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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-007237
Ensembl Protein ID AT1G80070.1
UniProt Accession Q9SSD2; PRP8A_ARATH
Genbank Protein ID AAD55467.1; AEE36353.1
Protein Name Pre-mRNA-processing-splicing factor 8A; PRP8 homolog A; Protein ABNORMAL SUSPENSOR 2; Protein EMBRYO DEFECTIVE 14; Protein EMBRYO DEFECTIVE 177; Protein EMBRYO DEFECTIVE 33; Protein SUPPRESSOR OF OVEREXPRESSED FCA 81
Genbank Nucleotide ID AC009322; CP002684
Gene Name PRP8A; EMB14; EMB177; EMB33; SOF81; SUS2; At1g80070; F18B13.15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G80070 AT1G80070.1 AT1G80070.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
Protein-protein Interaction
iRefIndexMentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Jab_MPN 61.99 0.00e+00 2941.00 IUUC-Sce-106157
UBD/Jab_MPN 61.95 0.00e+00 2940.00 IUUC-Ots-000011
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex (By similarity). Required for embryo development (Ref.3). Required for splicing efficiency of COOLAIR introns and usage of the proximal poly(A) site. COOLAIR is a set of long non-coding antisense transcripts produced at the FLOWERING LOCUS C (FLC). COOLAIR initiates just downstream of the major sense transcript poly(A) site and terminates either early or extends into the FLC promoter region. Splicing of COOLAIR by PRP8A is functionally important for FLC regulation (PubMed:24725596).
 Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex (By similarity). Required for embryo development (Ref.3). Required for splicing efficiency of COOLAIR introns and usage of the proximal poly(A) site. COOLAIR is a set of long non-coding antisense transcripts produced at the FLOWERING LOCUS C (FLC). COOLAIR initiates just downstream of the major sense transcript poly(A) site and terminates either early or extends into the FLC promoter region. Splicing of COOLAIR by PRP8A is functionally important for FLC regulation (PubMed:24725596).
Protein Sequence
(Fasta)
MWNNNDGMPL APPGTGGSMM PPPPAAHPSY TALPPPSNPT PPVEPTPEEA EAKLEEKARK 60
WMQLNSKRYG DKRKFGFVET QKEDMPPEHV RKIIRDHGDM SSKKFRHDKR VYLGALKFVP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-007237|UBD,Jab_MPN|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
CTGATCTGCT GATATAAGGC CGAACGGGAA TAAAAAAAAA AAAAAAGGAA GAAGCGACTC 60
ACCCGAAAAT GTTTTAGGGT TTTTCTTTAC TCGATTAAGC TCACTAGTTC TTCGCAACGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-007237|UBD,Jab_MPN|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0747--Spliceosome
Interpro

IPR000555--JAMM/MPN+_dom
IPR012591--PRO8NT
IPR012592--PROCN
IPR012984--PROCT
IPR027652--PRP8
IPR021983--PRP8_domainIV
IPR019581--Prp8_U5-snRNA-bd
IPR019580--Prp8_U6-snRNA-bd
IPR012337--RNaseH-like_dom
IPR019582--RRM_spliceosomal_PrP8
Pfam

PF01398--JAB
PF08082--PRO8NT
PF08083--PROCN
PF08084--PROCT
PF12134--PRP8_domainIV
PF10598--RRM_4
PF10597--U5_2-snRNA_bdg
PF10596--U6-snRNA_bdg
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0005681--C:spliceosomal complex
GO:0030623--F:U5 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0000398--P:mRNA splicing, via spliceosome
KEGG ath:AT1G80070
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001091 Aegilops tauschii 94.21 0.00e+00 4392.00
IUUC-Aml-002261 Ailuropoda melanoleuca 83.58 0.00e+00 3984.00
IUUC-Atr-002524 Amborella trichopoda 95.44 0.00e+00 4496.00
IUUC-Apl-004039 Anas platyrhynchos 83.55 0.00e+00 3879.00
IUUC-Aca-005394 Anolis carolinensis 84.34 0.00e+00 3239.00
IUUC-Aly-005909 Arabidopsis lyrata 98.07 0.00e+00 4610.00
IUUC-Ago-007815 Ashbya gossypii 62.41 0.00e+00 3049.00
IUUC-Acl-008111 Aspergillus clavatus 72.04 0.00e+00 3512.00
IUUC-Afl-008609 Aspergillus flavus 71.89 0.00e+00 2137.00
IUUC-Afu-009078 Aspergillus fumigatus 73.31 0.00e+00 2328.00
IUUC-Ani-009297 Aspergillus nidulans 72.72 0.00e+00 2293.00
IUUC-Ang-009749 Aspergillus niger 72.16 0.00e+00 3533.00
IUUC-Aor-010106 Aspergillus oryzae 72.29 0.00e+00 3526.00
IUUC-Ate-010566 Aspergillus terreus 72.21 0.00e+00 3518.00
IUUC-Ame-011416 Astyanax mexicanus 83.45 0.00e+00 4017.00
IUUC-Bgr-012078 Blumeria graminis 70.17 0.00e+00 2207.00
IUUC-Bta-013532 Bos taurus 83.58 0.00e+00 3984.00
IUUC-Bci-013914 Botrytis cinerea 73.20 0.00e+00 2324.00
IUUC-Bdi-014349 Brachypodium distachyon 94.23 0.00e+00 4435.00
IUUC-Bol-015707 Brassica oleracea 97.63 0.00e+00 4633.00
IUUC-Bra-017086 Brassica rapa 96.83 0.00e+00 4608.00
IUUC-Cel-018508 Caenorhabditis elegans 80.45 0.00e+00 3876.00
IUUC-Cja-019483 Callithrix jacchus 83.58 0.00e+00 3984.00
IUUC-Cfa-021018 Canis familiaris 83.58 0.00e+00 3984.00
IUUC-Cpo-022159 Cavia porcellus 83.58 0.00e+00 3984.00
IUUC-Cre-022998 Chlamydomonas reinhardtii 85.13 0.00e+00 4049.00
IUUC-Csa-023885 Chlorocebus sabaeus 83.58 0.00e+00 3984.00
IUUC-Cho-024639 Choloepus hoffmanni 84.52 0.00e+00 2341.00
IUUC-Cin-025356 Ciona intestinalis 70.76 0.00e+00 636.00
IUUC-Csv-025880 Ciona savignyi 81.06 0.00e+00 3926.00
IUUC-Cgl-026713 Colletotrichum gloeosporioides 69.35 0.00e+00 3393.00
IUUC-Cne-026874 Cryptococcus neoformans 73.84 0.00e+00 2180.00
IUUC-Cme-027252 Cyanidioschyzon merolae 34.73 0.00e+00 956.00
IUUC-Dre-027996 Danio rerio 83.41 0.00e+00 4019.00
IUUC-Dno-029708 Dasypus novemcinctus 84.90 0.00e+00 3729.00
IUUC-Dor-030119 Dipodomys ordii 80.17 0.00e+00 3577.00
IUUC-Dse-031333 Dothistroma septosporum 72.03 0.00e+00 3464.00
IUUC-Dme-031908 Drosophila melanogaster 83.11 0.00e+00 3956.00
IUUC-Ete-032766 Echinops telfairi 79.76 0.00e+00 3763.00
IUUC-Eca-034109 Equus caballus 83.58 0.00e+00 3984.00
IUUC-Eeu-035094 Erinaceus europaeus 84.73 0.00e+00 2053.00
IUUC-Fca-035567 Felis catus 85.94 0.00e+00 3328.00
IUUC-Fal-036613 Ficedula albicollis 83.67 0.00e+00 3989.00
IUUC-Fox-037855 Fusarium oxysporum 71.24 0.00e+00 3475.00
IUUC-Fso-038078 Fusarium solani 70.89 0.00e+00 3459.00
IUUC-Gmo-038986 Gadus morhua 82.28 0.00e+00 3961.00
IUUC-Ggr-039855 Gaeumannomyces graminis 70.10 0.00e+00 3417.00
IUUC-Gga-040719 Gallus gallus 83.67 0.00e+00 3989.00
IUUC-Gac-042502 Gasterosteus aculeatus 83.05 0.00e+00 4005.00
IUUC-Gma-043317 Glycine max 95.27 0.00e+00 4484.00
IUUC-Ggo-045622 Gorilla gorilla 79.24 0.00e+00 3709.00
IUUC-Hsa-046060 Homo sapiens 83.58 0.00e+00 3984.00
IUUC-Hvu-047251 Hordeum vulgare 95.13 0.00e+00 4131.00
IUUC-Itr-048517 Ictidomys tridecemlineatus 81.88 0.00e+00 1995.00
IUUC-Kpa-049289 Komagataella pastoris 64.22 0.00e+00 3114.00
IUUC-Lch-049690 Latimeria chalumnae 82.81 0.00e+00 3693.00
IUUC-Lpe-050868 Leersia perrieri 92.80 0.00e+00 4404.00
IUUC-Loc-052365 Lepisosteus oculatus 83.24 0.00e+00 4007.00
IUUC-Lma-053043 Leptosphaeria maculans 71.90 0.00e+00 3549.00
IUUC-Laf-053582 Loxodonta africana 83.58 0.00e+00 3984.00
IUUC-Mcc-055024 Macaca mulatta 83.58 0.00e+00 3984.00
IUUC-Meu-056637 Macropus eugenii 82.02 0.00e+00 3894.00
IUUC-Mor-057244 Magnaporthe oryzae 70.82 0.00e+00 3400.00
IUUC-Mpo-057580 Magnaporthe poae 70.27 0.00e+00 3423.00
IUUC-Mtr-058326 Medicago truncatula 95.36 0.00e+00 4514.00
IUUC-Mla-059121 Melampsora laricipopulina 74.36 0.00e+00 3489.00
IUUC-Mga-059789 Meleagris gallopavo 83.67 0.00e+00 3989.00
IUUC-Mvi-060563 Microbotryum violaceum 73.01 0.00e+00 3483.00
IUUC-Mmr-060880 Microcebus murinus 82.58 0.00e+00 3919.00
IUUC-Mdo-062237 Monodelphis domestica 83.49 0.00e+00 3981.00
IUUC-Mmu-064177 Mus musculus 83.67 0.00e+00 3986.00
IUUC-Mac-065558 Musa acuminata 92.66 0.00e+00 4281.00
IUUC-Mpu-066903 Mustela putorius furo 83.58 0.00e+00 3984.00
IUUC-Mlu-067424 Myotis lucifugus 83.43 0.00e+00 3974.00
IUUC-Nfi-068265 Neosartorya fischeri 73.26 0.00e+00 2321.00
IUUC-Ncr-068963 Neurospora crassa 71.23 0.00e+00 3484.00
IUUC-Nle-069111 Nomascus leucogenys 84.80 0.00e+00 2858.00
IUUC-Opr-070706 Ochotona princeps 82.92 0.00e+00 3890.00
IUUC-Ont-071405 Oreochromis niloticus 83.62 0.00e+00 4015.00
IUUC-Oan-073481 Ornithorhynchus anatinus 85.89 0.00e+00 1974.00
IUUC-Ocu-074231 Oryctolagus cuniculus 83.58 0.00e+00 3984.00
IUUC-Oba-075452 Oryza barthii 94.03 0.00e+00 4368.00
IUUC-Obr-076377 Oryza brachyantha 93.94 0.00e+00 4371.00
IUUC-Ogl-077666 Oryza glaberrima 94.05 0.00e+00 4424.00
IUUC-Ogu-078187 Oryza glumaepatula 94.07 0.00e+00 4370.00
IUUC-Oin-079234 Oryza indica 93.94 0.00e+00 4368.00
IUUC-Olo-080543 Oryza longistaminata 94.03 0.00e+00 4368.00
IUUC-Ome-081541 Oryza meridionalis 93.53 0.00e+00 4385.00
IUUC-Oni-082712 Oryza nivara 95.68 0.00e+00 3519.00
IUUC-Opu-083904 Oryza punctata 93.92 0.00e+00 4412.00
IUUC-Oru-084749 Oryza rufipogon 94.05 0.00e+00 4421.00
IUUC-Osa-085504 Oryza sativa 93.54 0.00e+00 2210.00
IUUC-Ola-087464 Oryzias latipes 83.19 0.00e+00 3789.00
IUUC-Olu-087705 Ostreococcus lucimarinus 84.58 0.00e+00 4102.00
IUUC-Oga-087910 Otolemur garnettii 93.02 1.00e-70 257.00
IUUC-Oar-089892 Ovis aries 83.47 0.00e+00 3977.00
IUUC-Ptr-090562 Pan troglodytes 89.51 0.00e+00 871.00
IUUC-Pan-092555 Papio anubis 83.70 0.00e+00 3940.00
IUUC-Psi-094049 Pelodiscus sinensis 83.58 0.00e+00 3985.00
IUUC-Pma-094240 Petromyzon marinus 82.01 0.00e+00 3803.00
IUUC-Pno-095146 Phaeosphaeria nodorum 70.31 0.00e+00 3425.00
IUUC-Ppa-095776 Physcomitrella patens 93.80 0.00e+00 4438.00
IUUC-Pfo-097177 Poecilia formosa 83.62 0.00e+00 4012.00
IUUC-Pab-097961 Pongo abelii 83.58 0.00e+00 3984.00
IUUC-Pop-099731 Populus trichocarpa 95.66 0.00e+00 4523.00
IUUC-Pca-100655 Procavia capensis 83.37 0.00e+00 1449.00
IUUC-Ppe-101199 Prunus persica 93.57 0.00e+00 4406.00
IUUC-Pva-103175 Pteropus vampyrus 86.87 0.00e+00 3225.00
IUUC-Pgr-103467 Puccinia graminis 74.28 0.00e+00 3502.00
IUUC-Ptt-103770 Puccinia triticina 68.55 0.00e+00 3133.00
IUUC-Pte-104210 Pyrenophora teres 71.55 0.00e+00 3504.00
IUUC-Pyt-104572 Pyrenophora triticirepentis 72.62 0.00e+00 2295.00
IUUC-Rno-105997 Rattus norvegicus 83.67 0.00e+00 3986.00
IUUC-Sce-106157 Saccharomyces cerevisiae 62.02 0.00e+00 2993.00
IUUC-Sha-107355 Sarcophilus harrisii 83.45 0.00e+00 3979.00
IUUC-Sja-107760 Schizosaccharomyces japonicus 73.10 0.00e+00 3469.00
IUUC-Spo-108160 Schizosaccharomyces pombe 73.56 0.00e+00 3523.00
IUUC-Ssl-108519 Sclerotinia sclerotiorum 73.39 0.00e+00 2319.00
IUUC-Smo-109278 Selaginella moellendorffii 93.15 0.00e+00 4406.00
IUUC-Sit-110777 Setaria italica 94.01 0.00e+00 4434.00
IUUC-Sly-110889 Solanum lycopersicum 95.83 0.00e+00 4513.00
IUUC-Stu-112016 Solanum tuberosum 95.79 0.00e+00 4514.00
IUUC-Sar-113245 Sorex araneus 80.26 0.00e+00 2303.00
IUUC-Sbi-114423 Sorghum bicolor 92.94 0.00e+00 1962.00
IUUC-Sre-115077 Sporisorium reilianum 66.88 0.00e+00 3195.00
IUUC-Ssc-116211 Sus scrofa 83.44 0.00e+00 3850.00
IUUC-Tgu-116697 Taeniopygia guttata 83.67 0.00e+00 3989.00
IUUC-Tru-117984 Takifugu rubripes 83.54 0.00e+00 4021.00
IUUC-Tsy-118893 Tarsius syrichta 83.52 0.00e+00 1344.00
IUUC-Tni-120620 Tetraodon nigroviridis 85.07 0.00e+00 3024.00
IUUC-Tca-121331 Theobroma cacao 96.26 0.00e+00 4536.00
IUUC-Tre-122031 Trichoderma reesei 71.25 0.00e+00 3468.00
IUUC-Tvi-122603 Trichoderma virens 71.16 0.00e+00 3460.00
IUUC-Tae-125167 Triticum aestivum 94.23 0.00e+00 4443.00
IUUC-Tur-126772 Triticum urartu 94.25 0.00e+00 4404.00
IUUC-Tme-126899 Tuber melanosporum 72.45 0.00e+00 3545.00
IUUC-Tbe-127364 Tupaia belangeri 88.33 0.00e+00 2669.00
IUUC-Ttr-129009 Tursiops truncatus 83.06 0.00e+00 3949.00
IUUC-Vda-130015 Verticillium dahliae 70.78 0.00e+00 2276.00
IUUC-Vpa-130769 Vicugna pacos 86.83 0.00e+00 1053.00
IUUC-Vvi-131030 Vitis vinifera 95.61 0.00e+00 4508.00
IUUC-Xtr-132067 Xenopus tropicalis 83.54 0.00e+00 3989.00
IUUC-Xma-134252 Xiphophorus maculatus 83.57 0.00e+00 4011.00
IUUC-Yli-134434 Yarrowia lipolytica 65.56 0.00e+00 3127.00
IUUC-Zma-134994 Zea mays 93.97 0.00e+00 4412.00
Created Date 25-Jun-2017

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