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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031691
UUCD1 version UUC-DrM-00010
Ensembl Protein ID FBpp0071994
UniProt Accession Q24371; Q9W1K9; L2DTL_DROME
Genbank Protein ID CAA58441.1; CAA66723.1; AAF47049.1; AAM51974.1
Protein Name Protein lethal(2)denticleless; Protein DTL83
Genbank Nucleotide ID X83414; X98094; AE013599; AY121647
Gene Name l(2)dtl; DTL83; CG11295
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0013548 FBtr0072085 FBpp0071994
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNA
Protein-protein Interaction
IIDiRefIndexPINA
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 19081076
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.40e-34 114.6 220 252
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           +++s+t+laf  +dtl+++G++Dg+ikvWDlr+
   Q: 220  TSSSITGLAFqdNDTLISCGAGDGVIKVWDLRR 252
           6899******9777****************985 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex.
 Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex.
Protein Sequence
(Fasta)
MNIYNKLRAR EHGYGNERTY DFALRRLSVA KEDSWRGIAP ANYCPDFNPE PPIFSAKFAN 60
CDGYRHILAI ANEDGKITLQ DTTQRNHQPE EQSLVGPQCH FNAVFDLEWA PGQMRFVSAS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031691|E3,WD_repeat|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
TTACTTCCCA TCTGAGCACG GTCACACTGC CCAAGAGTCC AGCTGCGTCG TTGAAAAATA 60
TTTTCGATGC CTCGAAGGTT GATTTATTTC AGAGGAAATA GCAGGAAATA AAGTTGAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031691|E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0346--Stress response
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0007049--P:cell cycle
GO:0022008--P:neurogenesis
GO:0016567--P:protein ubiquitination
GO:0051726--P:regulation of cell cycle
KEGG dme:Dmel_CG11295
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002111 Ailuropoda melanoleuca 42.06 7.00e-82 297.00
IUUC-Atr-003097 Amborella trichopoda 34.88 6.00e-48 184.00
IUUC-Apl-004088 Anas platyrhynchos 43.10 7.00e-79 287.00
IUUC-Aca-004732 Anolis carolinensis 42.24 3.00e-74 272.00
IUUC-Aly-005686 Arabidopsis lyrata 28.41 6.00e-44 171.00
IUUC-Ath-006970 Arabidopsis thaliana 30.23 4.00e-42 164.00
IUUC-Acl-008219 Aspergillus clavatus 22.71 2.00e-20 93.60
IUUC-Afu-008784 Aspergillus fumigatus 23.45 6.00e-22 98.60
IUUC-Ani-009304 Aspergillus nidulans 24.63 1.00e-12 67.80
IUUC-Ang-009842 Aspergillus niger 25.64 9.00e-17 81.30
IUUC-Aor-009883 Aspergillus oryzae 25.27 1.00e-19 90.90
IUUC-Ate-010454 Aspergillus terreus 25.24 8.00e-19 87.40
IUUC-Ame-010949 Astyanax mexicanus 41.08 8.00e-76 277.00
IUUC-Bta-012333 Bos taurus 41.78 2.00e-82 299.00
IUUC-Bdi-014494 Brachypodium distachyon 30.48 6.00e-42 164.00
IUUC-Bol-015301 Brassica oleracea 31.37 8.00e-44 170.00
IUUC-Bra-017384 Brassica rapa 31.08 3.00e-44 172.00
IUUC-Cel-018498 Caenorhabditis elegans 29.19 2.00e-34 139.00
IUUC-Cja-019534 Callithrix jacchus 42.42 1.00e-79 290.00
IUUC-Cfa-020847 Canis familiaris 42.34 1.00e-81 297.00
IUUC-Cpo-021695 Cavia porcellus 42.42 2.00e-81 296.00
IUUC-Cre-022762 Chlamydomonas reinhardtii 30.33 5.00e-35 143.00
IUUC-Csa-023748 Chlorocebus sabaeus 41.87 2.00e-82 299.00
IUUC-Cho-024445 Choloepus hoffmanni 41.13 7.00e-53 201.00
IUUC-Cgl-026664 Colletotrichum gloeosporioides 24.69 4.00e-16 79.30
IUUC-Cne-027008 Cryptococcus neoformans 26.74 3.00e-14 74.30
IUUC-Dre-027536 Danio rerio 41.28 7.00e-75 274.00
IUUC-Dno-030035 Dasypus novemcinctus 42.15 5.00e-81 295.00
IUUC-Dor-030814 Dipodomys ordii 38.05 1.00e-16 80.90
IUUC-Dse-031354 Dothistroma septosporum 23.21 2.00e-18 87.00
IUUC-Ete-032814 Echinops telfairi 43.60 2.00e-55 209.00
IUUC-Eca-033332 Equus caballus 41.50 5.00e-81 294.00
IUUC-Fca-035571 Felis catus 42.50 2.00e-81 296.00
IUUC-Fal-037421 Ficedula albicollis 44.83 5.00e-80 291.00
IUUC-Fox-038069 Fusarium oxysporum 22.84 5.00e-17 82.00
IUUC-Fso-038192 Fusarium solani 23.74 3.00e-18 86.30
IUUC-Gmo-039365 Gadus morhua 41.57 2.00e-75 276.00
IUUC-Gga-041153 Gallus gallus 44.00 4.00e-81 295.00
IUUC-Gac-041984 Gasterosteus aculeatus 37.59 3.00e-73 268.00
IUUC-Gma-043734 Glycine max 35.49 3.00e-48 185.00
IUUC-Ggo-044419 Gorilla gorilla 41.93 2.00e-80 293.00
IUUC-Hsa-045862 Homo sapiens 42.33 7.00e-82 297.00
IUUC-Hvu-047728 Hordeum vulgare 30.64 1.00e-44 173.00
IUUC-Itr-048786 Ictidomys tridecemlineatus 42.15 6.00e-82 298.00
IUUC-Lch-050616 Latimeria chalumnae 41.11 1.00e-73 270.00
IUUC-Lpe-051222 Leersia perrieri 31.18 4.00e-47 181.00
IUUC-Loc-052564 Lepisosteus oculatus 39.70 1.00e-71 263.00
IUUC-Lma-053098 Leptosphaeria maculans 23.46 2.00e-16 80.10
IUUC-Laf-053892 Loxodonta africana 42.82 2.00e-79 289.00
IUUC-Mcc-055854 Macaca mulatta 41.87 2.00e-82 299.00
IUUC-Mor-057144 Magnaporthe oryzae 25.43 3.00e-11 63.20
IUUC-Mtr-058510 Medicago truncatula 31.78 2.00e-42 166.00
IUUC-Mla-058823 Melampsora laricipopulina 25.92 6.00e-19 88.20
IUUC-Mga-060128 Meleagris gallopavo 44.29 1.00e-81 296.00
IUUC-Mvi-060475 Microbotryum violaceum 30.86 1.00e-44 173.00
IUUC-Mmr-061331 Microcebus murinus 42.36 5.00e-80 291.00
IUUC-Mdo-063020 Monodelphis domestica 41.48 1.00e-79 290.00
IUUC-Mmu-063713 Mus musculus 42.33 2.00e-81 296.00
IUUC-Mac-064653 Musa acuminata 32.45 3.00e-42 165.00
IUUC-Mpu-066490 Mustela putorius furo 42.06 3.00e-81 295.00
IUUC-Mlu-067900 Myotis lucifugus 42.61 2.00e-81 296.00
IUUC-Nfi-068433 Neosartorya fischeri 23.67 1.00e-22 101.00
IUUC-Ncr-068776 Neurospora crassa 27.05 1.00e-18 87.40
IUUC-Nle-069675 Nomascus leucogenys 39.83 3.00e-76 279.00
IUUC-Opr-070769 Ochotona princeps 32.68 4.00e-21 95.90
IUUC-Ont-071441 Oreochromis niloticus 40.79 7.00e-73 267.00
IUUC-Oan-072757 Ornithorhynchus anatinus 40.31 2.00e-78 286.00
IUUC-Ocu-074670 Oryctolagus cuniculus 42.90 3.00e-81 295.00
IUUC-Oba-075844 Oryza barthii 31.34 3.00e-46 179.00
IUUC-Obr-076625 Oryza brachyantha 32.02 4.00e-48 185.00
IUUC-Ogl-077771 Oryza glaberrima 31.34 3.00e-46 178.00
IUUC-Ogu-078475 Oryza glumaepatula 28.49 4.00e-37 148.00
IUUC-Oin-079958 Oryza indica 31.34 2.00e-46 179.00
IUUC-Olo-080311 Oryza longistaminata 32.76 6.00e-41 160.00
IUUC-Ome-081985 Oryza meridionalis 31.62 3.00e-46 178.00
IUUC-Oni-082921 Oryza nivara 31.34 2.00e-46 179.00
IUUC-Opu-083174 Oryza punctata 30.79 1.00e-46 180.00
IUUC-Oru-084338 Oryza rufipogon 31.34 3.00e-46 179.00
IUUC-Olu-087907 Ostreococcus lucimarinus 27.66 9.00e-23 100.00
IUUC-Oga-088358 Otolemur garnettii 42.94 1.00e-81 296.00
IUUC-Oar-089994 Ovis aries 41.23 2.00e-81 296.00
IUUC-Ptr-091338 Pan troglodytes 42.33 4.00e-82 298.00
IUUC-Pan-091759 Papio anubis 41.76 6.00e-81 294.00
IUUC-Psi-093211 Pelodiscus sinensis 43.59 2.00e-78 286.00
IUUC-Pma-094588 Petromyzon marinus 40.23 7.00e-46 176.00
IUUC-Pno-094964 Phaeosphaeria nodorum 26.42 2.00e-20 92.80
IUUC-Ppa-095159 Physcomitrella patens 34.07 2.00e-52 198.00
IUUC-Pfo-096592 Poecilia formosa 38.59 7.00e-63 234.00
IUUC-Pab-098597 Pongo abelii 28.98 6.00e-35 141.00
IUUC-Pop-099255 Populus trichocarpa 34.01 1.00e-49 189.00
IUUC-Pca-100593 Procavia capensis 36.92 5.00e-60 224.00
IUUC-Ppe-101333 Prunus persica 31.85 6.00e-45 174.00
IUUC-Pva-102283 Pteropus vampyrus 45.18 3.00e-75 275.00
IUUC-Pgr-103383 Puccinia graminis 25.69 8.00e-15 74.30
IUUC-Ptt-103974 Puccinia triticina 26.27 8.00e-14 70.90
IUUC-Pte-104329 Pyrenophora teres 28.52 1.00e-17 84.00
IUUC-Pyt-104424 Pyrenophora triticirepentis 28.14 4.00e-17 82.40
IUUC-Rno-105720 Rattus norvegicus 41.78 2.00e-81 296.00
IUUC-Sha-106891 Sarcophilus harrisii 40.90 7.00e-71 261.00
IUUC-Sja-107723 Schizosaccharomyces japonicus 28.21 5.00e-26 111.00
IUUC-Spo-108060 Schizosaccharomyces pombe 26.11 5.00e-22 98.20
IUUC-Ssl-108481 Sclerotinia sclerotiorum 26.15 1.00e-13 70.90
IUUC-Sit-109862 Setaria italica 32.29 2.00e-47 182.00
IUUC-Sly-111468 Solanum lycopersicum 30.59 1.00e-41 163.00
IUUC-Stu-112346 Solanum tuberosum 31.40 3.00e-42 165.00
IUUC-Sar-113734 Sorex araneus 40.28 3.00e-27 116.00
IUUC-Sbi-114076 Sorghum bicolor 32.08 5.00e-47 181.00
IUUC-Sre-114918 Sporisorium reilianum 24.22 5.00e-15 75.90
IUUC-Ssc-115561 Sus scrofa 41.67 7.00e-81 294.00
IUUC-Tgu-117011 Taeniopygia guttata 43.97 1.00e-79 290.00
IUUC-Tru-118411 Takifugu rubripes 39.38 2.00e-66 246.00
IUUC-Tsy-119367 Tarsius syrichta 40.20 2.00e-59 223.00
IUUC-Tni-120301 Tetraodon nigroviridis 39.38 1.00e-67 250.00
IUUC-Tca-121265 Theobroma cacao 32.02 5.00e-46 177.00
IUUC-Tre-121997 Trichoderma reesei 24.39 1.00e-16 81.30
IUUC-Tvi-122292 Trichoderma virens 23.84 5.00e-18 85.50
IUUC-Tae-123660 Triticum aestivum 30.97 3.00e-45 175.00
IUUC-Tur-126794 Triticum urartu 31.14 5.00e-37 147.00
IUUC-Tme-127090 Tuber melanosporum 27.51 4.00e-21 94.70
IUUC-Tbe-127646 Tupaia belangeri 37.33 4.00e-68 252.00
IUUC-Ttr-128171 Tursiops truncatus 41.78 8.00e-82 297.00
IUUC-Uma-129525 Ustilago maydis 23.03 2.00e-13 70.10
IUUC-Vda-129871 Verticillium dahliae 27.20 6.00e-17 82.00
IUUC-Vpa-130554 Vicugna pacos 36.65 2.00e-26 113.00
IUUC-Vvi-131698 Vitis vinifera 34.28 6.00e-48 184.00
IUUC-Xtr-131962 Xenopus tropicalis 41.55 3.00e-81 295.00
IUUC-Xma-133803 Xiphophorus maculatus 40.23 3.00e-71 262.00
IUUC-Zma-135932 Zea mays 29.89 1.00e-43 170.00
Created Date 25-Jun-2017

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