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Tag Content
iUUCD ID IUUC-Tru-118598
Ensembl Protein ID ENSTRUP00000021380.1
UniProt Accession H2T9P0; H2T9P0_TAKRU
Protein Name Ubiquitin-related modifier 1
Gene Name urm1; URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTRUG00000008530.1 ENSTRUT00000021468.1 ENSTRUP00000021380.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 37.36 4.00e-13 67.40 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Takifugu rubripes
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
SGGAELLFNG VKEHQVTLPG QSEPWDMKQL LVWIQQNLLK ERPELFVQGQ SVRPGILVLI 60
NDADWELMGE LGYQLQDRDN VVFISTLHGG
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Protein Fasta Sequence


>IUUC-Tru-118598|ULD,UBQ_Other|Takifugu rubripes
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Nucleotide Sequence
(Fasta)
AGTGGTGGAG CAGAGCTGCT TTTTAATGGT GTGAAGGAAC ATCAGGTGAC TCTTCCAGGC 60
CAGTCTGAAC CCTGTGAGTA TGTGTGTGTT CACCTATGAG CTCCTCTTCC TTTTGCTTTA 120
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Nucleotide Fasta Sequence


>IUUC-Tru-118598|ULD,UBQ_Other|Takifugu rubripes
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 80.90 2.00e-40 156.00
IUUC-Atr-003089 Amborella trichopoda 59.34 3.00e-28 115.00
IUUC-Apl-003382 Anas platyrhynchos 82.02 8.00e-40 154.00
IUUC-Aca-004981 Anolis carolinensis 82.02 2.00e-40 156.00
IUUC-Aly-005517 Arabidopsis lyrata 56.52 1.00e-27 114.00
IUUC-Ath-006718 Arabidopsis thaliana 55.95 6.00e-24 101.00
IUUC-Ago-007917 Ashbya gossypii 41.76 5.00e-17 79.00
IUUC-Acl-008054 Aspergillus clavatus 68.00 1.00e-15 74.30
IUUC-Afl-008704 Aspergillus flavus 53.33 4.00e-20 89.00
IUUC-Aor-009890 Aspergillus oryzae 53.68 7.00e-22 95.50
IUUC-Bta-012448 Bos taurus 82.02 1.00e-40 157.00
IUUC-Bci-013865 Botrytis cinerea 44.68 2.00e-19 87.00
IUUC-Bdi-014980 Brachypodium distachyon 68.75 3.00e-23 99.80
IUUC-Bol-016055 Brassica oleracea 56.58 3.00e-23 99.80
IUUC-Bra-016845 Brassica rapa 56.58 3.00e-23 99.80
IUUC-Cel-018485 Caenorhabditis elegans 32.98 1.00e-08 51.20
IUUC-Cja-019587 Callithrix jacchus 83.15 1.00e-40 157.00
IUUC-Cfa-020653 Canis familiaris 80.90 2.00e-40 156.00
IUUC-Cpo-021622 Cavia porcellus 83.15 1.00e-40 157.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 56.04 1.00e-23 100.00
IUUC-Csa-023756 Chlorocebus sabaeus 82.09 2.00e-29 121.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 45.74 4.00e-20 89.70
IUUC-Cne-026953 Cryptococcus neoformans 55.79 7.00e-25 105.00
IUUC-Cme-027314 Cyanidioschyzon merolae 50.79 4.00e-15 72.00
IUUC-Dre-027884 Danio rerio 84.27 1.00e-40 157.00
IUUC-Dno-029262 Dasypus novemcinctus 77.94 4.00e-28 117.00
IUUC-Dor-030601 Dipodomys ordii 69.23 2.00e-19 86.30
IUUC-Dme-031893 Drosophila melanogaster 62.22 2.00e-28 117.00
IUUC-Ete-032773 Echinops telfairi 79.55 5.00e-39 151.00
IUUC-Eca-034187 Equus caballus 82.02 1.00e-40 156.00
IUUC-Eeu-034808 Erinaceus europaeus 77.53 4.00e-39 152.00
IUUC-Fca-036107 Felis catus 80.90 9.00e-41 157.00
IUUC-Fal-036607 Ficedula albicollis 82.02 1.00e-39 153.00
IUUC-Fox-037698 Fusarium oxysporum 48.94 1.00e-21 94.40
IUUC-Gmo-039492 Gadus morhua 87.64 8.00e-42 160.00
IUUC-Ggr-039965 Gaeumannomyces graminis 48.94 3.00e-18 84.00
IUUC-Gga-041268 Gallus gallus 83.15 2.00e-40 156.00
IUUC-Gac-042111 Gasterosteus aculeatus 88.76 3.00e-42 162.00
IUUC-Gma-043240 Glycine max 67.19 4.00e-23 99.00
IUUC-Ggo-045176 Gorilla gorilla 79.10 3.00e-22 97.10
IUUC-Hsa-046077 Homo sapiens 79.78 2.00e-33 133.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 82.02 1.00e-33 133.00
IUUC-Kpa-049157 Komagataella pastoris 49.45 1.00e-18 84.30
IUUC-Lch-049889 Latimeria chalumnae 79.78 3.00e-40 155.00
IUUC-Lpe-050783 Leersia perrieri 57.14 1.00e-21 94.00
IUUC-Loc-052400 Lepisosteus oculatus 82.02 9.00e-40 154.00
IUUC-Lma-053259 Leptosphaeria maculans 47.87 9.00e-19 84.70
IUUC-Laf-053596 Loxodonta africana 82.42 1.00e-39 154.00
IUUC-Mcc-054845 Macaca mulatta 80.90 4.00e-40 155.00
IUUC-Meu-055968 Macropus eugenii 80.90 5.00e-40 155.00
IUUC-Mor-057126 Magnaporthe oryzae 47.87 4.00e-18 83.20
IUUC-Mpo-057311 Magnaporthe poae 48.94 3.00e-19 87.00
IUUC-Mtr-058266 Medicago truncatula 64.06 6.00e-22 95.10
IUUC-Mla-058847 Melampsora laricipopulina 40.00 9.00e-11 58.50
IUUC-Mga-059468 Meleagris gallopavo 83.15 2.00e-40 155.00
IUUC-Mvi-060235 Microbotryum violaceum 54.79 6.00e-17 79.70
IUUC-Mdo-061948 Monodelphis domestica 79.78 2.00e-39 153.00
IUUC-Mmu-063946 Mus musculus 80.90 4.00e-40 155.00
IUUC-Mac-064812 Musa acuminata 63.89 2.00e-24 103.00
IUUC-Mpu-066763 Mustela putorius furo 80.90 1.00e-39 153.00
IUUC-Mlu-066970 Myotis lucifugus 83.58 8.00e-30 120.00
IUUC-Ncr-068824 Neurospora crassa 48.94 2.00e-19 87.40
IUUC-Nle-069849 Nomascus leucogenys 80.60 4.00e-29 119.00
IUUC-Opr-070227 Ochotona princeps 83.15 1.00e-40 157.00
IUUC-Ont-072530 Oreochromis niloticus 92.13 9.00e-44 167.00
IUUC-Oan-073191 Ornithorhynchus anatinus 79.78 1.00e-39 154.00
IUUC-Ocu-074460 Oryctolagus cuniculus 82.02 9.00e-41 157.00
IUUC-Oba-075499 Oryza barthii 67.19 7.00e-22 96.30
IUUC-Obr-076896 Oryza brachyantha 65.62 1.00e-21 96.30
IUUC-Ogl-077834 Oryza glaberrima 67.19 2.00e-22 96.70
IUUC-Ogu-078622 Oryza glumaepatula 67.19 2.00e-22 96.70
IUUC-Oin-079358 Oryza indica 67.19 7.00e-22 96.70
IUUC-Olo-081035 Oryza longistaminata 55.21 1.00e-22 99.00
IUUC-Oni-082425 Oryza nivara 67.19 2.00e-22 96.70
IUUC-Opu-083461 Oryza punctata 66.67 1.00e-21 95.10
IUUC-Oru-084875 Oryza rufipogon 60.56 2.00e-20 89.70
IUUC-Oga-089128 Otolemur garnettii 82.02 2.00e-40 156.00
IUUC-Oar-089896 Ovis aries 82.02 1.00e-40 157.00
IUUC-Ptr-091618 Pan troglodytes 79.10 3.00e-22 97.10
IUUC-Pan-092238 Papio anubis 82.09 2.00e-29 121.00
IUUC-Psi-093879 Pelodiscus sinensis 80.90 1.00e-39 154.00
IUUC-Pma-094484 Petromyzon marinus 73.42 4.00e-31 125.00
IUUC-Ppa-095801 Physcomitrella patens 58.97 1.00e-22 97.40
IUUC-Pfo-097192 Poecilia formosa 88.76 1.00e-42 163.00
IUUC-Pab-098203 Pongo abelii 79.78 2.00e-33 133.00
IUUC-Pop-099614 Populus trichocarpa 55.95 3.00e-23 99.40
IUUC-Pca-100507 Procavia capensis 82.09 1.00e-29 120.00
IUUC-Ppe-101174 Prunus persica 59.34 2.00e-26 110.00
IUUC-Pva-102735 Pteropus vampyrus 82.02 2.00e-37 146.00
IUUC-Pgr-103510 Puccinia graminis 37.89 2.00e-09 54.30
IUUC-Ptt-103918 Puccinia triticina 36.84 7.00e-09 52.40
IUUC-Pte-104173 Pyrenophora teres 48.94 2.00e-20 90.10
IUUC-Pyt-104806 Pyrenophora triticirepentis 48.94 3.00e-20 89.70
IUUC-Rno-105820 Rattus norvegicus 82.02 2.00e-40 156.00
IUUC-Sce-106366 Saccharomyces cerevisiae 37.36 1.00e-13 67.40
IUUC-Sja-107727 Schizosaccharomyces japonicus 44.94 5.00e-16 75.90
IUUC-Spo-108074 Schizosaccharomyces pombe 42.39 1.00e-09 53.90
IUUC-Smo-108944 Selaginella moellendorffii 62.92 5.00e-27 111.00
IUUC-Sit-110277 Setaria italica 58.82 2.00e-23 100.00
IUUC-Sly-111505 Solanum lycopersicum 54.76 3.00e-23 99.80
IUUC-Stu-112076 Solanum tuberosum 55.95 1.00e-23 100.00
IUUC-Sbi-114274 Sorghum bicolor 59.74 3.00e-23 99.80
IUUC-Sre-114953 Sporisorium reilianum 57.45 7.00e-23 98.60
IUUC-Ssc-115418 Sus scrofa 82.02 2.00e-40 156.00
IUUC-Tgu-117311 Taeniopygia guttata 82.02 1.00e-39 153.00
IUUC-Tni-120109 Tetraodon nigroviridis 93.33 2.00e-42 163.00
IUUC-Tca-120942 Theobroma cacao 55.42 3.00e-23 99.40
IUUC-Tre-122099 Trichoderma reesei 47.87 7.00e-16 74.70
IUUC-Tvi-122285 Trichoderma virens 50.00 4.00e-17 79.30
IUUC-Tae-125193 Triticum aestivum 67.19 3.00e-22 96.30
IUUC-Tur-126677 Triticum urartu 56.58 9.00e-20 88.20
IUUC-Tme-127120 Tuber melanosporum 47.87 1.00e-19 87.80
IUUC-Tbe-128050 Tupaia belangeri 59.55 1.00e-23 101.00
IUUC-Ttr-129019 Tursiops truncatus 78.65 3.00e-37 145.00
IUUC-Uma-129483 Ustilago maydis 55.32 2.00e-20 90.10
IUUC-Vda-129690 Verticillium dahliae 39.29 3.00e-16 76.30
IUUC-Vvi-131174 Vitis vinifera 56.63 5.00e-23 98.60
IUUC-Xma-133862 Xiphophorus maculatus 88.76 1.00e-42 163.00
IUUC-Yli-134398 Yarrowia lipolytica 47.83 1.00e-17 80.90
IUUC-Zma-134964 Zea mays 56.47 3.00e-22 96.30
Created Date 25-Jun-2017

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