iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068910

Ensembl Protein ID

ESA42985

UniProt Accession

V5INP8; V5INP8_NEUCR

Genbank Protein ID

ESA42985.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

CM002239

Gene Name

NCU08040

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU08040	ESA42986	ESA42986
NCU08040	ESA42985	ESA42985

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.20e-56	189.7	23	539

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllv..GagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesite 99
           YDRQ+rlw + +q++l+sa++llv  Gag++G+E+lKnL+l G+g + ++D++ v+ ++l+ +F+++++  gk++A++ a  l elnp v+++ +    ++
   Q: 23   YDRQLRLWAASGQAALESANILLVnsGAGTVGVETLKNLILPGIGRFVIHDNALVDEADLGVNFFLDDSCYGKPRAQCLASLLGELNPEVDGDWSP---KT 120
           ***********************8557999**************************************************************9864...44 PP
   S: 100  leeeiv..Ffkk...fdvVvlald.nrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd.....dppqktiPfctlketpn........ 181
           ++++    ++k+   f+ ++ ++  n  +  ++ +   +++ pli + ++G++++ ++ ++g   + + ++      ++++  P+++l e+ n        
   Q: 121  KQNDSLgsLLKQsplFTAIMYTYPiNHVELETLEQYSKEHKTPLIAIHSTGFYSYFTIRLPGTFPIVDTHPdetatTDLRLLSPWPELVEFANtmtkdids 221
           4444335577774446888888742444445899999999*********************9755555554499999**************8888888888 PP
   S: 182  ...aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks....edeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv 274
               ++ ++++++++ ++l+++++ ++++ +++++ek+e++++v++++++      eenf+ea ++++k  a+++ +s  k+++++ ++d+  ++ s fw+
   Q: 222  ldnFEHGHLPYVAILLHYLDKWKATHNGTYPSTYKEKTEFRQLVRDAARTdnpeGGEENFDEAAAAVLKTVAPFSLPSgLKEVFEYEHKDP-IQERSTFWI 321
           887999999999*************************************966655689****************************99999.788889999 PP
   S: 275  .....................................................................sfcsnaealq..................vpek 288
                                                                                 fc+na+ ++                   ++ 
   Q: 322  iadavkafytkhgslplpgnvpdmkaqskvyvqlqniykakarkdaaevlqtaraiagtgrevdpaevdLFCKNAAFVKlinvegggdtaplgskerLQQV 422
           *********************************************************************88888888887777777666666655544466 PP
   S: 289  vekdeevvkasap.........lylllralerfekkkgrkpgelsfekddds.avdlvtaaa..nlraeslgiepkldddlikeiagniipaiattnavvg 377
             ++++++++++          +yl+          +g+ +  ++   +d+  +v+ vt+++  nl  e++g   +   ++ + +a+ + ++++ ++a  g
   Q: 423  LRQEMANDQVAEMtlqpmslfpIYLA---------LRGLAH--CGNASSDKTqIVEAVTSLLsdNLSSEEYGDLNEKLGNVAEDLARAEYGELHNISALTG 512
           66666666666553334443334444.........444433..3333333322666666665112333555444445567899****************** PP
   S: 378  GlaaqEviKvvsgkfeplknfflfdae 404
           G++aqE+iK++++++ p++n+ +fd++
   Q: 513  GMVAQEMIKIITKQYIPIDNTCVFDGI 539
           ************************985 PP

Organism

Neurospora crassa

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

Protein Sequence
(Fasta)

MTEIVMDQTP PILQGPSDKE RKYDRQLRLW AASGQAALES ANILLVNSGA GTVGVETLKN 60
LILPGIGRFV IHDNALVDEA DLGVNFFLDD SCYGKPRAQC LASLLGELNP EVDGDWSPKT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGCGACGGA CCTCATAATC ACGACCTACG TAACCGACAG CTCTTCCTCG GTCACGCCAG 60
CTGTACCATT AGCTGGAGAA AGTTATAATC CAAAATGACT GAGATTGTAA TGGACCAGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

ncr:NCU08040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	32.60	1.00e-69	255.00
IUUC-Aml-002333	Ailuropoda melanoleuca	34.30	8.00e-78	282.00
IUUC-Atr-002644	Amborella trichopoda	31.56	9.00e-57	212.00
IUUC-Apl-003446	Anas platyrhynchos	31.57	3.00e-65	240.00
IUUC-Aca-004450	Anolis carolinensis	33.45	2.00e-75	275.00
IUUC-Aly-005466	Arabidopsis lyrata	31.20	2.00e-65	241.00
IUUC-Ath-007600	Arabidopsis thaliana	31.65	2.00e-66	244.00
IUUC-Ago-007900	Ashbya gossypii	25.46	6.00e-36	143.00
IUUC-Acl-008333	Aspergillus clavatus	46.27	1.00e-134	471.00
IUUC-Afl-008529	Aspergillus flavus	47.48	4.00e-141	493.00
IUUC-Afu-009071	Aspergillus fumigatus	47.14	1.00e-137	481.00
IUUC-Ani-009443	Aspergillus nidulans	46.84	1.00e-131	461.00
IUUC-Ang-009669	Aspergillus niger	47.99	2.00e-148	516.00
IUUC-Aor-009914	Aspergillus oryzae	46.96	9.00e-142	494.00
IUUC-Ate-010450	Aspergillus terreus	48.08	2.00e-140	490.00
IUUC-Ame-011183	Astyanax mexicanus	33.51	4.00e-73	266.00
IUUC-Bgr-012111	Blumeria graminis	51.78	3.00e-144	503.00
IUUC-Bta-012583	Bos taurus	34.73	1.00e-79	288.00
IUUC-Bci-013892	Botrytis cinerea	58.50	1.00e-164	571.00
IUUC-Bdi-014592	Brachypodium distachyon	32.72	3.00e-66	244.00
IUUC-Bol-015487	Brassica oleracea	32.30	1.00e-70	258.00
IUUC-Bra-017506	Brassica rapa	33.15	4.00e-71	260.00
IUUC-Cel-018456	Caenorhabditis elegans	30.70	5.00e-58	216.00
IUUC-Cja-020007	Callithrix jacchus	33.82	1.00e-76	278.00
IUUC-Cfa-020324	Canis familiaris	34.55	2.00e-79	288.00
IUUC-Cpo-022248	Cavia porcellus	31.86	2.00e-42	164.00
IUUC-Csa-023149	Chlorocebus sabaeus	29.90	6.00e-54	203.00
IUUC-Cho-024537	Choloepus hoffmanni	27.95	1.00e-42	165.00
IUUC-Cin-025763	Ciona intestinalis	33.89	5.00e-78	283.00
IUUC-Csv-026113	Ciona savignyi	34.25	1.00e-82	298.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	58.45	8.00e-177	611.00
IUUC-Cne-026884	Cryptococcus neoformans	31.25	1.00e-51	196.00
IUUC-Dre-028140	Danio rerio	33.21	2.00e-76	278.00
IUUC-Dno-030033	Dasypus novemcinctus	35.25	4.00e-69	253.00
IUUC-Dor-030513	Dipodomys ordii	54.46	1.00e-22	99.00
IUUC-Dse-031536	Dothistroma septosporum	44.62	6.00e-131	459.00
IUUC-Dme-031683	Drosophila melanogaster	35.47	3.00e-68	250.00
IUUC-Ete-032420	Echinops telfairi	30.98	1.00e-59	222.00
IUUC-Eca-033992	Equus caballus	30.11	1.00e-51	195.00
IUUC-Eeu-034713	Erinaceus europaeus	54.08	2.00e-23	101.00
IUUC-Fca-036548	Felis catus	34.55	3.00e-78	283.00
IUUC-Fal-037600	Ficedula albicollis	31.33	2.00e-63	234.00
IUUC-Fox-038037	Fusarium oxysporum	58.53	0.00e+00	651.00
IUUC-Fso-038387	Fusarium solani	59.85	0.00e+00	659.00
IUUC-Gmo-038562	Gadus morhua	30.70	2.00e-70	258.00
IUUC-Ggr-040005	Gaeumannomyces graminis	62.32	0.00e+00	667.00
IUUC-Gga-041129	Gallus gallus	32.32	2.00e-69	254.00
IUUC-Gac-042558	Gasterosteus aculeatus	33.03	1.00e-72	265.00
IUUC-Gma-043610	Glycine max	32.29	2.00e-65	241.00
IUUC-Ggo-045611	Gorilla gorilla	34.30	3.00e-76	277.00
IUUC-Hsa-046563	Homo sapiens	33.88	1.00e-77	281.00
IUUC-Hvu-047790	Hordeum vulgare	29.21	7.00e-41	159.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	33.82	1.00e-76	278.00
IUUC-Kpa-049309	Komagataella pastoris	34.07	4.00e-68	250.00
IUUC-Lch-050038	Latimeria chalumnae	32.45	2.00e-71	261.00
IUUC-Lpe-051535	Leersia perrieri	29.38	2.00e-47	181.00
IUUC-Loc-051917	Lepisosteus oculatus	30.07	3.00e-64	237.00
IUUC-Lma-053112	Leptosphaeria maculans	46.96	3.00e-144	503.00
IUUC-Laf-053690	Loxodonta africana	34.30	6.00e-79	286.00
IUUC-Mcc-055117	Macaca mulatta	33.03	1.00e-73	268.00
IUUC-Meu-056761	Macropus eugenii	31.45	3.00e-42	164.00
IUUC-Mor-057230	Magnaporthe oryzae	61.93	0.00e+00	685.00
IUUC-Mpo-057514	Magnaporthe poae	63.59	0.00e+00	676.00
IUUC-Mtr-058551	Medicago truncatula	33.15	7.00e-65	239.00
IUUC-Mla-059183	Melampsora laricipopulina	34.47	1.00e-78	285.00
IUUC-Mga-060144	Meleagris gallopavo	31.10	2.00e-65	241.00
IUUC-Mvi-060221	Microbotryum violaceum	32.74	2.00e-69	254.00
IUUC-Mmr-061325	Microcebus murinus	32.79	3.00e-72	263.00
IUUC-Mdo-062532	Monodelphis domestica	34.54	3.00e-78	284.00
IUUC-Mmu-063956	Mus musculus	34.73	8.00e-79	285.00
IUUC-Mac-064521	Musa acuminata	33.03	1.00e-69	254.00
IUUC-Mpu-066716	Mustela putorius furo	38.10	1.00e-68	252.00
IUUC-Mlu-067459	Myotis lucifugus	35.27	5.00e-79	286.00
IUUC-Nfi-068245	Neosartorya fischeri	48.35	5.00e-139	486.00
IUUC-Nle-070034	Nomascus leucogenys	31.76	1.00e-68	251.00
IUUC-Opr-070552	Ochotona princeps	32.17	8.00e-60	222.00
IUUC-Ont-071426	Oreochromis niloticus	33.52	5.00e-74	270.00
IUUC-Oan-073389	Ornithorhynchus anatinus	32.20	3.00e-51	193.00
IUUC-Ocu-074911	Oryctolagus cuniculus	34.18	4.00e-78	283.00
IUUC-Oba-075437	Oryza barthii	30.80	3.00e-57	214.00
IUUC-Obr-076684	Oryza brachyantha	30.81	4.00e-53	200.00
IUUC-Ogl-077170	Oryza glaberrima	30.80	3.00e-57	214.00
IUUC-Ogu-078844	Oryza glumaepatula	30.37	7.00e-50	189.00
IUUC-Oin-079105	Oryza indica	30.80	2.00e-57	214.00
IUUC-Olo-080943	Oryza longistaminata	28.02	1.00e-42	166.00
IUUC-Oni-082891	Oryza nivara	28.76	1.00e-50	192.00
IUUC-Opu-083457	Oryza punctata	30.98	8.00e-57	213.00
IUUC-Oru-084960	Oryza rufipogon	28.02	1.00e-42	165.00
IUUC-Osa-085358	Oryza sativa	30.80	2.00e-57	214.00
IUUC-Ola-086420	Oryzias latipes	32.02	1.00e-50	191.00
IUUC-Olu-087625	Ostreococcus lucimarinus	27.35	2.00e-44	171.00
IUUC-Oga-088810	Otolemur garnettii	34.18	2.00e-77	281.00
IUUC-Oar-089196	Ovis aries	34.54	8.00e-78	282.00
IUUC-Ptr-090617	Pan troglodytes	34.30	3.00e-77	280.00
IUUC-Pan-092761	Papio anubis	34.00	6.00e-78	283.00
IUUC-Psi-093191	Pelodiscus sinensis	31.85	1.00e-66	245.00
IUUC-Pma-094380	Petromyzon marinus	36.66	6.00e-66	243.00
IUUC-Pno-095084	Phaeosphaeria nodorum	43.67	8.00e-124	436.00
IUUC-Ppa-095798	Physcomitrella patens	29.58	1.00e-63	235.00
IUUC-Pfo-096467	Poecilia formosa	33.21	2.00e-74	271.00
IUUC-Pab-098255	Pongo abelii	35.12	5.00e-68	249.00
IUUC-Pop-099722	Populus trichocarpa	32.49	4.00e-70	257.00
IUUC-Pca-100807	Procavia capensis	38.10	6.00e-24	103.00
IUUC-Ppe-101280	Prunus persica	32.72	3.00e-67	247.00
IUUC-Pva-102333	Pteropus vampyrus	33.63	2.00e-70	258.00
IUUC-Pgr-103401	Puccinia graminis	28.32	1.00e-62	232.00
IUUC-Ptt-103889	Puccinia triticina	27.58	1.00e-54	206.00
IUUC-Pte-104355	Pyrenophora teres	46.21	5.00e-146	509.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	46.03	1.00e-144	504.00
IUUC-Rno-105810	Rattus norvegicus	33.69	9.00e-77	279.00
IUUC-Sce-106397	Saccharomyces cerevisiae	23.55	2.00e-26	111.00
IUUC-Sha-106770	Sarcophilus harrisii	40.36	7.00e-47	178.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.17	9.00e-68	249.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.87	3.00e-74	270.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	59.42	2.00e-179	620.00
IUUC-Smo-109296	Selaginella moellendorffii	33.75	1.00e-72	265.00
IUUC-Sit-110157	Setaria italica	32.84	2.00e-68	251.00
IUUC-Sly-111105	Solanum lycopersicum	32.32	3.00e-67	247.00
IUUC-Stu-112469	Solanum tuberosum	32.73	6.00e-68	249.00
IUUC-Sar-113083	Sorex araneus	24.95	2.00e-36	144.00
IUUC-Sbi-113813	Sorghum bicolor	31.99	1.00e-67	248.00
IUUC-Sre-115058	Sporisorium reilianum	36.06	3.00e-59	221.00
IUUC-Tgu-116772	Taeniopygia guttata	31.83	1.00e-65	242.00
IUUC-Tru-118686	Takifugu rubripes	32.97	9.00e-77	279.00
IUUC-Tsy-119111	Tarsius syrichta	36.92	3.00e-38	150.00
IUUC-Tni-120231	Tetraodon nigroviridis	30.63	2.00e-64	237.00
IUUC-Tca-121491	Theobroma cacao	33.33	1.00e-62	232.00
IUUC-Tre-122103	Trichoderma reesei	60.55	0.00e+00	670.00
IUUC-Tvi-122672	Trichoderma virens	60.18	0.00e+00	652.00
IUUC-Tae-125316	Triticum aestivum	32.42	1.00e-69	255.00
IUUC-Tur-126487	Triticum urartu	31.62	7.00e-65	239.00
IUUC-Tme-127097	Tuber melanosporum	41.18	7.00e-98	349.00
IUUC-Ttr-128465	Tursiops truncatus	31.46	2.00e-62	231.00
IUUC-Uma-129645	Ustilago maydis	32.95	1.00e-68	252.00
IUUC-Vda-129989	Verticillium dahliae	53.51	9.00e-155	538.00
IUUC-Vpa-130529	Vicugna pacos	32.01	1.00e-65	241.00
IUUC-Vvi-131059	Vitis vinifera	33.46	3.00e-68	250.00
IUUC-Xtr-132002	Xenopus tropicalis	34.67	1.00e-79	288.00
IUUC-Xma-133930	Xiphophorus maculatus	32.60	2.00e-74	271.00
IUUC-Yli-134505	Yarrowia lipolytica	35.65	2.00e-84	304.00
IUUC-Zma-135895	Zea mays	31.73	5.00e-66	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence