iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108019

UUCD1 version

UUC-ScP-00294

Ensembl Protein ID

SPBC713.02c.1:pep

UniProt Accession

Q9UTT1; UBP21_SCHPO

Genbank Protein ID

AAF01440.1; CAC22603.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21

Genbank Nucleotide ID

AF187961; CU329671

Gene Name

ubp15; ubp21; ubpd; SPBC713.02c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC713.02c	SPBC713.02c.1	SPBC713.02c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.20e-72	241.6	230	544

Active Site

Position(s)	Description	Evidence
239	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
481	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +GlkN+g+tCYmNS+LQ+L++++ +r+ + +     ++ +n +++  +++ +lq++f +l +++++ vs++el++++++ +  f++++q+D 
   Q: 230  VGLKNQGATCYMNSLLQSLFFTNIFRKTVYK-----IPTDN-DDSRDSVAYALQRVFYNL-EKQREPVSTTELTRSFGWNS--FDSFMQHDI 312
           6******************************.....55554.57789*************.999**************655..99******* PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           qEf ++l d+le+++                          k ++ ++ ++d+F g++ks +kc + + +ssr e+f+d++l+v+g +    
   Q: 313  QEFNRVLQDNLEKKM--------------------------KGTEVENALNDIFVGKMKSYVKCIDVNYESSRVEDFWDIQLNVKGMD---- 374
           ***************..........................78999******************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekk 276
            +l+d++++  + e+l+g+nkyy e   ++q+a k + +++lP+vL l+LkRf ++  +++  kin++ efple+dl+p+++++ +k+ e++
   Q: 375  -TLEDSFRDAIQVETLTGDNKYYAEGH-GLQDAHKGIIFESLPNVLQLQLKRFDYDMLRDMMVKINDRHEFPLEIDLEPYLSETADKS-ESH 463
           .9*********************9986.79*****************************************************66655.7** PP
   S: 277  kYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg...................staYvlfYkr 337
            Y L++v+vH G l++GHY+a++k ek++ W++fdD++Vt  + +evle++                     +aY+l+Y r
   Q: 464  VYVLHGVLVHGGDLHGGHYYALIKPEKDSnWFKFDDDRVTRATIKEVLEDNYggepagrakgyngnpfkrfMNAYMLVYFR 544
           *************************88778*******************888***************************66 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Involved in regulating the steady-state levels of proteins including prp4.

Protein Sequence
(Fasta)

MVLSNVDAEE VNMDSSMELE ESSQEPLRAD NYEEIYNSLV HHEPDLEEAA HASYSWVVKN 60
FSTLEDKTYS PLFKAGHTTW RIVLFPKGCN QTEYASVFLE YLPQCKVEAI RKYEAELAAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTAGCGGCA TGTGGGTGAG CTGGCATCTA ATTATAACGG TCGTTGCCAG AACTAACCGC 60
CATCTAATCC TACACTACTA ACTTTGGAGA CCGACATATT TACGTTTATA GAGAAAATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00917--MATH
PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPBC713.02c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000761	Aegilops tauschii	34.33	2.00e-144	504.00
IUUC-Aml-002408	Ailuropoda melanoleuca	34.45	2.00e-160	558.00
IUUC-Atr-003067	Amborella trichopoda	36.11	7.00e-123	432.00
IUUC-Apl-003558	Anas platyrhynchos	34.56	5.00e-166	576.00
IUUC-Aca-004518	Anolis carolinensis	34.14	2.00e-158	551.00
IUUC-Aly-006427	Arabidopsis lyrata	36.77	4.00e-159	553.00
IUUC-Ath-006591	Arabidopsis thaliana	36.38	1.00e-156	545.00
IUUC-Ago-007849	Ashbya gossypii	35.65	0.00e+00	639.00
IUUC-Acl-008327	Aspergillus clavatus	43.32	0.00e+00	868.00
IUUC-Afl-008491	Aspergillus flavus	43.18	0.00e+00	844.00
IUUC-Afu-008804	Aspergillus fumigatus	43.60	0.00e+00	833.00
IUUC-Ani-009257	Aspergillus nidulans	29.66	8.00e-38	152.00
IUUC-Ang-009776	Aspergillus niger	42.96	0.00e+00	836.00
IUUC-Aor-009998	Aspergillus oryzae	42.28	0.00e+00	810.00
IUUC-Ate-010428	Aspergillus terreus	42.87	0.00e+00	846.00
IUUC-Ame-010903	Astyanax mexicanus	34.35	2.00e-164	571.00
IUUC-Bgr-012132	Blumeria graminis	38.36	0.00e+00	768.00
IUUC-Bta-013192	Bos taurus	34.54	1.00e-160	558.00
IUUC-Bci-013924	Botrytis cinerea	40.56	0.00e+00	799.00
IUUC-Bdi-015069	Brachypodium distachyon	35.63	3.00e-151	527.00
IUUC-Bol-015424	Brassica oleracea	36.21	2.00e-159	554.00
IUUC-Bra-017853	Brassica rapa	35.84	5.00e-158	550.00
IUUC-Cel-018219	Caenorhabditis elegans	30.39	6.00e-103	367.00
IUUC-Cja-019006	Callithrix jacchus	34.31	6.00e-158	549.00
IUUC-Cfa-020361	Canis familiaris	34.45	2.00e-160	558.00
IUUC-Cpo-022320	Cavia porcellus	34.54	3.00e-160	557.00
IUUC-Csa-024050	Chlorocebus sabaeus	34.45	4.00e-160	556.00
IUUC-Cho-024434	Choloepus hoffmanni	29.73	7.00e-89	320.00
IUUC-Cin-025689	Ciona intestinalis	33.52	8.00e-153	532.00
IUUC-Csv-025963	Ciona savignyi	32.62	7.00e-146	509.00
IUUC-Cgl-026650	Colletotrichum gloeosporioides	40.59	0.00e+00	796.00
IUUC-Cne-026968	Cryptococcus neoformans	42.59	0.00e+00	849.00
IUUC-Cme-027103	Cyanidioschyzon merolae	39.01	4.00e-113	401.00
IUUC-Dre-028510	Danio rerio	34.53	1.00e-165	575.00
IUUC-Dno-029696	Dasypus novemcinctus	34.54	1.00e-159	555.00
IUUC-Dor-030611	Dipodomys ordii	49.35	8.00e-73	266.00
IUUC-Dse-031433	Dothistroma septosporum	40.26	0.00e+00	795.00
IUUC-Dme-031583	Drosophila melanogaster	33.18	2.00e-141	494.00
IUUC-Ete-033191	Echinops telfairi	34.08	6.00e-155	539.00
IUUC-Eca-034122	Equus caballus	34.63	3.00e-161	560.00
IUUC-Eeu-035292	Erinaceus europaeus	35.21	2.00e-61	228.00
IUUC-Fca-036377	Felis catus	34.45	1.00e-160	558.00
IUUC-Fal-036964	Ficedula albicollis	34.54	6.00e-166	576.00
IUUC-Fox-037695	Fusarium oxysporum	41.26	0.00e+00	827.00
IUUC-Fso-038084	Fusarium solani	40.14	0.00e+00	806.00
IUUC-Gmo-038644	Gadus morhua	34.57	4.00e-167	580.00
IUUC-Ggr-040029	Gaeumannomyces graminis	41.06	0.00e+00	813.00
IUUC-Gga-040944	Gallus gallus	34.63	4.00e-167	580.00
IUUC-Gac-041740	Gasterosteus aculeatus	34.57	4.00e-167	580.00
IUUC-Gma-043081	Glycine max	35.59	1.00e-153	535.00
IUUC-Ggo-044947	Gorilla gorilla	34.45	3.00e-160	557.00
IUUC-Hsa-046278	Homo sapiens	34.45	4.00e-160	556.00
IUUC-Hvu-047749	Hordeum vulgare	36.31	3.00e-140	490.00
IUUC-Itr-047904	Ictidomys tridecemlineatus	36.67	3.00e-152	530.00
IUUC-Kpa-049121	Komagataella pastoris	36.14	0.00e+00	667.00
IUUC-Lch-049847	Latimeria chalumnae	34.27	2.00e-166	577.00
IUUC-Lpe-051543	Leersia perrieri	34.66	1.00e-145	509.00
IUUC-Lma-053169	Leptosphaeria maculans	40.05	0.00e+00	813.00
IUUC-Laf-053566	Loxodonta africana	34.54	1.00e-160	558.00
IUUC-Mcc-055549	Macaca mulatta	34.45	5.00e-160	556.00
IUUC-Meu-056887	Macropus eugenii	27.79	2.00e-64	239.00
IUUC-Mor-057149	Magnaporthe oryzae	39.76	0.00e+00	798.00
IUUC-Mpo-057536	Magnaporthe poae	40.31	0.00e+00	806.00
IUUC-Mtr-058583	Medicago truncatula	35.73	3.00e-154	537.00
IUUC-Mla-058899	Melampsora laricipopulina	41.51	0.00e+00	806.00
IUUC-Mga-060148	Meleagris gallopavo	34.63	5.00e-167	579.00
IUUC-Mvi-060207	Microbotryum violaceum	42.87	0.00e+00	868.00
IUUC-Mmr-060946	Microcebus murinus	34.54	1.00e-160	558.00
IUUC-Mdo-062079	Monodelphis domestica	35.93	2.00e-147	514.00
IUUC-Mmu-063678	Mus musculus	34.72	7.00e-160	556.00
IUUC-Mac-064796	Musa acuminata	36.36	7.00e-153	533.00
IUUC-Mpu-066744	Mustela putorius furo	34.45	7.00e-161	559.00
IUUC-Mlu-067949	Myotis lucifugus	34.77	7.00e-160	556.00
IUUC-Nfi-068342	Neosartorya fischeri	43.65	0.00e+00	836.00
IUUC-Ncr-068818	Neurospora crassa	41.39	0.00e+00	811.00
IUUC-Nle-070064	Nomascus leucogenys	34.45	4.00e-160	556.00
IUUC-Opr-071001	Ochotona princeps	35.34	4.00e-140	490.00
IUUC-Ont-072095	Oreochromis niloticus	34.17	4.00e-164	570.00
IUUC-Oan-073483	Ornithorhynchus anatinus	34.72	4.00e-160	556.00
IUUC-Ocu-073967	Oryctolagus cuniculus	34.60	7.00e-158	549.00
IUUC-Oba-075811	Oryza barthii	33.90	6.00e-138	483.00
IUUC-Obr-076857	Oryza brachyantha	35.97	5.00e-152	530.00
IUUC-Ogl-077038	Oryza glaberrima	35.68	6.00e-152	530.00
IUUC-Ogu-078130	Oryza glumaepatula	33.88	3.00e-135	474.00
IUUC-Oin-079513	Oryza indica	35.32	4.00e-143	500.00
IUUC-Olo-081067	Oryza longistaminata	33.90	7.00e-138	483.00
IUUC-Ome-081879	Oryza meridionalis	35.86	5.00e-146	509.00
IUUC-Oni-082461	Oryza nivara	34.08	8.00e-140	489.00
IUUC-Opu-083199	Oryza punctata	35.42	5.00e-145	506.00
IUUC-Oru-084739	Oryza rufipogon	33.85	9.00e-136	476.00
IUUC-Osa-085418	Oryza sativa	35.09	3.00e-132	464.00
IUUC-Ola-086640	Oryzias latipes	34.57	2.00e-166	577.00
IUUC-Oga-089059	Otolemur garnettii	32.44	3.00e-137	481.00
IUUC-Oar-089710	Ovis aries	34.54	5.00e-161	560.00
IUUC-Ptr-091334	Pan troglodytes	34.45	3.00e-160	557.00
IUUC-Pan-091717	Papio anubis	34.45	3.00e-160	557.00
IUUC-Psi-093933	Pelodiscus sinensis	34.56	6.00e-167	579.00
IUUC-Pma-094648	Petromyzon marinus	34.62	2.00e-158	551.00
IUUC-Pno-095020	Phaeosphaeria nodorum	38.51	0.00e+00	716.00
IUUC-Ppa-095922	Physcomitrella patens	34.73	4.00e-151	526.00
IUUC-Pfo-096181	Poecilia formosa	34.35	3.00e-165	574.00
IUUC-Pab-098231	Pongo abelii	33.00	3.00e-147	514.00
IUUC-Pop-100083	Populus trichocarpa	36.23	4.00e-155	540.00
IUUC-Pca-100543	Procavia capensis	34.94	1.00e-89	322.00
IUUC-Ppe-101847	Prunus persica	36.28	2.00e-151	528.00
IUUC-Pva-102472	Pteropus vampyrus	34.08	3.00e-154	537.00
IUUC-Pgr-103463	Puccinia graminis	40.95	0.00e+00	806.00
IUUC-Ptt-103716	Puccinia triticina	41.98	0.00e+00	778.00
IUUC-Pte-104360	Pyrenophora teres	40.76	0.00e+00	762.00
IUUC-Pyt-104581	Pyrenophora triticirepentis	40.94	0.00e+00	766.00
IUUC-Rno-105816	Rattus norvegicus	34.63	1.00e-160	558.00
IUUC-Sce-106230	Saccharomyces cerevisiae	43.91	8.00e-152	529.00
IUUC-Sha-107439	Sarcophilus harrisii	34.72	7.00e-160	556.00
IUUC-Sja-107690	Schizosaccharomyces japonicus	56.60	0.00e+00	1277.00
IUUC-Smo-109308	Selaginella moellendorffii	35.09	3.00e-152	530.00
IUUC-Sit-110367	Setaria italica	36.25	1.00e-156	545.00
IUUC-Sly-111774	Solanum lycopersicum	35.98	1.00e-157	548.00
IUUC-Stu-112387	Solanum tuberosum	36.57	5.00e-159	553.00
IUUC-Sar-113685	Sorex araneus	34.36	3.00e-157	547.00
IUUC-Sbi-114424	Sorghum bicolor	35.51	3.00e-151	527.00
IUUC-Sre-115156	Sporisorium reilianum	43.16	0.00e+00	874.00
IUUC-Ssc-116297	Sus scrofa	34.63	5.00e-161	560.00
IUUC-Tgu-116767	Taeniopygia guttata	34.47	1.00e-164	572.00
IUUC-Tru-118208	Takifugu rubripes	34.06	2.00e-163	567.00
IUUC-Tsy-119277	Tarsius syrichta	39.29	5.00e-67	247.00
IUUC-Tni-119890	Tetraodon nigroviridis	34.15	6.00e-164	569.00
IUUC-Tca-121501	Theobroma cacao	36.64	2.00e-156	544.00
IUUC-Tre-122169	Trichoderma reesei	40.56	0.00e+00	787.00
IUUC-Tvi-122600	Trichoderma virens	41.33	0.00e+00	814.00
IUUC-Tae-125264	Triticum aestivum	35.51	2.00e-152	531.00
IUUC-Tur-126287	Triticum urartu	34.64	8.00e-148	516.00
IUUC-Tme-127045	Tuber melanosporum	41.91	0.00e+00	861.00
IUUC-Tbe-127696	Tupaia belangeri	39.28	2.00e-63	235.00
IUUC-Ttr-129161	Tursiops truncatus	34.54	5.00e-159	553.00
IUUC-Uma-129535	Ustilago maydis	43.37	0.00e+00	895.00
IUUC-Vda-129708	Verticillium dahliae	40.48	0.00e+00	818.00
IUUC-Vpa-130141	Vicugna pacos	32.92	1.00e-51	196.00
IUUC-Vvi-130882	Vitis vinifera	36.64	1.00e-151	529.00
IUUC-Xtr-132073	Xenopus tropicalis	33.93	4.00e-160	556.00
IUUC-Xma-133949	Xiphophorus maculatus	34.44	3.00e-165	574.00
IUUC-Yli-134527	Yarrowia lipolytica	39.33	0.00e+00	723.00
IUUC-Zma-135550	Zea mays	35.54	4.00e-158	550.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence