iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059499

UUCD1 version

UUC-MeG-00016

Ensembl Protein ID

ENSMGAP00000006188.1

UniProt Accession

H9H0Y1; H9H0Y1_MELGA

Protein Name

Coatomer subunit alpha

Gene Name

COPA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000006128.1	ENSMGAT00000006935.1	ENSMGAP00000006188.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-36	122.1	50	80
UBD/Beta-Prp	4.10e-74	249.2	3	326

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H ++v++++f  + +l+vsG+dD +ikvW++
   Q: 50   HDGPVRGIDFhkQQPLFVSGGDDYKIKVWNY 80
           99********97449**************96 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++t+  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl g
   Q: 3    TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLG 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           h d+++++ f+ +  +++s+s+d+tirvw++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               
   Q: 92   HLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgaves 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                        t+ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   v+t++gh +nv++  f+p++e+++s s
   Q: 180  dvrgitgvdlfgTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAweVDTCRGHYNNVSCAVFHPRQELILSNS 268
           ************888888888777********************************888888*************************** PP
   S: 242  sDgsiriWdlrsg..dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ ++  + ++t+ + +++++  a+ +++ n +++g  d+   ++kl++++p
   Q: 269  EDKSIRVWDMSKRfsTGVQTFRRDHDRFWVLAA-HPNLNLFAAG-HDGGMIVFKLERERP 326
           ********887762256789*************.5554444444.589999999988765 PP

Organism

Meleagris gallopavo

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTACTTCCG GAGCGCCGAC GTGGAGGGTC GAGGAGGCGA CGGTTGGGGG TGCAGCTGTG 60
ATGTTGACTA AATTCGAGAC CAAATCGGCT CGGGTGAAAG GTAGCCGTAG GGCTGTGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030157--P:pancreatic juice secretion
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	62.25	0.00e+00	1104.00
IUUC-Aml-001758	Ailuropoda melanoleuca	95.87	0.00e+00	2407.00
IUUC-Atr-002493	Amborella trichopoda	54.38	0.00e+00	1319.00
IUUC-Apl-003385	Anas platyrhynchos	99.25	0.00e+00	2109.00
IUUC-Aca-005154	Anolis carolinensis	97.10	2.00e-121	427.00
IUUC-Aly-006020	Arabidopsis lyrata	61.68	0.00e+00	1096.00
IUUC-Ath-007058	Arabidopsis thaliana	61.96	0.00e+00	1090.00
IUUC-Ago-007992	Ashbya gossypii	44.17	0.00e+00	1013.00
IUUC-Acl-008027	Aspergillus clavatus	56.78	0.00e+00	1001.00
IUUC-Afl-008644	Aspergillus flavus	56.85	0.00e+00	999.00
IUUC-Afu-008964	Aspergillus fumigatus	56.70	0.00e+00	1004.00
IUUC-Ani-009379	Aspergillus nidulans	56.35	0.00e+00	1009.00
IUUC-Ang-009756	Aspergillus niger	57.43	0.00e+00	1016.00
IUUC-Aor-010174	Aspergillus oryzae	56.85	0.00e+00	999.00
IUUC-Ate-010302	Aspergillus terreus	49.48	0.00e+00	1221.00
IUUC-Ame-011229	Astyanax mexicanus	85.97	0.00e+00	2193.00
IUUC-Bgr-012300	Blumeria graminis	48.06	0.00e+00	1122.00
IUUC-Bta-012524	Bos taurus	96.33	0.00e+00	2391.00
IUUC-Bci-013781	Botrytis cinerea	48.63	0.00e+00	1192.00
IUUC-Bdi-014549	Brachypodium distachyon	54.31	0.00e+00	1341.00
IUUC-Bol-015925	Brassica oleracea	61.84	0.00e+00	1084.00
IUUC-Bra-016978	Brassica rapa	61.14	0.00e+00	1079.00
IUUC-Cel-018115	Caenorhabditis elegans	64.11	0.00e+00	1122.00
IUUC-Cja-019107	Callithrix jacchus	93.52	0.00e+00	2332.00
IUUC-Cfa-020675	Canis familiaris	96.05	0.00e+00	2379.00
IUUC-Cpo-021813	Cavia porcellus	96.49	0.00e+00	2411.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	64.77	0.00e+00	1113.00
IUUC-Csa-023523	Chlorocebus sabaeus	96.66	0.00e+00	2420.00
IUUC-Cho-024704	Choloepus hoffmanni	82.40	0.00e+00	1854.00
IUUC-Cin-025572	Ciona intestinalis	73.54	0.00e+00	1885.00
IUUC-Csv-025864	Ciona savignyi	76.02	0.00e+00	1297.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	57.33	0.00e+00	1021.00
IUUC-Cne-027053	Cryptococcus neoformans	59.36	0.00e+00	1046.00
IUUC-Cme-027222	Cyanidioschyzon merolae	39.65	3.00e-142	499.00
IUUC-Dre-027421	Danio rerio	85.82	0.00e+00	2190.00
IUUC-Dno-029303	Dasypus novemcinctus	96.59	0.00e+00	2412.00
IUUC-Dor-030290	Dipodomys ordii	94.16	0.00e+00	1044.00
IUUC-Dse-031543	Dothistroma septosporum	46.85	0.00e+00	1124.00
IUUC-Dme-031945	Drosophila melanogaster	75.51	0.00e+00	1290.00
IUUC-Ete-032873	Echinops telfairi	90.27	0.00e+00	2073.00
IUUC-Eca-033773	Equus caballus	94.46	0.00e+00	2340.00
IUUC-Eeu-034874	Erinaceus europaeus	83.07	0.00e+00	1461.00
IUUC-Fca-035739	Felis catus	95.21	0.00e+00	2323.00
IUUC-Fal-037263	Ficedula albicollis	89.68	0.00e+00	2152.00
IUUC-Fox-037738	Fusarium oxysporum	48.99	0.00e+00	1222.00
IUUC-Fso-038153	Fusarium solani	48.83	0.00e+00	1191.00
IUUC-Gmo-039602	Gadus morhua	81.77	0.00e+00	2055.00
IUUC-Ggr-039931	Gaeumannomyces graminis	56.41	0.00e+00	1014.00
IUUC-Gga-040590	Gallus gallus	99.67	0.00e+00	2469.00
IUUC-Gac-041318	Gasterosteus aculeatus	85.74	0.00e+00	2209.00
IUUC-Gma-043894	Glycine max	55.08	0.00e+00	1354.00
IUUC-Ggo-045029	Gorilla gorilla	95.87	0.00e+00	2409.00
IUUC-Hsa-046078	Homo sapiens	95.79	0.00e+00	2407.00
IUUC-Hvu-047556	Hordeum vulgare	54.77	0.00e+00	1357.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	94.43	0.00e+00	1658.00
IUUC-Kpa-049256	Komagataella pastoris	45.91	0.00e+00	1089.00
IUUC-Lch-049706	Latimeria chalumnae	93.15	0.00e+00	2312.00
IUUC-Lpe-051316	Leersia perrieri	62.84	0.00e+00	1111.00
IUUC-Loc-051867	Lepisosteus oculatus	71.88	0.00e+00	1215.00
IUUC-Lma-053138	Leptosphaeria maculans	56.30	0.00e+00	1021.00
IUUC-Laf-053510	Loxodonta africana	96.66	0.00e+00	2444.00
IUUC-Mcc-055836	Macaca mulatta	95.47	0.00e+00	2400.00
IUUC-Meu-056238	Macropus eugenii	87.16	0.00e+00	1176.00
IUUC-Mor-057172	Magnaporthe oryzae	48.68	0.00e+00	1193.00
IUUC-Mpo-057300	Magnaporthe poae	49.01	0.00e+00	1183.00
IUUC-Mtr-058248	Medicago truncatula	55.42	0.00e+00	1367.00
IUUC-Mla-059019	Melampsora laricipopulina	52.61	0.00e+00	1294.00
IUUC-Mvi-060336	Microbotryum violaceum	53.19	0.00e+00	1281.00
IUUC-Mmr-061102	Microcebus murinus	95.87	0.00e+00	2369.00
IUUC-Mdo-062594	Monodelphis domestica	97.15	0.00e+00	2451.00
IUUC-Mmu-063736	Mus musculus	95.55	0.00e+00	2394.00
IUUC-Mac-065398	Musa acuminata	52.43	0.00e+00	1249.00
IUUC-Mpu-066701	Mustela putorius furo	96.34	0.00e+00	2408.00
IUUC-Mlu-067392	Myotis lucifugus	96.01	0.00e+00	2402.00
IUUC-Nfi-068270	Neosartorya fischeri	57.02	0.00e+00	1005.00
IUUC-Ncr-068892	Neurospora crassa	49.36	0.00e+00	1195.00
IUUC-Nle-069634	Nomascus leucogenys	98.64	0.00e+00	1368.00
IUUC-Opr-070952	Ochotona princeps	83.16	0.00e+00	1717.00
IUUC-Ont-072488	Oreochromis niloticus	87.52	0.00e+00	2224.00
IUUC-Ocu-074211	Oryctolagus cuniculus	96.74	0.00e+00	2415.00
IUUC-Oba-075761	Oryza barthii	62.72	0.00e+00	1108.00
IUUC-Obr-076429	Oryza brachyantha	62.84	0.00e+00	1109.00
IUUC-Ogl-077364	Oryza glaberrima	62.72	0.00e+00	1110.00
IUUC-Ogu-078257	Oryza glumaepatula	62.98	0.00e+00	1111.00
IUUC-Oin-079274	Oryza indica	62.60	0.00e+00	1108.00
IUUC-Olo-080466	Oryza longistaminata	62.64	0.00e+00	1094.00
IUUC-Ome-081993	Oryza meridionalis	64.75	0.00e+00	1032.00
IUUC-Oni-082874	Oryza nivara	62.72	0.00e+00	1108.00
IUUC-Opu-083885	Oryza punctata	62.60	0.00e+00	1105.00
IUUC-Oru-084274	Oryza rufipogon	62.72	0.00e+00	1110.00
IUUC-Osa-085565	Oryza sativa	62.72	0.00e+00	1110.00
IUUC-Ola-086921	Oryzias latipes	85.61	0.00e+00	2165.00
IUUC-Olu-087639	Ostreococcus lucimarinus	56.33	0.00e+00	1368.00
IUUC-Oga-087991	Otolemur garnettii	91.22	0.00e+00	2271.00
IUUC-Oar-089590	Ovis aries	96.49	0.00e+00	2413.00
IUUC-Ptr-090808	Pan troglodytes	95.87	0.00e+00	2409.00
IUUC-Pan-092475	Papio anubis	96.17	0.00e+00	2406.00
IUUC-Psi-093044	Pelodiscus sinensis	81.20	0.00e+00	1696.00
IUUC-Pno-094839	Phaeosphaeria nodorum	54.72	0.00e+00	951.00
IUUC-Ppa-095254	Physcomitrella patens	56.66	0.00e+00	1409.00
IUUC-Pfo-097493	Poecilia formosa	87.11	0.00e+00	2194.00
IUUC-Pab-098497	Pongo abelii	96.66	0.00e+00	2420.00
IUUC-Pop-099992	Populus trichocarpa	56.26	0.00e+00	1346.00
IUUC-Pca-100413	Procavia capensis	88.61	0.00e+00	1001.00
IUUC-Ppe-101899	Prunus persica	54.54	0.00e+00	1334.00
IUUC-Pva-102126	Pteropus vampyrus	92.15	0.00e+00	2296.00
IUUC-Pgr-103376	Puccinia graminis	53.73	0.00e+00	1308.00
IUUC-Ptt-103978	Puccinia triticina	48.03	0.00e+00	1092.00
IUUC-Pte-104126	Pyrenophora teres	56.57	0.00e+00	978.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	45.66	1.00e-173	603.00
IUUC-Rno-105428	Rattus norvegicus	96.33	0.00e+00	2406.00
IUUC-Sce-106464	Saccharomyces cerevisiae	43.39	0.00e+00	1003.00
IUUC-Sha-107301	Sarcophilus harrisii	96.95	0.00e+00	2400.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	46.43	0.00e+00	1091.00
IUUC-Spo-108217	Schizosaccharomyces pombe	46.97	0.00e+00	1121.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	56.05	0.00e+00	1010.00
IUUC-Smo-109582	Selaginella moellendorffii	64.73	0.00e+00	1158.00
IUUC-Sit-109697	Setaria italica	62.37	0.00e+00	1102.00
IUUC-Sly-111759	Solanum lycopersicum	54.91	0.00e+00	1372.00
IUUC-Stu-112564	Solanum tuberosum	54.67	0.00e+00	1365.00
IUUC-Sar-113313	Sorex araneus	85.80	0.00e+00	1412.00
IUUC-Sbi-114388	Sorghum bicolor	62.96	0.00e+00	1111.00
IUUC-Sre-115209	Sporisorium reilianum	57.93	0.00e+00	1046.00
IUUC-Ssc-115933	Sus scrofa	96.74	0.00e+00	2419.00
IUUC-Tgu-117109	Taeniopygia guttata	84.44	0.00e+00	758.00
IUUC-Tru-117772	Takifugu rubripes	86.62	0.00e+00	2180.00
IUUC-Tsy-119105	Tarsius syrichta	82.83	0.00e+00	2072.00
IUUC-Tni-120556	Tetraodon nigroviridis	69.60	0.00e+00	1519.00
IUUC-Tca-121046	Theobroma cacao	54.26	0.00e+00	1368.00
IUUC-Tre-121951	Trichoderma reesei	57.16	0.00e+00	1016.00
IUUC-Tvi-122359	Trichoderma virens	57.01	0.00e+00	1024.00
IUUC-Tae-123688	Triticum aestivum	54.85	0.00e+00	1357.00
IUUC-Tur-126754	Triticum urartu	62.01	0.00e+00	1101.00
IUUC-Tme-127170	Tuber melanosporum	50.12	0.00e+00	1215.00
IUUC-Tbe-127882	Tupaia belangeri	71.08	0.00e+00	791.00
IUUC-Ttr-128217	Tursiops truncatus	93.68	0.00e+00	2335.00
IUUC-Uma-129337	Ustilago maydis	57.23	0.00e+00	1044.00
IUUC-Vda-129828	Verticillium dahliae	48.68	0.00e+00	1182.00
IUUC-Vpa-130537	Vicugna pacos	95.38	0.00e+00	2362.00
IUUC-Vvi-130958	Vitis vinifera	63.44	0.00e+00	1117.00
IUUC-Xtr-132857	Xenopus tropicalis	90.00	0.00e+00	2223.00
IUUC-Xma-133138	Xiphophorus maculatus	87.03	0.00e+00	2195.00
IUUC-Yli-134399	Yarrowia lipolytica	50.70	0.00e+00	865.00
IUUC-Zma-135612	Zea mays	54.49	0.00e+00	1343.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence