iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094189

UUCD1 version

UUC-PeM-00269

Ensembl Protein ID

ENSPMAP00000005646.1

UniProt Accession

S4RKB3; S4RKB3_PETMA

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000005090.1	ENSPMAT00000005670.1	ENSPMAP00000005646.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-41	138.3	342	376
UBD/Beta-Prp	4.40e-49	166.4	247	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           Ht++vt++++   +d+ l+sG+ D+ +k+WD+r+ 
   Q: 342  HTGWVTSVKWsphNDKQLISGAIDKMVKLWDTRSP 376
           ***********9877****************9886 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++t++gh++ v s+ +s+ +  + s+s+d tir+wd etg+       g ++vvn+++++p ++ ++sGs+Dr +r+Wd   k g
   Q: 247  TRTPIMTISGHNEAVSSVLWSE-DLEICSASWDHTIRLWDAETGEQKA--SLGGNKVVNSISYSPLCKRIASGSTDRHIRIWDPrsKGG 332
           6789******************.889*******************997..677788***************************965556 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlqtgec.vrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           +l++   t+ ht+ v+s+++++   k+l+sg+ d+ vklwd ++ +  ++ + +h++ +++v+   +++ l+sg++D+ +  ++
   Q: 333  SLVQLSlTS-HTGWVTSVKWSPHNdKQLISGAIDKMVKLWDTRSPKApLYDMAAHEEKILCVEWA-ENNMLLSGGADNKLVTFN 414
           777654365.*********998766******************76655***************99.9999*****999887775 PP

Organism

Petromyzon marinus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQVQARFVT KNKKYEVDAV PFSVVAQAEV TDLSNLINKL LEAQAGEHKH VEFDFLIGGQ 60
FLRMTLGKHM EQEGISTETV VEVEYVEKFT APQPEECILH DDWVSAVKVC DDWILSGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTTGAGTGA ACTACATTGT GGCCGGCCAC GGCCTGCGCG TTGAGTGGTA TCGCTAATCA 60
CCAAACTCAT TGCCATTATC ATCATAATCA CCACCGCTCA CTCGTTTATT TACGGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0539--Nucleus
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	35.05	5.00e-61	226.00
IUUC-Aml-001997	Ailuropoda melanoleuca	69.10	3.00e-164	569.00
IUUC-Atr-002544	Amborella trichopoda	35.05	6.00e-57	213.00
IUUC-Apl-003981	Anas platyrhynchos	68.16	4.00e-156	542.00
IUUC-Aca-004370	Anolis carolinensis	69.88	1.00e-173	601.00
IUUC-Aly-006455	Arabidopsis lyrata	33.10	7.00e-59	219.00
IUUC-Ath-006669	Arabidopsis thaliana	32.86	8.00e-55	206.00
IUUC-Ago-007864	Ashbya gossypii	30.00	3.00e-38	151.00
IUUC-Acl-008177	Aspergillus clavatus	28.02	3.00e-34	138.00
IUUC-Afl-008617	Aspergillus flavus	28.78	5.00e-35	140.00
IUUC-Afu-008752	Aspergillus fumigatus	28.05	3.00e-31	128.00
IUUC-Ani-009136	Aspergillus nidulans	29.71	1.00e-36	145.00
IUUC-Ang-009701	Aspergillus niger	29.37	7.00e-33	133.00
IUUC-Aor-009884	Aspergillus oryzae	28.78	5.00e-35	140.00
IUUC-Ame-011432	Astyanax mexicanus	67.22	7.00e-170	588.00
IUUC-Bgr-012218	Blumeria graminis	26.49	4.00e-33	134.00
IUUC-Bta-012829	Bos taurus	69.34	5.00e-171	592.00
IUUC-Bci-013953	Botrytis cinerea	29.51	2.00e-35	141.00
IUUC-Bdi-014351	Brachypodium distachyon	35.63	4.00e-59	220.00
IUUC-Bol-016514	Brassica oleracea	34.21	2.00e-56	211.00
IUUC-Bra-016988	Brassica rapa	34.21	3.00e-56	211.00
IUUC-Cel-018569	Caenorhabditis elegans	32.56	2.00e-47	181.00
IUUC-Cja-019468	Callithrix jacchus	68.63	1.00e-165	573.00
IUUC-Cfa-020471	Canis familiaris	68.40	5.00e-164	568.00
IUUC-Cpo-022260	Cavia porcellus	69.10	1.00e-167	580.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	30.71	8.00e-37	146.00
IUUC-Csa-023989	Chlorocebus sabaeus	68.40	1.00e-165	574.00
IUUC-Cho-024426	Choloepus hoffmanni	66.14	7.00e-124	435.00
IUUC-Cin-025789	Ciona intestinalis	42.34	6.00e-95	339.00
IUUC-Cne-027063	Cryptococcus neoformans	24.95	7.00e-17	80.10
IUUC-Dre-027907	Danio rerio	67.45	3.00e-170	589.00
IUUC-Dno-029225	Dasypus novemcinctus	68.40	5.00e-169	585.00
IUUC-Dor-031082	Dipodomys ordii	57.31	6.00e-126	442.00
IUUC-Dse-031308	Dothistroma septosporum	29.35	5.00e-39	154.00
IUUC-Dme-032189	Drosophila melanogaster	41.75	7.00e-93	332.00
IUUC-Ete-032247	Echinops telfairi	65.09	3.00e-157	546.00
IUUC-Eca-034285	Equus caballus	69.34	2.00e-171	593.00
IUUC-Eeu-035322	Erinaceus europaeus	64.48	9.00e-147	511.00
IUUC-Fca-036114	Felis catus	68.63	1.00e-169	587.00
IUUC-Fal-036891	Ficedula albicollis	69.58	2.00e-147	513.00
IUUC-Fox-037965	Fusarium oxysporum	25.05	4.00e-33	134.00
IUUC-Fso-038244	Fusarium solani	25.80	6.00e-34	137.00
IUUC-Gmo-039040	Gadus morhua	66.04	1.00e-169	587.00
IUUC-Gga-040610	Gallus gallus	67.92	5.00e-173	598.00
IUUC-Gac-042117	Gasterosteus aculeatus	65.57	6.00e-161	558.00
IUUC-Gma-043756	Glycine max	38.04	1.00e-67	248.00
IUUC-Ggo-045179	Gorilla gorilla	68.16	8.00e-165	571.00
IUUC-Hsa-046114	Homo sapiens	68.63	2.00e-165	573.00
IUUC-Hvu-047331	Hordeum vulgare	35.19	2.00e-55	207.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	67.69	7.00e-168	581.00
IUUC-Kpa-049304	Komagataella pastoris	28.48	6.00e-41	160.00
IUUC-Lch-050655	Latimeria chalumnae	66.27	3.00e-129	452.00
IUUC-Lpe-051675	Leersia perrieri	34.82	5.00e-61	227.00
IUUC-Loc-052868	Lepisosteus oculatus	69.58	3.00e-171	593.00
IUUC-Lma-053258	Leptosphaeria maculans	29.73	1.00e-36	147.00
IUUC-Laf-053993	Loxodonta africana	68.87	1.00e-169	587.00
IUUC-Mcc-055128	Macaca mulatta	54.72	2.00e-124	437.00
IUUC-Meu-056501	Macropus eugenii	63.64	1.00e-134	471.00
IUUC-Mor-057114	Magnaporthe oryzae	25.96	4.00e-28	117.00
IUUC-Mtr-058367	Medicago truncatula	36.28	3.00e-60	224.00
IUUC-Mla-059107	Melampsora laricipopulina	28.45	1.00e-30	125.00
IUUC-Mga-059745	Meleagris gallopavo	65.73	3.00e-165	572.00
IUUC-Mvi-060362	Microbotryum violaceum	26.55	6.00e-35	140.00
IUUC-Mdo-062257	Monodelphis domestica	69.05	3.00e-175	606.00
IUUC-Mmu-063546	Mus musculus	68.40	4.00e-169	585.00
IUUC-Mac-065540	Musa acuminata	32.54	5.00e-57	213.00
IUUC-Mpu-066284	Mustela putorius furo	68.40	2.00e-169	587.00
IUUC-Mlu-067241	Myotis lucifugus	68.40	8.00e-169	584.00
IUUC-Nfi-068260	Neosartorya fischeri	28.29	7.00e-34	136.00
IUUC-Ncr-068719	Neurospora crassa	25.57	2.00e-28	118.00
IUUC-Nle-068981	Nomascus leucogenys	68.40	1.00e-162	563.00
IUUC-Opr-071218	Ochotona princeps	63.32	6.00e-148	515.00
IUUC-Ont-071646	Oreochromis niloticus	65.14	1.00e-167	580.00
IUUC-Oan-073453	Ornithorhynchus anatinus	69.81	2.00e-179	619.00
IUUC-Ocu-074008	Oryctolagus cuniculus	68.40	6.00e-170	588.00
IUUC-Oba-075712	Oryza barthii	31.59	6.00e-47	180.00
IUUC-Obr-076721	Oryza brachyantha	34.20	1.00e-59	222.00
IUUC-Ogl-077229	Oryza glaberrima	34.75	6.00e-62	229.00
IUUC-Ogu-078977	Oryza glumaepatula	31.59	3.00e-47	181.00
IUUC-Oin-079683	Oryza indica	34.52	1.00e-61	228.00
IUUC-Olo-080291	Oryza longistaminata	31.23	9.00e-31	125.00
IUUC-Ome-081834	Oryza meridionalis	35.22	5.00e-63	233.00
IUUC-Oni-082507	Oryza nivara	34.36	2.00e-58	218.00
IUUC-Opu-083396	Oryza punctata	34.52	5.00e-61	227.00
IUUC-Oru-085220	Oryza rufipogon	34.12	1.00e-57	215.00
IUUC-Osa-085767	Oryza sativa	34.52	1.00e-61	228.00
IUUC-Ola-087420	Oryzias latipes	64.39	8.00e-165	571.00
IUUC-Olu-087740	Ostreococcus lucimarinus	30.02	8.00e-42	162.00
IUUC-Oga-088264	Otolemur garnettii	67.45	5.00e-165	572.00
IUUC-Oar-089335	Ovis aries	68.63	3.00e-169	586.00
IUUC-Ptr-091320	Pan troglodytes	68.63	2.00e-165	573.00
IUUC-Pan-092833	Papio anubis	68.40	2.00e-164	570.00
IUUC-Psi-093504	Pelodiscus sinensis	69.81	7.00e-174	601.00
IUUC-Pno-094929	Phaeosphaeria nodorum	28.45	3.00e-37	147.00
IUUC-Ppa-095429	Physcomitrella patens	35.33	3.00e-63	234.00
IUUC-Pfo-096337	Poecilia formosa	64.62	8.00e-169	584.00
IUUC-Pab-097571	Pongo abelii	68.16	4.00e-165	572.00
IUUC-Pop-099977	Populus trichocarpa	35.89	1.00e-63	235.00
IUUC-Pca-100394	Procavia capensis	64.15	1.00e-146	511.00
IUUC-Ppe-101848	Prunus persica	37.47	4.00e-65	240.00
IUUC-Pva-102921	Pteropus vampyrus	65.73	1.00e-86	311.00
IUUC-Pgr-103637	Puccinia graminis	27.14	6.00e-33	134.00
IUUC-Ptt-103781	Puccinia triticina	26.07	2.00e-32	132.00
IUUC-Pte-104135	Pyrenophora teres	31.04	2.00e-35	143.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	28.54	4.00e-36	144.00
IUUC-Rno-105114	Rattus norvegicus	68.87	9.00e-171	591.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.07	3.00e-39	154.00
IUUC-Sha-107122	Sarcophilus harrisii	69.17	2.00e-166	577.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	28.77	2.00e-44	172.00
IUUC-Spo-108134	Schizosaccharomyces pombe	28.15	2.00e-38	151.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.80	1.00e-36	145.00
IUUC-Smo-108720	Selaginella moellendorffii	34.04	3.00e-60	224.00
IUUC-Sit-110311	Setaria italica	34.12	4.00e-59	220.00
IUUC-Sly-111023	Solanum lycopersicum	33.99	2.00e-56	211.00
IUUC-Stu-112778	Solanum tuberosum	37.05	2.00e-62	231.00
IUUC-Sar-113596	Sorex araneus	58.25	4.00e-131	459.00
IUUC-Sbi-114193	Sorghum bicolor	34.13	4.00e-60	223.00
IUUC-Sre-115002	Sporisorium reilianum	25.74	6.00e-12	63.90
IUUC-Ssc-116066	Sus scrofa	68.63	2.00e-169	586.00
IUUC-Tgu-117048	Taeniopygia guttata	69.47	5.00e-159	551.00
IUUC-Tsy-119573	Tarsius syrichta	42.72	3.00e-89	320.00
IUUC-Tni-119820	Tetraodon nigroviridis	65.62	6.00e-167	578.00
IUUC-Tca-121605	Theobroma cacao	36.12	2.00e-62	231.00
IUUC-Tre-121947	Trichoderma reesei	26.72	1.00e-37	149.00
IUUC-Tvi-122481	Trichoderma virens	26.72	1.00e-37	149.00
IUUC-Tae-123847	Triticum aestivum	35.05	5.00e-61	226.00
IUUC-Tur-126586	Triticum urartu	34.68	1.00e-56	212.00
IUUC-Tme-126900	Tuber melanosporum	28.37	1.00e-40	159.00
IUUC-Tbe-127736	Tupaia belangeri	53.15	1.00e-108	384.00
IUUC-Ttr-129041	Tursiops truncatus	60.61	1.00e-142	497.00
IUUC-Vpa-130260	Vicugna pacos	68.87	2.00e-170	590.00
IUUC-Vvi-131009	Vitis vinifera	35.63	3.00e-61	227.00
IUUC-Xtr-132083	Xenopus tropicalis	66.27	3.00e-166	576.00
IUUC-Xma-133094	Xiphophorus maculatus	63.92	3.00e-167	579.00
IUUC-Yli-134531	Yarrowia lipolytica	25.44	5.00e-23	100.00
IUUC-Zma-135509	Zea mays	33.81	3.00e-61	227.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence