iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003250

Ensembl Protein ID

ENSAPLP00000004005.1

UniProt Accession

U3I9T4; U3I9T4_ANAPL

Genbank Protein ID

ENSAPLP00000004005

Protein Name

Histone deacetylase

Genbank Nucleotide ID

ADON01106767

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000004358.1	ENSAPLT00000004612.1	ENSAPLP00000004005.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	87.84	0.00e+00	1607.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
774	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Anas platyrhynchos

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

DVTTALPLQV APTSVPMDLR LDHQFSMPVT EPTLREQQLQ QELLALKQKQ QIQRQILIAE 60
FQRQHEQLSR QHEAQLHEHI KQHSGALLLE NVQTRLKGQS GSNRHKQGRG LEKSHRWPER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTTCCCA TCTTGAGAAC GATTAGAAGA TACTCTGCCA CCCTATTGGA TTATTTTGTA 60
TACAGCTCAG CATGTCACTG TGCCCTGGAT TTTATAAGGT GGCCATGATT TAATCCCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000749	Aegilops tauschii	47.13	1.00e-59	223.00
IUUC-Aml-002279	Ailuropoda melanoleuca	87.55	0.00e+00	1602.00
IUUC-Atr-002745	Amborella trichopoda	36.19	3.00e-70	259.00
IUUC-Aca-004668	Anolis carolinensis	83.92	0.00e+00	1608.00
IUUC-Aly-006432	Arabidopsis lyrata	40.56	1.00e-68	254.00
IUUC-Ath-007355	Arabidopsis thaliana	40.99	2.00e-74	273.00
IUUC-Ago-007972	Ashbya gossypii	38.25	3.00e-68	252.00
IUUC-Acl-008187	Aspergillus clavatus	40.20	1.00e-71	264.00
IUUC-Afl-008399	Aspergillus flavus	44.16	2.00e-40	159.00
IUUC-Afu-008954	Aspergillus fumigatus	35.71	4.00e-59	222.00
IUUC-Ani-009142	Aspergillus nidulans	38.56	2.00e-67	249.00
IUUC-Ang-009522	Aspergillus niger	29.08	2.00e-34	140.00
IUUC-Aor-010069	Aspergillus oryzae	38.38	4.00e-65	242.00
IUUC-Ate-010291	Aspergillus terreus	40.61	8.00e-74	271.00
IUUC-Ame-010780	Astyanax mexicanus	39.85	2.00e-73	270.00
IUUC-Bta-013215	Bos taurus	86.90	0.00e+00	1581.00
IUUC-Bci-013789	Botrytis cinerea	36.96	1.00e-66	247.00
IUUC-Bdi-014007	Brachypodium distachyon	41.13	5.00e-72	265.00
IUUC-Bol-015468	Brassica oleracea	41.22	1.00e-74	273.00
IUUC-Bra-016680	Brassica rapa	41.48	6.00e-75	275.00
IUUC-Cel-018220	Caenorhabditis elegans	36.82	1.00e-66	247.00
IUUC-Cja-019816	Callithrix jacchus	87.22	0.00e+00	1627.00
IUUC-Cfa-020861	Canis familiaris	87.91	0.00e+00	1594.00
IUUC-Cpo-021562	Cavia porcellus	86.24	0.00e+00	1605.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	49.55	2.00e-52	198.00
IUUC-Csa-023612	Chlorocebus sabaeus	87.84	0.00e+00	1616.00
IUUC-Csv-026359	Ciona savignyi	52.70	1.00e-89	322.00
IUUC-Cgl-026709	Colletotrichum gloeosporioides	36.36	9.00e-67	247.00
IUUC-Cne-026978	Cryptococcus neoformans	38.41	1.00e-72	267.00
IUUC-Dre-028284	Danio rerio	86.41	0.00e+00	864.00
IUUC-Dno-029951	Dasypus novemcinctus	84.05	0.00e+00	1493.00
IUUC-Dor-030362	Dipodomys ordii	76.37	0.00e+00	1308.00
IUUC-Dse-031186	Dothistroma septosporum	34.41	2.00e-61	230.00
IUUC-Dme-031766	Drosophila melanogaster	57.08	3.00e-159	555.00
IUUC-Ete-032279	Echinops telfairi	36.81	2.00e-56	213.00
IUUC-Eca-033842	Equus caballus	42.86	3.00e-76	280.00
IUUC-Eeu-034487	Erinaceus europaeus	50.41	7.00e-61	228.00
IUUC-Fca-036187	Felis catus	88.20	0.00e+00	1619.00
IUUC-Fox-038067	Fusarium oxysporum	39.31	3.00e-68	252.00
IUUC-Fso-038263	Fusarium solani	38.33	2.00e-68	253.00
IUUC-Gmo-038473	Gadus morhua	77.13	0.00e+00	759.00
IUUC-Ggr-040062	Gaeumannomyces graminis	40.17	3.00e-65	243.00
IUUC-Gga-040501	Gallus gallus	96.45	0.00e+00	1745.00
IUUC-Gac-042335	Gasterosteus aculeatus	67.64	0.00e+00	1220.00
IUUC-Gma-043738	Glycine max	41.16	2.00e-66	246.00
IUUC-Ggo-045380	Gorilla gorilla	87.22	0.00e+00	1596.00
IUUC-Hsa-046925	Homo sapiens	87.80	0.00e+00	1602.00
IUUC-Hvu-047285	Hordeum vulgare	41.26	2.00e-69	255.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	86.81	0.00e+00	1570.00
IUUC-Kpa-049281	Komagataella pastoris	38.52	3.00e-70	259.00
IUUC-Lch-050325	Latimeria chalumnae	83.77	0.00e+00	1474.00
IUUC-Lpe-051214	Leersia perrieri	41.67	6.00e-75	275.00
IUUC-Loc-052231	Lepisosteus oculatus	80.13	0.00e+00	1426.00
IUUC-Lma-053263	Leptosphaeria maculans	39.70	5.00e-74	272.00
IUUC-Laf-054490	Loxodonta africana	83.38	0.00e+00	1566.00
IUUC-Mcc-055265	Macaca mulatta	87.91	0.00e+00	1653.00
IUUC-Meu-056676	Macropus eugenii	88.54	0.00e+00	780.00
IUUC-Mor-057095	Magnaporthe oryzae	36.98	1.00e-67	250.00
IUUC-Mpo-057389	Magnaporthe poae	38.96	3.00e-64	239.00
IUUC-Mtr-058463	Medicago truncatula	41.16	3.00e-70	259.00
IUUC-Mla-059143	Melampsora laricipopulina	40.05	2.00e-69	256.00
IUUC-Mmr-061633	Microcebus murinus	80.73	0.00e+00	1439.00
IUUC-Mdo-062198	Monodelphis domestica	42.96	2.00e-77	284.00
IUUC-Mmu-063089	Mus musculus	87.36	0.00e+00	1551.00
IUUC-Mac-064630	Musa acuminata	40.79	1.00e-71	264.00
IUUC-Mpu-065887	Mustela putorius furo	87.80	0.00e+00	1593.00
IUUC-Mlu-067470	Myotis lucifugus	87.68	0.00e+00	1636.00
IUUC-Nfi-068404	Neosartorya fischeri	39.44	1.00e-70	260.00
IUUC-Ncr-068672	Neurospora crassa	37.84	4.00e-68	252.00
IUUC-Nle-069099	Nomascus leucogenys	83.12	0.00e+00	1019.00
IUUC-Opr-071074	Ochotona princeps	44.25	3.00e-87	316.00
IUUC-Ont-071613	Oreochromis niloticus	70.58	0.00e+00	1231.00
IUUC-Oan-073275	Ornithorhynchus anatinus	90.77	0.00e+00	1666.00
IUUC-Ocu-074627	Oryctolagus cuniculus	44.58	5.00e-84	305.00
IUUC-Oba-075489	Oryza barthii	41.26	7.00e-73	268.00
IUUC-Obr-076150	Oryza brachyantha	41.55	2.00e-74	273.00
IUUC-Ogl-077437	Oryza glaberrima	41.26	3.00e-73	269.00
IUUC-Ogu-078370	Oryza glumaepatula	41.26	2.00e-73	270.00
IUUC-Oin-079210	Oryza indica	41.26	2.00e-73	270.00
IUUC-Olo-080971	Oryza longistaminata	42.38	5.00e-64	238.00
IUUC-Oni-082031	Oryza nivara	41.26	4.00e-73	269.00
IUUC-Opu-083471	Oryza punctata	41.55	2.00e-73	270.00
IUUC-Oru-084755	Oryza rufipogon	41.26	3.00e-73	269.00
IUUC-Osa-085447	Oryza sativa	41.26	2.00e-73	269.00
IUUC-Ola-087031	Oryzias latipes	66.36	0.00e+00	1168.00
IUUC-Oga-088201	Otolemur garnettii	80.26	0.00e+00	1410.00
IUUC-Oar-089997	Ovis aries	81.53	0.00e+00	1371.00
IUUC-Ptr-091116	Pan troglodytes	87.51	0.00e+00	1633.00
IUUC-Pan-092132	Papio anubis	89.94	0.00e+00	1118.00
IUUC-Psi-093734	Pelodiscus sinensis	92.32	0.00e+00	1644.00
IUUC-Pma-094347	Petromyzon marinus	72.19	0.00e+00	717.00
IUUC-Pno-095131	Phaeosphaeria nodorum	45.85	2.00e-64	239.00
IUUC-Ppa-095550	Physcomitrella patens	43.61	1.00e-72	267.00
IUUC-Pfo-096293	Poecilia formosa	68.41	0.00e+00	1170.00
IUUC-Pab-098491	Pongo abelii	84.63	0.00e+00	1535.00
IUUC-Pop-099174	Populus trichocarpa	40.29	2.00e-70	260.00
IUUC-Pca-101004	Procavia capensis	79.32	0.00e+00	869.00
IUUC-Ppe-101644	Prunus persica	39.77	1.00e-71	263.00
IUUC-Pva-102961	Pteropus vampyrus	66.33	0.00e+00	834.00
IUUC-Ptt-103841	Puccinia triticina	38.56	3.00e-68	252.00
IUUC-Pte-104383	Pyrenophora teres	38.34	3.00e-71	263.00
IUUC-Pyt-104427	Pyrenophora triticirepentis	38.80	4.00e-71	262.00
IUUC-Rno-105005	Rattus norvegicus	87.26	0.00e+00	1523.00
IUUC-Sce-106274	Saccharomyces cerevisiae	36.56	5.00e-65	242.00
IUUC-Sha-107646	Sarcophilus harrisii	68.22	0.00e+00	1033.00
IUUC-Sja-107915	Schizosaccharomyces japonicus	37.66	8.00e-72	264.00
IUUC-Spo-108300	Schizosaccharomyces pombe	39.13	4.00e-74	272.00
IUUC-Smo-109615	Selaginella moellendorffii	42.38	7.00e-77	281.00
IUUC-Sit-110160	Setaria italica	41.09	1.00e-69	257.00
IUUC-Sly-111164	Solanum lycopersicum	39.90	1.00e-77	283.00
IUUC-Stu-112685	Solanum tuberosum	38.85	7.00e-59	221.00
IUUC-Sar-113692	Sorex araneus	35.00	8.00e-46	179.00
IUUC-Sbi-114301	Sorghum bicolor	40.69	8.00e-68	251.00
IUUC-Sre-115013	Sporisorium reilianum	40.56	1.00e-69	257.00
IUUC-Ssc-115428	Sus scrofa	86.80	0.00e+00	1556.00
IUUC-Tgu-116776	Taeniopygia guttata	94.82	0.00e+00	1721.00
IUUC-Tru-118180	Takifugu rubripes	69.29	0.00e+00	1236.00
IUUC-Tsy-119468	Tarsius syrichta	85.25	0.00e+00	733.00
IUUC-Tni-120196	Tetraodon nigroviridis	68.59	0.00e+00	1210.00
IUUC-Tca-121312	Theobroma cacao	42.61	4.00e-75	275.00
IUUC-Tre-121930	Trichoderma reesei	38.88	3.00e-72	265.00
IUUC-Tvi-122373	Trichoderma virens	39.36	5.00e-70	258.00
IUUC-Tae-123064	Triticum aestivum	39.54	8.00e-66	243.00
IUUC-Tme-127027	Tuber melanosporum	44.29	7.00e-60	224.00
IUUC-Tbe-127675	Tupaia belangeri	39.77	4.00e-19	90.10
IUUC-Ttr-128360	Tursiops truncatus	81.88	0.00e+00	960.00
IUUC-Uma-129408	Ustilago maydis	43.53	1.00e-68	253.00
IUUC-Vda-129994	Verticillium dahliae	41.39	3.00e-61	229.00
IUUC-Vpa-130525	Vicugna pacos	57.89	9.00e-17	82.00
IUUC-Vvi-131038	Vitis vinifera	39.61	6.00e-74	271.00
IUUC-Xtr-132956	Xenopus tropicalis	78.60	0.00e+00	1414.00
IUUC-Xma-134265	Xiphophorus maculatus	67.79	0.00e+00	1179.00
IUUC-Yli-134680	Yarrowia lipolytica	39.50	1.00e-68	254.00
IUUC-Zma-135110	Zea mays	40.69	2.00e-69	256.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence