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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046848
UUCD1 version UUC-HoS-01267
Ensembl Protein ID ENSP00000384109.3
UniProt Accession Q13620; B1APK5; B3KVX4; B7Z5K8; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7; CUL4B_HUMAN
Genbank Protein ID AAR13073.1; AAK16812.1; BAG53936.1; BAH12944.1; BAG37520.1; CAD97843.1; AAB67315.1; CAI41370.1; CAI41370.1; EAX11877.1; AAH36216.1; BAA31670.2; AAC50548.1
Protein Name Cullin-4B
Genbank Nucleotide ID AY365125; AF212995; AK123688; AK299081; AK315037; BX537787; AC002476; AL451005; AC002476; CH471107; BC036216; AB014595; U58091
Gene Name CUL4B; KIAA0695
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000158290.16 ENST00000371322.9 ENSP00000360373.5
ENSG00000158290.16 ENST00000336592.10 ENSP00000338919.6
ENSG00000158290.16 ENST00000404115.7 ENSP00000384109.3
ENSG00000158290.16 ENST00000371323.2 ENSP00000360374.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Cullin Cullin_N_terminal 17954973; 21352845
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/Cullin 1.30e-220 735.9 219 814
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkifayl 90
           kl+eav++i++++s+k+++eely+av+nlc++k++a+lYk+l++++e++i +q+++ +e+s d+  +Lk++ r+W+++++q+ ++r+if++l
   Q: 219  KLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIkAQIHQFREDSLDSVlFLKKIDRCWQNHCRQMIMIRSIFLFL 310
           589***********************************************99**************************************** PP
   S: 91   drtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefy 180
           drtyv +++++ ++++++l+l+r +i++d  +++++++ +l lie+eR+gea+dr+ll+++ ++l++L     +iy++sFE++fle+t+++y
   Q: 311  DRTYVLQNSMLPSIWDMGLELFRAHIISDqkVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QIYQDSFEQRFLEETNRLY 397
           *****************************9**********************************9998.....9****************** PP
   S: 181  kaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLlsrvlnglee 271
           +ae ++++qe+ev eYl++v++rl+ee +r+ +yl+++t+++L+++vek+l+ +hl+++l ++l++ll++++ +dls++y+L+srv+ g++ 
   Q: 398  AAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILqKGLNNLLDENRIQDLSLLYQLFSRVRGGVQV 489
           **********************************************************9989****************************** PP
   S: 272  llkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.EllAryiDqlLrk 362
           ll+++ ++ik  g+++++++ek+k+   +V++ll++k+k++++++ +F +++kF++a+++afetf+nk+     +++p El+A+y+D++Lr+
   Q: 490  LLQQWIEYIKAFGSTIVINPEKDKT---MVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKR-----PNKPaELIAKYVDSKLRA 573
           *************************...*****************************************.....66666************* PP
   S: 363  sskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkee 454
           ++k++t+eele++ldk++++f++i +kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+d+++S+d+++qFk+ 
   Q: 574  GNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQY 665
           ******************************************************************************************** PP
   S: 455  kenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLaf 546
           ++n++   ++el+v++L++g+Wpt+  +e v+LP+e+ k++e+f++fYl khsgRkLqWq tlg++ lkae+k+gk+elqVs fQ++vLL+f
   Q: 666  MQNQNVPGNIELTVNILTMGYWPTYVPME-VHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMF 756
           ***************************99.************************************************************** PP
   S: 547  nnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           n+ e++s+ee+k+at++++ eLrrtlqsL+++k++vl k+p++k+ie++d+f++N++f
   Q: 757  NEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDF 814
           ********************************************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
 Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
Protein Sequence
(Fasta)
MMSQSSGSGD GNDDEATTSK DGGFSSPSPS AAAAAQEVRS ATDGNTSTTP PTSAKKRKLN 60
SSSSSSSNSS NEREDFDSTS SSSSTPPLQP RDSASPSTSS FCLGVSVAAS SHVPIQKKLR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046848|E3,Cullin|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGTTCAGTTT AGAAACTGCC AGTCTTGGTA TAGAACAACC TAGGCTTATC TGTTTAAGTC 60
CCATAGGTAG TATTATTAGA GAATAACCCA GGCTTTGGGA ACTGTATAAC TCTGAGATCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046848|E3,Cullin|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0242--Dwarfism
KW-1017--Isopeptide bond
KW-0991--Mental retardation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0007049--P:cell cycle
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0070911--P:global genome nucleotide-excision repair
GO:0035518--P:histone H2A monoubiquitination
GO:0031175--P:neuron projection development
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0006295--P:nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296--P:nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0006293--P:nucleotide-excision repair, preincision complex stabilization
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0045732--P:positive regulation of protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0070914--P:UV-damage excision repair
KEGG hsa:8450
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000285 Aegilops tauschii 57.75 0.00e+00 830.00
IUUC-Aml-002062 Ailuropoda melanoleuca 99.22 0.00e+00 1699.00
IUUC-Atr-002727 Amborella trichopoda 57.31 0.00e+00 808.00
IUUC-Apl-004157 Anas platyrhynchos 94.08 0.00e+00 1513.00
IUUC-Aca-004430 Anolis carolinensis 92.29 0.00e+00 1457.00
IUUC-Aly-006547 Arabidopsis lyrata 58.98 0.00e+00 814.00
IUUC-Ath-006748 Arabidopsis thaliana 57.09 0.00e+00 809.00
IUUC-Acl-008359 Aspergillus clavatus 36.15 2.00e-124 440.00
IUUC-Ame-011580 Astyanax mexicanus 84.46 0.00e+00 1425.00
IUUC-Bta-013244 Bos taurus 96.49 0.00e+00 1658.00
IUUC-Bdi-014223 Brachypodium distachyon 55.18 0.00e+00 827.00
IUUC-Bol-016036 Brassica oleracea 58.21 0.00e+00 834.00
IUUC-Bra-017794 Brassica rapa 57.74 0.00e+00 836.00
IUUC-Cja-019180 Callithrix jacchus 99.89 0.00e+00 1708.00
IUUC-Cfa-021189 Canis familiaris 99.22 0.00e+00 1704.00
IUUC-Cpo-021928 Cavia porcellus 98.99 0.00e+00 1666.00
IUUC-Cre-022739 Chlamydomonas reinhardtii 46.35 1.00e-175 610.00
IUUC-Csa-023831 Chlorocebus sabaeus 99.89 0.00e+00 1709.00
IUUC-Cho-024959 Choloepus hoffmanni 96.55 0.00e+00 1015.00
IUUC-Cgl-026761 Colletotrichum gloeosporioides 39.85 1.00e-126 447.00
IUUC-Dre-027916 Danio rerio 88.90 0.00e+00 1421.00
IUUC-Dno-029483 Dasypus novemcinctus 89.47 0.00e+00 1526.00
IUUC-Dse-031159 Dothistroma septosporum 36.64 6.00e-123 435.00
IUUC-Ete-032775 Echinops telfairi 87.19 0.00e+00 1387.00
IUUC-Eca-033952 Equus caballus 96.88 0.00e+00 1645.00
IUUC-Eeu-034767 Erinaceus europaeus 92.86 0.00e+00 1495.00
IUUC-Fca-036211 Felis catus 98.47 0.00e+00 1521.00
IUUC-Fal-037248 Ficedula albicollis 94.88 0.00e+00 1514.00
IUUC-Gmo-038754 Gadus morhua 88.38 0.00e+00 1405.00
IUUC-Ggr-040003 Gaeumannomyces graminis 36.82 2.00e-106 380.00
IUUC-Gga-041002 Gallus gallus 90.43 0.00e+00 1521.00
IUUC-Gac-041555 Gasterosteus aculeatus 85.45 0.00e+00 1402.00
IUUC-Ggo-045468 Gorilla gorilla 99.89 0.00e+00 1664.00
IUUC-Itr-048365 Ictidomys tridecemlineatus 98.66 0.00e+00 1665.00
IUUC-Lch-049858 Latimeria chalumnae 86.45 0.00e+00 1491.00
IUUC-Lpe-051446 Leersia perrieri 56.75 0.00e+00 824.00
IUUC-Loc-052415 Lepisosteus oculatus 86.88 0.00e+00 1436.00
IUUC-Lma-053080 Leptosphaeria maculans 36.85 1.00e-135 477.00
IUUC-Laf-053701 Loxodonta africana 98.32 0.00e+00 1677.00
IUUC-Mcc-055538 Macaca mulatta 97.81 0.00e+00 1681.00
IUUC-Mor-057102 Magnaporthe oryzae 36.59 1.00e-118 421.00
IUUC-Mpo-057342 Magnaporthe poae 37.77 3.00e-104 373.00
IUUC-Mtr-058660 Medicago truncatula 57.97 0.00e+00 835.00
IUUC-Mla-058936 Melampsora laricipopulina 39.91 2.00e-114 406.00
IUUC-Mga-059754 Meleagris gallopavo 90.23 0.00e+00 1513.00
IUUC-Mvi-060455 Microbotryum violaceum 41.96 7.00e-146 511.00
IUUC-Mmr-060870 Microcebus murinus 98.65 0.00e+00 1682.00
IUUC-Mdo-062015 Monodelphis domestica 91.70 0.00e+00 1480.00
IUUC-Mmu-063751 Mus musculus 96.91 0.00e+00 1625.00
IUUC-Mac-064443 Musa acuminata 57.24 0.00e+00 842.00
IUUC-Mpu-065903 Mustela putorius furo 99.22 0.00e+00 1705.00
IUUC-Mlu-068213 Myotis lucifugus 98.32 0.00e+00 1678.00
IUUC-Nfi-068363 Neosartorya fischeri 38.51 2.00e-133 470.00
IUUC-Nle-069480 Nomascus leucogenys 99.89 0.00e+00 1709.00
IUUC-Opr-071164 Ochotona princeps 91.77 0.00e+00 634.00
IUUC-Ont-071562 Oreochromis niloticus 81.83 0.00e+00 1261.00
IUUC-Oan-073607 Ornithorhynchus anatinus 94.64 0.00e+00 1493.00
IUUC-Ocu-074446 Oryctolagus cuniculus 99.44 0.00e+00 1701.00
IUUC-Oba-075198 Oryza barthii 57.02 0.00e+00 827.00
IUUC-Obr-076095 Oryza brachyantha 57.02 0.00e+00 828.00
IUUC-Ogl-077032 Oryza glaberrima 57.02 0.00e+00 828.00
IUUC-Ogu-078051 Oryza glumaepatula 57.46 0.00e+00 827.00
IUUC-Olo-080988 Oryza longistaminata 56.19 0.00e+00 818.00
IUUC-Ome-081600 Oryza meridionalis 56.19 0.00e+00 820.00
IUUC-Oni-082623 Oryza nivara 56.33 0.00e+00 820.00
IUUC-Opu-083762 Oryza punctata 56.06 0.00e+00 820.00
IUUC-Oru-084499 Oryza rufipogon 57.02 0.00e+00 827.00
IUUC-Ola-087157 Oryzias latipes 88.03 0.00e+00 1401.00
IUUC-Olu-087650 Ostreococcus lucimarinus 48.29 1.00e-180 626.00
IUUC-Oga-088416 Otolemur garnettii 96.81 0.00e+00 1601.00
IUUC-Oar-090230 Ovis aries 98.21 0.00e+00 1658.00
IUUC-Ptr-091153 Pan troglodytes 100.00 0.00e+00 1664.00
IUUC-Pan-091729 Papio anubis 99.89 0.00e+00 1709.00
IUUC-Psi-093773 Pelodiscus sinensis 94.29 0.00e+00 1506.00
IUUC-Pma-094678 Petromyzon marinus 85.06 0.00e+00 1059.00
IUUC-Pno-094946 Phaeosphaeria nodorum 35.62 6.00e-113 402.00
IUUC-Ppa-095688 Physcomitrella patens 59.65 0.00e+00 885.00
IUUC-Pfo-096828 Poecilia formosa 89.00 0.00e+00 1420.00
IUUC-Pab-097816 Pongo abelii 92.00 0.00e+00 1546.00
IUUC-Pca-100858 Procavia capensis 78.59 0.00e+00 1248.00
IUUC-Ppe-101142 Prunus persica 59.94 0.00e+00 850.00
IUUC-Pva-102995 Pteropus vampyrus 92.47 0.00e+00 1575.00
IUUC-Ptt-103903 Puccinia triticina 41.34 4.00e-97 349.00
IUUC-Pte-104167 Pyrenophora teres 36.91 1.00e-134 474.00
IUUC-Pyt-104736 Pyrenophora triticirepentis 36.20 1.00e-133 470.00
IUUC-Rno-106119 Rattus norvegicus 97.60 0.00e+00 1637.00
IUUC-Sha-106958 Sarcophilus harrisii 87.60 0.00e+00 1495.00
IUUC-Sja-107940 Schizosaccharomyces japonicus 34.48 4.00e-112 399.00
IUUC-Spo-108109 Schizosaccharomyces pombe 34.32 7.00e-112 398.00
IUUC-Ssl-108537 Sclerotinia sclerotiorum 39.56 4.00e-129 455.00
IUUC-Smo-108872 Selaginella moellendorffii 60.00 0.00e+00 909.00
IUUC-Sit-110626 Setaria italica 58.03 0.00e+00 830.00
IUUC-Sly-111497 Solanum lycopersicum 60.23 0.00e+00 855.00
IUUC-Sar-113581 Sorex araneus 85.74 0.00e+00 1050.00
IUUC-Sbi-113931 Sorghum bicolor 58.03 0.00e+00 830.00
IUUC-Tgu-116462 Taeniopygia guttata 94.50 0.00e+00 1504.00
IUUC-Tru-118299 Takifugu rubripes 88.49 0.00e+00 1417.00
IUUC-Tsy-119517 Tarsius syrichta 100.00 0.00e+00 726.00
IUUC-Tni-120811 Tetraodon nigroviridis 87.10 0.00e+00 1392.00
IUUC-Tca-121626 Theobroma cacao 59.41 0.00e+00 843.00
IUUC-Tae-123442 Triticum aestivum 57.75 0.00e+00 830.00
IUUC-Tur-126032 Triticum urartu 57.75 0.00e+00 829.00
IUUC-Tbe-127658 Tupaia belangeri 95.41 0.00e+00 1608.00
IUUC-Ttr-129112 Tursiops truncatus 90.57 0.00e+00 1503.00
IUUC-Vda-129701 Verticillium dahliae 39.02 4.00e-135 475.00
IUUC-Vpa-130217 Vicugna pacos 89.81 0.00e+00 1531.00
IUUC-Xtr-132724 Xenopus tropicalis 91.76 0.00e+00 1460.00
IUUC-Xma-134149 Xiphophorus maculatus 89.24 0.00e+00 1433.00
Created Date 25-Jun-2017

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