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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105153
UUCD1 version UUC-RaN-00119
Ensembl Protein ID ENSRNOP00000000365.4
UniProt Accession D3ZBM7; D3ZBM8; HACE1_RAT
Protein Name E3 ubiquitin-protein ligase HACE1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1
Gene Name Hace1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000000327.5 ENSRNOT00000000365.4 ENSRNOP00000000365.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.20e-119 399.2 576 905
Active Site
Position(s) Description Evidence
876 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 661
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 662  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 747
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e++++eer  +LqFvT
   Q: 748  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDMTQEERVLLLQFVT 836
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 837  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 905
           ******************8888888868888********************************986555 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
 E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Protein Sequence
(Fasta)
MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105153|E3,HECT|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGAGAG CGATGGAGCA GCTCAACCGT CTGACGCGCT CGCTGCGCCG CGCGCGCACC 60
GTGGAGCTGC CCGAGGGTGA GGCGCCCGGA GAACGCGCGC TGCACTTTTC AGAGGCTGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105153|E3,HECT|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
Pfam

PF12796--Ank_2
PF00632--HECT
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00119--HECTc
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0032580--C:Golgi cisterna membrane
GO:0000139--C:Golgi membrane
GO:0017137--F:Rab GTPase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007049--P:cell cycle
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG rno:361866
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000627 Aegilops tauschii 40.59 2.00e-83 306.00
IUUC-Aml-001490 Ailuropoda melanoleuca 96.27 0.00e+00 1837.00
IUUC-Atr-002582 Amborella trichopoda 43.41 2.00e-99 358.00
IUUC-Apl-003400 Anas platyrhynchos 87.87 0.00e+00 1150.00
IUUC-Aca-005375 Anolis carolinensis 91.10 0.00e+00 1736.00
IUUC-Aly-006157 Arabidopsis lyrata 44.32 2.00e-100 362.00
IUUC-Ath-007160 Arabidopsis thaliana 42.76 6.00e-95 344.00
IUUC-Afl-008712 Aspergillus flavus 42.11 4.00e-96 346.00
IUUC-Afu-009022 Aspergillus fumigatus 42.66 1.00e-95 346.00
IUUC-Ani-009412 Aspergillus nidulans 42.79 1.00e-97 353.00
IUUC-Ate-010253 Aspergillus terreus 42.79 3.00e-96 348.00
IUUC-Ame-011847 Astyanax mexicanus 84.32 0.00e+00 1638.00
IUUC-Bta-012831 Bos taurus 96.18 0.00e+00 1801.00
IUUC-Bdi-014884 Brachypodium distachyon 42.99 1.00e-97 353.00
IUUC-Bol-016533 Brassica oleracea 52.55 2.00e-78 285.00
IUUC-Bra-016726 Brassica rapa 44.32 7.00e-101 363.00
IUUC-Cja-019160 Callithrix jacchus 97.03 0.00e+00 1853.00
IUUC-Cfa-020346 Canis familiaris 96.37 0.00e+00 1844.00
IUUC-Cpo-021766 Cavia porcellus 96.26 0.00e+00 1846.00
IUUC-Cre-022900 Chlamydomonas reinhardtii 43.35 7.00e-99 353.00
IUUC-Csa-023768 Chlorocebus sabaeus 96.70 0.00e+00 1852.00
IUUC-Cho-024688 Choloepus hoffmanni 92.19 0.00e+00 1159.00
IUUC-Cin-025417 Ciona intestinalis 50.52 5.00e-139 488.00
IUUC-Csv-025993 Ciona savignyi 43.82 0.00e+00 758.00
IUUC-Cne-027095 Cryptococcus neoformans 39.13 3.00e-81 298.00
IUUC-Cme-027267 Cyanidioschyzon merolae 42.23 3.00e-87 317.00
IUUC-Dre-027819 Danio rerio 84.87 0.00e+00 1626.00
IUUC-Dno-029027 Dasypus novemcinctus 95.63 0.00e+00 1821.00
IUUC-Dor-030327 Dipodomys ordii 89.01 0.00e+00 1617.00
IUUC-Ete-032966 Echinops telfairi 89.23 0.00e+00 1687.00
IUUC-Eca-034339 Equus caballus 96.48 0.00e+00 1843.00
IUUC-Eeu-034544 Erinaceus europaeus 68.01 0.00e+00 676.00
IUUC-Fca-035617 Felis catus 96.14 0.00e+00 1313.00
IUUC-Fal-036687 Ficedula albicollis 90.45 0.00e+00 1758.00
IUUC-Gmo-039508 Gadus morhua 87.93 0.00e+00 831.00
IUUC-Gga-040845 Gallus gallus 90.76 0.00e+00 1774.00
IUUC-Gac-041894 Gasterosteus aculeatus 84.60 0.00e+00 1578.00
IUUC-Gma-044216 Glycine max 44.09 3.00e-101 365.00
IUUC-Ggo-044465 Gorilla gorilla 93.09 0.00e+00 1771.00
IUUC-Hsa-045731 Homo sapiens 96.92 0.00e+00 1855.00
IUUC-Hvu-047697 Hordeum vulgare 42.76 1.00e-96 350.00
IUUC-Itr-048716 Ictidomys tridecemlineatus 96.81 0.00e+00 1847.00
IUUC-Lch-050436 Latimeria chalumnae 88.99 0.00e+00 1693.00
IUUC-Lpe-051550 Leersia perrieri 43.21 1.00e-98 356.00
IUUC-Loc-052287 Lepisosteus oculatus 84.86 0.00e+00 1666.00
IUUC-Lma-053159 Leptosphaeria maculans 40.73 2.00e-93 339.00
IUUC-Laf-053846 Loxodonta africana 96.70 0.00e+00 1846.00
IUUC-Mcc-055845 Macaca mulatta 96.81 0.00e+00 1854.00
IUUC-Meu-056060 Macropus eugenii 95.68 0.00e+00 696.00
IUUC-Mtr-057633 Medicago truncatula 44.32 9.00e-102 367.00
IUUC-Mga-059935 Meleagris gallopavo 93.22 0.00e+00 1752.00
IUUC-Mmr-060960 Microcebus murinus 97.14 0.00e+00 1859.00
IUUC-Mdo-061851 Monodelphis domestica 91.72 0.00e+00 1799.00
IUUC-Mmu-063657 Mus musculus 98.35 0.00e+00 1873.00
IUUC-Mac-065229 Musa acuminata 43.41 4.00e-99 358.00
IUUC-Mpu-066161 Mustela putorius furo 98.49 0.00e+00 828.00
IUUC-Mlu-067354 Myotis lucifugus 94.49 0.00e+00 1767.00
IUUC-Nfi-068278 Neosartorya fischeri 42.66 7.00e-96 347.00
IUUC-Nle-069112 Nomascus leucogenys 97.03 0.00e+00 1857.00
IUUC-Opr-070686 Ochotona princeps 88.61 0.00e+00 811.00
IUUC-Ont-072398 Oreochromis niloticus 84.10 0.00e+00 1580.00
IUUC-Oan-073194 Ornithorhynchus anatinus 94.29 0.00e+00 1728.00
IUUC-Ocu-074397 Oryctolagus cuniculus 84.64 0.00e+00 1560.00
IUUC-Oba-075757 Oryza barthii 42.99 5.00e-98 354.00
IUUC-Obr-076553 Oryza brachyantha 43.44 1.00e-98 356.00
IUUC-Ogl-077520 Oryza glaberrima 42.99 8.00e-98 353.00
IUUC-Ogu-078278 Oryza glumaepatula 42.99 7.00e-98 353.00
IUUC-Oin-079767 Oryza indica 42.99 6.00e-98 354.00
IUUC-Olo-080380 Oryza longistaminata 42.83 2.00e-96 349.00
IUUC-Ome-081925 Oryza meridionalis 42.83 2.00e-96 349.00
IUUC-Oni-082619 Oryza nivara 42.99 8.00e-98 353.00
IUUC-Opu-083684 Oryza punctata 42.83 2.00e-96 349.00
IUUC-Oru-084501 Oryza rufipogon 42.99 7.00e-98 353.00
IUUC-Osa-086251 Oryza sativa 42.82 8.00e-98 351.00
IUUC-Ola-086777 Oryzias latipes 80.78 0.00e+00 1566.00
IUUC-Oga-088684 Otolemur garnettii 96.92 0.00e+00 1853.00
IUUC-Oar-089428 Ovis aries 95.76 0.00e+00 1803.00
IUUC-Ptr-090529 Pan troglodytes 96.81 0.00e+00 1854.00
IUUC-Pan-091702 Papio anubis 96.70 0.00e+00 1852.00
IUUC-Psi-093969 Pelodiscus sinensis 90.53 0.00e+00 1704.00
IUUC-Pno-094871 Phaeosphaeria nodorum 40.73 4.00e-93 338.00
IUUC-Ppa-095834 Physcomitrella patens 43.74 1.00e-97 353.00
IUUC-Pfo-097364 Poecilia formosa 85.20 0.00e+00 1605.00
IUUC-Pab-098574 Pongo abelii 96.92 0.00e+00 1855.00
IUUC-Pop-099468 Populus trichocarpa 44.32 3.00e-101 365.00
IUUC-Pca-100525 Procavia capensis 85.20 9.00e-177 613.00
IUUC-Ppe-101641 Prunus persica 43.86 4.00e-100 361.00
IUUC-Pva-102365 Pteropus vampyrus 85.15 0.00e+00 1576.00
IUUC-Pgr-103465 Puccinia graminis 40.37 7.00e-99 357.00
IUUC-Ptt-103813 Puccinia triticina 37.86 2.00e-88 323.00
IUUC-Pyt-104713 Pyrenophora triticirepentis 40.96 3.00e-94 342.00
IUUC-Sha-107319 Sarcophilus harrisii 91.83 0.00e+00 1797.00
IUUC-Smo-109640 Selaginella moellendorffii 43.28 4.00e-99 358.00
IUUC-Sit-110598 Setaria italica 43.67 3.00e-98 355.00
IUUC-Sly-111706 Solanum lycopersicum 44.55 4.00e-101 364.00
IUUC-Stu-112894 Solanum tuberosum 35.04 2.00e-54 207.00
IUUC-Sar-113449 Sorex araneus 79.61 3.00e-174 605.00
IUUC-Sbi-114042 Sorghum bicolor 43.96 9.00e-99 357.00
IUUC-Sre-114958 Sporisorium reilianum 45.43 8.00e-109 387.00
IUUC-Ssc-115865 Sus scrofa 96.48 0.00e+00 1848.00
IUUC-Tgu-117225 Taeniopygia guttata 90.45 0.00e+00 1768.00
IUUC-Tru-118026 Takifugu rubripes 82.17 0.00e+00 1565.00
IUUC-Tsy-119407 Tarsius syrichta 83.94 0.00e+00 1554.00
IUUC-Tni-120234 Tetraodon nigroviridis 83.31 0.00e+00 1266.00
IUUC-Tca-121479 Theobroma cacao 44.09 3.00e-102 368.00
IUUC-Tae-125214 Triticum aestivum 42.26 2.00e-96 348.00
IUUC-Tur-126774 Triticum urartu 29.41 2.00e-46 180.00
IUUC-Tbe-127708 Tupaia belangeri 85.77 0.00e+00 860.00
IUUC-Ttr-128667 Tursiops truncatus 96.37 0.00e+00 1848.00
IUUC-Uma-129355 Ustilago maydis 46.10 2.00e-109 389.00
IUUC-Vpa-130200 Vicugna pacos 96.26 0.00e+00 1787.00
IUUC-Vvi-131078 Vitis vinifera 43.86 2.00e-101 365.00
IUUC-Xtr-132176 Xenopus tropicalis 87.39 0.00e+00 1704.00
IUUC-Xma-133936 Xiphophorus maculatus 81.56 0.00e+00 939.00
Created Date 25-Jun-2017

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