iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-018077

Ensembl Protein ID

Bra025277.1-P

UniProt Accession

M4E921; M4E921_BRARP

Protein Name

Eukaryotic translation initiation factor 3 subunit I

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra025277	Bra025277.1	Bra025277.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-21	75.7	50	87
UBD/Beta-Prp	4.60e-43	148.5	6	218

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c++   d  +l++Gs D t k+WD++tg++l
   Q: 50   GHNGAVWCCDVsRDsSRLITGSADQTAKLWDVKTGTQL 87
           8***********77799******************987 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
           ++ h+ ++t + + +d+++l++  +d+t ++w +++g    ++ gh+++v++++ s+d++ l+tgs D+t+k+wd++tg+++ ++k  ++ ++s++
   Q: 6    MKGHERPLTFLRYNRDGDMLFSCAKDHTPTLWYADNGERHGTYRGHNGAVWCCDVSRDSSRLITGSADQTAKLWDVKTGTQLFSFK-FSSPARSVD 100
           44566677777777777777777777777777777777777777777777777777777777777777777777777777777777.777777777 PP
   S: 102  fspsgdklvsGshdrtirvwdletgqclee............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsv 183
           fs  ++  v++++  ++r   ++ +    +             + + ++ +n +v+ p ++ +vsG+ D ++r+Wd +tgkll++   + gh++ +
   Q: 101  FSVGDKLAVITTDPFMARTSAIHVKRIADDpqdqdgesvlvlENPEGRKRINRAVWGPLNQTIVSGGEDAVLRIWDAETGKLLKETdkEVGHKQTI 196
           77744555555555566666665555555599999999999766666789999*********************************99667***** PP
   S: 184  yslsfdsngkelvsgsldgtvk 205
           +sl  + +  ++++gsld+t k
   Q: 197  TSLCKSADDSHFLTGSLDKTAK 218
           *******************976 PP

Organism

Brassica rapa

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

Protein Sequence
(Fasta)

MRPILMKGHE RPLTFLRYNR DGDMLFSCAK DHTPTLWYAD NGERHGTYRG HNGAVWCCDV 60
SRDSSRLITG SADQTAKLWD VKTGTQLFSF KFSSPARSVD FSVGDKLAVI TTDPFMARTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGCCGA TATTGATGAA GGGACATGAA CGTCCATTGA CGTTCCTGAG GTACAACAGA 60
GATGGAGACA TGCTTTTCTC CTGCGCCAAG GATCACACTC CCACTCTCTG GTATGCCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR027525--eIF3i
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cel-018226	Caenorhabditis elegans	37.94	2.00e-66	245.00
IUUC-Cme-027304	Cyanidioschyzon merolae	49.42	3.00e-83	301.00
IUUC-Dor-030257	Dipodomys ordii	34.83	1.00e-28	119.00
IUUC-Mvi-060399	Microbotryum violaceum	42.15	4.00e-74	271.00
IUUC-Ome-081228	Oryza meridionalis	59.92	6.00e-77	280.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence