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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063751
UUCD1 version UUC-MuM-00075
Ensembl Protein ID ENSMUSP00000110771.1
UniProt Accession A2A432; Q3TU30; Q8BSL3; Q8CHD6; Q91YZ7; Q99KS9; Q9CZM5; CUL4B_MOUSE
Genbank Protein ID AAP84984.1; BAB28222.2; BAC27992.1; BAE36141.1; CAM17145.1; EDL29019.1; AAH04026.1; AAH10347.1; BAC41443.3
Protein Name Cullin-4B
Genbank Nucleotide ID AY330868; AK012410; AK032701; AK160998; AL513356; CH466570; BC004026; BC010347; AB093259
Gene Name Cul4b; mKIAA0695
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031095.15 ENSMUST00000016681.14 ENSMUSP00000016681.8
ENSMUSG00000031095.15 ENSMUST00000115118.7 ENSMUSP00000110771.1
ENSMUSG00000031095.15 ENSMUST00000147129.7 ENSMUSP00000136083.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDABioGRIDmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 1.00e-220 735.7 276 871
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav++i++++s+k+++eely+av+nlc++k++a+lYk+l++++e++i +q+++ +e+s d+  +Lk++ r+W+++++q+ ++r+if
   Q: 276  KLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIkAQIHQFREDSLDSVlFLKKIDRCWQNHCRQMIMIRSIF 364
           589***********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r +i++d  +++++++ +l lie+eR+gea+dr+ll+++ ++l++L     +iy++sFE++fl+
   Q: 365  LFLDRTYVLQNSMLPSIWDMGLELFRAHIISDqkVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QIYQDSFEQQFLQ 448
           ********************************99*********************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+++y+ae ++++qe+ev eYl++v++rl+ee +r+ +yl+++t+++L++ vek+l+ +hl+++l ++l++ll++++ +dls++y+L+
   Q: 449  ETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILqKGLNSLLDENRIQDLSLLYQLF 537
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g++ ll+++ ++ik  g+++++++ek+k+   +V++ll++k+k++++++++F +++kF++a+++afetf+nk+     +++p E
   Q: 538  SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKT---MVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKR-----PNKPaE 618
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+y+D++Lr+++k++t+eele++ldk++++f++i +kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 619  LIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 707
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkk 528
           d+++S+d+++qFk+ ++n++   ++el+v++L++g+Wpt+  +e v+LP+e+ k++e+f++fYl khsgRkLqWq tlg++ lkae+k+
   Q: 708  DMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPME-VHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKE 795
           ******************************************99.******************************************** PP
   S: 529  gkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           gk+elqVs fQ++vLL+fn+ e++s+ee+k+at++++ eLrrtlqsL+++k++vl k+p++k+ie++d+f++N++f
   Q: 796  GKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDF 871
           **************************************************************************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (By similarity).
 Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (By similarity).
Protein Sequence
(Fasta)
MSRSTRSKER RENDTDSEDN SSETSNQERR RCRQGPPRPP YPPLLPPVFP PPTPPPQVRR 60
TRGLQDLGAM KSVCPGTSGF SSPNPSAASA AAQEVRSATD GNTSTTPPTS AKKRKLNSSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063751|E3,Cullin|Mus musculus
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Nucleotide Sequence
(Fasta)
AGTCTGGTCC GGGCGCAGTC GACGACAGAC GTCTTCCAGA AGGTCTCTGA TTCATGAGGT 60
ATGAGAGCCC CAACGGATGA ATGTTAGAAC AAAATCTTTG TTGATCCTCC AGTGACTGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063751|E3,Cullin|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0007049--P:cell cycle
GO:0006974--P:cellular response to DNA damage stimulus
GO:0035518--P:histone H2A monoubiquitination
GO:0031175--P:neuron projection development
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0045732--P:positive regulation of protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0070914--P:UV-damage excision repair
KEGG mmu:72584
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000285 Aegilops tauschii 57.61 0.00e+00 831.00
IUUC-Aml-002062 Ailuropoda melanoleuca 96.18 0.00e+00 1679.00
IUUC-Atr-002727 Amborella trichopoda 57.31 0.00e+00 808.00
IUUC-Apl-004157 Anas platyrhynchos 93.60 0.00e+00 1494.00
IUUC-Aca-004430 Anolis carolinensis 91.44 0.00e+00 1446.00
IUUC-Aly-006547 Arabidopsis lyrata 58.84 0.00e+00 816.00
IUUC-Ath-006748 Arabidopsis thaliana 56.95 0.00e+00 810.00
IUUC-Acl-008359 Aspergillus clavatus 36.27 2.00e-125 443.00
IUUC-Afl-008567 Aspergillus flavus 38.06 7.00e-136 478.00
IUUC-Ang-009622 Aspergillus niger 39.31 2.00e-134 473.00
IUUC-Aor-010241 Aspergillus oryzae 37.82 3.00e-132 465.00
IUUC-Ame-011580 Astyanax mexicanus 83.89 0.00e+00 1420.00
IUUC-Bgr-012219 Blumeria graminis 37.21 7.00e-116 411.00
IUUC-Bta-013244 Bos taurus 93.08 0.00e+00 1653.00
IUUC-Bci-013744 Botrytis cinerea 39.97 5.00e-129 455.00
IUUC-Bdi-014223 Brachypodium distachyon 55.60 0.00e+00 828.00
IUUC-Bol-016036 Brassica oleracea 58.07 0.00e+00 835.00
IUUC-Bra-017794 Brassica rapa 57.61 0.00e+00 836.00
IUUC-Cja-019180 Callithrix jacchus 96.82 0.00e+00 1650.00
IUUC-Cfa-021189 Canis familiaris 96.82 0.00e+00 1648.00
IUUC-Cpo-021928 Cavia porcellus 95.80 0.00e+00 1630.00
IUUC-Cre-022739 Chlamydomonas reinhardtii 46.49 7.00e-177 614.00
IUUC-Csa-023831 Chlorocebus sabaeus 96.57 0.00e+00 1664.00
IUUC-Cho-024959 Choloepus hoffmanni 92.41 0.00e+00 986.00
IUUC-Csv-026117 Ciona savignyi 52.83 0.00e+00 843.00
IUUC-Cgl-026761 Colletotrichum gloeosporioides 39.72 4.00e-126 445.00
IUUC-Dre-027916 Danio rerio 87.95 0.00e+00 1416.00
IUUC-Dno-029483 Dasypus novemcinctus 87.50 0.00e+00 1524.00
IUUC-Dse-031159 Dothistroma septosporum 36.59 2.00e-123 437.00
IUUC-Dme-031652 Drosophila melanogaster 67.03 0.00e+00 945.00
IUUC-Ete-032775 Echinops telfairi 85.18 0.00e+00 1350.00
IUUC-Eca-033952 Equus caballus 93.17 0.00e+00 1636.00
IUUC-Eeu-034767 Erinaceus europaeus 88.70 0.00e+00 1457.00
IUUC-Fca-036211 Felis catus 96.69 0.00e+00 1489.00
IUUC-Fal-037248 Ficedula albicollis 94.15 0.00e+00 1494.00
IUUC-Fox-037854 Fusarium oxysporum 38.52 3.00e-124 439.00
IUUC-Fso-038138 Fusarium solani 39.25 6.00e-128 451.00
IUUC-Gmo-038754 Gadus morhua 87.42 0.00e+00 1401.00
IUUC-Ggr-040003 Gaeumannomyces graminis 36.28 2.00e-105 377.00
IUUC-Gga-041002 Gallus gallus 94.26 0.00e+00 1501.00
IUUC-Gac-041555 Gasterosteus aculeatus 85.08 0.00e+00 1399.00
IUUC-Gma-043960 Glycine max 59.38 0.00e+00 843.00
IUUC-Ggo-045468 Gorilla gorilla 96.82 0.00e+00 1586.00
IUUC-Hsa-046848 Homo sapiens 96.94 0.00e+00 1652.00
IUUC-Itr-048365 Ictidomys tridecemlineatus 95.09 0.00e+00 1653.00
IUUC-Lch-049858 Latimeria chalumnae 85.76 0.00e+00 1480.00
IUUC-Lpe-051446 Leersia perrieri 56.75 0.00e+00 826.00
IUUC-Loc-052415 Lepisosteus oculatus 85.83 0.00e+00 1429.00
IUUC-Lma-053080 Leptosphaeria maculans 36.72 8.00e-134 471.00
IUUC-Laf-053701 Loxodonta africana 93.82 0.00e+00 1664.00
IUUC-Mcc-055538 Macaca mulatta 94.89 0.00e+00 1604.00
IUUC-Mor-057102 Magnaporthe oryzae 35.96 1.00e-119 424.00
IUUC-Mpo-057342 Magnaporthe poae 37.20 3.00e-103 369.00
IUUC-Mtr-058660 Medicago truncatula 58.82 0.00e+00 835.00
IUUC-Mla-058936 Melampsora laricipopulina 39.46 7.00e-114 404.00
IUUC-Mga-059754 Meleagris gallopavo 94.15 0.00e+00 1492.00
IUUC-Mvi-060455 Microbotryum violaceum 41.67 6.00e-146 511.00
IUUC-Mmr-060870 Microcebus murinus 95.20 0.00e+00 1654.00
IUUC-Mdo-062015 Monodelphis domestica 90.85 0.00e+00 1462.00
IUUC-Mac-064443 Musa acuminata 57.24 0.00e+00 843.00
IUUC-Mpu-065903 Mustela putorius furo 96.07 0.00e+00 1681.00
IUUC-Mlu-068213 Myotis lucifugus 96.03 0.00e+00 1638.00
IUUC-Nfi-068363 Neosartorya fischeri 38.03 1.00e-133 471.00
IUUC-Ncr-068950 Neurospora crassa 36.33 3.00e-119 423.00
IUUC-Nle-069480 Nomascus leucogenys 96.57 0.00e+00 1664.00
IUUC-Opr-071164 Ochotona princeps 87.38 1.00e-172 600.00
IUUC-Ont-071562 Oreochromis niloticus 81.43 0.00e+00 1258.00
IUUC-Oan-073607 Ornithorhynchus anatinus 93.42 0.00e+00 1481.00
IUUC-Ocu-074446 Oryctolagus cuniculus 94.84 0.00e+00 1681.00
IUUC-Oba-075198 Oryza barthii 57.02 0.00e+00 829.00
IUUC-Obr-076095 Oryza brachyantha 57.02 0.00e+00 830.00
IUUC-Ogl-077032 Oryza glaberrima 57.02 0.00e+00 829.00
IUUC-Ogu-078051 Oryza glumaepatula 57.46 0.00e+00 829.00
IUUC-Oin-079399 Oryza indica 60.24 0.00e+00 722.00
IUUC-Olo-080988 Oryza longistaminata 56.19 0.00e+00 820.00
IUUC-Ome-081600 Oryza meridionalis 56.19 0.00e+00 821.00
IUUC-Oni-082623 Oryza nivara 56.33 0.00e+00 822.00
IUUC-Opu-083762 Oryza punctata 56.06 0.00e+00 822.00
IUUC-Oru-084499 Oryza rufipogon 57.02 0.00e+00 829.00
IUUC-Ola-087157 Oryzias latipes 87.20 0.00e+00 1397.00
IUUC-Olu-087650 Ostreococcus lucimarinus 48.29 2.00e-180 626.00
IUUC-Oga-088416 Otolemur garnettii 93.63 0.00e+00 1572.00
IUUC-Oar-090230 Ovis aries 95.24 0.00e+00 1621.00
IUUC-Ptr-091153 Pan troglodytes 97.28 0.00e+00 1610.00
IUUC-Pan-091729 Papio anubis 96.57 0.00e+00 1664.00
IUUC-Psi-093773 Pelodiscus sinensis 93.56 0.00e+00 1489.00
IUUC-Pma-094678 Petromyzon marinus 84.07 0.00e+00 1048.00
IUUC-Pno-094946 Phaeosphaeria nodorum 35.62 3.00e-111 396.00
IUUC-Ppa-095688 Physcomitrella patens 59.71 0.00e+00 892.00
IUUC-Pfo-096828 Poecilia formosa 88.17 0.00e+00 1416.00
IUUC-Pab-097816 Pongo abelii 88.99 0.00e+00 1470.00
IUUC-Pca-100858 Procavia capensis 75.86 0.00e+00 1194.00
IUUC-Ppe-101142 Prunus persica 59.19 0.00e+00 852.00
IUUC-Pva-102995 Pteropus vampyrus 89.66 0.00e+00 1521.00
IUUC-Pte-104167 Pyrenophora teres 36.78 3.00e-134 473.00
IUUC-Pyt-104736 Pyrenophora triticirepentis 36.71 4.00e-133 468.00
IUUC-Rno-106119 Rattus norvegicus 97.43 0.00e+00 1736.00
IUUC-Sha-106958 Sarcophilus harrisii 84.69 0.00e+00 1482.00
IUUC-Sja-107940 Schizosaccharomyces japonicus 34.24 2.00e-112 400.00
IUUC-Spo-108109 Schizosaccharomyces pombe 34.04 6.00e-112 398.00
IUUC-Ssl-108537 Sclerotinia sclerotiorum 39.59 1.00e-129 457.00
IUUC-Smo-108872 Selaginella moellendorffii 60.00 0.00e+00 910.00
IUUC-Sit-110626 Setaria italica 57.89 0.00e+00 831.00
IUUC-Sly-111497 Solanum lycopersicum 60.08 0.00e+00 854.00
IUUC-Sar-113581 Sorex araneus 84.63 0.00e+00 1039.00
IUUC-Sbi-113931 Sorghum bicolor 57.89 0.00e+00 830.00
IUUC-Tgu-116462 Taeniopygia guttata 93.77 0.00e+00 1483.00
IUUC-Tru-118299 Takifugu rubripes 82.82 0.00e+00 1413.00
IUUC-Tsy-119517 Tarsius syrichta 99.43 0.00e+00 725.00
IUUC-Tni-120811 Tetraodon nigroviridis 86.53 0.00e+00 1388.00
IUUC-Tca-121626 Theobroma cacao 59.26 0.00e+00 844.00
IUUC-Tae-123442 Triticum aestivum 57.61 0.00e+00 831.00
IUUC-Tur-126032 Triticum urartu 57.61 0.00e+00 829.00
IUUC-Tme-127162 Tuber melanosporum 41.32 8.00e-140 491.00
IUUC-Tbe-127658 Tupaia belangeri 92.64 0.00e+00 1535.00
IUUC-Ttr-129112 Tursiops truncatus 88.55 0.00e+00 1464.00
IUUC-Vda-129701 Verticillium dahliae 39.28 8.00e-137 481.00
IUUC-Vpa-130217 Vicugna pacos 87.98 0.00e+00 1456.00
IUUC-Vvi-131133 Vitis vinifera 59.33 0.00e+00 853.00
IUUC-Xtr-132724 Xenopus tropicalis 90.42 0.00e+00 1447.00
IUUC-Xma-134149 Xiphophorus maculatus 88.40 0.00e+00 1428.00
IUUC-Zma-135529 Zea mays 56.97 0.00e+00 832.00
Created Date 25-Jun-2017

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