S: 248  iWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           iWd r+g++ +t+++h     +v+++++gd+ +++gsed++v++++++
   Q: 625  IWDPRTGKCERTFTGHS---GPVTCIGLGDSRFATGSEDCEVRMYSFQ 669
           ***************88...55555666*****************996 PP

Organism

Aspergillus niger

Functional Description
(View)

Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.

Protein Sequence
(Fasta)

MSSPPPFTSI FGGPAESAEE IDADADNSQL KPHNRSNVTA TSAKLVGKSV APFLAKHVPD 60
QYAPLGSQNR EPAALSSANS RYCYRHRPDR KCRRQADEPT MDKLQRELES LPQSDQQGIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCTCCC CTCCGCCCTT CACATCGATC TTCGGTGGCC CCGCCGAGTC CGCGGAGGAG 60
ATCGATGCTG ATGCCGACAA TAGCCAGCTG AAGCCCCACA ATCGCAGCAA CGTAACAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0071276--P:cellular response to cadmium ion
GO:0006270--P:DNA replication initiation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0046685--P:response to arsenic-containing substance
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007794	Ashbya gossypii	42.24	4.00e-135	473.00
IUUC-Acl-008078	Aspergillus clavatus	80.60	0.00e+00	1122.00
IUUC-Afl-008744	Aspergillus flavus	82.71	0.00e+00	1087.00
IUUC-Afu-008939	Aspergillus fumigatus	80.75	0.00e+00	1110.00
IUUC-Ani-009383	Aspergillus nidulans	81.10	0.00e+00	1081.00
IUUC-Aor-010217	Aspergillus oryzae	82.63	0.00e+00	1065.00
IUUC-Ate-010336	Aspergillus terreus	83.03	0.00e+00	1105.00
IUUC-Bgr-012225	Blumeria graminis	57.12	0.00e+00	742.00
IUUC-Bci-013916	Botrytis cinerea	65.32	0.00e+00	845.00
IUUC-Cgl-026550	Colletotrichum gloeosporioides	53.20	0.00e+00	675.00
IUUC-Cne-026800	Cryptococcus neoformans	35.84	7.00e-122	429.00
IUUC-Dse-031413	Dothistroma septosporum	57.88	0.00e+00	732.00
IUUC-Fox-037683	Fusarium oxysporum	47.70	0.00e+00	642.00
IUUC-Fso-038092	Fusarium solani	55.17	0.00e+00	729.00
IUUC-Ggr-039842	Gaeumannomyces graminis	53.43	0.00e+00	715.00
IUUC-Kpa-049101	Komagataella pastoris	45.11	8.00e-165	572.00
IUUC-Lma-053200	Leptosphaeria maculans	56.65	0.00e+00	771.00
IUUC-Mor-057039	Magnaporthe oryzae	54.46	0.00e+00	695.00
IUUC-Mpo-057381	Magnaporthe poae	53.45	0.00e+00	699.00
IUUC-Mla-059099	Melampsora laricipopulina	38.51	4.00e-122	430.00
IUUC-Mvi-060426	Microbotryum violaceum	35.40	5.00e-88	317.00
IUUC-Nfi-068464	Neosartorya fischeri	80.15	0.00e+00	1096.00
IUUC-Ncr-068962	Neurospora crassa	51.41	0.00e+00	697.00
IUUC-Pno-095133	Phaeosphaeria nodorum	52.29	7.00e-160	555.00
IUUC-Pgr-103527	Puccinia graminis	40.60	1.00e-64	238.00
IUUC-Ptt-103819	Puccinia triticina	34.57	4.00e-55	207.00
IUUC-Pte-104035	Pyrenophora teres	56.50	0.00e+00	718.00
IUUC-Pyt-104799	Pyrenophora triticirepentis	55.83	0.00e+00	722.00
IUUC-Sce-106343	Saccharomyces cerevisiae	41.13	9.00e-134	468.00
IUUC-Sja-107945	Schizosaccharomyces japonicus	38.20	1.00e-114	405.00
IUUC-Spo-108115	Schizosaccharomyces pombe	39.02	7.00e-110	389.00
IUUC-Sre-115173	Sporisorium reilianum	40.90	3.00e-101	361.00
IUUC-Tre-122126	Trichoderma reesei	56.36	0.00e+00	741.00
IUUC-Tvi-122482	Trichoderma virens	56.90	0.00e+00	738.00
IUUC-Tme-127212	Tuber melanosporum	55.45	0.00e+00	737.00
IUUC-Uma-129406	Ustilago maydis	40.39	5.00e-101	360.00
IUUC-Vda-129799	Verticillium dahliae	53.42	0.00e+00	699.00
IUUC-Yli-134408	Yarrowia lipolytica	46.37	2.00e-169	587.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence